{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:05:46Z","timestamp":1793912746613,"version":"4.8.0"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009702","name":"Fondazione IRCCS Ca&apos; Granda Ospedale Maggiore Policlinico","doi-asserted-by":"publisher","award":["RC5100020B"],"award-info":[{"award-number":["RC5100020B"]}],"id":[{"id":"10.13039\/501100009702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2019-12370172"],"award-info":[{"award-number":["GR-2019-12370172"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2021-12374481"],"award-info":[{"award-number":["RF-2021-12374481"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jare.2024.02.007","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T02:41:19Z","timestamp":1708137679000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["A narrative review about cognitive impairment in Metabolic Dysfunction\u2013Associated Steatotic Liver Disease (MASLD): Another matter to face through a holistic approach"],"prefix":"10.1016","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-4178","authenticated-orcid":false,"given":"Marica","family":"Meroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-8329","authenticated-orcid":false,"given":"Erika","family":"Paolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-7213","authenticated-orcid":false,"given":"Paola","family":"Dongiovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jare.2024.02.007_b0005","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jhep.2023.04.035","article-title":"A global research priority agenda to advance public health responses to fatty liver disease","volume":"79","author":"Lazarus","year":"2023","journal-title":"J Hepatol"},{"issue":"9","key":"10.1016\/j.jare.2024.02.007_b0010","article-title":"The burden of non-alcoholic steatohepatitis: A systematic review of health-related quality of life and patient-reported outcomes","volume":"4","author":"Younossi","year":"2022","journal-title":"JHEP Rep"},{"issue":"9","key":"10.1016\/j.jare.2024.02.007_b0015","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.dld.2019.05.015","article-title":"Brain involvement in non-alcoholic fatty liver disease (NAFLD): A systematic review","volume":"51","author":"Lombardi","year":"2019","journal-title":"Dig Liver Dis"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41398-023-02447-w","article-title":"Obesity as pleiotropic risk state for metabolic and mental health throughout life","volume":"13","author":"Leutner","year":"2023","journal-title":"Transl Psychiatry"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10040673","article-title":"Cognitive Dysfunction in Non-Alcoholic Fatty Liver Disease-Current Knowledge, Mechanisms and Perspectives","volume":"10","author":"Kj\u00e6rgaard","year":"2021","journal-title":"J Clin Med"},{"issue":"12","key":"10.1016\/j.jare.2024.02.007_b0030","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/WNL.0000000000002498","article-title":"Nonalcoholic fatty liver disease is associated with cognitive function in adults","volume":"86","author":"Seo","year":"2016","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jare.2024.02.007_b0035","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/liv.14161","article-title":"Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study","volume":"39","author":"Weinstein","year":"2019","journal-title":"Liver Int"},{"issue":"6","key":"10.1016\/j.jare.2024.02.007_b0040","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.psym.2018.06.001","article-title":"Cognitive Performance in Individuals With Non-Alcoholic Fatty Liver Disease and\/or Type 2 Diabetes Mellitus","volume":"59","author":"Weinstein","year":"2018","journal-title":"Psychosomatics"},{"issue":"7","key":"10.1016\/j.jare.2024.02.007_b0045","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/liv.12165","article-title":"Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease","volume":"33","author":"Youssef","year":"2013","journal-title":"Liver Int"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12933-018-0670-7","article-title":"Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study","volume":"17","author":"Tuttolomondo","year":"2018","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0055","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/jamaneurol.2017.3229","article-title":"Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study","volume":"75","author":"Weinstein","year":"2018","journal-title":"JAMA Neurol"},{"issue":"2","key":"10.1016\/j.jare.2024.02.007_b0060","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11065-013-9224-7","article-title":"Systematic review: are overweight and obese individuals impaired on behavioural tasks of executive functioning?","volume":"23","author":"Fitzpatrick","year":"2013","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.jare.2024.02.007_b0065","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuropsychologia.2014.10.004","article-title":"Working memory and reward association learning impairments in obesity","volume":"65","author":"Coppin","year":"2014","journal-title":"Neuropsychologia"},{"issue":"7","key":"10.1016\/j.jare.2024.02.007_b0070","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000238082.13860.50","article-title":"Relation between body mass index and cognitive function in healthy middle-aged men and women","volume":"67","author":"Cournot","year":"2006","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jare.2024.02.007_b0075","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/jpepsy\/jsac071","article-title":"Inflammation, Executive Function, and Adiposity in Children With or at Risk for Obesity: A Pilot Study","volume":"48","author":"King","year":"2023","journal-title":"J Pediatr Psychol"},{"key":"10.1016\/j.jare.2024.02.007_b0080","doi-asserted-by":"crossref","unstructured":"Moh, M.C., et al., Association of traditional and novel measures of central obesity with cognitive performance in older multi-ethnic Asians with type 2 diabetes. 2020. 10(2): p. e12352.","DOI":"10.1111\/cob.12352"},{"issue":"2","key":"10.1016\/j.jare.2024.02.007_b0085","doi-asserted-by":"crossref","first-page":"e2146324","DOI":"10.1001\/jamanetworkopen.2021.46324","article-title":"Evaluation of Adiposity and Cognitive Function in Adults","volume":"5","author":"Anand","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jare.2024.02.007_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2023.101082","article-title":"Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies","volume":"70","author":"Song","year":"2023","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.jare.2024.02.007_b0095","doi-asserted-by":"crossref","first-page":"1160426","DOI":"10.3389\/fmed.2023.1160426","article-title":"The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review","volume":"10","author":"Boccara","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0100","doi-asserted-by":"crossref","first-page":"e0282633","DOI":"10.1371\/journal.pone.0282633","article-title":"Nonalcoholic fatty liver disease and cognitive impairment: A prospective cohort study","volume":"18","author":"Cushman","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2024.02.007_b0105","article-title":"Association of triglyceride-glucose index with cognitive function and brain atrophy: A population-based study","author":"Tian","year":"2023","journal-title":"Am J Geriatr Psychiatry"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2337\/dc16-1229","article-title":"Cognitive dysfunction in older adults with diabetes: What a clinician needs to know","volume":"40","author":"Munshi","year":"2017","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.31083\/j.jin2201008","article-title":"Aberrant spontaneous brain activity and its association with cognitive function in non-obese nonalcoholic fatty liver disease: A resting-state fMRI study","volume":"22","author":"Xu","year":"2023","journal-title":"J Integr Neurosci"},{"issue":"7","key":"10.1016\/j.jare.2024.02.007_b0120","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000203","article-title":"The prevalence and risk factors for cognitive impairment in obesity and NAFLD","volume":"7","author":"Wernberg","year":"2023","journal-title":"Hepatol Commun"},{"issue":"6","key":"10.1016\/j.jare.2024.02.007_b0125","first-page":"e565","article-title":"Association of nonalcoholic fatty liver disease and fibrosis with incident dementia and cognition","volume":"99","author":"Xiao","year":"2022","journal-title":"The Rotterdam Study"},{"issue":"6","key":"10.1016\/j.jare.2024.02.007_b0130","first-page":"e574","article-title":"Nonalcoholic fatty liver disease and risk of dementia","volume":"99","author":"Shang","year":"2022","journal-title":"A Population-Based Cohort Study"},{"key":"10.1016\/j.jare.2024.02.007_b0135","doi-asserted-by":"crossref","unstructured":"Miao, Y., et al., The presence and severity of NAFLD are associated with cognitive impairment and hippocampal damage. 2023.","DOI":"10.1210\/clinem\/dgad352"},{"issue":"6","key":"10.1016\/j.jare.2024.02.007_b0140","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/liv.15549","article-title":"Subclinical liver traits are associated with structural and hemodynamic brain imaging markers","volume":"43","author":"Yilmaz","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.jare.2024.02.007_b0145","first-page":"9638797","article-title":"Cognitive changes and brain volume reduction in patients with nonalcoholic fatty liver disease","volume":"2018","author":"Filipovi\u0107","year":"2018","journal-title":"Can J Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2024.02.007_b0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.atherosclerosis.2017.11.012","article-title":"Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis","volume":"268","author":"Airaghi","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jare.2024.02.007_b0155","article-title":"Risk of dementia or cognitive impairment in non-alcoholic fatty liver disease: A systematic review and meta-analysis","volume":"14","author":"Wang","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jare.2024.02.007_b0160","doi-asserted-by":"crossref","unstructured":"Yu, Q., et al., Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment. J Clin Transl Hepatol, 2022. 10(6): p. 1034-1041.","DOI":"10.14218\/JCTH.2021.00490"},{"key":"10.1016\/j.jare.2024.02.007_b0165","doi-asserted-by":"crossref","unstructured":"Gao, P.Y., et al., Associations of liver dysfunction with incident dementia, cognition, and brain structure: A prospective cohort study of 431\u2009699 adults. J Neurochem, 2024. 168(1): p. 26-38.","DOI":"10.1111\/jnc.15988"},{"key":"10.1016\/j.jare.2024.02.007_b0170","doi-asserted-by":"crossref","unstructured":"Sheptulina, A.F., et al., Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease. J Pers Med, 2023. 13(6).","DOI":"10.3390\/jpm13060932"},{"key":"10.1016\/j.jare.2024.02.007_b0175","doi-asserted-by":"crossref","unstructured":"Moretti, R. and M. Giuffr\u00e9, Nonalcoholic Fatty Liver Disease and Altered Neuropsychological Functions in Patients with Subcortical Vascular Dementia. J Pers Med, 2022. 12(7).","DOI":"10.3390\/jpm12071106"},{"issue":"3","key":"10.1016\/j.jare.2024.02.007_b0180","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3390\/medicina59030638","article-title":"Role of nutrition in the etiopathogenesis and prevention of nonalcoholic fatty liver disease (NAFLD) in a group of obese adults","volume":"59","author":"Metro","year":"2023","journal-title":"Medicina"},{"key":"10.1016\/j.jare.2024.02.007_b0185","doi-asserted-by":"crossref","unstructured":"Weinstein, A.A., et al., Association of physical activity and fine motor performance in individuals with type 2 diabetes mellitus and\/or non-alcoholic fatty liver disease. Ann Med, 2023. 55(1): p. 1345-1353.","DOI":"10.1080\/07853890.2023.2193422"},{"issue":"5","key":"10.1016\/j.jare.2024.02.007_b0190","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/SGA.0000000000000753","article-title":"Impact of mediterranean dietary education on symptoms for adults at risk for nonalcoholic fatty liver disease","volume":"46","author":"Jerome","year":"2023","journal-title":"Gastroenterol Nurs"},{"issue":"9","key":"10.1016\/j.jare.2024.02.007_b0195","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.3390\/nu15092154","article-title":"Nutrient therapy for the improvement of fatigue symptoms","volume":"15","author":"Barnish","year":"2023","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.jare.2024.02.007_b0200","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/jnen\/nly061","article-title":"Histological features of cerebellar neuropathology in patients with alcoholic and nonalcoholic steatohepatitis","volume":"77","author":"Balzano","year":"2018","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jare.2024.02.007_b0205","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fendo.2018.00496","article-title":"Links between obesity-induced brain insulin resistance, brain mitochondrial dysfunction, and dementia","volume":"9","author":"Sripetchwandee","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"10.1016\/j.jare.2024.02.007_b0210","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1523\/JNEUROSCI.3567-08.2009","article-title":"Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation","volume":"29","author":"D'Mello","year":"2009","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0215","first-page":"3004","article-title":"The cerebellum of patients with steatohepatitis shows lymphocyte infiltration","volume":"8","author":"Balzano","year":"2018","journal-title":"Microglial Activation and Loss of Purkinje and Granular Neurons"},{"key":"10.1016\/j.jare.2024.02.007_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2023.110927","article-title":"Unravelling the liver-brain connection: A two-sample Mendelian randomization study investigating the causal relationship between NAFLD and cortical structure","volume":"204","author":"Jiang","year":"2023","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0225","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12877-021-02721-w","article-title":"Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review","volume":"22","author":"George","year":"2022","journal-title":"BMC Geriatr"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0230","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3233\/JAD-2009-0983","article-title":"Mechanisms of ceramide-mediated neurodegeneration","volume":"16","author":"Tong","year":"2009","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0235","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2045-8118-11-8","article-title":"Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC\/D3 cell line","volume":"11","author":"Sajja","year":"2014","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0240","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/jnnp.74.1.70","article-title":"Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging","volume":"74","author":"Starr","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jare.2024.02.007_b0245","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yhbeh.2015.04.023","article-title":"Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions","volume":"72","author":"Pratchayasakul","year":"2015","journal-title":"Horm Behav"},{"key":"10.1016\/j.jare.2024.02.007_b0250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnmol.2016.00057","article-title":"Ammonia as a potential neurotoxic factor in alzheimer's disease","volume":"9","author":"Adlimoghaddam","year":"2016","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0255","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jhep.2022.08.008","article-title":"Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction","volume":"78","author":"Hadjihambi","year":"2023","journal-title":"J Hepatol"},{"issue":"Suppl 2","key":"10.1016\/j.jare.2024.02.007_b0260","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.neurobiolaging.2014.03.037","article-title":"Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease","volume":"35","author":"Poirier","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.jare.2024.02.007_b0265","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.18632\/aging.203880","article-title":"Cholesterol metabolism in aging simultaneously altered in liver and nervous system","volume":"14","author":"Nunes","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"10.1016\/j.jare.2024.02.007_b0270","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"7","key":"10.1016\/j.jare.2024.02.007_b0275","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.1096\/fj.201900071R","article-title":"APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology","volume":"33","author":"Tran","year":"2019","journal-title":"Faseb j"},{"issue":"7","key":"10.1016\/j.jare.2024.02.007_b0280","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1001\/archneur.59.7.1154","article-title":"The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period","volume":"59","author":"Wilson","year":"2002","journal-title":"Arch Neurol"},{"issue":"5","key":"10.1016\/j.jare.2024.02.007_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.09.033","article-title":"A genome-wide scan for common variants affecting the rate of age-related cognitive decline","volume":"33","author":"De Jager","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jare.2024.02.007_b0290","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neurobiolaging.2018.10.028","article-title":"Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study","volume":"80","author":"Lutz","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jare.2024.02.007_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2018.03.015","article-title":"The role of genetic variation of human metabolism for BMI, mental traits and mental disorders","volume":"12","author":"Hebebrand","year":"2018","journal-title":"Mol Metab"},{"key":"10.1016\/j.jare.2024.02.007_b0300","doi-asserted-by":"crossref","first-page":"1159258","DOI":"10.3389\/fendo.2023.1159258","article-title":"Causal relationship between nonalcoholic fatty liver disease and different sleep traits: a bidirectional Mendelian randomized study","volume":"14","author":"Sun","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jare.2024.02.007_b0305","doi-asserted-by":"crossref","unstructured":"Meroni, M. and M. Longo, The Role of Probiotics in Nonalcoholic Fatty Liver Disease: A New Insight into Therapeutic Strategies. Nutrients, 2019. 11(11).","DOI":"10.3390\/nu11112642"},{"key":"10.1016\/j.jare.2024.02.007_b0310","doi-asserted-by":"crossref","unstructured":"Hoyles, L., J.M. Fern\u00e1ndez-Real, and M. Federici, Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat Med, 2018. 24(7): p. 1070-1080.","DOI":"10.1038\/s41591-018-0061-3"},{"key":"10.1016\/j.jare.2024.02.007_b0315","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ebiom.2017.09.020","article-title":"Microbiota-related changes in bile acid & tryptophan metabolism are associated with gastrointestinal dysfunction in a mouse model of autism","volume":"24","author":"Golubeva","year":"2017","journal-title":"EBioMedicine"},{"issue":"11","key":"10.1016\/j.jare.2024.02.007_b0320","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.clnu.2022.09.012","article-title":"The gut microbiome, mild cognitive impairment, and probiotics: A randomized clinical trial in middle-aged and older adults","volume":"41","author":"Aljumaah","year":"2022","journal-title":"Clin Nutr"},{"issue":"9","key":"10.1016\/j.jare.2024.02.007_b0325","doi-asserted-by":"crossref","first-page":"e0223019","DOI":"10.1371\/journal.pone.0223019","article-title":"Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits","volume":"14","author":"Higarza","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jare.2024.02.007_b0330","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/hep.30827","article-title":"Neuroinflammation in murine cirrhosis is dependent on the gut microbiome and is attenuated by fecal transplant","volume":"71","author":"Liu","year":"2020","journal-title":"Hepatology"},{"issue":"42","key":"10.1016\/j.jare.2024.02.007_b0335","doi-asserted-by":"crossref","first-page":"E4485","DOI":"10.1073\/pnas.1415174111","article-title":"Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity","volume":"111","author":"Leclercq","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2024.02.007_b0340","doi-asserted-by":"crossref","unstructured":"Custodio, R.J.P., Z. Hobloss, and M. Myllys, Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet. Cells, 2023. 12(18).","DOI":"10.3390\/cells12182331"},{"key":"10.1016\/j.jare.2024.02.007_b0345","doi-asserted-by":"crossref","unstructured":"Yang, G., et al., Uncovering the Gut-Liver Axis Biomarkers for Predicting Metabolic Burden in Mice. Cells, 2023. 15(15).","DOI":"10.3390\/nu15153406"},{"key":"10.1016\/j.jare.2024.02.007_b0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398.2023.2299744","article-title":"The therapeutic potential of dietary intervention: based on the mechanism of a tryptophan derivative-indole propionic acid on metabolic disorders","author":"Niu","year":"2024","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jare.2024.02.007_b0355","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2016.02.009","article-title":"Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?","volume":"625","author":"Bourassa","year":"2016","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jare.2024.02.007_b0360","doi-asserted-by":"crossref","unstructured":"Sanborn, V. and M.A. Azcarate-Peril, Randomized Clinical Trial Examining the Impact of Lactobacillus rhamnosus GG Probiotic Supplementation on Cognitive Functioning in Middle-aged and Older Adults. Neuropsychiatr Dis Treat, 2020. 16: p. 2765-2777.","DOI":"10.2147\/NDT.S270035"},{"key":"10.1016\/j.jare.2024.02.007_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2019.112762","article-title":"Modulation of hippocampal TLR4\/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model","volume":"214","author":"Mohammed","year":"2020","journal-title":"Physiol Behav"},{"issue":"5","key":"10.1016\/j.jare.2024.02.007_b0370","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hep4.1325","article-title":"Effect of a multistrain probiotic on cognitive function and risk of falls in patients with cirrhosis: A randomized trial","volume":"3","author":"Rom\u00e1n","year":"2019","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jare.2024.02.007_b0375","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.bbi.2023.11.016","article-title":"Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis","volume":"115","author":"Zheng","year":"2024","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jare.2024.02.007_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.11.051","article-title":"Role of gut microbiota in type 2 diabetes pathophysiology","volume":"51","author":"Gurung","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jare.2024.02.007_b0385","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1016\/j.csbj.2021.10.032","article-title":"Gut microbiome signatures distinguish type 2 diabetes mellitus from non-alcoholic fatty liver disease","volume":"19","author":"Si","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"issue":"12","key":"10.1016\/j.jare.2024.02.007_b0390","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1136\/gutjnl-2013-306541","article-title":"Exercise and associated dietary extremes impact on gut microbial diversity","volume":"63","author":"Clarke","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jare.2024.02.007_b0395","doi-asserted-by":"crossref","unstructured":"Leone, P. and G. Mincheva, Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation. Biomedicines, 2022. 10(6).","DOI":"10.3390\/biomedicines10061263"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0400","doi-asserted-by":"crossref","first-page":"e60042","DOI":"10.1371\/journal.pone.0060042","article-title":"Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy","volume":"8","author":"Bajaj","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2024.02.007_b0405","doi-asserted-by":"crossref","unstructured":"Balzano, T. and P. Leone, Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage. Biomedicines, 2021. 9(8).","DOI":"10.3390\/biomedicines9081002"},{"key":"10.1016\/j.jare.2024.02.007_b0410","doi-asserted-by":"crossref","unstructured":"Bajaj, J.S., et al., Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology, 2017. 66(6): p. 1727-1738.","DOI":"10.1002\/hep.29306"},{"issue":"24","key":"10.1016\/j.jare.2024.02.007_b0415","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133410","article-title":"Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis","volume":"4","author":"Bajaj","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jare.2024.02.007_b0420","doi-asserted-by":"crossref","unstructured":"Liu, R., et al., Neuroinflammation in Murine Cirrhosis Is Dependent on the Gut Microbiome and Is Attenuated by Fecal Transplant. 2020. 71(2): p. 611-626.","DOI":"10.1002\/hep.30827"},{"issue":"8","key":"10.1016\/j.jare.2024.02.007_b0425","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/hep4.1950","article-title":"Fecal microbiota transplant improves cognition in hepatic encephalopathy and its effect varies by donor and recipient","volume":"6","author":"Bloom","year":"2022","journal-title":"Hepatol Commun"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0430","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jhep.2018.06.023","article-title":"Urea cycle dysregulation in non-alcoholic fatty liver disease","volume":"69","author":"De Chiara","year":"2018","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.jare.2024.02.007_b0435","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.jceh.2014.06.004","article-title":"Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation","volume":"5","author":"Aldridge","year":"2015","journal-title":"J Clin Exp Hepatol"},{"issue":"3","key":"10.1016\/j.jare.2024.02.007_b0440","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s11064-016-2014-x","article-title":"Neurotoxicity of Ammonia","volume":"42","author":"Oja","year":"2017","journal-title":"Neurochem Res"},{"issue":"7","key":"10.1016\/j.jare.2024.02.007_b0445","article-title":"Role of ammonia in NAFLD: An unusual suspect","volume":"5","author":"Thomsen","year":"2023","journal-title":"JHEP Rep"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0450","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jhep.2015.11.019","article-title":"Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension","volume":"64","author":"Jalan","year":"2016","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.jare.2024.02.007_b0455","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cld.2023.01.005","article-title":"Clinics in liver disease: update on nonalcoholic steatohepatitis: Sarcopenia and nonalcoholic fatty liver disease","volume":"27","author":"Kawaguchi","year":"2023","journal-title":"Clin Liver Dis"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0460","first-page":"1461","article-title":"The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH","volume":"9","author":"Lie","year":"2019","journal-title":"AMPK and mTORC1"},{"key":"10.1016\/j.jare.2024.02.007_b0465","doi-asserted-by":"crossref","unstructured":"Cifre, M. and A. Palou, Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells. Mol Neurodegener, 2018. 13(1): p. 14.","DOI":"10.1186\/s13024-018-0246-8"},{"key":"10.1016\/j.jare.2024.02.007_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109146","article-title":"Alternate-day fasting prevents non-alcoholic fatty liver disease and working memory impairment in diet-induced obese mice","volume":"110","author":"Zhang","year":"2022","journal-title":"J Nutr Biochem"},{"issue":"3","key":"10.1016\/j.jare.2024.02.007_b0475","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3233\/JAD-221151","article-title":"Relationship Between Cognitive Performance, Physical Activity, and Socio-Demographic\/Individual Characteristics Among Aging Americans","volume":"92","author":"Dowllah","year":"2023","journal-title":"J Alzheimers Dis"},{"issue":"18","key":"10.1016\/j.jare.2024.02.007_b0480","article-title":"Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. JCI","volume":"7","author":"Kullmann","year":"2022","journal-title":"Insight"},{"key":"10.1016\/j.jare.2024.02.007_b0485","doi-asserted-by":"crossref","first-page":"e83604","DOI":"10.7554\/eLife.83604","article-title":"The effect of weight loss following 18 months of lifestyle intervention on brain age assessed with resting-state functional connectivity","volume":"12","author":"Levakov","year":"2023","journal-title":"Elife"},{"issue":"11","key":"10.1016\/j.jare.2024.02.007_b0490","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1111\/sms.14464","article-title":"Effects of 2-year dietary and physical activity intervention on cognition in children-a nonrandomized controlled trial","volume":"33","author":"Naveed","year":"2023","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.jare.2024.02.007_b0495","doi-asserted-by":"crossref","unstructured":"McGrattan, A., et al., Nutritional interventions for the prevention of cognitive impairment and dementia in developing economies in East-Asia: a systematic review and meta-analysis. Crit Rev Food Sci Nutr, 2022. 62(7): p. 1838-1855.","DOI":"10.1080\/10408398.2020.1848785"},{"key":"10.1016\/j.jare.2024.02.007_b0500","doi-asserted-by":"crossref","unstructured":"Gentile, F., P.E. Doneddu, and N. Riva, Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration. Int J Mol Sci, 2020. 21(20).","DOI":"10.3390\/ijms21207471"},{"key":"10.1016\/j.jare.2024.02.007_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101079","article-title":"Nutrition and the ageing brain: Moving towards clinical applications","volume":"62","author":"Flanagan","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jare.2024.02.007_b0510","doi-asserted-by":"crossref","unstructured":"Akash, M.S.H., M. Akbar, and K. Rehman, Biochemical profiling of berberine-enriched extract in aluminum chloride induced oxidative damage and neuroinflammation. Environ Sci Pollut Res Int., 2023. 30(36): p. 85263-85275.","DOI":"10.1007\/s11356-023-28392-1"},{"key":"10.1016\/j.jare.2024.02.007_b0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122112","article-title":"Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment","volume":"333","author":"Li","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.jare.2024.02.007_b0520","doi-asserted-by":"crossref","first-page":"1093180","DOI":"10.3389\/fnins.2023.1093180","article-title":"The efficacy and mechanism of berberine in improving aging-related cognitive dysfunction: A study based on network pharmacology","volume":"17","author":"Yao","year":"2023","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0525","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13020-023-00746-4","article-title":"Berberine improves negative symptoms and cognitive function in patients with chronic schizophrenia via anti-inflammatory effect: a randomized clinical trial","volume":"18","author":"Pu","year":"2023","journal-title":"Chin Med"},{"key":"10.1016\/j.jare.2024.02.007_b0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114871","article-title":"Exercise and Syzygium aromaticum reverse memory deficits, apoptosis and mitochondrial dysfunction of the hippocampus in Alzheimer's disease","volume":"286","author":"Panahzadeh","year":"2022","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"10.1016\/j.jare.2024.02.007_b0535","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3122\/jabfm.2018.04.170261","article-title":"Socioeconomic status and other factors associated with childhood obesity","volume":"31","author":"Williams","year":"2018","journal-title":"J Am Board Fam Med"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0540","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12944-021-01590-x","article-title":"Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats","volume":"20","author":"Gao","year":"2021","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jare.2024.02.007_b0545","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3389\/fendo.2019.00434","article-title":"Resveratrol reduces glucolipid metabolic dysfunction and learning and memory impairment in a NAFLD rat model: involvement in regulating the imbalance of nesfatin-1 abundance and copine 6 expression","volume":"10","author":"Chen","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"10.1016\/j.jare.2024.02.007_b0550","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s12877-021-02239-1","article-title":"Associations between nut intake, cognitive function and non-alcoholic fatty liver disease (NAFLD) in older adults in the United States: NHANES 2011\u201314","volume":"21","author":"Tan","year":"2021","journal-title":"BMC Geriatr"},{"issue":"3","key":"10.1016\/j.jare.2024.02.007_b0555","doi-asserted-by":"crossref","DOI":"10.3390\/nu14030578","article-title":"The Mediation Role of the Risk of Non-Alcoholic Fatty Liver Disease in Relationship between Lutein and Zeaxanthin and Cognitive Functions among Older Adults in the United States","volume":"14","author":"Chen","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jare.2024.02.007_b0560","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.994404","article-title":"The gut-microbiota-brain changes across the liver disease spectrum","volume":"16","author":"Higarza","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jare.2024.02.007_b0565","doi-asserted-by":"crossref","unstructured":"Yan, M. and S. Man, Gut liver brain axis in diseases: the implications for therapeutic interventions. Signal Transduct Target Ther., 2023. 8(1): p. 443.","DOI":"10.1038\/s41392-023-01673-4"},{"key":"10.1016\/j.jare.2024.02.007_b0570","first-page":"15","article-title":"Epidemiology and Risk Factors of Alzheimer\u2019s Disease","author":"Samieri","year":"2018","journal-title":"A Focus on Diet"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224000699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224000699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T10:14:41Z","timestamp":1740651281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224000699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":114,"alternative-id":["S2090123224000699"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.02.007","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A narrative review about cognitive impairment in Metabolic Dysfunction\u2013Associated Steatotic Liver Disease (MASLD): Another matter to face through a holistic approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}