{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:32:27Z","timestamp":1791772347972,"version":"4.3.4"},"reference-count":225,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31830053"],"award-info":[{"award-number":["31830053"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31920103007"],"award-info":[{"award-number":["31920103007"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203629"],"award-info":[{"award-number":["82203629"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2020YFA0803201"],"award-info":[{"award-number":["2020YFA0803201"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jare.2023.04.018","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T21:50:59Z","timestamp":1683323459000},"page":"45-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Immunoregulation in cancer-associated cachexia"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-5274","authenticated-orcid":false,"given":"Qi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-e","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41574-018-0123-0","article-title":"Inter-tissue communication in cancer cachexia","volume":"15","author":"Argil\u00e9s","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41577-021-00624-w","article-title":"The interplay of immunology and cachexia in infection and cancer","volume":"22","author":"Baazim","year":"2022","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jare.2023.04.018_b0020","doi-asserted-by":"crossref","unstructured":"Li C, Wu Q, Li Z, Wang Z, Tu Y, Chen C, et al. Exosomal microRNAs in cancer-related sarcopenia: Tumor-derived exosomal microRNAs in muscle atrophy. Exp Biol Med (Maywood). 2021;246(10):1156-66.","DOI":"10.1177\/1535370221990322"},{"key":"10.1016\/j.jare.2023.04.018_b0025","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","volume":"4","author":"Baracos","year":"2018","journal-title":"Cancer-associated cachexia Nat Rev Dis Primers"},{"key":"10.1016\/j.jare.2023.04.018_b0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.semcdb.2017.11.011","article-title":"Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis","volume":"72","author":"Zammit","year":"2017","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40364-020-00257-6","article-title":"Cancer-associated adipocytes as immunomodulators in cancer","volume":"9","author":"Wu","year":"2021","journal-title":"Biomarker Res"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.trecan.2022.01.004","article-title":"Emerging signaling mediators in the anorexia-cachexia syndrome of cancer","volume":"8","author":"Talbert","year":"2022","journal-title":"Trends Cancer"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0050","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41419-021-04171-z","article-title":"Extracellular vesicles and immunogenic stress in cancer","volume":"12","author":"Wu","year":"2021","journal-title":"Cell Death Dis"},{"issue":"7","key":"10.1016\/j.jare.2023.04.018_b0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41568-022-00462-5","article-title":"Context-dependent functions of pattern recognition receptors in cancer","volume":"22","author":"Man","year":"2022","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13045-019-0778-6","article-title":"Cancer-associated adipocytes: key players in breast cancer progression","volume":"12","author":"Wu","year":"2019","journal-title":"J Hematol Oncol"},{"issue":"21","key":"10.1016\/j.jare.2023.04.018_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217841","article-title":"Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia","volume":"21","author":"Rosa-Caldwell","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0070","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41584-019-0277-8","article-title":"The IL-1 family of cytokines and receptors in rheumatic diseases","volume":"15","author":"Dinarello","year":"2019","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0075","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/SPC.0000000000000398","article-title":"Targeting IL-1\u03b1 in cancer cachexia: a narrative review","volume":"12","author":"McDonald","year":"2018","journal-title":"Curr Opin Support Palliat Care"},{"issue":"12","key":"10.1016\/j.jare.2023.04.018_b0080","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20111020","article-title":"Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis","volume":"208","author":"Braun","year":"2011","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0085","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/jcsm.12417","article-title":"Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention","volume":"10","author":"Li","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jare.2023.04.018_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.729182","article-title":"Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia","volume":"12","author":"de Jesus","year":"2021","journal-title":"Front Immunol"},{"issue":"18","key":"10.1016\/j.jare.2023.04.018_b0095","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1523\/JNEUROSCI.3919-15.2016","article-title":"The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis","volume":"36","author":"Francesconi","year":"2016","journal-title":"J Neurosci"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b0100","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41575-021-00473-x","article-title":"New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology","volume":"18","author":"Giraldez","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.jare.2023.04.018_b0105","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0110","doi-asserted-by":"crossref","first-page":"C128","DOI":"10.1152\/ajpcell.00025.2012","article-title":"Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway","volume":"304","author":"Hoene","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0115","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cmet.2014.06.011","article-title":"A switch from white to brown fat increases energy expenditure in cancer-associated cachexia","volume":"20","author":"Petruzzelli","year":"2014","journal-title":"Cell Metab"},{"issue":"21","key":"10.1016\/j.jare.2023.04.018_b0120","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1038\/onc.2016.437","article-title":"Blockade of the IL-6 trans-signalling\/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma","volume":"36","author":"Miller","year":"2017","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0125","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190450","article-title":"Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia","volume":"218","author":"Rupert","year":"2021","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0130","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/s41467-017-01645-7","article-title":"Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival","volume":"8","author":"Segatto","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12943-018-0899-5","article-title":"Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression","volume":"17","author":"Wu","year":"2018","journal-title":"Mol Cancer"},{"issue":"7888","key":"10.1016\/j.jare.2023.04.018_b0140","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41586-021-04127-5","article-title":"IL-27 signalling promotes adipocyte thermogenesis and energy expenditure","volume":"600","author":"Wang","year":"2021","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.jare.2023.04.018_b0145","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1158\/0008-5472.CAN-14-0160","article-title":"Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak\/STAT3 signaling","volume":"74","author":"Lapeire","year":"2014","journal-title":"Cancer Res"},{"issue":"14","key":"10.1016\/j.jare.2023.04.018_b0150","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121221","article-title":"Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin","volume":"3","author":"Arora","year":"2018","journal-title":"JCI insight"},{"issue":"12","key":"10.1016\/j.jare.2023.04.018_b0155","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nri3766","article-title":"The IL-20 subfamily of cytokines\u2013from host defence to tissue homeostasis","volume":"14","author":"Rutz","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0160","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1038\/s41467-020-18244-8","article-title":"IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models","volume":"11","author":"Lu","year":"2020","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0165","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/jcsm.12864","article-title":"Development of ovarian tumour causes significant loss of muscle and adipose tissue: a novel mouse model for cancer cachexia study","volume":"13","author":"Luan","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0170","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcsm.12912","article-title":"A systematic review examining the relationship between cytokines and cachexia in incurable cancer","volume":"13","author":"Paval","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0175","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jcsm.12129","article-title":"Toll-like receptor 4 signalling mediates inflammation in skeletal muscle of patients with chronic kidney disease","volume":"8","author":"Verzola","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jcsm.12138","article-title":"New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss","volume":"8","author":"Johns","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"47","key":"10.1016\/j.jare.2023.04.018_b0185","doi-asserted-by":"crossref","first-page":"40477","DOI":"10.1074\/jbc.M111.257923","article-title":"Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-\u03b1 (TNF-\u03b1)-induced lipolysis in adipocytes","volume":"286","author":"Yang","year":"2011","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0190","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.bbrc.2015.02.026","article-title":"TNF alpha inhibits myogenic differentiation of C2C12 cells through NF-\u03baB activation and impairment of IGF-1 signaling pathway","volume":"458","author":"Zhao","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0195","doi-asserted-by":"crossref","first-page":"622","DOI":"10.15252\/emmm.201607052","article-title":"STAT3 promotes IFN\u03b3\/TNF\u03b1-induced muscle wasting in an NF-\u03baB-dependent and IL-6-independent manner","volume":"9","author":"Ma","year":"2017","journal-title":"EMBO Mol Med"},{"issue":"5488","key":"10.1016\/j.jare.2023.04.018_b0200","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1126\/science.289.5488.2363","article-title":"NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia","volume":"289","author":"Guttridge","year":"2000","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0205","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jcsm.12710","article-title":"Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia","volume":"12","author":"Lu","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0210","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41591-018-0054-2","article-title":"Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle","volume":"24","author":"Wang","year":"2018","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0215","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.cell.2015.08.031","article-title":"Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival","volume":"162","author":"Johnston","year":"2015","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0220","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1083\/jcb.200909117","article-title":"The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice","volume":"188","author":"Mittal","year":"2010","journal-title":"J Cell Biol"},{"issue":"29","key":"10.1016\/j.jare.2023.04.018_b0225","doi-asserted-by":"crossref","first-page":"19985","DOI":"10.1074\/jbc.M114.568626","article-title":"DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy","volume":"289","author":"Tajrishi","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2023.04.018_b0230","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fphys.2014.00503","article-title":"Mitochondria dysfunction in lung cancer-induced muscle wasting in C2C12 myotubes","volume":"5","author":"McLean","year":"2014","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0235","first-page":"15","article-title":"Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia","volume":"27","author":"Constantinou","year":"2011","journal-title":"Int J Mol Med"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0240","doi-asserted-by":"crossref","first-page":"C681","DOI":"10.1152\/ajpcell.00462.2020","article-title":"Mitochondria-cytokine crosstalk following skeletal muscle injury and disuse: a mini-review","volume":"320","author":"Qualls","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0245","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jcsm.12251","article-title":"Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-na\u00efve pancreatic cancer patients","volume":"9","author":"Talbert","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"7","key":"10.1016\/j.jare.2023.04.018_b0250","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708307","article-title":"The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting","volume":"10","author":"Hall","year":"2018","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jare.2023.04.018_b0255","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cyto.2016.02.015","article-title":"White adipose tissue IFN-\u03b3 expression and signalling along the progression of rodent cancer cachexia","volume":"89","author":"Yamashita","year":"2017","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0260","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.ccell.2018.03.001","article-title":"Adipocyte p62\/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor","volume":"33","author":"Huang","year":"2018","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0265","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41590-022-01132-2","article-title":"Immunogenic cell stress and death","volume":"23","author":"Kroemer","year":"2022","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0270","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41467-017-00726-x","article-title":"Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0275","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1038\/s41598-017-02347-2","article-title":"Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.jare.2023.04.018_b0280","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1073\/pnas.1402714111","article-title":"Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7","volume":"111","author":"He","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0285","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1038\/s41467-019-12657-w","article-title":"The TLR7\/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer","volume":"10","author":"Michaelis","year":"2019","journal-title":"Nat Commun"},{"issue":"23","key":"10.1016\/j.jare.2023.04.018_b0290","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1158\/0008-5472.CAN-17-3878","article-title":"The TLR7\/8\/9 Antagonist IMO-8503 Inhibits Cancer-Induced Cachexia","volume":"78","author":"Calore","year":"2018","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0295","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming Growth Factor-\u03b2 Signaling in Immunity and Cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b0300","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nm.3961","article-title":"Excess TGF-\u03b2 mediates muscle weakness associated with bone metastases in mice","volume":"21","author":"Waning","year":"2015","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0305","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/emmm.201201869","article-title":"TSC22D4 is a molecular output of hepatic wasting metabolism","volume":"5","author":"Jones","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0310","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccell.2018.12.002","article-title":"Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis","volume":"35","author":"Ishay-Ronen","year":"2019","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0315","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/jcsm.12441","article-title":"Tumour-derived transforming growth factor-\u03b2 signalling contributes to fibrosis in patients with cancer cachexia","volume":"10","author":"Lima","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0320","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00395-017-0639-9","article-title":"Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting","volume":"112","author":"Zimmers","year":"2017","journal-title":"Basic Res Cardiol"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0325","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"10.1016\/j.jare.2023.04.018_b0330","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/iub.1392","article-title":"Myostatin: expanding horizons","volume":"67","author":"Sharma","year":"2015","journal-title":"IUBMB Life"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0335","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","article-title":"Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival","volume":"142","author":"Zhou","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jare.2023.04.018_b0340","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-physiol-022020-045449","article-title":"The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?","volume":"83","author":"Breit","year":"2021","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0345","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cmet.2018.07.018","article-title":"The MIC-1\/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases","volume":"28","author":"Tsai","year":"2018","journal-title":"Cell Metab"},{"issue":"8","key":"10.1016\/j.jare.2023.04.018_b0350","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41591-020-0945-x","article-title":"Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice","volume":"26","author":"Suriben","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0355","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2018","article-title":"Activin A in Mammalian Physiology","volume":"99","author":"Bloise","year":"2019","journal-title":"Physiol Rev"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0360","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/jcsm.12461","article-title":"The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy","volume":"10","author":"Zhong","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0365","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1016\/j.cllc.2019.10.013","article-title":"Elevated Circulating Activin A Levels in Patients With Malignant Pleural Mesothelioma Are Related to Cancer Cachexia and Reduced Response to Platinum-based Chemotherapy","volume":"21","author":"Paajanen","year":"2020","journal-title":"Clin Lung Cancer"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0370","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jcsm.12489","article-title":"Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia","volume":"11","author":"Pettersen","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"605","key":"10.1016\/j.jare.2023.04.018_b0375","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay9592","article-title":"Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia","volume":"13","author":"Sartori","year":"2021","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0380","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MCO.0000000000000357","article-title":"Parathyroid hormone stimulates adipose tissue browning: a pathway to muscle wasting","volume":"20","author":"Thomas","year":"2017","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0385","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/jcsm.12985","article-title":"Inhibition of epidermal growth factor receptor suppresses parathyroid hormone-related protein expression in tumours and ameliorates cancer-associated cachexia","volume":"13","author":"Weber","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"7","key":"10.1016\/j.jare.2023.04.018_b0390","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1158\/2159-8290.CD-20-1098","article-title":"PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability","volume":"11","author":"Pitarresi","year":"2021","journal-title":"Cancer Discov"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0395","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41419-020-03382-0","article-title":"Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis"},{"issue":"135","key":"10.1016\/j.jare.2023.04.018_b0400","doi-asserted-by":"crossref","first-page":"135ra66","DOI":"10.1126\/scitranslmed.3003759","article-title":"PTH\/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection","volume":"4","author":"Muehleisen","year":"2012","journal-title":"Sci Transl Med"},{"issue":"8","key":"10.1016\/j.jare.2023.04.018_b0405","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/1346-8138.16411","article-title":"Successful treatment with dacarbazine against a parathyroid hormone-related protein-producing melanoma causing hypercalcemia after immune checkpoint inhibitor failure","volume":"49","author":"Waki","year":"2022","journal-title":"J Dermatol"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0410","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1210\/jc.2015-3785","article-title":"Serum PTHrP Predicts Weight Loss in Cancer Patients Independent of Hypercalcemia, Inflammation, and Tumor Burden","volume":"101","author":"Hong","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b0415","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.tem.2019.07.011","article-title":"PTH\/PTHrP Receptor Signaling, Allostery, and Structures","volume":"30","author":"Sutkeviciute","year":"2019","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0420","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cmet.2015.11.003","article-title":"PTH\/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer","volume":"23","author":"Kir","year":"2016","journal-title":"Cell Metab"},{"issue":"7516","key":"10.1016\/j.jare.2023.04.018_b0425","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature13528","article-title":"Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia","volume":"513","author":"Kir","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jare.2023.04.018_b0430","doi-asserted-by":"crossref","unstructured":"Wei G, Sun H, Dong K, Hu L, Wang Q, Zhuang Q, et al. The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy. Cell Metab. 2021;33(10):2021-39.e8.","DOI":"10.1016\/j.cmet.2021.08.012"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0435","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1158\/1078-0432.CCR-06-1487","article-title":"Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides","volume":"13","author":"Hashimoto","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0440","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.metabol.2011.05.011","article-title":"Serum adipokine zinc \u03b12-glycoprotein and lipolysis in cachectic and noncachectic heart failure patients: relationship with neurohormonal and inflammatory biomarkers","volume":"61","author":"Tedeschi","year":"2012","journal-title":"Metab Clin Exp"},{"issue":"14","key":"10.1016\/j.jare.2023.04.018_b0445","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144860","article-title":"The Adipokines in Cancer Cachexia","volume":"21","author":"Mannelli","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0450","article-title":"Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model","volume":"12","author":"Yang","year":"2019","journal-title":"Dis Model Mech"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0455","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1158\/0008-5472.CAN-20-2818","article-title":"Combinatorial Normalization of Liver-Derived Cytokine Pathways Alleviates Hepatic Tumor-Associated Cachexia in Zebrafish","volume":"81","author":"Fei","year":"2021","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.jare.2023.04.018_b0460","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1096\/fj.201701465RR","article-title":"The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting","volume":"32","author":"Elattar","year":"2018","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0465","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1365-2796.2011.02441.x","article-title":"Adipose zinc-\u03b12-glycoprotein is a catabolic marker in cancer and noncancerous states","volume":"271","author":"Ryd\u00e9n","year":"2012","journal-title":"J Intern Med"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0470","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11101541","article-title":"Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice","volume":"11","author":"Re Cecconi","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0475","doi-asserted-by":"crossref","first-page":"E150","DOI":"10.1152\/ajpendo.00161.2020","article-title":"Myostatin deficiency not only prevents muscle wasting but also improves survival in septic mice","volume":"320","author":"Kobayashi","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0480","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/jcsm.12409","article-title":"Fibroblast growth factor 21 controls mitophagy and muscle mass","volume":"10","author":"Oost","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"7","key":"10.1016\/j.jare.2023.04.018_b0485","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/jcp.25735","article-title":"Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21-SIRT1-AMPK-PGC1alpha Pathway","volume":"232","author":"Liu","year":"2017","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0490","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/jcsm.13141","article-title":"Irisin ameliorates age-associated sarcopenia and metabolic dysfunction","volume":"14","author":"Guo","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0495","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/jcsm.12085","article-title":"Irisin - a myokine potentially bridging muscle and fat tissue in cachexia","volume":"6","author":"Konishi","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jare.2023.04.018_b0500","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fphar.2020.00142","article-title":"Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies","volume":"11","author":"Ahmad","year":"2020","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0505","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13578-021-00579-4","article-title":"Extracellular matrix: an important regulator of cell functions and skeletal muscle development","volume":"11","author":"Zhang","year":"2021","journal-title":"Cell Biosci"},{"issue":"9","key":"10.1016\/j.jare.2023.04.018_b0510","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091970","article-title":"Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy","volume":"9","author":"Yoshida","year":"2020","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0515","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.devcel.2018.12.003","article-title":"Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation","volume":"48","author":"Song","year":"2019","journal-title":"Dev Cell"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0520","doi-asserted-by":"crossref","first-page":"312","DOI":"10.15698\/cst2019.10.200","article-title":"Acyl-CoA-binding protein (ACBP): the elusive 'hunger factor' linking autophagy to food intake","volume":"3","author":"Pedro","year":"2019","journal-title":"Cell Stress"},{"key":"10.1016\/j.jare.2023.04.018_b0525","doi-asserted-by":"crossref","unstructured":"Duman C, Yaqubi K, Hoffmann A, Acikgoz AA, Korshunov A, Bendszus M, et al. Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation. Cell Metab. 2019;30(2):274-89 e5.","DOI":"10.1016\/j.cmet.2019.04.004"},{"issue":"7902","key":"10.1016\/j.jare.2023.04.018_b0530","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41586-022-04494-7","article-title":"A genome-scale screen for synthetic drivers of T cell proliferation","volume":"603","author":"Legut","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jare.2023.04.018_b0535","doi-asserted-by":"crossref","unstructured":"Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, et al. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity. Cell Metab. 2019;30(4):754-67.e9.","DOI":"10.1016\/j.cmet.2019.07.010"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0540","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41419-021-03864-9","article-title":"Effects of acyl-coenzyme A binding protein (ACBP)\/diazepam-binding inhibitor (DBI) on body mass index","volume":"12","author":"Joseph","year":"2021","journal-title":"Cell Death Dis"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b0545","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1500107","article-title":"Adipose PD-L1 Modulates PD-1\/PD-L1 Checkpoint Blockade Immunotherapy Efficacy in Breast Cancer","volume":"7","author":"Wu","year":"2018","journal-title":"Oncoimmunology"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0550","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000964","article-title":"Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation","volume":"8","author":"Wu","year":"2020","journal-title":"J Immunother Cancer"},{"issue":"635","key":"10.1016\/j.jare.2023.04.018_b0555","doi-asserted-by":"crossref","first-page":"eabj6879","DOI":"10.1126\/scitranslmed.abj6879","article-title":"Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity","volume":"14","author":"Schwartz","year":"2022","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0560","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41467-017-00799-8","article-title":"PD-L1 is an activation-independent marker of brown adipocytes","volume":"8","author":"Ingram","year":"2017","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0565","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jamaoncol.2019.5241","article-title":"Association Between Body Mass Index and Overall Survival With Immune Checkpoint Inhibitor Therapy for Advanced Non-Small Cell Lung Cancer","volume":"6","author":"Kichenadasse","year":"2020","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0570","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40425-019-0527-y","article-title":"A multicenter study of body mass index in cancer patients treated with anti-PD-1\/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable","volume":"7","author":"Cortellini","year":"2019","journal-title":"J Immunother Cancer"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0575","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001403","article-title":"Baseline BMI and BMI variation during first line pembrolizumab in NSCLC patients with a PD-L1 expression \u2265 50%: a multicenter study with external validation","volume":"8","author":"Cortellini","year":"2020","journal-title":"J Immunother Cancer"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0580","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41591-018-0221-5","article-title":"Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade","volume":"25","author":"Wang","year":"2019","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0585","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/1759-7714.14421","article-title":"Impact of losing adipose tissue on outcomes from PD-1\/PD-L1 inhibitor monotherapy in non-small cell lung cancer","volume":"13","author":"Nishioka","year":"2022","journal-title":"Thorac Cancer"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0590","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258831","article-title":"Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer","volume":"16","author":"Buss","year":"2021","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jare.2023.04.018_b0595","doi-asserted-by":"crossref","first-page":"836","DOI":"10.7326\/L19-0635","article-title":"Lipodystrophic Nonalcoholic Fatty Liver Disease Induced by Immune Checkpoint Blockade","volume":"172","author":"Eigentler","year":"2020","journal-title":"Ann Intern Med"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0600","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.2337\/dc18-2535","article-title":"Acquired Generalized Lipodystrophy: A New Cause of Anti-PD-1 Immune-Related Diabetes","volume":"42","author":"Jehl","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2023.04.018_b0605","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejca.2018.09.033","article-title":"Myositis and neuromuscular side-effects induced by immune checkpoint inhibitors","volume":"106","author":"Moreira","year":"2019","journal-title":"Eur J Cancer"},{"issue":"7","key":"10.1016\/j.jare.2023.04.018_b0610","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.118.035898","article-title":"Immune Checkpoint Inhibitor-Associated Myositis: Expanding the Spectrum of Cardiac Complications of the Immunotherapy Revolution","volume":"138","author":"Anquetil","year":"2018","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.jare.2023.04.018_b0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109285","article-title":"Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer","volume":"35","author":"Pingili","year":"2021","journal-title":"Cell Rep"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0620","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1158\/1078-0432.CCR-20-2584","article-title":"B7\u2013H3: An Attractive Target for Antibody-based Immunotherapy","volume":"27","author":"Kontos","year":"2021","journal-title":"Clin Cancer Res"},{"issue":"17","key":"10.1016\/j.jare.2023.04.018_b0625","doi-asserted-by":"crossref","first-page":"eabm7012","DOI":"10.1126\/sciadv.abm7012","article-title":"The immune checkpoint B7\u2013H3 (CD276) regulates adipocyte progenitor metabolism and obesity development","volume":"8","author":"Picarda","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2023.04.018_b0630","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smim.2018.02.007","article-title":"Pathogen clearance and immune adherence \u201crevisited\u201d: Immuno-regulatory roles for CRIg","volume":"37","author":"van Lookeren","year":"2018","journal-title":"Semin Immunol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0635","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41467-022-28239-2","article-title":"Accumulation of microbial DNAs promotes to islet inflammation and \u03b2 cell abnormalities in obesity in mice","volume":"13","author":"Gao","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0640","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1158\/1541-7786.MCR-18-0522","article-title":"The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells","volume":"17","author":"Bianchi-Frias","year":"2019","journal-title":"Mol Cancer Res"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0645","doi-asserted-by":"crossref","first-page":"eaau7426","DOI":"10.1126\/sciadv.aau7426","article-title":"VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1\u03b2 in macrophages","volume":"5","author":"Huang","year":"2019","journal-title":"Sci Adv"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0650","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13219","article-title":"Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue","volume":"19","author":"Hall","year":"2020","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0655","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41571-020-0382-2","article-title":"The adenosine pathway in immuno-oncology","volume":"17","author":"Allard","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jare.2023.04.018_b0660","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108130","article-title":"ATP and cancer immunosurveillance","author":"Kepp","year":"2021","journal-title":"Embo j"},{"key":"10.1016\/j.jare.2023.04.018_b0665","doi-asserted-by":"crossref","unstructured":"Pandolfi JB, Ferraro AA, Sananez I, Gancedo MC, Baz P, Billordo LA, et al. ATP-Induced Inflammation Drives Tissue-Resident Th17 Cells in Metabolically Unhealthy Obesity. Journal of immunology (Baltimore, Md : 1950). 2016;196(8):3287-96.","DOI":"10.4049\/jimmunol.1502506"},{"issue":"9","key":"10.1016\/j.jare.2023.04.018_b0670","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/term.2914","article-title":"Mesenchymal stem cells: Cell therapy and regeneration potential","volume":"13","author":"Brown","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0675","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/13813455.2012.755547","article-title":"Deletion of CD73 promotes dyslipidemia and intramyocellular lipid accumulation in muscle of mice","volume":"119","author":"Burghoff","year":"2013","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.jare.2023.04.018_b0680","doi-asserted-by":"crossref","unstructured":"Carri\u00e8re A, Jeanson Y, C\u00f4t\u00e9 JA, Dromard C, Galinier A, Menzel S, et al. Identification of the ectoenzyme CD38 as a marker of committed preadipocytes. International journal of obesity (2005). 2017;41(10):1539-46.","DOI":"10.1038\/ijo.2017.140"},{"key":"10.1016\/j.jare.2023.04.018_b0685","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012860","article-title":"CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype","author":"de Z\u00e9licourt","year":"2022","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jare.2023.04.018_b0690","doi-asserted-by":"crossref","unstructured":"Tarrag\u00f3 MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline. Cell Metab. 2018;27(5):1081-95.e10.","DOI":"10.1016\/j.cmet.2018.03.016"},{"issue":"10","key":"10.1016\/j.jare.2023.04.018_b0695","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nm.4171","article-title":"An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice","volume":"22","author":"Rohm","year":"2016","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0700","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nm.4093","article-title":"Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia","volume":"22","author":"Fukawa","year":"2016","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0705","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cmet.2014.08.010","article-title":"Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages","volume":"20","author":"Kratz","year":"2014","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0710","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0715","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.immuni.2013.05.015","article-title":"Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation","volume":"38","author":"Yan","year":"2013","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0720","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/jcsm.12450","article-title":"Macrophages protect against loss of adipose tissue during cancer cachexia","volume":"10","author":"Erdem","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jare.2023.04.018_b0725","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2020.04.017","article-title":"Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia","volume":"484","author":"Shukla","year":"2020","journal-title":"Cancer Lett"},{"issue":"8","key":"10.1016\/j.jare.2023.04.018_b0730","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm.2172","article-title":"Lipid accumulation and dendritic cell dysfunction in cancer","volume":"16","author":"Herber","year":"2010","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0735","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.it.2014.12.005","article-title":"Fatty acid metabolism in the regulation of T cell function","volume":"36","author":"Lochner","year":"2015","journal-title":"Trends Immunol"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0740","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.immuni.2016.10.032","article-title":"Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer","volume":"45","author":"Plitas","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jare.2023.04.018_b0745","doi-asserted-by":"crossref","unstructured":"Ringel AE, Drijvers JM, Baker GJ, Catozzi A, Garcia-Canaveras JC, Gassaway BM, et al. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183(7):1848-66 e26.","DOI":"10.1016\/j.cell.2020.11.009"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0750","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","article-title":"Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development","volume":"36","author":"van der Windt","year":"2012","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0755","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41590-019-0397-y","article-title":"CD8(+) T cells induce cachexia during chronic viral infection","volume":"20","author":"Baazim","year":"2019","journal-title":"Nat Immunol"},{"issue":"9","key":"10.1016\/j.jare.2023.04.018_b0760","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1038\/s41375-019-0417-9","article-title":"Constitutively active MyD88\/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies","volume":"33","author":"Collinson-Pautz","year":"2019","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0765","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1084\/jem.20130110","article-title":"Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia","volume":"210","author":"Tran","year":"2013","journal-title":"J Exp Med"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b0770","article-title":"Mitochondrial Dysfunction in Cancer Cachexia","volume":"10","author":"Beltra","year":"2021","journal-title":"Impact on Muscle Health and Regeneration Cells"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0775","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/jcsm.12630","article-title":"Diverging metabolic programmes and behaviours during states of starvation, protein malnutrition, and cachexia","volume":"11","author":"Olson","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0780","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jcsm.12498","article-title":"Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction","volume":"11","author":"Kunzke","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0785","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.14336\/AD.2020.0314","article-title":"Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence","volume":"11","author":"Wu","year":"2020","journal-title":"Aging Dis"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0790","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/jcsm.12714","article-title":"Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia","volume":"12","author":"Widner","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"7745","key":"10.1016\/j.jare.2023.04.018_b0795","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-019-0915-y","article-title":"Neutrophils escort circulating tumour cells to enable cell cycle progression","volume":"566","author":"Szczerba","year":"2019","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0800","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jcsm.12424","article-title":"Cancer-driven changes link T cell frequency to muscle strength in people with cancer: a pilot study","volume":"10","author":"Narsale","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0805","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13395-019-0209-y","article-title":"Immunohistochemical phenotyping of T cells, granulocytes, and phagocytes in the muscle of cancer patients: association with radiologically defined muscle mass and gene expression","volume":"9","author":"Anoveros-Barrera","year":"2019","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.jare.2023.04.018_b0810","doi-asserted-by":"crossref","unstructured":"Wang Z, Zhao C, Moya R, Davies JD. A novel role for CD4+ T cells in the control of cachexia. Journal of immunology (Baltimore, Md : 1950). 2008;181(7):4676-84.","DOI":"10.4049\/jimmunol.181.7.4676"},{"issue":"8","key":"10.1016\/j.jare.2023.04.018_b0815","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.micinf.2015.04.002","article-title":"Adoptive transfer of CD4(+)Foxp3(+) regulatory T cells to C57BL\/6J mice during acute infection with Toxoplasma gondii down modulates the exacerbated Th1 immune response","volume":"17","author":"Olgu\u00edn","year":"2015","journal-title":"Microbes Infect"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0820","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41568-019-0106-z","article-title":"Immune control by amino acid catabolism during tumorigenesis and therapy","volume":"19","author":"Lemos","year":"2019","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0825","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1038\/s41467-019-10979-3","article-title":"Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma","volume":"10","author":"Czystowska-Kuzmicz","year":"2019","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0830","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2016.12.011","article-title":"Serine Is an Essential Metabolite for Effector T Cell Expansion","volume":"25","author":"Ma","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2023.04.018_b0835","doi-asserted-by":"crossref","unstructured":"Kurniawan H, Franchina DG, Guerra L, Bonetti L, Baguet LS, Grusdat M, et al. Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function. Cell Metab. 2020;31(5):920-36 e7.","DOI":"10.1016\/j.cmet.2020.03.004"},{"issue":"6468","key":"10.1016\/j.jare.2023.04.018_b0840","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.aav2588","article-title":"Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion","volume":"366","author":"Leone","year":"2019","journal-title":"Science (New York, NY)"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0845","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ni.2556","article-title":"Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation","volume":"14","author":"Sinclair","year":"2013","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_b0850","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/jcsm.12449","article-title":"Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa","volume":"10","author":"Costa","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0855","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/2159-8290.CD-21-0999","article-title":"Cancer Induces a Stress Ileopathy Depending on beta-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis","volume":"12","author":"Yonekura","year":"2022","journal-title":"Cancer Discov"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0860","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.immuni.2015.09.003","article-title":"Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.jare.2023.04.018_b0865","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/ecco-jcc\/jjy051","article-title":"Pathogenicity of In Vivo Generated Intestinal Th17 Lymphocytes is IFN\u03b3 Dependent","volume":"12","author":"Nizzoli","year":"2018","journal-title":"J Crohns Colitis"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0870","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jcmgh.2020.07.004","article-title":"Regulation of Intestinal Epithelial Barrier and Immune Function by Activated T Cells","volume":"11","author":"Le","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0875","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jcsm.12684","article-title":"Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice","volume":"12","author":"Potgens","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0880","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101508","article-title":"Gut microbiota and metabolic aspects of cancer cachexia","volume":"35","author":"Ziemons","year":"2021","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b0885","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1038\/s41396-021-00998-8","article-title":"Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients","volume":"15","author":"Ni","year":"2021","journal-title":"ISME J"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0890","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jcsm.12798","article-title":"Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome","volume":"12","author":"Feng","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0895","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/jcsm.12784","article-title":"Understanding the gut microbiota and sarcopenia: a systematic review","volume":"12","author":"Liu","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b0900","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/jcsm.12804","article-title":"Gut microbiota and short-chain fatty acid alterations in cachectic cancer patients","volume":"12","author":"Ubachs","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0905","article-title":"Fungal Dysbiosis Correlates with the Development of Tumor-Induced Cachexia in Mice","volume":"6","author":"Jabes","year":"2020","journal-title":"Journal of fungi (Basel, Switzerland)"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0910","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.cmet.2018.02.008","article-title":"The Homeostatic Force of Ghrelin","volume":"27","author":"Yanagi","year":"2018","journal-title":"Cell Metab"},{"issue":"35","key":"10.1016\/j.jare.2023.04.018_b0915","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.18632\/oncotarget.27705","article-title":"Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways","volume":"11","author":"Liu","year":"2020","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.jare.2023.04.018_b0920","first-page":"611","article-title":"Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice","volume":"123","author":"Porporato","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2023.04.018_b0925","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.freeradbiomed.2019.09.012","article-title":"Ghrelin effects on mitochondrial fitness modulates macrophage function","volume":"145","author":"Corr\u00eaa da Silva","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0930","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1172\/JCI200421134","article-title":"Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells","volume":"114","author":"Dixit","year":"2004","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0935","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12031-007-0004-9","article-title":"Elevated serum ghrelin exerts an orexigenic effect that may maintain body mass index in patients with metastatic neuroendocrine tumors","volume":"33","author":"Wang","year":"2007","journal-title":"Journal of molecular neuroscience : MN"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_b0940","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10147-008-0856-1","article-title":"Ghrelin and leptin levels in cachectic patients with cancer of the digestive organs","volume":"14","author":"Takahashi","year":"2009","journal-title":"Int J Clin Oncol"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0945","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jcsm.12156","article-title":"Cancer anorexia: hypothalamic activity and its association with inflammation and appetite-regulating peptides in lung cancer","volume":"8","author":"Molfino","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b0950","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173113","article-title":"Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model","volume":"12","author":"Terawaki","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2023.04.018_b0955","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2015.10.038","article-title":"The central role of hypothalamic inflammation in the acute illness response and cachexia","volume":"54","author":"Burfeind","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jare.2023.04.018_b0960","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54095","article-title":"Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer","volume":"9","author":"Burfeind","year":"2020","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.jare.2023.04.018_b0965","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/glia.23796","article-title":"Microglia in the hypothalamus respond to tumor-derived factors and are protective against cachexia during pancreatic cancer","volume":"68","author":"Burfeind","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.jare.2023.04.018_b0970","doi-asserted-by":"crossref","unstructured":"Wiedemann SJ, Trimigliozzi K, Dror E, Meier DT, Molina-Tijeras JA, Rachid L, et al. The cephalic phase of insulin release is modulated by IL-1beta. Cell Metab. 2022;34(7):991-1003 e6.","DOI":"10.1016\/j.cmet.2022.06.001"},{"issue":"9","key":"10.1016\/j.jare.2023.04.018_b0975","doi-asserted-by":"crossref","first-page":"F1315","DOI":"10.1152\/ajprenal.00341.2012","article-title":"Melanocortin antagonism ameliorates muscle wasting and inflammation in chronic kidney disease","volume":"303","author":"Cheung","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jare.2023.04.018_b0980","doi-asserted-by":"crossref","unstructured":"Gomez-Valades AG, Pozo M, Varela L, Boudjadja MB, Ramirez S, Chivite I, et al. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca(2+) homeostasis with adipose tissue lipolysis. Cell Metab. 2021;33(9):1820-35 e9.","DOI":"10.1016\/j.cmet.2021.07.008"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0985","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1038\/s41467-021-25380-2","article-title":"Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity","volume":"12","author":"Xiao","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2023.04.018_b0990","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbi.2021.07.002","article-title":"Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment","volume":"97","author":"Olson","year":"2021","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b0995","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/s41467-021-22361-3","article-title":"Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia","volume":"12","author":"Olson","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b1000","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41467-020-20733-9","article-title":"Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung","volume":"12","author":"Tyagi","year":"2021","journal-title":"Nat Commun"},{"issue":"7645","key":"10.1016\/j.jare.2023.04.018_b1005","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature21697","article-title":"MC4R-dependent suppression of appetite by bone-derived lipocalin 2","volume":"543","author":"Mosialou","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b1010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13539-011-0039-1","article-title":"The orally active melanocortin-4 receptor antagonist BL-6020\/979: a promising candidate for the treatment of cancer cachexia","volume":"2","author":"Dallmann","year":"2011","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"9","key":"10.1016\/j.jare.2023.04.018_b1015","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1172\/JCI138392","article-title":"Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease-associated cachexia","volume":"130","author":"Zhu","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2023.04.018_b1020","article-title":"Neuroendocrine regulations in tissue-specific immunity: From mechanism to applications in tumor","volume":"10","author":"Liu","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"7818","key":"10.1016\/j.jare.2023.04.018_b1025","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41586-020-2527-y","article-title":"A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue","volume":"583","author":"Wang","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b1030","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1038\/s41467-021-25766-2","article-title":"Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue","volume":"12","author":"Cui","year":"2021","journal-title":"Nat Commun"},{"issue":"7755","key":"10.1016\/j.jare.2023.04.018_b1035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41586-019-1156-9","article-title":"Innervation of thermogenic adipose tissue via a calsyntenin 3\u03b2-S100b axis","volume":"569","author":"Zeng","year":"2019","journal-title":"Nature"},{"issue":"S1","key":"10.1016\/j.jare.2023.04.018_b1040","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2021.35.S1.02296","article-title":"An immune-neuron axis guides adipose tissue loss in cancer-associated cachexia","volume":"35","author":"Schweiger","year":"2021","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.jare.2023.04.018_b1045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112840119","article-title":"An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia","volume":"119","author":"Xie","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_b1050","doi-asserted-by":"crossref","first-page":"2085432","DOI":"10.1080\/2162402X.2022.2085432","article-title":"Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression","volume":"11","author":"Liu","year":"2022","journal-title":"Oncoimmunology"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b1055","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s42255-021-00482-9","article-title":"Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue","volume":"3","author":"Wang","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.jare.2023.04.018_b1060","doi-asserted-by":"crossref","unstructured":"Knights AJ, Liu S, Ma Y, Nudell VS, Perkey E, Sorensen MJ, et al. Acetylcholine-synthesizing macrophages in subcutaneous fat are regulated by \u03b2(2) -adrenergic signaling. Embo j. 2021:e106061.","DOI":"10.15252\/embj.2020106061"},{"issue":"11","key":"10.1016\/j.jare.2023.04.018_b1065","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/nm.4422","article-title":"Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine","volume":"23","author":"Pirzgalska","year":"2017","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.jare.2023.04.018_b1070","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/ni.3746","article-title":"Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure","volume":"18","author":"Wolf","year":"2017","journal-title":"Nat Immunol"},{"issue":"7876","key":"10.1016\/j.jare.2023.04.018_b1075","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-021-03830-7","article-title":"Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit","volume":"597","author":"Cardoso","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_b1080","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112281119","article-title":"Eosinophils regulate intra-adipose axonal plasticity","volume":"119","author":"Meng","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_bib1081","doi-asserted-by":"crossref","first-page":"E877","DOI":"10.1152\/ajpendo.00509.2019","article-title":"Targeting FFA1 and FFA4 receptors in cancer-induced cachexia","volume":"319","author":"Freitas","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.jare.2023.04.018_bib1082","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/jcsm.12331","article-title":"LY2495655, an antimyostatin antibody, in pancreatic cancer: a randomized, phase 2 trial","volume":"9","author":"Golan","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_bib1083","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/jcsm.12031","article-title":"Activin-betaC modulates cachexia by repressing the ubiquitin-proteasome and autophagic degradation pathways","volume":"6","author":"Marino","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"18","key":"10.1016\/j.jare.2023.04.018_bib1084","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1158\/1078-0432.CCR-19-1065","article-title":"First-in-Human Phase I Study of the Activin A Inhibitor, STM 434, in Patients with Granulosa Cell Ovarian Cancer and Other Advanced Solid Tumors","volume":"25","author":"Tao","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.jare.2023.04.018_bib1085","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1136\/gut.2004.047563","article-title":"Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial","volume":"54","author":"Gordon","year":"2005","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.jare.2023.04.018_bib1086","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S2213-8587(20)30364-8","article-title":"Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials","volume":"8","author":"Clement","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"8","key":"10.1016\/j.jare.2023.04.018_bib1087","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1007\/s00520-016-3144-z","article-title":"Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial","volume":"24","author":"Takayama","year":"2016","journal-title":"Support Care Cancer"},{"issue":"3","key":"10.1016\/j.jare.2023.04.018_bib1088","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/cncr.31128","article-title":"Anamorelin (ONO-7643) for the treatment of patients with non-small cell lung cancer and cachexia: Results from a randomized, double-blind, placebo-controlled, multicenter study of Japanese patients (ONO-7643-04)","volume":"124","author":"Katakami","year":"2018","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.jare.2023.04.018_bib1089","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-018-07859-7","article-title":"Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway","volume":"10","author":"Singh","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2023.04.018_bib1090","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cyto.2017.04.019","article-title":"L-leucine dietary supplementation modulates muscle protein degradation and increases pro-inflammatory cytokines in tumour-bearing rats","volume":"96","author":"Cruz","year":"2017","journal-title":"Cytokine"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123223001248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123223001248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T04:07:43Z","timestamp":1711253263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123223001248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":225,"alternative-id":["S2090123223001248"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2023.04.018","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoregulation in cancer-associated cachexia","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2023.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}