{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:27:02Z","timestamp":1791332822774,"version":"4.3.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873656"],"award-info":[{"award-number":["81873656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81920108009"],"award-info":[{"award-number":["81920108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100931"],"award-info":[{"award-number":["82100931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130023"],"award-info":[{"award-number":["82130023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100823"],"award-info":[{"award-number":["82100823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200926"],"award-info":[{"award-number":["82200926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270885"],"award-info":[{"award-number":["82270885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100892"],"award-info":[{"award-number":["82100892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070808"],"award-info":[{"award-number":["82070808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200923"],"award-info":[{"award-number":["82200923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270893"],"award-info":[{"award-number":["82270893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010888","name":"Wuhan Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022020801020450"],"award-info":[{"award-number":["2022020801020450"]}],"id":[{"id":"10.13039\/501100010888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["54000-0106540081"],"award-info":[{"award-number":["54000-0106540081"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["54000-0106540080"],"award-info":[{"award-number":["54000-0106540080"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","award":["2022A15"],"award-info":[{"award-number":["2022A15"]}],"id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0806101"],"award-info":[{"award-number":["2022YFA0806101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jare.2024.06.017","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T19:53:36Z","timestamp":1718826816000},"page":"521-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-2157","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Rao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1112-8088","authenticated-orcid":false,"given":"Weikuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weining","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2024.06.017_b0005","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0140-6736(17)30866-8","article-title":"Idiopathic pulmonary fibrosis","volume":"389","author":"Richeldi","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2024.06.017_b0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/annrheumdis-2020-217230","article-title":"Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs)","volume":"80","author":"Spagnolo","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2024.06.017_b0015","doi-asserted-by":"crossref","first-page":"eabo5070","DOI":"10.1126\/scitranslmed.abo5070","article-title":"SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice","volume":"14","author":"Dinnon","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jare.2024.06.017_b0020","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41467-021-27684-9","article-title":"Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating beta-catenin signaling","volume":"13","author":"Hu","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2024.06.017_b0025","first-page":"8","article-title":"Immune checkpoints as promising targets for the treatment of idiopathic pulmonary fibrosis?","author":"Duitman","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jare.2024.06.017_b0030","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.7150\/thno.61085","article-title":"Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jare.2024.06.017_b0035","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s41591-018-0087-6","article-title":"Metformin reverses established lung fibrosis in a bleomycin model","volume":"24","author":"Rangarajan","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2024.06.017_b0040","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/nm.4419","article-title":"ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis","volume":"23","author":"Lagares","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2024.06.017_b0045","first-page":"11","article-title":"Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis","author":"Ng","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jare.2024.06.017_b0050","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01346-2019","article-title":"TRIM33 prevents pulmonary fibrosis by impairing TGF-beta1 signalling","volume":"55","author":"Boutanquoi","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jare.2024.06.017_b0055","doi-asserted-by":"crossref","first-page":"e12131","DOI":"10.15252\/emmm.202012131","article-title":"Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis","volume":"12","author":"Kasam","year":"2020","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jare.2024.06.017_b0060","doi-asserted-by":"crossref","DOI":"10.1177\/2040622320940185","article-title":"Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis","volume":"11","author":"Miao","year":"2020","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1016\/j.jare.2024.06.017_b0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12931-020-1300-y","article-title":"Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-beta-induced fibroblast to myofibroblast differentiation","volume":"21","author":"Liu","year":"2020","journal-title":"Respir Res"},{"key":"10.1016\/j.jare.2024.06.017_b0070","doi-asserted-by":"crossref","first-page":"C689","DOI":"10.1152\/ajpcell.00586.2020","article-title":"Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids","volume":"320","author":"Roque","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jare.2024.06.017_b0075","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/resp.13465","article-title":"Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis","volume":"24","author":"Gaugg","year":"2019","journal-title":"Respirology"},{"key":"10.1016\/j.jare.2024.06.017_b0080","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ymthe.2021.02.023","article-title":"Arginine is a key player in fibroblasts during the course of IPF development","volume":"29","author":"Wang","year":"2021","journal-title":"Mol Ther"},{"key":"10.1016\/j.jare.2024.06.017_b0085","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1165\/rcmb.2017-0186OC","article-title":"Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis","volume":"58","author":"Hamanaka","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jare.2024.06.017_b0090","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1165\/rcmb.2019-0008OC","article-title":"Glutamine metabolism is required for collagen protein synthesis in lung fibroblasts","volume":"61","author":"Hamanaka","year":"2019","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jare.2024.06.017_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165663","article-title":"Metabolic Dysregulation in Idiopathic Pulmonary Fibrosis","volume":"21","author":"Bargagli","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2024.06.017_b0100","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jare.2024.06.017_b0105","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/blood-2009-09-246124","article-title":"Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity","volume":"115","author":"Liu","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jare.2024.06.017_b0110","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1080\/10408398.2019.1598334","article-title":"Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)","volume":"60","author":"Sun","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"586\u2013600","key":"10.1016\/j.jare.2024.06.017_b0115","first-page":"e6","article-title":"Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps","volume":"141","author":"Wang","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jare.2024.06.017_b0120","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/oby.23065","article-title":"Kynurenine-Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia","volume":"29","author":"Rojas","year":"2021","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jare.2024.06.017_b0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12890-021-01462-1","article-title":"Distinct metabolic features in the plasma of patients with silicosis and dust-exposed workers in China: a case-control study","volume":"21","author":"Xue","year":"2021","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jare.2024.06.017_b0130","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jare.2024.06.017_b0135","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2024.06.017_b0140","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03697-2020","article-title":"The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation","volume":"60","author":"Wang","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jare.2024.06.017_b0145","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4156","article-title":"Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5-hydroxytryptamine in human plasma by LC-MS\/MS and its application to acute myocardial infarction monitoring","volume":"32","author":"Tong","year":"2018","journal-title":"Biomed Chromatogr"},{"key":"10.1016\/j.jare.2024.06.017_b0150","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1038\/s41467-022-31126-5","article-title":"Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR\/STAT3\/IL-6 signaling","volume":"13","author":"Huang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2024.06.017_b0155","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.7150\/thno.48152","article-title":"Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis","volume":"11","author":"Pan","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jare.2024.06.017_b0160","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/mt.2016.36","article-title":"Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage Production","volume":"24","author":"Yao","year":"2016","journal-title":"Mol Ther"},{"issue":"1550\u201361","key":"10.1016\/j.jare.2024.06.017_b0165","first-page":"e8","article-title":"Role of C\/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4\/signal transducer and activator of transcription 6\/transcription factor EC\/IL-4 receptor alpha positive feedback loop in M2 macrophages","volume":"140","author":"Wang","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jare.2024.06.017_b0170","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.omto.2020.01.010","article-title":"Tartrate-Resistant Acid Phosphatase 5\/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma","volume":"16","author":"Hu","year":"2020","journal-title":"Mol Ther Oncolytics"},{"key":"10.1016\/j.jare.2024.06.017_b0175","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41418-020-00650-6","article-title":"IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages","volume":"28","author":"Rao","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jare.2024.06.017_b0180","doi-asserted-by":"crossref","first-page":"19336","DOI":"10.1073\/pnas.1306369110","article-title":"Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K\/AKT pathway","volume":"110","author":"Wang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2024.06.017_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172724","article-title":"Negative regulation of PI3K\/AKT\/mTOR axis regulates fibroblast proliferation, apoptosis and autophagy play a vital role in triptolide-induced epidural fibrosis reduction","volume":"864","author":"Dai","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jare.2024.06.017_b0190","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11010-017-3101-2","article-title":"Cytoglobin inhibits migration through PI3K\/AKT\/mTOR pathway in fibroblast cells","volume":"437","author":"Demirci","year":"2018","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jare.2024.06.017_b0195","doi-asserted-by":"crossref","first-page":"12420","DOI":"10.1073\/pnas.1305656110","article-title":"PTEN loss defines a PI3K\/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma","volume":"110","author":"Pfeifer","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2024.06.017_b0200","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0269-2020","article-title":"The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis","volume":"29","author":"Plate","year":"2020","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jare.2024.06.017_b0205","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1164\/rccm.201504-0780OC","article-title":"Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis","volume":"192","author":"Xie","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jare.2024.06.017_b0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124257","article-title":"Lipid mediators regulate pulmonary fibrosis: potential mechanisms and signaling pathways","volume":"21","author":"Suryadevara","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2024.06.017_b0215","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.ymthe.2021.01.028","article-title":"Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis","volume":"29","author":"Li","year":"2021","journal-title":"Mol Ther"},{"key":"10.1016\/j.jare.2024.06.017_b0220","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.2147\/OTT.S252929","article-title":"TDO Promotes Hepatocellular Carcinoma Progression","volume":"13","author":"Li","year":"2020","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.jare.2024.06.017_b0225","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1166\/jbn.2015.2146","article-title":"Synergistic Effect of Immunoliposomal Gemcitabine and Bevacizumab in Glioblastoma Stem Cell-Targeted Therapy","volume":"11","author":"Shin","year":"2015","journal-title":"J Biomed Nanotechnol"},{"key":"10.1016\/j.jare.2024.06.017_b0230","doi-asserted-by":"crossref","first-page":"15917","DOI":"10.1038\/s41598-018-34166-4","article-title":"Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6\/stat3 signalling","volume":"8","author":"Yamamoto","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.06.017_b0235","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1002\/jcp.25383","article-title":"Kynurenine Modulates MMP-1 and Type-I Collagen expression via aryl hydrocarbon receptor activation in dermal fibroblasts","volume":"231","author":"Poormasjedi-Meibod","year":"2016","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jare.2024.06.017_b0240","first-page":"661","article-title":"Botulinum toxin type A prevents the phenotypic transformation of fibroblasts induced by TGFbeta1 via the PTEN\/PI3K\/Akt signaling pathway","volume":"44","author":"Zhang","year":"2019","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jare.2024.06.017_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100886","article-title":"Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR","volume":"297","author":"Rijo","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2024.06.017_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101573","article-title":"Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process","volume":"75","author":"Salminen","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jare.2024.06.017_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106886","article-title":"Aryl hydrocarbon receptor signaling activation in systemic sclerosis attenuates collagen production and is a potential antifibrotic target","volume":"88","author":"Shi","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2024.06.017_b0260","doi-asserted-by":"crossref","first-page":"e00741","DOI":"10.1002\/prp2.741","article-title":"Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers","volume":"9","author":"Al-Karagholi","year":"2021","journal-title":"Pharmacol Res Perspect"}],"updated-by":[{"DOI":"10.1016\/j.jare.2025.12.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000}},{"DOI":"10.1016\/j.jare.2025.12.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000}}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:56:00Z","timestamp":1778835360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224002546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":52,"alternative-id":["S2090123224002546"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.06.017","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}