{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:13:29Z","timestamp":1793218409674,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jare.2024.05.002","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T05:56:40Z","timestamp":1715407000000},"page":"545-553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study"],"prefix":"10.1016","volume":"70","author":[{"given":"Guorui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyanan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhewei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"137\u2013150","key":"10.1016\/j.jare.2024.05.002_b0005","first-page":"20220110","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet","volume":"9","author":"Ferrari","year":"2022","journal-title":"Psychiatry"},{"issue":"270\u2013280","key":"10.1016\/j.jare.2024.05.002_b0010","first-page":"20220916","article-title":"Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders","volume":"48","author":"Liu","year":"2023","journal-title":"Neuropsychopharmacology"},{"issue":"110209","key":"10.1016\/j.jare.2024.05.002_b0015","first-page":"20201214","article-title":"Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis","volume":"107","author":"Person","year":"2021","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"359\u2013370","key":"10.1016\/j.jare.2024.05.002_b0020","first-page":"20210312","article-title":"Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"6","author":"Barberio","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"120\u2013124","key":"10.1016\/j.jare.2024.05.002_b0025","first-page":"20190115","article-title":"Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study","volume":"247","author":"Kao","year":"2019","journal-title":"J Affect Disord"},{"issue":"101986","key":"10.1016\/j.jare.2024.05.002_b0030","first-page":"20230505","article-title":"Longitudinal trajectories of anxiety, depression, and bipolar disorder in inflammatory bowel disease: a population-based cohort study","volume":"59","author":"Bisgaard","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jare.2024.05.002_b0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"176\u2013185","key":"10.1016\/j.jare.2024.05.002_b0040","first-page":"20210716","article-title":"Associations of immunological proteins\/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study","volume":"97","author":"Perry","year":"2021","journal-title":"Brain Behav Immun"},{"issue":"2307\u20132319","key":"10.1016\/j.jare.2024.05.002_b0045","first-page":"20190823","article-title":"An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis","volume":"49","author":"\u00c7akici","year":"2019","journal-title":"Psychol Med"},{"key":"10.1016\/j.jare.2024.05.002_b0050","doi-asserted-by":"crossref","unstructured":"Davey Smith G and Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014; 23: R89-98. 2014\/07\/30. DOI: 10.1093\/hmg\/ddu328.","DOI":"10.1093\/hmg\/ddu328"},{"issue":"767\u2013782","key":"10.1016\/j.jare.2024.05.002_b0055","first-page":"20220421","article-title":"Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches","volume":"109","author":"Zuber","year":"2022","journal-title":"Am J Hum Genet"},{"issue":"e0279381","key":"10.1016\/j.jare.2024.05.002_b0060","first-page":"20221229","article-title":"Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization","volume":"17","author":"Aman","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2024.05.002_b0065","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/jamapsychiatry.2021.0005","article-title":"Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study","volume":"78","author":"Chauquet","year":"2021","journal-title":"JAMA Psychiat"},{"issue":"53","key":"10.1016\/j.jare.2024.05.002_b0070","first-page":"20190301","article-title":"Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis","volume":"16","author":"Ma","year":"2019","journal-title":"J Neuroinflammation"},{"issue":"737197","key":"10.1016\/j.jare.2024.05.002_b0075","first-page":"20220204","article-title":"Gut Microbiota and Psychiatric Disorders: A Two-Sample Mendelian Randomization Study","volume":"12","author":"Ni","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jare.2024.05.002_b0080","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jare.2024.05.002_b0085","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gky1075","article-title":"ChEMBL: towards direct deposition of bioassay data","volume":"47","author":"Mendez","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jare.2024.05.002_b0090","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Aguet","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jare.2024.05.002_b0095","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ajhg.2017.09.003","article-title":"Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk","volume":"101","author":"Richardson","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"143\u2013146","key":"10.1016\/j.jare.2024.05.002_b0100","first-page":"20210128","article-title":"Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis","volume":"53","author":"Wingo","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.jare.2024.05.002_b0105","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious Orders Study and Rush Memory and Aging Project","volume":"64","author":"Bennett","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jare.2024.05.002_b0110","first-page":"1961","article-title":"Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic","volume":"45","author":"Bowden","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"817\u2013829","key":"10.1016\/j.jare.2024.05.002_b0115","first-page":"20210517","article-title":"Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology","volume":"53","author":"Mullins","year":"2021","journal-title":"Nat Genet"},{"issue":"502\u2013508","key":"10.1016\/j.jare.2024.05.002_b0120","first-page":"20220408","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizophrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"issue":"343\u2013352","key":"10.1016\/j.jare.2024.05.002_b0125","first-page":"20190204","article-title":"Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions","volume":"22","author":"Howard","year":"2019","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jare.2024.05.002_b0130","doi-asserted-by":"crossref","unstructured":"Burgess S, Butterworth A and Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013; 37: 658-665. 2013\/10\/12. DOI: 10.1002\/gepi.21758.","DOI":"10.1002\/gepi.21758"},{"key":"10.1016\/j.jare.2024.05.002_b0135","doi-asserted-by":"crossref","first-page":"2018\/05\/31","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"218","key":"10.1016\/j.jare.2024.05.002_b0140","first-page":"20220906","article-title":"The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study","volume":"19","author":"Shi","year":"2022","journal-title":"J Neuroinflammation"},{"issue":"1300\u20131310","key":"10.1016\/j.jare.2024.05.002_b0145","first-page":"20210902","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat Genet"},{"issue":"73\u201379","key":"10.1016\/j.jare.2024.05.002_b0150","first-page":"20180606","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jare.2024.05.002_b0155","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1126\/science.aav8130","article-title":"Single-cell genomics identifies cell type-specific molecular changes in autism","volume":"364","author":"Velmeshev","year":"2019","journal-title":"Science"},{"issue":"156\u2013165","key":"10.1016\/j.jare.2024.05.002_b0160","first-page":"20210118","article-title":"Large-scale association analyses identify host factors influencing human gut microbiome composition","volume":"53","author":"Kurilshikov","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.jare.2024.05.002_b0165","doi-asserted-by":"crossref","unstructured":"VanderWeele TJ. Mediation Analysis: A Practitioner's Guide. Annu Rev Public Health. 2016; 37: 17-32. 2015\/12\/15. DOI: 10.1146\/annurev-publhealth-032315-021402.","DOI":"10.1146\/annurev-publhealth-032315-021402"},{"key":"10.1016\/j.jare.2024.05.002_b0170","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3724\/SP.J.1042.2014.00731","article-title":"Analyses of Mediating Effects: The Development of Methods and Models","volume":"22","author":"Wen","year":"2014","journal-title":"Adv Psychol Sci"},{"key":"10.1016\/j.jare.2024.05.002_b0175","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1399-5618.2012.01022.x","article-title":"The functional neuroanatomy of bipolar disorder: a consensus model","volume":"14","author":"Strakowski","year":"2012","journal-title":"Bipolar Disord"},{"issue":"161\u2013171","key":"10.1016\/j.jare.2024.05.002_b0180","first-page":"20121012","article-title":"Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities","volume":"31","author":"Savitz","year":"2013","journal-title":"Brain Behav Immun"},{"issue":"1614\u20131626","key":"10.1016\/j.jare.2024.05.002_b0185","first-page":"20220217","article-title":"Association between resting-state functional connectivity of amygdala subregions and peripheral pro-inflammation cytokines levels in bipolar disorder","volume":"16","author":"Gong","year":"2022","journal-title":"Brain Imaging Behav"},{"issue":"57\u201374","key":"10.1016\/j.jare.2024.05.002_b0190","first-page":"20201112","article-title":"Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?","volume":"42","author":"Chaves Filho","year":"2021","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jare.2024.05.002_b0195","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0009-9236(97)90125-9","article-title":"Olsalazine and 6-mercaptopurine-related bone marrow suppression: a possible drug-drug interaction","volume":"62","author":"Lewis","year":"1997","journal-title":"Clin Pharmacol Ther"},{"issue":"116592","key":"10.1016\/j.jare.2024.05.002_b0200","first-page":"20190619","article-title":"The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target","volume":"232","author":"Goudarzi","year":"2019","journal-title":"Life Sci"},{"issue":"21","key":"10.1016\/j.jare.2024.05.002_b0205","first-page":"20200129","article-title":"Editorial: Metabolic Disturbances in Mental Illness: Neuropathogenetic Mechanisms and Therapeutic Implications","volume":"14","author":"Deng","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jare.2024.05.002_b0210","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s44220-023-00110-3","article-title":"Neuroimaging and multiomics reveal cross-scale circuit abnormalities in schizophrenia","volume":"1","author":"Wang","year":"2023","journal-title":"Nature Mental Health"},{"issue":"689473","key":"10.1016\/j.jare.2024.05.002_b0215","first-page":"20210920","article-title":"The Neurometabolic Basis of Mood Instability: The Parvalbumin Interneuron Link-A Systematic Review and Meta-Analysis","volume":"12","author":"Pinna","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1069496","key":"10.1016\/j.jare.2024.05.002_b0220","first-page":"20221124","article-title":"Function and development of interneurons involved in brain tissue oxygen regulation","volume":"15","author":"Aksenov","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"757718","key":"10.1016\/j.jare.2024.05.002_b0225","first-page":"20211122","article-title":"Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species","volume":"11","author":"Nie","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"1900752","key":"10.1016\/j.jare.2024.05.002_b0230","first-page":"20190515","article-title":"Gut Microbiota Changes in Patients with Bipolar Depression","volume":"6","author":"Hu","year":"2019","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jare.2024.05.002_b0235","doi-asserted-by":"crossref","unstructured":"Davies NM, Holmes MV and Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. Bmj. 2018; 362: k601. 2018\/07\/14. DOI: 10.1136\/bmj.k601.","DOI":"10.1136\/bmj.k601"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224001796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224001796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:39:10Z","timestamp":1742431150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224001796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":47,"alternative-id":["S2090123224001796"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.05.002","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}