{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:37Z","timestamp":1792794697344,"version":"4.5.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["HX23C1734"],"award-info":[{"award-number":["HX23C1734"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007334","name":"Ministry of Health and Family Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["NRF-2021R1A2C2007189"],"award-info":[{"award-number":["NRF-2021R1A2C2007189"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023\\u201300278231"],"award-info":[{"award-number":["RS-2023\\u201300278231"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jare.2024.07.011","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T15:52:18Z","timestamp":1721058738000},"page":"433-449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Tumor necrosis factor-\u03b1-treated human adipose-derived stem cells enhance inherent radiation tolerance and alleviate in vivo radiation-induced capsular contracture"],"prefix":"10.1016","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-3163","authenticated-orcid":false,"given":"Chanutchamon","family":"Sutthiwanjampa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hyun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Hwa Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Koo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hyun","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hui","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Hyuk","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jare.2024.07.011_b0005","doi-asserted-by":"crossref","first-page":"124e","DOI":"10.1097\/PRS.0b013e318213a2e6","article-title":"Breast reconstruction after breast cancer","volume":"127","author":"Serletti","year":"2011","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0010","doi-asserted-by":"crossref","first-page":"513e","DOI":"10.1097\/PRS.0b013e318262f059","article-title":"Current status of implant-based breast reconstruction in patients receiving postmastectomy radiation therapy","volume":"130","author":"Kronowitz","year":"2012","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.21037\/gs.2017.01.02","article-title":"Capsular contracture in implant based breast reconstruction-the effect of porcine acellular dermal matrix","volume":"6","author":"Lardi","year":"2017","journal-title":"Gland Surg"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.5152\/ejbh.2019.4713","article-title":"Treatment of capsular contracture after radiotherapy in breast reconstruction","volume":"15","author":"Cihan","year":"2019","journal-title":"Eur J Breast Health"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0025","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1053\/ejso.1999.0896","article-title":"Morbidity of immediate breast reconstruction (IBR) after mastectomy by a subpectorally placed silicone prosthesis: the adverse effect of radiotherapy","volume":"26","author":"Contant","year":"2000","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"10.1016\/j.jare.2024.07.011_b0030","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00432-015-1974-6","article-title":"Radiation-induced fibrosis: mechanisms and implications for therapy","volume":"141","author":"Straub","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0035","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"issue":"S1","key":"10.1016\/j.jare.2024.07.011_b0040","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/trf.14836","article-title":"Wound healing and fibrosis: current stem cell therapies","volume":"59","author":"Jones","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.jare.2024.07.011_b0045","doi-asserted-by":"crossref","first-page":"126S","DOI":"10.1097\/PRS.0b013e3182605d18","article-title":"Use of dermal matrix to prevent capsular contracture in aesthetic breast surgery","volume":"130","author":"Hester","year":"2012","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0050","first-page":"293","article-title":"Halofuginone inhibits collagen deposition in fibrous capsules around implants","volume":"54","author":"Olbrich","year":"2005","journal-title":"Ann Plast Surg"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0055","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/SAP.0000000000002260","article-title":"Comparison of the effects of acellular dermal matrix and montelukast on radiation-induced peri-implant capsular formation in rabbits","volume":"85","author":"Woo","year":"2020","journal-title":"Ann Plast Surg"},{"issue":"5","key":"10.1016\/j.jare.2024.07.011_b0060","doi-asserted-by":"crossref","first-page":"592e","DOI":"10.1097\/PRS.0000000000001683","article-title":"Prevention of capsular contracture using leukotriene antagonists","volume":"136","author":"Graf","year":"2015","journal-title":"Plast Reconstr Surg"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0065","doi-asserted-by":"crossref","first-page":"e2414","DOI":"10.1097\/GOX.0000000000002414","article-title":"Acellular dermal matrix performance compared with latissimus dorsi myocutaneous flap in expander-based breast reconstruction","volume":"7","author":"Patrinely","year":"2019","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"6","key":"10.1016\/j.jare.2024.07.011_b0070","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/PRS.0b013e31824ecae6","article-title":"Human adipose stem cells: current clinical applications","volume":"129","author":"Gir","year":"2012","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s13287-020-01831-3","article-title":"Therapeutic applications of adipose cell-free derivatives: a review","volume":"11","author":"Cai","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jare.2024.07.011_b0080","doi-asserted-by":"crossref","first-page":"3206807","DOI":"10.1155\/2016\/3206807","article-title":"Advances in adipose-derived stem cells isolation, characterization, and application in regenerative tissue engineering","volume":"2016","author":"Wankhade","year":"2016","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jare.2024.07.011_b0085","article-title":"The therapeutic role of ADSC-EVs in skin regeneration","volume":"9","author":"Wang","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"10.1016\/j.jare.2024.07.011_b0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/scrt336","article-title":"Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells","volume":"4","author":"Ribeiro","year":"2013","journal-title":"Stem Cell Res Ther"},{"issue":"11","key":"10.1016\/j.jare.2024.07.011_b0095","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/j.bjps.2009.10.028","article-title":"Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications","volume":"63","author":"Sterodimas","year":"2010","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"23","key":"10.1016\/j.jare.2024.07.011_b0100","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.3390\/ijms21239262","article-title":"The Crosstalk of Adipose-Derived Stem Cells (ADSC), Oxidative stress, and inflammation in protective and adaptive responses","volume":"21","author":"Rochette","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jare.2024.07.011_b0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/PRS.0000000000000326","article-title":"Studies in fat grafting: Part III. Fat grafting irradiated tissue\u2013improved skin quality and decreased fat graft retention","volume":"134","author":"Garza","year":"2014","journal-title":"Plast Reconstr Surg"},{"issue":"4S Suppl 1","key":"10.1016\/j.jare.2024.07.011_b0110","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1097\/SAP.0000000000002098","article-title":"Radiation-unduced skin fibrosis: pathogenesis, current treatment options, and emerging therapeutics","volume":"83","author":"Borrelli","year":"2019","journal-title":"Ann Plast Surg"},{"issue":"2","key":"10.1016\/j.jare.2024.07.011_b0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1194\/jlr.R021089","article-title":"Adipose tissue stem cells meet preadipocyte commitment: going back to the future","volume":"53","author":"Cawthorn","year":"2012","journal-title":"J Lipid Res"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0120","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.4049\/jimmunol.1401636","article-title":"Differential efficacy of human mesenchymal stem cells based on source of origin","volume":"193","author":"Collins","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jare.2024.07.011_b0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-pathol-011110-130230","article-title":"Mesenchymal stem cells: mechanisms of inflammation","volume":"6","author":"Singer","year":"2011","journal-title":"Annu Rev Pathol"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0130","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/PRS.0000000000010260","article-title":"Stem cell-enriched hybrid breast reconstruction reduces risk for capsular contracture in a hybrid breast model","volume":"152","author":"Diehm","year":"2023","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jare.2024.07.011_b0135","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.actbio.2016.11.052","article-title":"Development, fabrication and evaluation of a novel biomimetic human breast tissue derived breast implant surface","volume":"49","author":"Barr","year":"2017","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2024.07.011_b0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jiec.2020.03.036","article-title":"Inhibition of capsular contracture of poly (dimethyl siloxane) medical implants by surface modification with itaconic acid conjugated gelatin","volume":"89","author":"Birajdar","year":"2020","journal-title":"J Ind Eng Chem"},{"key":"10.1016\/j.jare.2024.07.011_b0145","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.apsusc.2017.12.125","article-title":"Surface conjugation of poly (dimethyl siloxane) with itaconic acid-based materials for antibacterial effects","volume":"437","author":"Birajdar","year":"2017","journal-title":"Appl Surf Sci"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0150","doi-asserted-by":"crossref","first-page":"e10260","DOI":"10.1002\/btm2.10260","article-title":"Assessment of human adipose-derived stem cell on surface-modified silicone implant to reduce capsular contracture formation","volume":"7","author":"Sutthiwanjampa","year":"2021","journal-title":"Bioeng Transl Med"},{"issue":"7","key":"10.1016\/j.jare.2024.07.011_b0155","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.3390\/ijms19071988","article-title":"Radiation sensitivity of adipose-derived stem cells isolated from breast tissue","volume":"19","author":"Baa\u00dfe","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.jare.2024.07.011_b0160","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.3390\/ijms21113885","article-title":"Adipose-derived stem cells promote intussusceptive lymphangiogenesis by restricting dermal fibrosis in irradiated tissue of mice","volume":"21","author":"Ogino","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","article-title":"Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies","volume":"10","author":"Noronha","year":"2019","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0170","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12015-014-9495-2","article-title":"Interferon-gamma modification of mesenchymal stem cells: implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation","volume":"10","author":"Sivanathan","year":"2014","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13287-017-0558-6","article-title":"The therapeutic potential of three-dimensional multipotent mesenchymal stromal cell spheroids","volume":"8","author":"Petrenko","year":"2017","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0180","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s12265-010-9193-7","article-title":"The paradoxical role of inflammation in cardiac repair and regeneration","volume":"3","author":"Jiang","year":"2010","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.jare.2024.07.011_b0185","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: Integrating mammalian biology","volume":"104","author":"Locksley","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jare.2024.07.011_b0190","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/mt.2011.211","article-title":"Mesenchymal stem\/stromal cells (MSCs): role as guardians of inflammation","volume":"1","author":"Prockop","year":"2012","journal-title":"Mol Ther"},{"issue":"7","key":"10.1016\/j.jare.2024.07.011_b0195","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/jid.2011.64","article-title":"Tumor necrosis factor-\u03b1-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms","volume":"131","author":"Heo","year":"2011","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0200","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1021\/pr900898n","article-title":"Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells","volume":"9","author":"Lee","year":"2010","journal-title":"J Proteome Res"},{"issue":"7","key":"10.1016\/j.jare.2024.07.011_b0205","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1634\/stemcells.2007-0054","article-title":"The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities","volume":"25","author":"Ponte","year":"2007","journal-title":"Stem Cells"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0210","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1182\/blood-2006-10-051060","article-title":"MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines","volume":"109","author":"Ries","year":"2007","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jare.2024.07.011_b0215","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/PRS.0b013e3181ef8b8e","article-title":"A novel animal model for studying silicone gel-related capsular contracture","volume":"126","author":"Katzel","year":"2010","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0220","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/2000656X.2018.1444617","article-title":"A murine model of radiation-induced capsule-tissue reactions around smooth silicone implants","volume":"52","author":"Kim","year":"2018","journal-title":"J Plast Surg Hand Surg"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/smll.201000946","article-title":"Microfluidic devices for bioapplications","volume":"7","author":"Yeo","year":"2011","journal-title":"Small"},{"issue":"2","key":"10.1016\/j.jare.2024.07.011_b0230","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jcyt.2015.11.008","article-title":"International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials","volume":"18","author":"Galipeau","year":"2016","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-02006-w","article-title":"Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19","volume":"12","author":"Mazini","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0240","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0245","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/4\/4\/045002","article-title":"Influence of surface wettability on competitive protein adsorption and initial attachment of osteoblasts","volume":"4","author":"Wei","year":"2009","journal-title":"Biomed Mater"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0250","first-page":"1","article-title":"TNF-\u03b1 induces human neural progenitor cell survival after oxygen-glucose deprivation by activating the NF-\u03baB pathway","volume":"50","author":"Kim","year":"2018","journal-title":"Exp Mol Med"},{"issue":"8","key":"10.1016\/j.jare.2024.07.011_b0255","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/jcp.24330","article-title":"Activation and promotion of adipose stem cells by tumour necrosis factor-\u03b1 preconditioning for bone regeneration","volume":"228","author":"Lu","year":"2013","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0260","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jcb.25263","article-title":"Regulation of adipose tissue stem cells angiogenic potential by tumor necrosis factor-alpha","volume":"117","author":"Zubkova","year":"2016","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jare.2024.07.011_b0265","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1242\/jcs.112.17.2983","article-title":"Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1","volume":"112","author":"Puls","year":"1999","journal-title":"J Cell Sci"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0270","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ejcb.2012.03.010","article-title":"Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation","volume":"91","author":"M\u00f6pert","year":"2012","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jare.2024.07.011_b0275","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.584497","article-title":"Mesenchymal stem cells early response to low-dose ionizing radiation","volume":"8","author":"Konkova","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0280","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jcyt.2015.12.001","article-title":"Adipose mesenchymal stromal cells response to ionizing radiation","volume":"18","author":"Maria","year":"2016","journal-title":"Cytotherapy"},{"issue":"34","key":"10.1016\/j.jare.2024.07.011_b0285","doi-asserted-by":"crossref","first-page":"15211","DOI":"10.1073\/pnas.1006442107","article-title":"Proangiogenic scaffolds as functional templates for cardiac tissue engineering","volume":"107","author":"Madden","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2024.07.011_b0290","doi-asserted-by":"crossref","first-page":"2202333","DOI":"10.1002\/admi.202202333","article-title":"Hydrophilic modification strategies to enhance the surface biocompatibility of poly(dimethylsiloxane)-based biomaterials for medical applications","volume":"10","author":"Sutthiwanjampa","year":"2023","journal-title":"Adv Mater Interfaces"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0295","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nrc1950","article-title":"Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology","volume":"6","author":"Bentzen","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jare.2024.07.011_b0300","series-title":"Robbins and Cotran pathologic basis of disease","author":"Kumar","year":"2015"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0305","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1359-6101(97)00010-5","article-title":"Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts","volume":"8","author":"Grotendorst","year":"1997","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jare.2024.07.011_b0310","doi-asserted-by":"crossref","unstructured":"Bochaton-Piallat ML, Gabbiani G, Hinz B. The myofibroblast in wound healing and fibrosis: answered and unanswered questions. F1000Res. 2016;5:F1000 Faculty Rev-752. doi:10.12688\/f1000research.8190.1.","DOI":"10.12688\/f1000research.8190.1"},{"issue":"15","key":"10.1016\/j.jare.2024.07.011_b0315","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S1286-4579(99)00250-6","article-title":"TGF-beta and fibrosis","volume":"1","author":"Branton","year":"1999","journal-title":"Microbes Infect"},{"issue":"28","key":"10.1016\/j.jare.2024.07.011_b0320","doi-asserted-by":"crossref","first-page":"eaaz8272","DOI":"10.1126\/sciadv.aaz8272","article-title":"Attenuation of Dupuytren's fibrosis via targeting of the STAT1 modulated IL-13R\u03b11 response","volume":"6","author":"Akbar","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2024.07.011_b0325","series-title":"Biochemistry of Collagens, Laminins and Elastin","first-page":"21","article-title":"Chapter 3 - type III collagen","author":"Nielsen","year":"2016"},{"issue":"2","key":"10.1016\/j.jare.2024.07.011_b0330","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0360-3016(00)00435-1","article-title":"TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?","volume":"47","author":"Martin","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.jare.2024.07.011_b0335","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"issue":"15","key":"10.1016\/j.jare.2024.07.011_b0340","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S1286-4579(99)00257-9","article-title":"Bidirectional regulation of macrophage function by TGF-beta","volume":"1","author":"Ashcroft","year":"1999","journal-title":"Microbes Infect"},{"issue":"2","key":"10.1016\/j.jare.2024.07.011_b0345","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00918135","article-title":"Transforming growth factor beta (TGF-beta) in inflammation: a cause and a cure","volume":"12","author":"Wahl","year":"1992","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jare.2024.07.011_b0350","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/ndt\/gfm789","volume":"5","author":"Sebe","year":"2008","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"10.1016\/j.jare.2024.07.011_b0355","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mattod.2015.01.019","article-title":"Biomaterial based modulation of macrophage polarization: a review and suggested design principles","volume":"18","author":"Sridharan","year":"2015","journal-title":"Mater Today"},{"issue":"5","key":"10.1016\/j.jare.2024.07.011_b0360","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41374-018-0181-x","article-title":"Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K\/STAT3 pathway","volume":"99","author":"Lee","year":"2019","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0365","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13287-021-02270-4","article-title":"Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6","volume":"12","author":"Yang","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0370","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s13287-022-02952-7","article-title":"The therapeutic effect of adipose-derived stem cells on soft tissue injury after radiotherapy and their value for breast reconstruction","volume":"13","author":"Tang","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"7\u20138","key":"10.1016\/j.jare.2024.07.011_b0375","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0891-5849(98)00273-1","article-title":"Antioxidant defenses in the TNF-treated MCF-7 cells: selective increase in MnSOD","volume":"26","author":"Siemankowski","year":"1999","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0380","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/s13287-021-02516-1","article-title":"Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression","volume":"12","author":"Yao","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"24","key":"10.1016\/j.jare.2024.07.011_b0385","doi-asserted-by":"crossref","first-page":"17214","DOI":"10.3390\/ijms242417214","article-title":"Therapeutic ootential of adipose-derived stem cell-conditioned medium and extracellular vesicles in an in vitro radiation-induced skin injury model","volume":"24","author":"Lin","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0390","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2220\/biomedres.31.27","article-title":"Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion","volume":"31","author":"Park","year":"2010","journal-title":"Biomed Res"},{"issue":"10","key":"10.1016\/j.jare.2024.07.011_b0395","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","article-title":"Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells","volume":"109","author":"Rehman","year":"2004","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jare.2024.07.011_b0400","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1517\/14712598.2010.522987","article-title":"The pivotal role of VEGF in adipose-derived-stem-cell-mediated regeneration","volume":"10","author":"Song","year":"2010","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jare.2024.07.011_b0405","doi-asserted-by":"crossref","first-page":"1318256","DOI":"10.1155\/2016\/1318256","article-title":"Cytokines TNF-\u03b1, IL-6, IL-17F, and IL-4 differentially affect osteogenic differentiation of human adipose stem cells","volume":"2016","author":"Bastidas-Coral","year":"2016","journal-title":"Stem Cells Int"},{"issue":"10","key":"10.1016\/j.jare.2024.07.011_b0410","doi-asserted-by":"crossref","first-page":"e73673","DOI":"10.1371\/journal.pone.0073673","article-title":"VEGF-mediated proliferation of human adipose tissue-derived stem cells","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jare.2024.07.011_b0415","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1524-475X.2009.00499.x","article-title":"Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF","volume":"17","author":"Lee","year":"2009","journal-title":"Wound Repair Regen"},{"issue":"10","key":"10.1016\/j.jare.2024.07.011_b0420","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/bjc.2016.327","article-title":"IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma","volume":"115","author":"Matsuoka","year":"2016","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0425","doi-asserted-by":"crossref","first-page":"16328","DOI":"10.1038\/s41598-020-73310-x","article-title":"VEGF knockdown enhances radiosensitivity of nasopharyngeal carcinoma by inhibiting autophagy through the activation of mTOR pathway","volume":"10","author":"Chen","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.07.011_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.108158","article-title":"IL-8 is involved in radiation therapy resistance of esophageal squamous cell carcinoma via regulation of PCNA","volume":"676","author":"Hua","year":"2019","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"10.1016\/j.jare.2024.07.011_b0435","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/PRS.0000000000004609","article-title":"Therapeutic effects of human adipose-derived products on impaired wound healing in irradiated tissue","volume":"142","author":"Wu","year":"2018","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.jare.2024.07.011_b0440","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cps.2012.04.005","article-title":"Early experiences with stem cells in treating chronic wounds","volume":"39","author":"Akita","year":"2012","journal-title":"Clin Plast Surg"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0445","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006452","article-title":"VEGF-directed blood vessel patterning: from cells to organism","volume":"2","author":"Bautch","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"10.1016\/j.jare.2024.07.011_b0450","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCULATIONAHA.118.034165","article-title":"Antiangiogenic VEGF165b regulates macrophage polarization via S100A8\/S100A9 in peripheral artery disease","volume":"139","author":"Ganta","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jare.2024.07.011_b0455","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.jacc.2013.07.057","article-title":"Macrophage subpopulations are essential for infarct repair with and without stem cell therapy","volume":"12","author":"Ben-Mordechai","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.jare.2024.07.011_b0460","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41584-018-0056-y","article-title":"MMP12 makes the cut","volume":"14","author":"Collison","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jare.2024.07.011_b0465","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cyto.2016.06.018","article-title":"IL-10 is required for polarization of macrophages to M2-like phenotype by mycobacterial DnaK (heat shock protein 70)","volume":"85","author":"Lopes","year":"2016","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.jare.2024.07.011_b0470","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jare.2024.07.011_b0475","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ni.2865","article-title":"Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin","volume":"15","author":"Mauer","year":"2014","journal-title":"Nat Immunol"},{"issue":"7","key":"10.1016\/j.jare.2024.07.011_b0480","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.it.2016.04.010","article-title":"Targeted therapy and checkpoint immunotherapy combinations for the treatment of cancer","volume":"37","author":"Hughes","year":"2016","journal-title":"Trends Immunol"},{"issue":"1","key":"10.1016\/j.jare.2024.07.011_b0485","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s13287-018-1059-y","article-title":"Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2Akita mouse","volume":"9","author":"Elshaer","year":"2018","journal-title":"Stem Cell Res Ther"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224002959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:56:58Z","timestamp":1778835418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224002959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":97,"alternative-id":["S2090123224002959"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.07.011","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor necrosis factor-\u03b1-treated human adipose-derived stem cells enhance inherent radiation tolerance and alleviate in vivo radiation-induced capsular contracture","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}