{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:15:23Z","timestamp":1773980123769,"version":"3.50.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH330"],"award-info":[{"award-number":["ZR2021MH330"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272601"],"award-info":[{"award-number":["82272601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jare.2024.07.025","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T19:47:32Z","timestamp":1722023252000},"page":"467-484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection"],"prefix":"10.1016","volume":"72","author":[{"given":"Guangping","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanfang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlian","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2024.07.025_b0005","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jacc.2020.01.018","article-title":"Lipid accumulation in hearts transplanted from nondiabetic donors to diabetic recipients","volume":"75","author":"Marfella","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jare.2024.07.025_b0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","article-title":"Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease","volume":"61","author":"Jia","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.jare.2024.07.025_b0015","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/db17-0219","article-title":"Metallothionein preserves Akt2 activity and cardiac function via inhibiting TRB3 in diabetic hearts","volume":"67","author":"Gu","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2024.07.025_b0020","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2024.07.025_b0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2337\/db15-1274","article-title":"Metallothionein is downstream of Nrf2 and partially mediates sulforaphane prevention of diabetic cardiomyopathy","volume":"66","author":"Gu","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2024.07.025_b0030","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.phrs.2009.11.009","article-title":"Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels","volume":"61","author":"Piao","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jare.2024.07.025_b0035","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3109\/09637486.2012.665043","article-title":"Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial","volume":"63","author":"Bahadoran","year":"2012","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.jare.2024.07.025_b0040","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1038\/s41598-021-87367-9","article-title":"Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis","volume":"11","author":"Du","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.07.025_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.154002","article-title":"Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function","volume":"102","author":"Sun","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.jare.2024.07.025_b0050","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1210\/er.2011-1042","article-title":"The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases","volume":"33","author":"Prudente","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jare.2024.07.025_b0055","doi-asserted-by":"crossref","first-page":"e1057","DOI":"10.1210\/clinem\/dgab780","article-title":"TRIB3 is highly expressed in the adipose tissue of obese patients and is associated with insulin resistance","volume":"107","author":"Lee","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jare.2024.07.025_b0060","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jfma.2016.07.010","article-title":"Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia","volume":"116","author":"Cheng","year":"2017","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jare.2024.07.025_b0065","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1161\/CIRCRESAHA.109.211920","article-title":"TRB3 function in cardiac endoplasmic reticulum stress","volume":"106","author":"Avery","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.jare.2024.07.025_b0070","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1053\/j.gastro.2017.04.017","article-title":"Antagonistic effects of p53 and HIF1A on microRNA-34a regulation of PPP1R11 and STAT3 and hypoxia-induced epithelial to mesenchymal transition in colorectal cancer cells","volume":"153","author":"Li","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jare.2024.07.025_b0075","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/ng.3702","article-title":"p53 partners with RNA in the DNA damage response","volume":"48","author":"Huarte","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jare.2024.07.025_b0080","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00109-011-0735-5","article-title":"Metabolic regulation by p53","volume":"89","author":"Maddocks","year":"2011","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.jare.2024.07.025_b0085","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41419-017-0093-5","article-title":"Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis","volume":"9","author":"Gu","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jare.2024.07.025_b0090","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1038\/s41467-021-25390-0","article-title":"O-GlcNAcylated p53 in the liver modulates hepatic glucose production","volume":"12","author":"Gonzalez-Rellan","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2024.07.025_b0095","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2011.12.006","article-title":"p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure","volume":"15","author":"Shimizu","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2024.07.025_b0100","article-title":"Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2","volume":"52","author":"Wang","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2024.07.025_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102219","article-title":"A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity","volume":"49","author":"Xiao","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2024.07.025_b0110","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.metabol.2014.06.012","article-title":"Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate","volume":"63","author":"Liu","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.jare.2024.07.025_b0115","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.metabol.2013.02.007","article-title":"Berberine improves insulin resistance in cardiomyocytes via activation of 5'-adenosine monophosphate-activated protein kinase","volume":"62","author":"Chang","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.jare.2024.07.025_b0120","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/emm.2005.23","article-title":"Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts","volume":"37","author":"Ha","year":"2005","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jare.2024.07.025_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.11.006","article-title":"Rare ginsenosides ameliorate lipid overload-induced myocardial insulin resistance via modulating metabolic flexibility","volume":"58","author":"Peng","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jare.2024.07.025_b0130","doi-asserted-by":"crossref","first-page":"2052675","DOI":"10.1155\/2019\/2052675","article-title":"Mangiferin improved palmitate-induced-insulin resistance by promoting free fatty acid metabolism in HepG2 and C2C12 cells via PPARalpha: mangiferin improved insulin resistance","volume":"2019","author":"Zhang","year":"2019","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jare.2024.07.025_b0135","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/ptr.6379","article-title":"Anthocyanins ameliorate palmitate-induced inflammation and insulin resistance in 3T3-L1 adipocytes","volume":"33","author":"Muscara","year":"2019","journal-title":"Phytother Res"},{"key":"10.1016\/j.jare.2024.07.025_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145209","article-title":"Irisin improves insulin resistance by inhibiting autophagy through the PI3K\/Akt pathway in H9c2 cells","volume":"769","author":"Song","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.jare.2024.07.025_b0145","doi-asserted-by":"crossref","first-page":"e1900109","DOI":"10.1002\/mnfr.201900109","article-title":"Vitamin D deficiency in rats causes cardiac dysfunction by inducing myocardial insulin resistance","volume":"63","author":"Nizami","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jare.2024.07.025_b0150","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jare.2024.07.025_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101514","article-title":"Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor","volume":"32","author":"Wang","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2024.07.025_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2019.10.002","article-title":"Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer","volume":"33","author":"Lacroix","year":"2020","journal-title":"Mol Metab"},{"key":"10.1016\/j.jare.2024.07.025_b0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cell.2016.03.003","article-title":"Types of ubiquitin ligases","volume":"165","author":"Morreale","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jare.2024.07.025_b0170","doi-asserted-by":"crossref","first-page":"D719","DOI":"10.1093\/nar\/gkab962","article-title":"UbiBrowser 2.0: a comprehensive resource for proteome-wide known and predicted ubiquitin ligase\/deubiquitinase-substrate interactions in eukaryotic species","volume":"50","author":"Wang","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jare.2024.07.025_b0175","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00125-014-3295-8","article-title":"Dichotomous role of pancreatic HUWE1\/MULE\/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions","volume":"57","author":"Wang","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.jare.2024.07.025_b0180","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/jphp.13298","article-title":"LncRNA Fendrr inhibits hypoxia\/reoxygenation-induced cardiomyocyte apoptosis by downregulating p53 expression","volume":"72","author":"Li","year":"2020","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jare.2024.07.025_b0185","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.omtn.2022.03.001","article-title":"Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy","volume":"28","author":"Wang","year":"2022","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jare.2024.07.025_b0190","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2024.07.025_b0200","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pharmthera.2016.11.013","article-title":"Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential","volume":"172","author":"Faria","year":"2017","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jare.2024.07.025_b0205","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.2337\/db16-0154","article-title":"Skeletal muscle TRIB3 mediates glucose toxicity in diabetes and high-fat diet-induced insulin resistance","volume":"65","author":"Zhang","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2024.07.025_b0210","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.mad.2008.02.010","article-title":"Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart","volume":"129","author":"Preston","year":"2008","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.jare.2024.07.025_b0215","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.2337\/db19-0423","article-title":"Disturbed fatty acid oxidation, endoplasmic reticulum stress, and apoptosis in left ventricle of patients with type 2 diabetes","volume":"68","author":"Ljubkovic","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2024.07.025_b0220","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.molcel.2020.12.008","article-title":"Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53","volume":"81","author":"Jiang","year":"2021","journal-title":"Mol Cell"},{"key":"10.1016\/j.jare.2024.07.025_b0225","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1161\/CIRCRESAHA.116.309463","article-title":"Phosphorylation of CHOP (C\/EBP homologous protein) by the AMP-activated protein kinase alpha 1 in macrophages promotes CHOP degradation and reduces injury-induced neointimal disruption in vivo","volume":"119","author":"Dai","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jare.2024.07.025_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105917","article-title":"Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models","volume":"177","author":"Hu","year":"2022","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jare.2024.07.025_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/nu15194279","article-title":"Type 1 and type 2 diabetes mellitus: commonalities, differences and the importance of exercise and nutrition","volume":"15","author":"Krause","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jare.2024.07.025_b0240","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00125-004-1507-3","article-title":"Insulin resistance is a risk factor for progression to type 1 diabetes","volume":"47","author":"Fourlanos","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.jare.2024.07.025_b0245","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2337\/db10-0328","article-title":"Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study","volume":"60","author":"Schauer","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2024.07.025_b0250","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2337\/diacare.13.6.610","article-title":"Glucose toxicity","volume":"13","author":"Rossetti","year":"1990","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2024.07.025_b0255","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yjmcc.2013.01.008","article-title":"Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation","volume":"57","author":"Bai","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jare.2024.07.025_b0260","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrc2715","article-title":"p53 and metabolism","volume":"9","author":"Vousden","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jare.2024.07.025_b0270","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jhep.2010.08.007","article-title":"Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease","volume":"54","author":"Derdak","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jare.2024.07.025_b0275","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/nm.2014","article-title":"A crucial role for adipose tissue p53 in the regulation of insulin resistance","volume":"15","author":"Minamino","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2024.07.025_b0280","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/oxfordjournals.aje.a009738","article-title":"Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women","volume":"149","author":"Yochum","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jare.2024.07.025_b0285","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1101\/gad.247452.114","article-title":"Limiting the power of p53 through the ubiquitin proteasome pathway","volume":"28","author":"Pant","year":"2014","journal-title":"Genes Dev"},{"key":"10.1016\/j.jare.2024.07.025_b0290","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1182\/blood-2009-07-230730","article-title":"Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation","volume":"115","author":"Jabbour","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jare.2024.07.025_b0295","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s00125-010-1772-2","article-title":"Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans","volume":"53","author":"Oberkofler","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.jare.2024.07.025_b0300","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.2337\/diabetes.54.9.2807","article-title":"The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy","volume":"54","author":"Prudente","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2024.07.025_b0305","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/acel.12674","article-title":"Deficiency of CCAAT\/enhancer-binding protein homologous protein (CHOP) prevents diet-induced aortic valve calcification in vivo","volume":"16","author":"Cai","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.jare.2024.07.025_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/cells11010096","article-title":"Autophagy and endoplasmic reticulum stress during onset and progression of arrhythmogenic cardiomyopathy","volume":"11","author":"Pitsch","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jare.2024.07.025_b0315","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1161\/CIRCEP.113.000274","article-title":"Unfolded protein response regulates cardiac sodium current in systolic human heart failure","volume":"6","author":"Gao","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"366","key":"10.1016\/j.jare.2024.07.025_b0320","first-page":"e1","article-title":"Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress, and apoptosis","volume":"215","author":"Wu","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jare.2024.07.025_b0325","doi-asserted-by":"crossref","first-page":"40514","DOI":"10.1074\/jbc.M306404200","article-title":"CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation","volume":"278","author":"Ubeda","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2024.07.025_b0330","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1126\/science.272.5266.1347","article-title":"Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase","volume":"272","author":"Wang","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jare.2024.07.025_b0335","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cardiores.2005.04.018","article-title":"Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism","volume":"67","author":"Liao","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jare.2024.07.025_b0340","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/HYPERTENSIONAHA.111.174128","article-title":"AMP activated protein kinase-alpha2 regulates expression of estrogen-related receptor-alpha, a metabolic transcription factor related to heart failure development","volume":"58","author":"Hu","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.jare.2024.07.025_b0345","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41419-017-0123-3","article-title":"Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKalpha\/Smad3 signaling","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224003072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123224003072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:50:34Z","timestamp":1762599034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123224003072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":67,"alternative-id":["S2090123224003072"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.07.025","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}