{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:11:08Z","timestamp":1790284268725,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772101"],"award-info":[{"award-number":["81772101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772101,82072196"],"award-info":[{"award-number":["81772101,82072196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002066"],"award-info":[{"award-number":["82002066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072196"],"award-info":[{"award-number":["82072196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["2020J009"],"award-info":[{"award-number":["2020J009"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jare.2024.01.002","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T04:40:06Z","timestamp":1704948006000},"page":"237-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds"],"prefix":"10.1016","volume":"66","author":[{"given":"Xiaoqi","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-8163","authenticated-orcid":false,"given":"Ting","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2024.01.002_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138077","article-title":"In-situ forming hydrogel incorporated with reactive oxygen species responsive and antibacterial properties for diabetic infected chronic wound healing","volume":"450","author":"Chengwei","year":"2022","journal-title":"Chem Eng J"},{"key":"10.1016\/j.jare.2024.01.002_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2022.111085","article-title":"Zinc alginate hydrogels with embedded RL-QN15 peptide-loaded hollow polydopamine nanoparticles for diabetic wound healing therapy","volume":"222","author":"Sun","year":"2022","journal-title":"Mater Des"},{"key":"10.1016\/j.jare.2024.01.002_b0015","doi-asserted-by":"crossref","first-page":"14970","DOI":"10.1039\/D2NR04171E","article-title":"Nanoenzyme\u2013chitosan hydrogel complex with cascade catalytic and self-reinforced antibacterial performance for accelerated healing of diabetic wounds","volume":"14","author":"Li","year":"2022","journal-title":"Nanoscale"},{"key":"10.1016\/j.jare.2024.01.002_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2022.111284","article-title":"Graphene oxide-based injectable conductive hydrogel dressing with immunomodulatory for chronic infected diabetic wounds","volume":"224","author":"Ou","year":"2022","journal-title":"Mater Des"},{"key":"10.1016\/j.jare.2024.01.002_b0025","first-page":"1","article-title":"Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing","volume":"17","author":"Zhou","year":"2022","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0030","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1515\/med-2021-0395","article-title":"Usage of intermingled skin allografts and autografts in a senior patient with major burn injury","volume":"16","author":"Luo","year":"2021","journal-title":"Open Med"},{"key":"10.1016\/j.jare.2024.01.002_b0035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13036-021-00268-3","article-title":"Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded polydopamine-modified graphene oxide","volume":"15","author":"Fu","year":"2021","journal-title":"J Biol Eng"},{"key":"10.1016\/j.jare.2024.01.002_b0040","doi-asserted-by":"crossref","first-page":"2109469","DOI":"10.1002\/adfm.202109469","article-title":"Infection micromilieu-activated nanocatalytic membrane for orchestrating rapid sterilization and stalled chronic wound regeneration","volume":"32","author":"Zhou","year":"2022","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0045","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.1016\/j.jamcollsurg.2021.07.429","article-title":"Negative pressure wound therapy promotes murine diabetic wound healing by enhancing lymphangiogenesis","volume":"233","author":"Panayi","year":"2021","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jare.2024.01.002_b0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.actbio.2021.07.033","article-title":"Bio-engineering a prevascularized human tri-layered skin substitute containing a hypodermis","volume":"134","author":"Zimoch","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2024.01.002_b0055","doi-asserted-by":"crossref","first-page":"S233","DOI":"10.1016\/j.jcyt.2017.02.339","article-title":"Clinical, histological and homeostasis evaluation of an autologous tissue bio-engineered skin substitute in a patient with 70% of total body surface area (TBSA) burn","volume":"19","author":"Fern\u00e1ndez-Gonz\u00e1lez","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jare.2024.01.002_b0060","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/jbcr\/irab037","article-title":"Combined complex skin repair in patient with extensive burns: a case report","volume":"42","author":"Gao","year":"2021","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jare.2024.01.002_b0065","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/sur.2019.263","article-title":"Comparison of traditional and skin-sparing approaches for surgical treatment of necrotizing soft-tissue infections","volume":"21","author":"Tom","year":"2020","journal-title":"Surg Infect (Larchmt)"},{"key":"10.1016\/j.jare.2024.01.002_b0070","doi-asserted-by":"crossref","first-page":"1700897","DOI":"10.1002\/adhm.201700897","article-title":"Biomaterials for skin substitutes","volume":"7","author":"Sheikholeslam","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0075","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/wrr.12585","article-title":"Accelerated epithelialization and improved wound healing metrics in porcine full-thickness wounds transplanted with full-thickness skin micrografts","volume":"25","author":"Rettinger","year":"2017","journal-title":"Wound Repair Regener"},{"key":"10.1016\/j.jare.2024.01.002_b0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jss.2018.02.004","article-title":"Evaluation of the efficacy of cell and micrograft transplantation for full-thickness wound healing","volume":"227","author":"Kruse","year":"2018","journal-title":"J Surg Res"},{"key":"10.1016\/j.jare.2024.01.002_b0085","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.burns.2022.01.016","article-title":"Comparative study between skin micrografting (Meek technique) and meshed skin grafts in paediatric burns","volume":"48","author":"Noureldin","year":"2022","journal-title":"Burns"},{"key":"10.1016\/j.jare.2024.01.002_b0090","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/jocd.14115","article-title":"Matriderm dermal substitute in the treatment of post traumatic hand\u2019s fingertip tissue loss","volume":"21","author":"Fulchignoni","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.jare.2024.01.002_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/5043518","article-title":"A multicentre study: the use of micrografts in the reconstruction of full-thickness posttraumatic skin defects of the limbs\u2014a whole innovative concept in regenerative surgery","volume":"2019","author":"Riccio","year":"2019","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jare.2024.01.002_b0100","doi-asserted-by":"crossref","unstructured":"Chang P, Li S, Sun Q, Guo K, Wang H, Li S, et al. Large full-thickness wounded skin regeneration using 3D-printed elastic scaffold with minimal functional unit of skin. J Tissue Eng 2022;13:204173142110630. https:\/\/doi.org\/10\/gqp9qw.","DOI":"10.1177\/20417314211063022"},{"key":"10.1016\/j.jare.2024.01.002_b0105","doi-asserted-by":"crossref","unstructured":"Komorowska-Timek E, Gabriel A, Bennett DC, Miles D, Garberoglio C, Cheng C, et al. Artificial dermis as an alternative for coverage of complex scalp defects following excision of malignant tumors: plastic and reconstructive surgery 2005;115:1010\u20137. https:\/\/doi.org\/10\/b7ppq3.","DOI":"10.1097\/01.PRS.0000154210.60284.C6"},{"key":"10.1016\/j.jare.2024.01.002_b0110","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3390\/biomedicines10061327","article-title":"Characterization and cytocompatibility of collagen\u2013gelatin\u2013elastin (CollaGee) acellular skin substitute towards human dermal fibroblasts","volume":"10","author":"Sallehuddin","year":"2022","journal-title":"In Vitro Assessment Biomedicines"},{"key":"10.1016\/j.jare.2024.01.002_b0115","doi-asserted-by":"crossref","first-page":"e10386","DOI":"10.1002\/btm2.10386","article-title":"Cell loaded hydrogel containing Ag-doped bioactive glass\u2013ceramic nanoparticles as skin substitute: antibacterial properties, immune response, and scarless cutaneous wound regeneration","volume":"7","author":"Sharifi","year":"2022","journal-title":"Bioeng Transl Med"},{"key":"10.1016\/j.jare.2024.01.002_b0120","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actbio.2022.04.041","article-title":"Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing","volume":"146","author":"Chen","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2024.01.002_b0125","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1021\/acs.molpharmaceut.3c00352","article-title":"Oxygenated wound dressings for hypoxia mitigation and enhanced wound healing","volume":"20","author":"Han","year":"2023","journal-title":"Mol Pharm"},{"key":"10.1016\/j.jare.2024.01.002_b0130","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/wound.2013.0473","article-title":"Epithelialization in wound healing: a comprehensive review","volume":"3","author":"Pastar","year":"2014","journal-title":"Adv Wound Care"},{"key":"10.1016\/j.jare.2024.01.002_b0135","doi-asserted-by":"crossref","first-page":"2103317","DOI":"10.1002\/advs.202103317","article-title":"Polydopamine decorated microneedles with Fe-MSC-derived nanovesicles encapsulation for wound healing","volume":"9","author":"Ma","year":"2022","journal-title":"Adv Sci"},{"key":"10.1016\/j.jare.2024.01.002_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113919","article-title":"Microneedle-mediated vaccination: innovation and translation","volume":"179","author":"Sheng","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jare.2024.01.002_b0145","doi-asserted-by":"crossref","first-page":"1902825","DOI":"10.1002\/adma.201902825","article-title":"Encoded microneedle arrays for detection of skin interstitial fluid biomarkers","volume":"31","author":"Zhang","year":"2019","journal-title":"Adv Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0150","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.biomaterials.2004.04.024","article-title":"Variable cytocompatibility of six cell lines with photoinitiators used for polymerizing hydrogels and cell encapsulation","volume":"26","author":"Williams","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2024.01.002_b0155","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ijbiomac.2021.06.112","article-title":"6-deoxy-aminocellulose derivatives embedded soft gelatin methacryloyl (GelMA) hydrogels for improved wound healing applications: In vitro and in vivo studies","volume":"185","author":"Nazir","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jare.2024.01.002_b0160","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ijbiomac.2021.06.162","article-title":"An injectable, dual crosslinkable hybrid pectin methacrylate (PECMA)\/gelatin methacryloyl (GelMA) hydrogel for skin hemostasis applications","volume":"185","author":"Wang","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jare.2024.01.002_b0165","doi-asserted-by":"crossref","first-page":"2001410","DOI":"10.1002\/adhm.202001410","article-title":"Hybrid printing using cellulose nanocrystals reinforced GelMA\/HAMA hydrogels for improved structural integration","volume":"9","author":"Fan","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0170","doi-asserted-by":"crossref","first-page":"2006596","DOI":"10.1002\/smll.202006596","article-title":"Injectable GelMA cryogel microspheres for modularized cell delivery and potential vascularized bone regeneration","volume":"17","author":"Yuan","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.jare.2024.01.002_b0175","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1021\/acsami.8b21268","article-title":"On low-concentration inks formulated by nanocellulose assisted with gelatin methacrylate (GelMA) for 3D printing toward wound healing application","volume":"11","author":"Xu","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jare.2024.01.002_b0180","doi-asserted-by":"crossref","unstructured":"Yi S, Liu Q, Luo Z, He JJ, Ma H, Li W, et al. Micropore\u2010forming gelatin methacryloyl (GelMA) bioink toolbox 2.0: designable tunability and adaptability for 3D bioprinting applications. Small 2022;18:2106357.","DOI":"10.1002\/smll.202106357"},{"key":"10.1016\/j.jare.2024.01.002_b0185","first-page":"267","article-title":"Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics","volume":"8","author":"Kurian","year":"2022","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0190","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.1039\/C8TB02483A","article-title":"Enzymatic synthesis of a thiolated chitosan-based wound dressing crosslinked with chicoric acid","volume":"6","author":"Stefanov","year":"2018","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.jare.2024.01.002_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2022.105200","article-title":"Hydrogel-based microneedles of chitosan derivatives for drug delivery","volume":"172","author":"Wei","year":"2022","journal-title":"React Funct Polym"},{"key":"10.1016\/j.jare.2024.01.002_b0200","first-page":"253","article-title":"Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing","volume":"5","author":"Chi","year":"2020","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0205","doi-asserted-by":"crossref","first-page":"8855","DOI":"10.2147\/IJN.S148179","article-title":"Guided bone regeneration with asymmetric collagen-chitosan membranes containing aspirin-loaded chitosan nanoparticles","volume":"12","author":"Zhang","year":"2017","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jare.2024.01.002_b0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.carbpol.2019.05.069","article-title":"Chitosan\/glycosaminoglycan scaffolds for skin reparation","volume":"220","author":"Sandri","year":"2019","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.jare.2024.01.002_b0215","doi-asserted-by":"crossref","first-page":"2209986","DOI":"10.1002\/adfm.202209986","article-title":"Living microneedle patch with adipose-derived stem cells embedding for diabetic ulcer healing","volume":"33","author":"Xu","year":"2023","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0220","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.ymthe.2018.06.013","article-title":"Therapeutic effects of adipose stem cells from diabetic mice for the treatment of type 2 diabetes","volume":"26","author":"Wang","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.jare.2024.01.002_b0225","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.ijbiomac.2022.10.054","article-title":"Skin-adaptive film dressing with smart-release of growth factors accelerated diabetic wound healing","volume":"222","author":"Zhao","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jare.2024.01.002_b0230","doi-asserted-by":"crossref","first-page":"2300250","DOI":"10.1002\/adhm.202300250","article-title":"Multifunctional MOF-based microneedle patch with synergistic chemo-photodynamic antibacterial effect and sustained release of growth factor for chronic wound healing","volume":"12","author":"Zeng","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.jare.2024.01.002_b0235","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.ijbiomac.2019.09.219","article-title":"Anti-inflammatory effect of epidermal growth factor conjugated silk fibroin immobilized polyurethane ameliorates diabetic burn wound healing","volume":"143","author":"Sen","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jare.2024.01.002_b0240","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.biomaterials.2017.06.043","article-title":"Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice","volume":"141","author":"Devalliere","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2024.01.002_b0245","first-page":"1","article-title":"Polymethoxyflavones in citrus regulate lipopolysaccharide-induced oscillating decay of circadian rhythm genes by inhibiting Nlrp3 expression","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jare.2024.01.002_b0250","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1021\/acsnano.1c11016","article-title":"Down-regulating scar formation by microneedles directly via a mechanical communication pathway","volume":"16","author":"Zhang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jare.2024.01.002_b0255","first-page":"465","article-title":"Interleukin-1 enhances epidermal wound healing","volume":"9","author":"Sauder","year":"1990","journal-title":"Lymphokine Res"},{"key":"10.1016\/j.jare.2024.01.002_b0260","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1524-475X.1995.30412.x","article-title":"Interleukin-1\u03b1 gene expression during wound healing","volume":"3","author":"Robertson","year":"1995","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jare.2024.01.002_b0265","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1016\/j.biomaterials.2010.04.022","article-title":"The functional behavior of a macrophage\/fibroblast co-culture model derived from normal and diabetic mice with a marine gelatin\u2013oxidized alginate hydrogel","volume":"31","author":"Zeng","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2024.01.002_b0270","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkab003","article-title":"Exosomes of adult human fibroblasts cultured on 3D silk fibroin nonwovens intensely stimulate neoangiogenesis","volume":"9","author":"Hu","year":"2021","journal-title":"Burns Trauma"},{"key":"10.1016\/j.jare.2024.01.002_b0275","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevA.103.042415","article-title":"Quantum spectral clustering","volume":"103","author":"Kerenidis","year":"2021","journal-title":"Phys Rev A"},{"key":"10.1016\/j.jare.2024.01.002_b0280","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/taap.2002.9442","article-title":"Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1\u03b1 and IL-1\u03b2 during Irritant- and allergen-induced cutaneous immune responses","volume":"182","author":"Cumberbatch","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jare.2024.01.002_b0285","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.7150\/thno.31884","article-title":"Synechococcus elongatus PCC7942 secretes extracellular vesicles to accelerate cutaneous wound healing by promoting angiogenesis","volume":"9","author":"Yin","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jare.2024.01.002_b0290","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1006\/brbi.2001.0623","article-title":"Altered kinetics of IL-1\u03b1, IL-1\u03b2, and KGF-1 gene expression in early wounds of restrained mice","volume":"16","author":"Mercado","year":"2002","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jare.2024.01.002_b0295","first-page":"1","article-title":"Autocrine and paracrine effects of vascular endothelial cells promote cutaneous wound healing","volume":"2021","author":"Lu","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jare.2024.01.002_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101904","article-title":"bFGF alleviates diabetes-associated endothelial impairment by downregulating inflammation via S-nitrosylation pathway","volume":"41","author":"Chen","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2024.01.002_b0305","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.burns.2022.08.005","article-title":"Identification of TGF-\u03b21 expression pathway in the improvement of burn wound healing","volume":"48","author":"Akhoondian","year":"2022","journal-title":"Burns"},{"key":"10.1016\/j.jare.2024.01.002_b0310","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"PERSPECTIVE ARTICLE: growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regener"},{"key":"10.1016\/j.jare.2024.01.002_b0315","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1091\/mbc.E19-08-0474","article-title":"Suppression of \u03b1-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-\u03b1 autocrine\/paracrine signaling","volume":"32","author":"Bunker","year":"2021","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jare.2024.01.002_b0320","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1078\/0171-9335-00389","article-title":"Keratinocyte growth factor: effects on keratinocytes and mechanisms of action","volume":"83","author":"Auf Dem Keller","year":"2004","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jare.2024.01.002_b0325","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cytogfr.2018.11.002","article-title":"Novel non-angiogenic role for mesenchymal stem cell-derived vascular endothelial growth factor on keratinocytes during wound healing","volume":"44","author":"Ong","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jare.2024.01.002_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102203","article-title":"1,25-Dihydroxyvitamin D3 attenuates IL-1\u03b2 secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes","volume":"48","author":"Nakajo","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2024.01.002_b0335","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1016\/j.biomaterials.2004.09.054","article-title":"Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition","volume":"26","author":"Witte","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2024.01.002_b0340","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.semcdb.2015.12.014","article-title":"Fibroblast growth factors, old kids on the new block","volume":"53","author":"Li","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jare.2024.01.002_b0345","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ncb1230","article-title":"Cdc42\u2013MRCK and Rho\u2013ROCK signalling cooperate in myosin phosphorylation and cell invasion","volume":"7","author":"Wilkinson","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jare.2024.01.002_b0350","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf5143","article-title":"Small GTPase Cdc42, WASP, and scaffold proteins for higher-order assembly of the F-BAR domain protein","volume":"9","author":"Wan Mohamad Noor","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2024.01.002_b0355","article-title":"Spatiotemporal coordination of Rac1 and Cdc42 at the whole cell level during cell ruffling","author":"Hladyshau","year":"2023","journal-title":"Cell Biology"},{"key":"10.1016\/j.jare.2024.01.002_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124027","article-title":"Intelectin enhances the phagocytosis of macrophages via CDC42-WASF2-ARPC2 signaling axis in Megalobrama amblycephala","volume":"236","author":"Cui","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jare.2024.01.002_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2018.09.016","article-title":"A mechanosensitive RhoA pathway that protects epithelia against acute tensile stress","volume":"47","author":"Acharya","year":"2018","journal-title":"Dev Cell"},{"key":"10.1016\/j.jare.2024.01.002_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2023.05.009","article-title":"Rap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell migration in vivo","volume":"33","author":"Rothenberg","year":"2023","journal-title":"Curr Biol"},{"key":"10.1016\/j.jare.2024.01.002_b0375","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41586-020-2236-6","article-title":"The architecture of the Gram-positive bacterial cell wall","volume":"582","author":"Pasquina-Lemonche","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jare.2024.01.002_b0380","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3390\/polym13060904","article-title":"Antimicrobial actions and applications of chitosan","volume":"13","author":"Ke","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.jare.2024.01.002_b0385","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1089\/ten.tea.2013.0123","article-title":"Differential response of human adipose tissue-derived mesenchymal stem cells, dermal fibroblasts, and keratinocytes to burn wound exudates: potential role of skin-specific chemokine CCL27","volume":"20","author":"Van Den Broek","year":"2014","journal-title":"Tissue Eng A"},{"key":"10.1016\/j.jare.2024.01.002_b0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2177\/jsci.40.1","article-title":"Skin-resident stem cells and wound healing","volume":"40","author":"Iwata","year":"2017","journal-title":"Japanese J Clin Immunol"},{"key":"10.1016\/j.jare.2024.01.002_b0395","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mad.2018.03.007","article-title":"Laminin-332 regulates differentiation of human interfollicular epidermal stem cells","volume":"171","author":"Yamada","year":"2018","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.jare.2024.01.002_b0400","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1038\/srep05831","article-title":"TLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis","volume":"4","author":"Yin","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.01.002_b0405","article-title":"Exosomes as a novel pathway for regulating development and diseases of the skin (Review)","author":"Liu","year":"2018","journal-title":"Biomed Rep"},{"key":"10.1016\/j.jare.2024.01.002_b0410","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.amjsurg.2017.04.010","article-title":"Cell-based skin substitutes accelerate regeneration of extensive burn wounds in rats","volume":"214","author":"Motamed","year":"2017","journal-title":"Am J Surg"},{"key":"10.1016\/j.jare.2024.01.002_b0415","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cytogfr.2018.01.003","article-title":"Dermal fibroblasts\u2014a heterogeneous population with regulatory function in wound healing","volume":"39","author":"Stunova","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jare.2024.01.002_b0420","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/13880209.2018.1446029","article-title":"Protective properties of geniposide against UV-B-induced photooxidative stress in human dermal fibroblasts","volume":"56","author":"Shin","year":"2018","journal-title":"Pharm Biol"},{"key":"10.1016\/j.jare.2024.01.002_b0425","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/1534734613502052","article-title":"Macrophage activation dysfunction in impaired wound healing: a potential therapeutic target","volume":"12","author":"Miao","year":"2013","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.jare.2024.01.002_b0430","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1007\/s00018-003-3020-0","article-title":"Regulation of macrophage activation","volume":"60","author":"Ma","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jare.2024.01.002_b0435","doi-asserted-by":"crossref","first-page":"1900513","DOI":"10.1002\/advs.201900513","article-title":"Exosome-guided phenotypic switch of M1 to M2 macrophages for cutaneous wound healing","volume":"6","author":"Kim","year":"2019","journal-title":"Adv Sci"},{"key":"10.1016\/j.jare.2024.01.002_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172894","article-title":"Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: a novel mechanism in skin wound healing","volume":"869","author":"Belvedere","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jare.2024.01.002_b0445","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cellsig.2017.12.008","article-title":"HBP induces the expression of monocyte chemoattractant protein-1 via the FAK\/PI3K\/AKT and p38 MAPK\/NF-\u03baB pathways in vascular endothelial cells","volume":"43","author":"Chang","year":"2018","journal-title":"Cell Signal"},{"key":"10.1016\/j.jare.2024.01.002_b0450","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.1038\/s41598-018-23420-4","article-title":"Canagliflozin inhibits interleukin-1\u03b2-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms","volume":"8","author":"Mancini","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.01.002_b0455","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1002\/jcp.26291","article-title":"The use of cell conditioned medium for musculoskeletal tissue regeneration","volume":"233","author":"Veronesi","year":"2018","journal-title":"J Cell Physiol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322400002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322400002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T05:30:30Z","timestamp":1733808630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209012322400002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":91,"alternative-id":["S209012322400002X"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.01.002","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}