{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:28:16Z","timestamp":1784118496595,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974162"],"award-info":[{"award-number":["81974162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671066"],"award-info":[{"award-number":["81671066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jare.2024.07.003","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T21:14:10Z","timestamp":1720214050000},"page":"369-385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Targeting MAD2B as a strategy for ischemic stroke therapy"],"prefix":"10.1016","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8756-2793","authenticated-orcid":false,"given":"Lijing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-6425","authenticated-orcid":false,"given":"Hengzhen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-0714","authenticated-orcid":false,"given":"Xianfang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-8024","authenticated-orcid":false,"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jare.2024.07.003_b0005","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/STROKEAHA.122.042127","article-title":"Incremental value of stroke-induced structural disconnection in predicting global cognitive impairment after stroke","volume":"54","author":"Pan","year":"2023","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.jare.2024.07.003_b0010","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/STROKEAHA.110.598839","article-title":"Self-reported long-term needs after stroke","volume":"42","author":"McKevitt","year":"2011","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.jare.2024.07.003_b0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1474-4422(12)70029-7","article-title":"Top ten research priorities relating to life after stroke","volume":"11","author":"Pollock","year":"2012","journal-title":"Lancet Neurol"},{"issue":"9","key":"10.1016\/j.jare.2024.07.003_b0020","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1161\/STROKEAHA.123.042507","article-title":"Sex differences in poststroke cognitive impairment: a multicenter study in 2343 patients with acute ischemic stroke","volume":"54","author":"Exalto","year":"2023","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0025","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02435-9","article-title":"Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate","volume":"19","author":"Wang","year":"2022","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2024.07.003_b0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","article-title":"Diverse roles of mitochondria in ischemic stroke","volume":"16","author":"Yang","year":"2018","journal-title":"Redox Biol"},{"issue":"2","key":"10.1016\/j.jare.2024.07.003_b0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/jcbfm.2011.150","article-title":"Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives","volume":"32","author":"Zille","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"issue":"12","key":"10.1016\/j.jare.2024.07.003_b0040","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/febs.14088","article-title":"Rev7, the regulatory subunit of Pol\u03b6, undergoes UV-induced and Cul4-dependent degradation","volume":"284","author":"Bhat","year":"2017","journal-title":"FEBS J"},{"issue":"3","key":"10.1016\/j.jare.2024.07.003_b0045","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/1878-0261.12173","article-title":"MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation","volume":"12","author":"Li","year":"2018","journal-title":"Mol Oncol"},{"issue":"8","key":"10.1016\/j.jare.2024.07.003_b0050","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1128\/MCB.02276-06","article-title":"Rev7\/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"46","key":"10.1016\/j.jare.2024.07.003_b0055","doi-asserted-by":"crossref","first-page":"28922","DOI":"10.1073\/pnas.2016067117","article-title":"Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer","volume":"117","author":"Vassel","year":"2020","journal-title":"PNAS"},{"issue":"15","key":"10.1016\/j.jare.2024.07.003_b0060","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.7150\/ijbs.62238","article-title":"MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS","volume":"17","author":"Bao","year":"2021","journal-title":"Int J Biol Sci"},{"issue":"14","key":"10.1016\/j.jare.2024.07.003_b0065","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1101\/gad.898701","article-title":"MAD2B is an inhibitor of the anaphase-promoting complex","volume":"15","author":"Chen","year":"2001","journal-title":"Genes Dev"},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/lm.027383.112","article-title":"The E3 ligase APC\/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice","volume":"20","author":"Pick","year":"2013","journal-title":"Learn Mem"},{"issue":"4","key":"10.1016\/j.jare.2024.07.003_b0075","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s12264-019-00351-2","article-title":"Comparative study of ROCK1 and ROCK2 in hippocampal spine formation and synaptic function","volume":"35","author":"Yan","year":"2019","journal-title":"Neurosci Bull"},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0080","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5114\/fn.2021.105130","article-title":"Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK\/MAPK and activating Nrf2 signalling pathways in APP\/PS1 mice","volume":"59","author":"Wei","year":"2021","journal-title":"Folia Neuropathol"},{"key":"10.1016\/j.jare.2024.07.003_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146902","article-title":"Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1\/Fyn\/ROCK pathway and activating the BDNF\/NRG1\/PI3K pathway in rats","volume":"1743","author":"Niu","year":"2020","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.jare.2024.07.003_b0090","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13305","article-title":"Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor","volume":"20","author":"Wong","year":"2021","journal-title":"Aging Cell"},{"issue":"17","key":"10.1016\/j.jare.2024.07.003_b0095","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1073\/pnas.1616024114","article-title":"APC\/C Cdh1-Rock2 pathway controls dendritic integrity and memory","volume":"114","author":"Bobo-Jim\u00e9nez","year":"2017","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.jare.2024.07.003_b0100","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/mp.2017.22","article-title":"Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders","volume":"23","author":"Yan","year":"2018","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.jare.2024.07.003_b0105","article-title":"Resveratrol attenuates learning, memory, and social interaction impairments in rats exposed to arsenic","volume":"2021","author":"Zadeh","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jare.2024.07.003_b0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.phrs.2019.01.035","article-title":"NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia","volume":"142","author":"Ward","year":"2019","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.jare.2024.07.003_b0115","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.336","article-title":"Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP-43 pathology","volume":"11","author":"Gen\u00e7","year":"2021","journal-title":"Clin Transl Med"},{"issue":"11","key":"10.1016\/j.jare.2024.07.003_b0120","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/acn3.19","article-title":"Selective ROCK2 inhibition in focal cerebral ischemia","volume":"1","author":"Lee","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.jare.2024.07.003_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.956029","article-title":"Conditional deletion of MAD2B in forebrain neurons enhances hippocampus-dependent learning and memory in mice","volume":"16","author":"Cheng","year":"2022","journal-title":"Front Cell Neurosci"},{"issue":"8","key":"10.1016\/j.jare.2024.07.003_b0135","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-stroke cognitive impairment and dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.jare.2024.07.003_b0140","doi-asserted-by":"crossref","unstructured":"Biesbroek JM, Weaver NA, Aben HP, Kuijf HJ, Abrigo J, Bae HJ, et al. Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke. Neuroimage-Clinical 2022, 34.","DOI":"10.1016\/j.nicl.2022.103018"},{"key":"10.1016\/j.jare.2024.07.003_b0145","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-017-0779-7","article-title":"Post-stroke dementia - a comprehensive review","volume":"15","author":"Mijajlovic","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.jare.2024.07.003_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.987293","article-title":"DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress","volume":"13","author":"Zhang","year":"2023","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.jare.2024.07.003_b0155","doi-asserted-by":"crossref","DOI":"10.1161\/STR.0000000000000430","article-title":"Cognitive impairment after ischemic and hemorrhagic stroke: a scientific statement from the american heart association\/American stroke association","volume":"54","author":"El Husseini","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.jare.2024.07.003_b0160","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.freeradbiomed.2022.10.001","article-title":"Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway","volume":"193","author":"Li","year":"2022","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"10.1016\/j.jare.2024.07.003_b0165","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1007\/s12031-020-01533-8","article-title":"Post-stroke cognitive impairment: a review focusing on molecular biomarkers","volume":"70","author":"Zhang","year":"2020","journal-title":"J Mol Neurosci"},{"issue":"3","key":"10.1016\/j.jare.2024.07.003_b0170","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/0891988710373598","article-title":"The relationship between inflammatory markers and post stroke cognitive impairment","volume":"23","author":"Rothenburg","year":"2010","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"8","key":"10.1016\/j.jare.2024.07.003_b0175","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1017\/S0033291717003130","article-title":"High-sensitivity C-reactive protein and cognitive decline: the English longitudinal study of ageing","volume":"48","author":"Zheng","year":"2018","journal-title":"Psychol Med"},{"key":"10.1016\/j.jare.2024.07.003_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102558","article-title":"Modulation of hippocampal plasticity in learning and memory","volume":"75","author":"Fuchsberger","year":"2022","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0185","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28057-6","article-title":"Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events","volume":"13","author":"Shahbaba","year":"2022","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.jare.2024.07.003_b0190","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3727\/096504017X15049209129277","article-title":"Mitotic arrest-deficient protein 2B overexpressed in lung cancer promotes proliferation, EMT, and metastasis","volume":"27","author":"Zhang","year":"2019","journal-title":"Oncol Res"},{"issue":"7553","key":"10.1016\/j.jare.2024.07.003_b0195","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature14216","article-title":"MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5\u2032 end resection","volume":"521","author":"Boersma","year":"2015","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jare.2024.07.003_b0200","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4103\/1673-5374.380904","article-title":"Treatment with \u03b2-sitosterol ameliorates the effects of cerebral ischemia\/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis","volume":"19","author":"Tang","year":"2024","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jare.2024.07.003_b0205","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-016-0858-0","article-title":"Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion","volume":"14","author":"Liu","year":"2016","journal-title":"J Transl Med"},{"issue":"4","key":"10.1016\/j.jare.2024.07.003_b0210","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/01.STR.32.4.1012","article-title":"Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells","volume":"32","author":"Veizovic","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jare.2024.07.003_b0215","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5126042","article-title":"Xuesaitong combined with dexmedetomidine improves cerebral ischemia-reperfusion injury in rats by activating Keap1\/Nrf2 signaling and mitophagy in hippocampal tissue","volume":"2022","author":"Han","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1016\/j.jare.2024.07.003_b0220","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/STROKEAHA.122.038263","article-title":"Hippocampal vascular supply and its role in vascular cognitive impairment","volume":"54","author":"Johnson","year":"2023","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.jare.2024.07.003_b0225","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0306-3623(97)00311-X","article-title":"Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion","volume":"30","author":"Mizuno","year":"1998","journal-title":"General Pharmacology-the Vascular System"},{"issue":"4","key":"10.1016\/j.jare.2024.07.003_b0230","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/01.STR.19.4.480","article-title":"Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger","volume":"19","author":"Abe","year":"1988","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.jare.2024.07.003_b0235","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0022-3565(25)38652-0","article-title":"Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions","volume":"268","author":"Watanabe","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"10.1016\/j.jare.2024.07.003_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050805","article-title":"LIMK1 and LIMK2, are crucial node actors of the cell fate: molecular to pathological features","volume":"12","author":"Villalonga","year":"2023","journal-title":"Cells"},{"issue":"16","key":"10.1016\/j.jare.2024.07.003_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/cells12162029","article-title":"The activation of the LIMK\/Cofilin signaling pathway via extracellular matrix-integrin interactions is critical for the generation of mature and vascularized cardiac organoids","volume":"12","author":"Noh","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jare.2024.07.003_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116391","article-title":"Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization","volume":"271","author":"Champire","year":"2024","journal-title":"Eur J Med Chem"},{"issue":"19","key":"10.1016\/j.jare.2024.07.003_b0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914520","article-title":"Baicalin attenuates panton-valentine leukocidin (PVL)-induced cytoskeleton rearrangement via regulating the RhoA\/ROCK\/LIMK and PI3K\/AKT\/GSK-3\u03b2 pathways in bovine mammary epithelial cells","volume":"24","author":"Yang","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.jare.2024.07.003_b0260","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1212\/WNL.0000000000207779","article-title":"What Is the role of the Rho-ROCK pathway in neurologic disorders?","volume":"101","author":"Benarroch","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.jare.2024.07.003_b0265","first-page":"946","article-title":"A focus on Rho\/ROCK signaling pathway: an emerging therapeutic target in depression","author":"Hanifa","year":"2023","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0270","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3233\/CBM-181949","article-title":"Targeted regulation by ROCK2 on bladder carcinoma via Wnt signaling under hypoxia","volume":"24","author":"Luo","year":"2019","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.jare.2024.07.003_b0275","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.12659\/MSM.910184","article-title":"Ripasudil attenuates lipopolysaccharide (LPS)-mediated apoptosis and inflammation in pulmonary microvascular endothelial cells via ROCK2\/eNOS signaling","volume":"24","author":"Yang","year":"2018","journal-title":"Med Sci Monit"},{"issue":"3S_SUPPL","key":"10.1016\/j.jare.2024.07.003_b0280","first-page":"854","article-title":"ROCK2 promotes sepsis-triggered liver injury by stabilizing HIF-1\u03b1 via negative regulation of VHL","volume":"133","author":"Lu","year":"2021","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jare.2024.07.003_b0285","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbrc.2020.10.106","article-title":"The Rho kinase 2 (ROCK2)-specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension","volume":"534","author":"Yamamura","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0290","article-title":"Belumosudil, ROCK2-specific inhibitor, alleviates cardiac fibrosis by inhibiting cardiac fibroblasts activation","volume":"323","author":"Liu","year":"2022","journal-title":"Am. J. Phys.-Heart and Circulatory Physiol."},{"issue":"1","key":"10.1016\/j.jare.2024.07.003_b0295","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1096\/fj.201901174RR","article-title":"ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice","volume":"34","author":"Wei","year":"2020","journal-title":"FASEB J"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:57:09Z","timestamp":1778835429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224002698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":59,"alternative-id":["S2090123224002698"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.07.003","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting MAD2B as a strategy for ischemic stroke therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}