{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:01:00Z","timestamp":1793361660605,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011614"],"award-info":[{"award-number":["2023A1515011614"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073532"],"award-info":[{"award-number":["82073532"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373554"],"award-info":[{"award-number":["82373554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jare.2024.06.024","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T01:03:00Z","timestamp":1719882180000},"page":"501-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target I\u03baB\u03b1 and activate NF-\u03baB signaling"],"prefix":"10.1016","volume":"71","author":[{"given":"Huiyu","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongdaixi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-2162","authenticated-orcid":false,"given":"Longying","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2024.06.024_b0005","unstructured":"WHO: WHO reveals leading causes of death and disability worldwide:2000-2019. In.; 2019."},{"issue":"12","key":"10.1016\/j.jare.2024.06.024_b0010","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2449","article-title":"Nutrient sensing and inflammation in metabolic diseases","volume":"8","author":"Hotamisligil","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2024.06.024_b0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cytogfr.2019.12.008","article-title":"Microvesicles and exosomes in metabolic diseases and inflammation","volume":"51","author":"Dini","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jare.2024.06.024_b0020","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","article-title":"The Metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00395-020-0781-7","article-title":"M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment","volume":"115","author":"Liu","year":"2020","journal-title":"Basic Res Cardiol"},{"issue":"12","key":"10.1016\/j.jare.2024.06.024_b0030","doi-asserted-by":"crossref","first-page":"e13140","DOI":"10.1111\/cpr.13140","article-title":"Bone marrow macrophage-derived exosomal miR-143-5p contributes to insulin resistance in hepatocytes by repressing MKP5","volume":"54","author":"Li","year":"2021","journal-title":"Cell Prolif"},{"issue":"8","key":"10.1016\/j.jare.2024.06.024_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102847","article-title":"High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis","volume":"24","author":"Bouchareychas","year":"2021","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tem.2016.10.003","article-title":"Extracellular vesicles: novel mediators of cell communication in metabolic disease","volume":"28","author":"Huang-Doran","year":"2017","journal-title":"Trends Endocrinol Metab"},{"issue":"6478","key":"10.1016\/j.jare.2024.06.024_b0045","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/ATVBAHA.117.309795","article-title":"Extracellular vesicles secreted by atherogenic macrophages transfer MicroRNA to inhibit cell migration","volume":"38","author":"Nguyen","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.jare.2024.06.024_b0055","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cmet.2020.12.019","article-title":"MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice","volume":"33","author":"Ying","year":"2021","journal-title":"Cell Metab"},{"issue":"9","key":"10.1016\/j.jare.2024.06.024_b0060","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00125-021-05489-1","article-title":"M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt\/GSK-3\u03b2\/\u03b2-catenin pathway in mice","volume":"64","author":"Qian","year":"2021","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0065","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jare.2024.06.024_b0070","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ-linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr Rev"},{"issue":"20","key":"10.1016\/j.jare.2024.06.024_b0075","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1080\/15384101.2019.1654797","article-title":"Exosomes derived from oxLDL-stimulated macrophages induce neutrophil extracellular traps to drive atherosclerosis","volume":"18","author":"Zhang","year":"2019","journal-title":"Cell Cycle"},{"issue":"23","key":"10.1016\/j.jare.2024.06.024_b0080","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.7150\/thno.37357","article-title":"Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p\/PTEN-mediated VSMC migration and proliferation","volume":"9","author":"Zhu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jare.2024.06.024_b0085","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2147\/IJN.S350250","article-title":"Exosomes as promising nanostructures in diabetes mellitus: from insulin sensitivity to ameliorating diabetic complications","volume":"17","author":"Ashrafizadeh","year":"2022","journal-title":"Int J Nanomed"},{"issue":"4","key":"10.1016\/j.jare.2024.06.024_b0090","doi-asserted-by":"crossref","DOI":"10.1172\/JCI135197","article-title":"TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis","volume":"131","author":"Hou","year":"2021","journal-title":"J Clin Invest"},{"issue":"20","key":"10.1016\/j.jare.2024.06.024_b0095","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1111\/jcmm.17541","article-title":"Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-\u03baB P65 signalling activation","volume":"26","author":"Liu","year":"2022","journal-title":"J Cell Mol Med"},{"issue":"3","key":"10.1016\/j.jare.2024.06.024_b0100","first-page":"4605","article-title":"Exosomes derived from oxidized LDL-stimulated macrophages attenuate the growth and tube formation of endothelial cells","volume":"17","author":"Huang","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jare.2024.06.024_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2015.12.007","article-title":"The relation of saturated fatty acids with low-grade inflammation and cardiovascular disease","volume":"36","author":"Ruiz-N\u00fa\u00f1ez","year":"2016","journal-title":"J Nutr Biochem"},{"issue":"13","key":"10.1016\/j.jare.2024.06.024_b0110","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1007\/s00018-019-03092-7","article-title":"Palmitic acid is an intracellular signaling molecule involved in disease development","volume":"76","author":"Fatima","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"10.1016\/j.jare.2024.06.024_b0115","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00011-019-01273-5","article-title":"The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms","volume":"68","author":"Korbecki","year":"2019","journal-title":"Inflamm Res"},{"issue":"3","key":"10.1016\/j.jare.2024.06.024_b0120","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jare.2024.06.024_b0125","article-title":"Dittel BN: Isolation of mouse peritoneal cavity cells","volume":"35","author":"Ray","year":"2010","journal-title":"J Vis Exp"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0130","article-title":"Protocol for Primary Mouse Hepatocyte Isolation","volume":"1","author":"Charni-Natan","year":"2020","journal-title":"Star Protoc"},{"key":"10.1016\/j.jare.2024.06.024_b0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.scr.2018.05.017","article-title":"Efficient and high yield isolation of myoblasts from skeletal muscle","volume":"30","author":"Shahini","year":"2018","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.jare.2024.06.024_b0140","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-4939-7799-4_21","article-title":"Isolation and differentiation of murine primary brown\/beige preadipocytes","volume":"1773","author":"Yu","year":"2018","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jare.2024.06.024_b0145","unstructured":"Wu X: Preliminary Study on the Macrophage Exosomes and its miRNAs-Mediated Mechanism Underlying the Proinflammatory Activity of Palmitate.; 2020."},{"key":"10.1016\/j.jare.2024.06.024_b0150","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jot.2022.08.003","article-title":"Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function","volume":"37","author":"Zhang","year":"2022","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jare.2024.06.024_b0155","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jare.2021.09.009","article-title":"The prognostic miR-532-5p-correlated ceRNA-mediated lipid droplet accumulation drives nodal metastasis of cervical cancer","volume":"37","author":"Shang","year":"2022","journal-title":"J ADV RES"},{"key":"10.1016\/j.jare.2024.06.024_b0160","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-1-4939-7592-1_18","article-title":"GC-MS analysis of medium- and long-chain fatty acids in blood samples","volume":"1730","author":"Hoving","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"30","key":"10.1016\/j.jare.2024.06.024_b0165","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1007\/s00216-018-1421-z","article-title":"Investigation of mycobacteria fatty acid profile using different ionization energies in GC-MS","volume":"410","author":"Beccaria","year":"2018","journal-title":"Anal Bioanal Chem"},{"issue":"18","key":"10.1016\/j.jare.2024.06.024_b0170","doi-asserted-by":"crossref","first-page":"11663","DOI":"10.1074\/jbc.M115.649483","article-title":"Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation","volume":"290","author":"Pardo","year":"2015","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jare.2024.06.024_b0175","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.118.312758","article-title":"Transplanted mesenchymal stem cells reduce autophagic flux in infarcted hearts via the exosomal transfer of miR-125b","volume":"123","author":"Xiao","year":"2018","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jare.2024.06.024_b0180","doi-asserted-by":"crossref","first-page":"e12056","DOI":"10.1002\/jev2.12056","article-title":"Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p","volume":"10","author":"Yu","year":"2021","journal-title":"J Extracell Vesicles"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0185","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s12035-018-1113-x","article-title":"LPS-Induced inflammation abolishes the effect of DYRK1A on IkB stability in the brain of mice","volume":"56","author":"Latour","year":"2019","journal-title":"Mol Neurobiol"},{"issue":"9","key":"10.1016\/j.jare.2024.06.024_b0190","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood-2007-03-079152","article-title":"Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo","volume":"110","author":"Bhatnagar","year":"2007","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jare.2024.06.024_b0195","doi-asserted-by":"crossref","first-page":"e1800149","DOI":"10.1002\/pmic.201800149","article-title":"Exosomes in inflammation and inflammatory disease","volume":"19","author":"Chan","year":"2019","journal-title":"Proteomics"},{"issue":"4","key":"10.1016\/j.jare.2024.06.024_b0200","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.gastro.2015.12.037","article-title":"Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes","volume":"150","author":"Hirsova","year":"2016","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.jare.2024.06.024_b0205","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.pain.2014.04.029","article-title":"Functional significance of macrophage-derived exosomes in inflammation and pain","volume":"155","author":"McDonald","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.jare.2024.06.024_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106551","article-title":"Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-\u03baB signaling pathway in vitro and in vivo","volume":"84","author":"Zhu","year":"2020","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10.1016\/j.jare.2024.06.024_b0215","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s13105-018-0622-4","article-title":"Effects of exosomes from LPS-activated macrophages on adipocyte gene expression, differentiation, and insulin-dependent glucose uptake","volume":"74","author":"De Silva","year":"2018","journal-title":"J Physiol Biochem"},{"issue":"4","key":"10.1016\/j.jare.2024.06.024_b0220","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/ecco-jcc\/jjaa214","article-title":"M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1\/YAP\/ \u03b2-Catenin Signalling Axis","volume":"15","author":"Deng","year":"2021","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jare.2024.06.024_b0225","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3389\/fimmu.2020.01603","article-title":"M1 Macrophage derived exosomes aggravate experimental autoimmune neuritis via modulating Th1 response","volume":"11","author":"Du","year":"2020","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.jare.2024.06.024_b0230","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1111\/jcmm.16348","article-title":"M1 Macrophage exosomes MiR-21a-5p aggravates inflammatory bowel disease through decreasing E-cadherin and subsequent ILC2 activation","volume":"25","author":"Lu","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jare.2024.06.024_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110447","article-title":"Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223","volume":"121","author":"Chang","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0240","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1080\/21655979.2021.2010368","article-title":"Mechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.jare.2024.06.024_b0245","doi-asserted-by":"crossref","first-page":"7218067","DOI":"10.1155\/2021\/7218067","article-title":"Exosomes derived from M2 macrophages exert a therapeutic effect via inhibition of the PI3K\/AKT\/mTOR pathway in rats with knee osteoarthritic","volume":"2021","author":"Da-Wa","year":"2021","journal-title":"Biomed Res Int"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0250","doi-asserted-by":"crossref","first-page":"2295432","DOI":"10.1080\/19490976.2023.2295432","article-title":"Diets intervene osteoporosis via gut-bone axis","volume":"16","author":"Zhang","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jare.2024.06.024_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102196","article-title":"Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis","volume":"94","author":"Zhang","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"6","key":"10.1016\/j.jare.2024.06.024_b0260","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.7150\/thno.49874","article-title":"Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0265","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0270","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2017.12.001","article-title":"Extracellular vesicles provide a means for tissue crosstalk during exercise","volume":"27","author":"Whitham","year":"2018","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0275","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat Cell Biol"},{"issue":"6","key":"10.1016\/j.jare.2024.06.024_b0280","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1159\/000452512","article-title":"Cell-derived microparticles in patients with Type 2 diabetes mellitus: a systematic review and meta-analysis","volume":"39","author":"Li","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"9","key":"10.1016\/j.jare.2024.06.024_b0285","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-\u03baB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends Immunol"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0290","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-065X.2012.01098.x","article-title":"Regulation of NF-\u03baB by ubiquitination and degradation of the I\u03baBs","volume":"246","author":"Kanarek","year":"2012","journal-title":"Immunol Rev"},{"issue":"7","key":"10.1016\/j.jare.2024.06.024_b0295","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1023\/B:NERE.0000026410.56000.dd","article-title":"The effects of calpain inhibition on IkB alpha degradation after activation of PBMCs: identification of the calpain cleavage sites","volume":"29","author":"Schaecher","year":"2004","journal-title":"Neurochem Res"},{"issue":"10","key":"10.1016\/j.jare.2024.06.024_b0300","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.3390\/cimb44100328","article-title":"The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-\/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes","volume":"44","author":"Luo","year":"2022","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.jare.2024.06.024_b0305","article-title":"MiR-3064 in epicardial adipose-derived exosomes targets neuronatin to regulate adipogenic differentiation of epicardial adipose stem cells","volume":"8","author":"Yang","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10.1016\/j.jare.2024.06.024_b0310","doi-asserted-by":"crossref","first-page":"e23346","DOI":"10.1002\/jbt.23346","article-title":"Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6\/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage","volume":"37","author":"Wang","year":"2023","journal-title":"J Biochem Mol Toxicol"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0315","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bbrc.2019.05.113","article-title":"Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance","volume":"515","author":"Liu","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.jare.2024.06.024_b0320","doi-asserted-by":"crossref","first-page":"587","DOI":"10.21037\/tp-23-142","article-title":"Adipose tissue macrophage-derived exosomal miR-210-5p in modulating insulin sensitivity in rats born small for gestational age with catch-up growth","volume":"12","author":"Xiong","year":"2023","journal-title":"Transl Pediatr"},{"key":"10.1016\/j.jare.2024.06.024_b0325","doi-asserted-by":"crossref","first-page":"6894684","DOI":"10.1155\/2020\/6894684","article-title":"miR-210 in exosomes derived from macrophages under high glucose promotes mouse diabetic obesity pathogenesis by suppressing NDUFA4 expression","volume":"2020","author":"Tian","year":"2020","journal-title":"J Diabetes Res"},{"issue":"12","key":"10.1016\/j.jare.2024.06.024_b0335","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1007\/s00125-023-05992-7","article-title":"Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice","volume":"66","author":"Li","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.jare.2024.06.024_b0340","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.freeradbiomed.2022.02.033","article-title":"Adipose tissue macrophage-derived exosomes induce ferroptosis via glutathione synthesis inhibition by targeting SLC7A11 in obesity-induced cardiac injury","volume":"182","author":"Zhao","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jare.2024.06.024_b0345","first-page":"181","article-title":"Macrophage-derived exosomes modulate wear particle-induced osteolysis via miR-3470b targeting TAB3\/NF-\u03baB signaling","volume":"26","author":"Pan","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2024.06.024_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107138","article-title":"M1 macrophages-derived extracellular vesicles elevate microRNA-185-3p to aggravate the development of atherosclerosis in ApoE(-\/-) mice by inhibiting small mothers against decapentaplegic 7","volume":"90","author":"Li","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2024.06.024_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2022.104368","article-title":"Exosomal microRNA-16-5p from macrophage exacerbates atherosclerosis via modulating mothers against decapentaplegic homolog 7","volume":"142","author":"Chen","year":"2022","journal-title":"Microvasc Res"},{"key":"10.1016\/j.jare.2024.06.024_b0360","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.823450","article-title":"Extracellular vesicles from LPS-treated macrophages aggravate smooth muscle cell calcification by propagating inflammation and oxidative stress","volume":"10","author":"Yaker","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jare.2024.06.024_b0365","doi-asserted-by":"crossref","first-page":"1609244","DOI":"10.1155\/2022\/1609244","article-title":"M2 Macrophage-derived exosomes inhibit apoptosis of HUVEC cell through regulating miR-221-3p expression","volume":"2022","author":"Cheng","year":"2022","journal-title":"Biomed Res Int"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107881","article-title":"Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo","volume":"32","author":"Bouchareychas","year":"2020","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.jare.2024.06.024_b0375","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00125-017-4526-6","article-title":"Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses","volume":"61","author":"Boutens","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.jare.2024.06.024_b0380","doi-asserted-by":"crossref","unstructured":"Ken\u0111el JG, Mrakovcic-Sutic I, Pavi\u010di\u0107 }S, \u0160u\u0161a B, Raheli\u0107 D, Klobu\u010dar MS: The efficacy of an energy-restricted anti-inflammatory diet for the management of obesity in younger adults. Nutrients 2020, 12(11).","DOI":"10.3390\/nu12113583"},{"issue":"14","key":"10.1016\/j.jare.2024.06.024_b0385","article-title":"Roles of palmitoleic acid and its positional isomers, hypogeic and sapienic acids, in inflammation, metabolic diseases and cancer","volume":"11","author":"Berm\u00fadez","year":"2022","journal-title":"CELLS-BASEL"},{"key":"10.1016\/j.jare.2024.06.024_b0390","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3389\/fphys.2017.00902","article-title":"Palmitic acid: physiological role, metabolism and nutritional implications","volume":"8","author":"Carta","year":"2017","journal-title":"Front Physiol"},{"issue":"3","key":"10.1016\/j.jare.2024.06.024_b0395","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11745-013-3874-3","article-title":"Plasma levels of 14:0, 16:0, 16:1n\u20137, and 20:3n\u20136 are positively associated, but 18:0 and 18:2n\u20136 are inversely associated with markers of inflammation in young healthy adults","volume":"49","author":"Perreault","year":"2014","journal-title":"Lipids"},{"issue":"1","key":"10.1016\/j.jare.2024.06.024_b0400","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3945\/ajcn.110.006502","article-title":"Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine?","volume":"93","author":"Gong","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jare.2024.06.024_b0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.07.011","article-title":"Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain","volume":"142","author":"Yuan","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2024.06.024_b0410","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jconrel.2015.07.030","article-title":"Using exosomes, naturally-equipped nanocarriers, for drug delivery","volume":"219","author":"Batrakova","year":"2015","journal-title":"J Control Release"},{"issue":"3","key":"10.1016\/j.jare.2024.06.024_b0415","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11481-019-09884-9","article-title":"Macrophage-derived extracellular vesicles as drug delivery systems for triple negative breast cancer (TNBC) therapy","volume":"15","author":"Haney","year":"2020","journal-title":"J Neuroimmune Pharmacol"},{"issue":"2","key":"10.1016\/j.jare.2024.06.024_b0420","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1039\/C9NR09011H","article-title":"Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer","volume":"12","author":"Nie","year":"2020","journal-title":"Nanoscale"},{"issue":"16","key":"10.1016\/j.jare.2024.06.024_b0425","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1002\/cam4.3248","article-title":"Exosome-mediated delivery of miR-204-5p inhibits tumor growth and chemoresistance","volume":"9","author":"Yao","year":"2020","journal-title":"Cancer Med"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:51:17Z","timestamp":1762599077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224002613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":84,"alternative-id":["S2090123224002613"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.06.024","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target I\u03baB\u03b1 and activate NF-\u03baB signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}