{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:46:23Z","timestamp":1791639983620,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jare.2024.04.020","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T18:04:59Z","timestamp":1713722699000},"page":"481-497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury"],"prefix":"10.1016","volume":"70","author":[{"given":"Chenxi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangrui","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-2359","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2024.04.020_b0005","doi-asserted-by":"crossref","unstructured":"Katz D, and Gavin MC, Stable Ischemic Heart Disease Ann Intern Med 2019; 171(3): Itc17-itc32.","DOI":"10.7326\/AITC201908060"},{"key":"10.1016\/j.jare.2024.04.020_b0010","doi-asserted-by":"crossref","unstructured":"Su SA, Zhang Y, Li W, et al., Cardiac Piezo1 Exacerbates Lethal Ventricular Arrhythmogenesis by Linking Mechanical Stress with Ca(2+) Handling After Myocardial Infarction Research (Wash D C) 2023;6(0165).","DOI":"10.34133\/research.0165"},{"issue":"11","key":"10.1016\/j.jare.2024.04.020_b0015","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJMoa1505489","article-title":"Cyclosporine before PCI in Patients with Acute Myocardial Infarction","volume":"373","author":"Cung","year":"2015","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.jare.2024.04.020_b0020","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jacc.2006.10.059","article-title":"Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET","volume":"49","author":"Remme","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jare.2024.04.020_b0025","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2314149","article-title":"FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction","author":"B\u00f6hm","year":"2024","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1016\/j.jare.2024.04.020_b0030","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","article-title":"Evolving therapies for myocardial ischemia\/reperfusion injury","volume":"65","author":"Ib\u00e1\u00f1ez","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"23","key":"10.1016\/j.jare.2024.04.020_b0035","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Fr\u00f6hlich","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jare.2024.04.020_b0040","doi-asserted-by":"crossref","unstructured":"Cadenas S, ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection Free Radic Biol Med 2018; 117(76-89).","DOI":"10.1016\/j.freeradbiomed.2018.01.024"},{"issue":"2","key":"10.1016\/j.jare.2024.04.020_b0045","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/physrev.00024.2007","article-title":"Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury","volume":"88","author":"Murphy","year":"2008","journal-title":"Physiol Rev"},{"issue":"12","key":"10.1016\/j.jare.2024.04.020_b0050","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrc3847","article-title":"The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer","volume":"14","author":"Graham","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.jare.2024.04.020_b0055","doi-asserted-by":"crossref","first-page":"H1207","DOI":"10.1152\/ajpheart.00020.2004","article-title":"Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells","volume":"287","author":"Hasanbasic","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.jare.2024.04.020_b0060","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2004.05.070","article-title":"Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts","volume":"319","author":"Stenhoff","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jare.2024.04.020_b0065","doi-asserted-by":"crossref","unstructured":"Shan S, Liu Z, Guo T, et al., Growth arrest-specific gene 6 transfer promotes mesenchymal stem cell survival and cardiac repair under hypoxia and ischemia via enhanced autocrine signaling and paracrine action Arch Biochem Biophys 2018; 660(108-120).","DOI":"10.1016\/j.abb.2018.10.016"},{"issue":"8","key":"10.1016\/j.jare.2024.04.020_b0070","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1182\/blood-2007-05-089565","article-title":"Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes","volume":"111","author":"Tjwa","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jare.2024.04.020_b0075","doi-asserted-by":"crossref","unstructured":"Yang YF, Ai Q, Huang C, et al., A 1.1Mb deletion in distal 13q deletion syndrome region with congenital heart defect and postaxial polydactyly: additional support for a CHD locus at distal 13q34 region Gene 2013; 528(1):51-4.","DOI":"10.1016\/j.gene.2013.03.145"},{"issue":"5","key":"10.1016\/j.jare.2024.04.020_b0080","doi-asserted-by":"crossref","first-page":"H1829","DOI":"10.1152\/ajpheart.00240.2010","article-title":"Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure","volume":"300","author":"Shuvy","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.jare.2024.04.020_b0085","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/HYPERTENSIONAHA.115.06254","article-title":"Growth Arrest-Specific 6 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy","volume":"67","author":"Zhao","year":"2016","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.jare.2024.04.020_b0090","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/hep.23833","article-title":"Growth arrest-specific protein 6 is hepatoprotective against murine ischemia\/reperfusion injury","volume":"52","author":"Llacuna","year":"2010","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jare.2024.04.020_b0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jpsychores.2013.11.015","article-title":"Personality and self-esteem in emerging adults with Type 1 diabetes","volume":"76","author":"Rassart","year":"2014","journal-title":"J Psychosom Res"},{"issue":"3","key":"10.1016\/j.jare.2024.04.020_b0100","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1152\/physrev.00022.2011","article-title":"Sirtuin 1 and sirtuin 3: physiological modulators of metabolism","volume":"92","author":"Nogueiras","year":"2012","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.jare.2024.04.020_b0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrc2562","article-title":"How does SIRT1 affect metabolism, senescence and cancer?","volume":"9","author":"Brooks","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"21","key":"10.1016\/j.jare.2024.04.020_b0110","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.110.958033","article-title":"Silent information regulator 1 protects the heart from ischemia\/reperfusion","volume":"122","author":"Hsu","year":"2010","journal-title":"Circulation"},{"issue":"48","key":"10.1016\/j.jare.2024.04.020_b0115","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1093\/eurheartj\/ehv290","article-title":"Protective effects of sirtuins in cardiovascular diseases: from bench to bedside","volume":"36","author":"Winnik","year":"2015","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jare.2024.04.020_b0120","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jpi.12161","article-title":"Melatonin receptor-mediated protection against myocardial ischemia\/reperfusion injury: role of SIRT1","volume":"57","author":"Yu","year":"2014","journal-title":"J Pineal Res"},{"issue":"9","key":"10.1016\/j.jare.2024.04.020_b0125","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/ATVBAHA.118.311298","article-title":"miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)","volume":"38","author":"Badi","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.jare.2024.04.020_b0130","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","article-title":"HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte","volume":"95","author":"Claycomb","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2024.04.020_b0135","doi-asserted-by":"crossref","unstructured":"Tanaka M, and Siemann DW, Gas6\/Axl Signaling Pathway in the Tumor Immune Microenvironment Cancers (Basel) 2020; 12(7).","DOI":"10.3390\/cancers12071850"},{"key":"10.1016\/j.jare.2024.04.020_b0140","doi-asserted-by":"crossref","unstructured":"van der Meer JH, van der Poll T, and van 't Veer C, TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis Blood 2014; 123(16):2460-9.","DOI":"10.1182\/blood-2013-09-528752"},{"issue":"3","key":"10.1016\/j.jare.2024.04.020_b0145","doi-asserted-by":"crossref","first-page":"220","DOI":"10.24272\/j.issn.2095-8137.2020.042","article-title":"The pathological role of ferroptosis in ischemia\/reperfusion-related injury","volume":"41","author":"Yan","year":"2020","journal-title":"Zool Res"},{"key":"10.1016\/j.jare.2024.04.020_b0150","doi-asserted-by":"crossref","unstructured":"Wang L, Yu P, Wang J, et al., Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression Research (Wash D C) 2022; 2022(9825916).","DOI":"10.34133\/2022\/9825916"},{"issue":"3","key":"10.1016\/j.jare.2024.04.020_b0155","first-page":"1398","article-title":"Effects of reperfusion on ischemic right ventricular dysfunction","volume":"90","author":"Laster","year":"1994","journal-title":"Disparate mechanisms of benefit related to duration of ischemia Circulation"},{"key":"10.1016\/j.jare.2024.04.020_b0160","doi-asserted-by":"crossref","unstructured":"Palee S, McSweeney CM, Maneechote C, et al., PCSK9 inhibitor improves cardiac function and reduces infarct size in rats with ischaemia\/reperfusion injury: Benefits beyond lipid-lowering effects 2019; 23(11):7310-7319.","DOI":"10.1111\/jcmm.14586"},{"issue":"2","key":"10.1016\/j.jare.2024.04.020_b0165","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jss.2015.05.049","article-title":"Growth arrest-specific protein 6 protects against renal ischemia-reperfusion injury","volume":"199","author":"Giangola","year":"2015","journal-title":"J Surg Res"},{"key":"10.1016\/j.jare.2024.04.020_b0170","doi-asserted-by":"crossref","unstructured":"Peng CK, Wu CP, Lin JY, et al., Gas6\/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway PLoS One 2019; 14(7):e0219788.","DOI":"10.1371\/journal.pone.0219788"},{"key":"10.1016\/j.jare.2024.04.020_b0175","doi-asserted-by":"crossref","unstructured":"Niu X, Cheng Y, Zhang M, et al., Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia\/Reoxygenation Injury via Activating GAS6\/Axl Signaling Pathway in Neuroblastoma Cells Front Cell Dev Biol 2021; 9(784035).","DOI":"10.3389\/fcell.2021.784035"},{"key":"10.1016\/j.jare.2024.04.020_b0180","doi-asserted-by":"crossref","unstructured":"Ji T, Liu Q, Yu L, et al., GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism Free Radic Biol Med 2024: 210(195-211).","DOI":"10.1016\/j.freeradbiomed.2023.11.007"},{"key":"10.1016\/j.jare.2024.04.020_b0185","doi-asserted-by":"crossref","unstructured":"Chen YQ, Zhou HM, Chen FF, et al., Testosterone ameliorates vascular aging via the Gas6\/Axl signaling pathway Aging (Albany NY) 2020; 12(16):16111-16125.","DOI":"10.18632\/aging.103584"},{"key":"10.1016\/j.jare.2024.04.020_b0190","doi-asserted-by":"crossref","unstructured":"Guo ZN, Liu J, Chang J, et al., GAS6\/Axl Signaling Modulates Blood-Brain Barrier Function Following Intravenous Thrombolysis in Acute Ischemic Stroke Front Immunol 2021; 12(742359).","DOI":"10.3389\/fimmu.2021.742359"},{"issue":"12","key":"10.1016\/j.jare.2024.04.020_b0195","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/glia.23214","article-title":"Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure","volume":"65","author":"Ray","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.jare.2024.04.020_b0200","doi-asserted-by":"crossref","unstructured":"Zhang B, Zhai M, Li B, et al., Honokiol Ameliorates Myocardial Ischemia\/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway 2018; 2018(3159801).","DOI":"10.1155\/2018\/3159801"},{"issue":"6","key":"10.1016\/j.jare.2024.04.020_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103687","article-title":"Role of marination, natural antimicrobial compounds, and packaging on microbiota during storage of chicken tawook","volume":"103","author":"Osaili","year":"2024","journal-title":"Poult Sci"},{"key":"10.1016\/j.jare.2024.04.020_b0210","doi-asserted-by":"crossref","unstructured":"Dallali D, Fakhfakh J, Paris C, et al., HPLC-HESI-MS\/MS Analysis of Phenolic Compounds from Cynoglossum tubiflorus Leaf Extracts: An Assessment of Their Cytotoxic, Antioxidant, and Antibacterial Properties Plants (Basel) 2024; 13(6).","DOI":"10.3390\/plants13060909"},{"key":"10.1016\/j.jare.2024.04.020_b0215","first-page":"9","article-title":"Pharmacology of Catechins in Ischemia-Reperfusion Injury of the","volume":"10","author":"Ferenczyov\u00e1","year":"2021","journal-title":"Heart"},{"key":"10.1016\/j.jare.2024.04.020_b0220","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/ijms19020628","article-title":"Epigallocatechin Gallate Reduces Ischemia\/Reperfusion Injury in Isolated Perfused Rabbit Hearts","volume":"19","author":"Salameh","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2024.04.020_b0225","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12929-017-0345-9","article-title":"Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis","volume":"24","author":"Tian","year":"2017","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jare.2024.04.020_b0230","doi-asserted-by":"crossref","unstructured":"Hou K, Shen J, Yan J, et al., Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin EBioMedicine 2021; 69(103456).","DOI":"10.1016\/j.ebiom.2021.103456"},{"issue":"4","key":"10.1016\/j.jare.2024.04.020_b0235","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cardiores.2003.11.031","article-title":"Hypoxia regulates the adenosine transporter, mENT1, in the murine cardiomyocyte cell line, HL-1","volume":"61","author":"Chaudary","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jare.2024.04.020_b0240","doi-asserted-by":"crossref","unstructured":"Zhang Z, Zhao X, Gao M, et al., Dioscin alleviates myocardial infarction injury via regulating BMP4\/NOX1-mediated oxidative stress and inflammation Phytomedicine 2022; 103(154222).","DOI":"10.1016\/j.phymed.2022.154222"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224001632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224001632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T20:35:02Z","timestamp":1742416502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224001632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":48,"alternative-id":["S2090123224001632"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.04.020","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}