{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:26:59Z","timestamp":1792708019881,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","award":["J2020044"],"award-info":[{"award-number":["J2020044"]}],"id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jare.2023.03.008","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T14:02:56Z","timestamp":1680012176000},"page":"89-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice"],"prefix":"10.1016","volume":"52","author":[{"given":"Jiaxiu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-2661","authenticated-orcid":false,"given":"Xiaodong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2023.03.008_b0005","article-title":"Foodborne pathogens in the omics era","volume":"1\u201316","author":"Vieira","year":"2021","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0010","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12917-021-02900-2","article-title":"Prevalence, virulence factor and antimicrobial resistance analysis of Salmonella Enteritidis from poultry and egg samples in Iran","volume":"17","author":"Bahramianfard","year":"2021","journal-title":"BMC Vet Res"},{"issue":"2","key":"10.1016\/j.jare.2023.03.008_b0015","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"7183","key":"10.1016\/j.jare.2023.03.008_b0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jare.2023.03.008_b0025","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1084\/jem.20100257","article-title":"Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella","volume":"207","author":"Broz","year":"2010","journal-title":"J Exp Med"},{"issue":"7","key":"10.1016\/j.jare.2023.03.008_b0030","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1590\/0074-0276140154","article-title":"NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection","volume":"109","author":"Kamada","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0035","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.celrep.2018.03.097","article-title":"The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection","volume":"23","author":"Alhallaf","year":"2018","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.jare.2023.03.008_b0040","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41564-017-0095-1","article-title":"Sieving through gut models of colonization resistance","volume":"3","author":"Mullineaux-Sanders","year":"2018","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0045","doi-asserted-by":"crossref","first-page":"e00027","DOI":"10.1128\/MMBR.00027-19","article-title":"Salmonella versus the Microbiome","volume":"85","author":"Rogers","year":"2021","journal-title":"Microbiol Mol Biol Rev"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tim.2018.01.006","article-title":"Antibacterial Weapons: Targeted Destruction in the Microbiota","volume":"26","author":"Chassaing","year":"2018","journal-title":"Trends Microbiol"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0055","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.molcel.2020.03.001","article-title":"Immune-Microbiota Interplay and Colonization Resistance in Infection","volume":"78","author":"Leshem","year":"2020","journal-title":"Mol Cell"},{"issue":"7533","key":"10.1016\/j.jare.2023.03.008_b0060","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1084\/jem.20181639","article-title":"Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification","volume":"216","author":"Sorbara","year":"2019","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.jare.2023.03.008_b0070","doi-asserted-by":"crossref","first-page":"eaai7732","DOI":"10.1126\/sciimmunol.aai7732","article-title":"Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance","volume":"1","author":"Pedicord","year":"2016","journal-title":"Sci Immunol"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0075","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4161\/gmic.1.4.12778","article-title":"Mucin-bacterial interactions in the human oral cavity and digestive tract","volume":"1","author":"Derrien","year":"2010","journal-title":"Gut Microbes"},{"issue":"5","key":"10.1016\/j.jare.2023.03.008_b0080","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/19490976.2020.1737307","article-title":"Pasteurized increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice","volume":"11","author":"Depommier","year":"2020","journal-title":"Gut Microbes"},{"issue":"11","key":"10.1016\/j.jare.2023.03.008_b0085","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1136\/gutjnl-2019-320105","article-title":"A purified membrane protein from or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 T cells in mice","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"issue":"22","key":"10.1016\/j.jare.2023.03.008_b0090","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JME-16-0054","article-title":"Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice","volume":"58","author":"Zhao","year":"2017","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0105","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1039\/D1FO04094D","article-title":"A \u03b2-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila protects against dextran sulfate sodium-induced colitis in mice by enhancing intestinal barrier and modulating gut microbiota","volume":"13","author":"Qian","year":"2022","journal-title":"Food Funct"},{"key":"10.1016\/j.jare.2023.03.008_b0110","doi-asserted-by":"crossref","unstructured":"Jiang Y., Y. Xu, C. Zheng, L. Ye, P. Jiang, S. Malik, G. Xu, Q. Zhou and M. Zhang. Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment. Gut. 2023: gutjnl-2022-327853.","DOI":"10.1136\/gutjnl-2022-327853"},{"issue":"5","key":"10.1016\/j.jare.2023.03.008_b0115","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41564-021-00880-5","article-title":"Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice","volume":"6","author":"Yoon","year":"2021","journal-title":"Nat Microbiol"},{"issue":"7921","key":"10.1016\/j.jare.2023.03.008_b0120","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41586-022-04985-7","article-title":"Akkermansia muciniphila phospholipid induces homeostatic immune responses","volume":"608","author":"Bae","year":"2022","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jare.2023.03.008_b0125","doi-asserted-by":"crossref","first-page":"e74963","DOI":"10.1371\/journal.pone.0074963","article-title":"Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice","volume":"8","author":"Ganesh","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0130","doi-asserted-by":"crossref","first-page":"1972757","DOI":"10.1080\/19490976.2021.1972757","article-title":"Hyaluronan-induced alterations of the gut microbiome protects mice against Citrobacter rodentium infection and intestinal inflammation","volume":"13","author":"Mao","year":"2021","journal-title":"Gut Microbes"},{"issue":"Pt 5","key":"10.1016\/j.jare.2023.03.008_b0135","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1099\/ijs.0.02873-0","article-title":"Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium","volume":"54","author":"Derrien","year":"2004","journal-title":"Int J Syst Evol Microbiol"},{"issue":"2","key":"10.1016\/j.jare.2023.03.008_b0140","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chom.2018.07.002","article-title":"A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection","volume":"24","author":"Jacobson","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.jare.2023.03.008_b0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tim.2007.12.008","article-title":"The role of microbiota in infectious disease","volume":"16","author":"Stecher","year":"2008","journal-title":"Trends Microbiol"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0150","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1172\/JCI200519229","article-title":"Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity","volume":"115","author":"Smythies","year":"2005","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.jare.2023.03.008_b0155","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.chom.2009.05.002","article-title":"An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans","volume":"5","author":"Hise","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"9","key":"10.1016\/j.jare.2023.03.008_b0160","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.celrep.2019.04.106","article-title":"Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract","volume":"27","author":"Furter","year":"2019","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0165","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.chom.2016.02.021","article-title":"Host Selection of Microbiota via Differential Adhesion","volume":"19","author":"McLoughlin","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0170","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.jare.2023.03.008_b0175","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jare.2023.03.008_b0180","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1128\/IAI.06165-11","article-title":"Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice","volume":"80","author":"van Ampting","year":"2012","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0185","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/mi.2013.109","article-title":"REG3\u03b3-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum","volume":"7","author":"Loonen","year":"2014","journal-title":"Mucosal Immunol"},{"issue":"2","key":"10.1016\/j.jare.2023.03.008_b0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/19490976.2017.1387344","article-title":"Inflammatory bactericidal lectin RegIII\u03b2: Friend or foe for the host?","volume":"9","author":"Miki","year":"2018","journal-title":"Gut Microbes"},{"issue":"6","key":"10.1016\/j.jare.2023.03.008_b0195","doi-asserted-by":"crossref","first-page":"e00587","DOI":"10.1128\/mSystems.00587-20","article-title":"Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages","volume":"5","author":"Wu","year":"2020","journal-title":"mSystems"},{"issue":"21","key":"10.1016\/j.jare.2023.03.008_b0200","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.3390\/foods11213493","article-title":"Propionate and Butyrate Inhibit Biofilm Formation of Salmonella Typhimurium Grown in Laboratory Media and Food Models","volume":"11","author":"Liu","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.jare.2023.03.008_b0205","article-title":"Next-generation probiotics: the spectrum from probiotics to live biotherapeutics","volume":"2:17057","author":"O\u2019Toole","year":"2017","journal-title":"Nat Microbiol"},{"issue":"3","key":"10.1016\/j.jare.2023.03.008_b0210","doi-asserted-by":"crossref","first-page":"e1008448","DOI":"10.1371\/journal.ppat.1008448","article-title":"Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production","volume":"16","author":"Osbelt","year":"2020","journal-title":"PLoS Pathog"},{"issue":"5","key":"10.1016\/j.jare.2023.03.008_b0215","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41575-019-0261-4","article-title":"Epithelial Toll-like receptors and their role in gut homeostasis and disease","volume":"17","author":"Burgue\u00f1o","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jare.2023.03.008_b0220","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/imr.12287","article-title":"Pyroptotic cell death defends against intracellular pathogens","volume":"265","author":"Jorgensen","year":"2015","journal-title":"Immunol Rev"},{"issue":"6","key":"10.1016\/j.jare.2023.03.008_b0225","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.immuni.2020.04.010","article-title":"Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis","volume":"52","author":"Tummers","year":"2020","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.jare.2023.03.008_b0230","doi-asserted-by":"crossref","first-page":"e1008498","DOI":"10.1371\/journal.ppat.1008498","article-title":"Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes","volume":"16","author":"Crowley","year":"2020","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.jare.2023.03.008_b0235","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.07.002","article-title":"Noncanonical inflammasome activation of caspase-4\/caspase-11 mediates epithelial defenses against enteric bacterial pathogens","volume":"16","author":"Knodler","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.jare.2023.03.008_b0240","doi-asserted-by":"crossref","first-page":"e0073021","DOI":"10.1128\/Spectrum.00730-21","article-title":"Akkermansia muciniphila alleviates dextran sulfate sodium (DSS)-induced acute colitis by NLRP3 activation","volume":"9","author":"Qu","year":"2021","journal-title":"Microbiol Spectr"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123223000905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123223000905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:58:23Z","timestamp":1761857903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123223000905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":48,"alternative-id":["S2090123223000905"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2023.03.008","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2023.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}