{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:06:20Z","timestamp":1792397180198,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jare.2023.06.001","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T21:08:43Z","timestamp":1686863323000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["CRISPR\/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"58","author":[{"given":"Haijun","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-9472","authenticated-orcid":false,"given":"Ming D.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10194","key":"10.1016\/j.jare.2023.06.001_b0005","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0140-6736(19)30934-1","article-title":"New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis","volume":"394","author":"Charlson","year":"2019","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jare.2023.06.001_b0010","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1192\/bjp.184.5.386","article-title":"Global burden of depressive disorders in the year 2000","volume":"184","author":"\u00dcst\u00fcn","year":"2004","journal-title":"Br J Psychiatry"},{"issue":"10158","key":"10.1016\/j.jare.2023.06.001_b0015","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(18)32207-4","article-title":"Changes in health in the countries of the UK and 150 English Local Authority areas 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"392","author":"Steel","year":"2018","journal-title":"Lancet"},{"issue":"10161","key":"10.1016\/j.jare.2023.06.001_b0020","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"issue":"30","key":"10.1016\/j.jare.2023.06.001_b0025","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf0634","article-title":"Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression","volume":"7","author":"Li","year":"2021","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell"},{"issue":"7","key":"10.1016\/j.jare.2023.06.001_b0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/gb-2004-5-7-234","article-title":"The Frizzled family: receptors for multiple signal transduction pathways","volume":"5","author":"Huang","year":"2004","journal-title":"Genome Biol"},{"key":"10.1016\/j.jare.2023.06.001_b0040","doi-asserted-by":"crossref","DOI":"10.1111\/cns.13661","article-title":"Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt\/beta-catenin signaling following ischemic stroke","author":"Ji","year":"2021","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/jnr.24104","article-title":"Sonic hedgehog, Wnt, and brain-derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression","volume":"96","author":"Tayyab","year":"2018","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jare.2023.06.001_b0050","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/bs.pmbts.2017.11.018","article-title":"Wnt Signaling in the Central Nervous System: New Insights in Health and Disease","volume":"153","author":"Oliva","year":"2018","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"2","key":"10.1016\/j.jare.2023.06.001_b0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/clpt.2011.296","article-title":"The roles of neurotrophic factor and Wnt signaling in depression","volume":"91","author":"Voleti","year":"2012","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.jare.2023.06.001_b0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/157015912803217279","article-title":"The wnt pathway in mood disorders","volume":"10","author":"Sani","year":"2012","journal-title":"Curr Neuropharmacol"},{"issue":"7","key":"10.1016\/j.jare.2023.06.001_b0065","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1038\/oncsis.2017.69","article-title":"Non-canonical WNT\/PCP signalling in cancer: Fzd6 takes centre stage","volume":"6","author":"Corda","year":"2017","journal-title":"Oncogenesis"},{"issue":"2","key":"10.1016\/j.jare.2023.06.001_b0070","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/humu.21643","article-title":"FZD6 is a novel gene for human neural tube defects","volume":"33","author":"De Marco","year":"2012","journal-title":"Hum Mutat"},{"issue":"11","key":"10.1016\/j.jare.2023.06.001_b0075","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s10072-014-1815-4","article-title":"Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population","volume":"35","author":"Shi","year":"2014","journal-title":"Neurol Sci"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0080","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/dvdy.22127","article-title":"Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect","volume":"239","author":"Stuebner","year":"2010","journal-title":"Dev Dyn"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biopsych.2011.08.004","article-title":"Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression","volume":"71","author":"Voleti","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"15","key":"10.1016\/j.jare.2023.06.001_b0090","article-title":"Identification of a novel functional nonsynonymous single nucleotide polymorphism in Frizzled 6 (FZD6) gene for involvement in depressive symptoms","author":"Han","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"10.1016\/j.jare.2023.06.001_b0095","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat Protoc"},{"issue":"4","key":"10.1016\/j.jare.2023.06.001_b0100","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s11481-019-09845-2","article-title":"Involvement of Interferon Regulatory Factor 7 in Nicotine's Suppression of Antiviral Immune Responses","volume":"14","author":"Han","year":"2019","journal-title":"J Neuroimmune Pharmacol"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0105","doi-asserted-by":"crossref","first-page":"e12718","DOI":"10.1111\/adb.12718","article-title":"Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies","volume":"25","author":"Chen","year":"2020","journal-title":"Addict Biol"},{"issue":"4","key":"10.1016\/j.jare.2023.06.001_b0110","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nmeth.2857","article-title":"Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects","volume":"11","author":"Shen","year":"2014","journal-title":"Nat Methods"},{"issue":"7692","key":"10.1016\/j.jare.2023.06.001_b0115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature25509","article-title":"Ketamine blocks bursting in the lateral habenula to rapidly relieve depression","volume":"554","author":"Yang","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jare.2023.06.001_b0120","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41591-018-0299-9","article-title":"Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior","volume":"25","author":"Shen","year":"2019","journal-title":"Nat Med"},{"issue":"7433","key":"10.1016\/j.jare.2023.06.001_b0125","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nature11713","article-title":"Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons","volume":"493","author":"Chaudhury","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jare.2023.06.001_b0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biopsych.2006.03.021","article-title":"Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors","volume":"61","author":"Monteggia","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abio.1999.4085","article-title":"Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro","volume":"270","author":"Winer","year":"1999","journal-title":"Anal Biochem"},{"issue":"4","key":"10.1016\/j.jare.2023.06.001_b0140","first-page":"468","article-title":"Stress and the HPA axis: role of glucocorticoids in alcohol dependence","volume":"34","author":"Stephens","year":"2012","journal-title":"Alcohol Res"},{"key":"10.1016\/j.jare.2023.06.001_b0145","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"10.1016\/j.jare.2023.06.001_b0150","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"key":"10.1016\/j.jare.2023.06.001_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104843","article-title":"Toll-Like Receptor Signaling in Depression","volume":"121","author":"Figueroa-Hall","year":"2020","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.jare.2023.06.001_b0160","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2004.11.003","article-title":"Cytokines and major depression","volume":"29","author":"Schiepers","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jare.2023.06.001_b0165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbi.2017.03.002","article-title":"NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings","volume":"64","author":"Kaufmann","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jare.2023.06.001_b0170","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2018.03.023","article-title":"Kynurenine pathway in depression: A systematic review and meta-analysis","volume":"90","author":"Ogyu","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"issue":"21","key":"10.1016\/j.jare.2023.06.001_b0175","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.2174\/1381612823666170111141915","article-title":"BDNF\/NF-kappaB Signaling in the Neurobiology of Depression","volume":"23","author":"Caviedes","year":"2017","journal-title":"Curr Pharm Des"},{"issue":"1-2","key":"10.1016\/j.jare.2023.06.001_b0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.lfs.2014.02.014","article-title":"The role of mTOR in depression and antidepressant responses","volume":"101","author":"Abelaira","year":"2014","journal-title":"Life Sci"},{"issue":"6","key":"10.1016\/j.jare.2023.06.001_b0185","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3727\/096504020X16014648664459","article-title":"Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies","volume":"28","author":"Sun","year":"2021","journal-title":"Oncol Res"},{"key":"10.1016\/j.jare.2023.06.001_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134754","article-title":"Genetic variants associated with psychotic symptoms across psychiatric disorders","volume":"720","author":"Calabro","year":"2020","journal-title":"Neurosci Lett"},{"issue":"9","key":"10.1016\/j.jare.2023.06.001_b0195","doi-asserted-by":"crossref","first-page":"e892","DOI":"10.1038\/tp.2016.122","article-title":"The antidepressant roles of Wnt2 and Wnt3 in stress-induced depression-like behaviors","volume":"6","author":"Zhou","year":"2016","journal-title":"Transl Psychiatry"},{"issue":"Suppl 6","key":"10.1016\/j.jare.2023.06.001_b0200","first-page":"46","article-title":"Consensus statement and research needs: the role of dopamine and norepinephrine in depression and antidepressant treatment","volume":"67","author":"Nutt","year":"2006","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-018-0183-x","article-title":"Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study","volume":"8","author":"Pan","year":"2018","journal-title":"Transl Psychiatry"},{"issue":"10","key":"10.1016\/j.jare.2023.06.001_b0210","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1007\/s11033-022-07848-6","article-title":"Construction of Fzd6(Q152E)mice through CRISPR\/Cas9 technology and their reproduction and identification","volume":"49","author":"Yan","year":"2022","journal-title":"Mol Biol Rep"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuropharm.2011.08.032","article-title":"The dynamic role of beta-catenin in synaptic plasticity","volume":"62","author":"Maguschak","year":"2012","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0220","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000487764","article-title":"Brain Beta-Catenin Signalling During Stress and Depression","volume":"26","author":"Teo","year":"2018","journal-title":"Neurosignals"},{"issue":"20","key":"10.1016\/j.jare.2023.06.001_b0225","doi-asserted-by":"crossref","first-page":"14566","DOI":"10.1016\/S0021-9258(17)36661-9","article-title":"Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine\/threonine phosphorylation","volume":"269","author":"Wang","year":"1994","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jare.2023.06.001_b0230","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1017\/S1461145712001010","article-title":"Altered Wnt signalling in the teenage suicide brain: focus on glycogen synthase kinase-3beta and beta-catenin","volume":"16","author":"Ren","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"issue":"4","key":"10.1016\/j.jare.2023.06.001_b0235","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.brainresbull.2012.03.004","article-title":"The effect of citalopram on chronic stress-induced depressive-like behavior in rats through GSK3beta\/beta-catenin activation in the medial prefrontal cortex","volume":"88","author":"Chen","year":"2012","journal-title":"Brain Res Bull"},{"issue":"8","key":"10.1016\/j.jare.2023.06.001_b0240","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/mp.2011.161","article-title":"Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3beta\/beta-catenin signaling","volume":"17","author":"Garza","year":"2012","journal-title":"Mol Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.jare.2023.06.001_b0245","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jad.2011.09.024","article-title":"Protein levels of beta-catenin and activation state of glycogen synthase kinase-3beta in major depression. A study with postmortem prefrontal cortex","volume":"136","author":"Karege","year":"2012","journal-title":"J Affect Disord"},{"issue":"1","key":"10.1016\/j.jare.2023.06.001_b0250","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2045-3701-4-13","article-title":"Regulation of Wnt\/beta-catenin signaling by posttranslational modifications","volume":"4","author":"Gao","year":"2014","journal-title":"Cell Biosci"},{"issue":"2","key":"10.1016\/j.jare.2023.06.001_b0255","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s11689-011-9083-6","article-title":"Synaptic Wnt signaling-a contributor to major psychiatric disorders?","volume":"3","author":"Okerlund","year":"2011","journal-title":"J Neurodev Disord"},{"key":"10.1016\/j.jare.2023.06.001_b0260","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/bs.pmbts.2018.04.005","article-title":"Wnt Signaling in the Hippocampus in Relation to Neurogenesis, Neuroplasticity, Stress and Epigenetics","volume":"158","author":"Zwamborn","year":"2018","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"25","key":"10.1016\/j.jare.2023.06.001_b0265","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.1523\/JNEUROSCI.0039-11.2011","article-title":"A novel role of the WNT-dishevelled-GSK3beta signaling cascade in the mouse nucleus accumbens in a social defeat model of depression","volume":"31","author":"Wilkinson","year":"2011","journal-title":"J Neurosci"},{"issue":"8","key":"10.1016\/j.jare.2023.06.001_b0270","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tins.2005.06.005","article-title":"The many faces of CREB","volume":"28","author":"Carlezon","year":"2005","journal-title":"Trends Neurosci"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123223001510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123223001510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T15:08:10Z","timestamp":1729091290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123223001510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":54,"alternative-id":["S2090123223001510"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2023.06.001","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRISPR\/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2023.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}