{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:17:05Z","timestamp":1792876625816,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ24H090001"],"award-info":[{"award-number":["LZ24H090001"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LQ23H090017"],"award-info":[{"award-number":["LQ23H090017"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870910"],"award-info":[{"award-number":["81870910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171271"],"award-info":[{"award-number":["82171271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jare.2024.08.016","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T05:48:25Z","timestamp":1723528105000},"page":"575-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Impaired microglial glycolysis promotes inflammatory responses after intracerebral haemorrhage via HK2-dependent mitochondrial dysfunction"],"prefix":"10.1016","volume":"73","author":[{"given":"Yin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingji","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-2209","authenticated-orcid":false,"given":"Peili","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-4930","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jare.2024.08.016_b0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1474-4422(09)70340-0","article-title":"Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis","volume":"9","author":"van Asch","year":"2010","journal-title":"Lancet Neurol"},{"issue":"7","key":"10.1016\/j.jare.2024.08.016_b0010","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/ijs.12309","article-title":"European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage","volume":"9","author":"Steiner","year":"2014","journal-title":"Int J Stroke"},{"issue":"5","key":"10.1016\/j.jare.2024.08.016_b0015","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1016\/S2214-109X(13)70089-5","article-title":"Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010","volume":"1","author":"Krishnamurthi","year":"2013","journal-title":"Lancet Glob Health"},{"issue":"7","key":"10.1016\/j.jare.2024.08.016_b0020","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.STR.24.7.987","article-title":"Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality","volume":"24","author":"Broderick","year":"1993","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0025","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/jcbfm.2008.114","article-title":"Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes","volume":"29","author":"Loftspring","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"10.1016\/j.jare.2024.08.016_b0030","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S1474-4422(19)30108-5","article-title":"Reduction of iron neurotoxicity in intracerebral haemorrhage","volume":"18","author":"Anderson","year":"2019","journal-title":"Lancet Neurol"},{"issue":"11","key":"10.1016\/j.jare.2024.08.016_b0035","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1130","article-title":"Quantitative proteomic analysis of intracerebral hemorrhage in rats with a focus on brain energy metabolism","volume":"8","author":"Liu","year":"2018","journal-title":"Brain Behav"},{"issue":"11","key":"10.1016\/j.jare.2024.08.016_b0040","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000014748","article-title":"Association between serum glucose level and spot sign in intracerebral hemorrhage","volume":"98","author":"Zhang","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"47","key":"10.1016\/j.jare.2024.08.016_b0045","doi-asserted-by":"crossref","first-page":"E4502","DOI":"10.1073\/pnas.1317918110","article-title":"Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease","volume":"110","author":"Benzinger","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2024.08.016_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106208","article-title":"Glycolysis inhibition ameliorates brain injury after ischemic stroke by promoting the function of myeloid-derived suppressor cells","volume":"179","author":"Yan","year":"2022","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0055","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3171\/2011.3.JNS10899","article-title":"Relation between brain interstitial and systemic glucose concentrations after subarachnoid hemorrhage","volume":"115","author":"Zetterling","year":"2011","journal-title":"J Neurosurg"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/STROKEAHA.117.019189","article-title":"Prospective study of fasting blood glucose and intracerebral hemorrhagic risk","volume":"49","author":"Jin","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jare.2024.08.016_b0065","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2147\/NDT.S433488","article-title":"Acute phase blood glucose levels and functional outcomes in patients with spontaneous intracerebral hemorrhage","volume":"19","author":"Zhou","year":"2023","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"7","key":"10.1016\/j.jare.2024.08.016_b0070","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrneurol.2017.69","article-title":"Modulators of microglial activation and polarization after intracerebral haemorrhage","volume":"13","author":"Lan","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"10.1016\/j.jare.2024.08.016_b0075","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/brain\/awz393","article-title":"Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities","volume":"143","author":"Bai","year":"2020","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0080","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1172\/JCI88647","article-title":"TGF-beta1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage","volume":"127","author":"Taylor","year":"2017","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.jare.2024.08.016_b0085","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI95612","article-title":"Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage","volume":"128","author":"Chang","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2024.08.016_b0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pneurobio.2013.11.003","article-title":"Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation","volume":"115","author":"Zhou","year":"2014","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jare.2024.08.016_b0095","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J Inflamm Res"},{"issue":"5","key":"10.1016\/j.jare.2024.08.016_b0100","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/glia.23760","article-title":"mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP","volume":"68","author":"Hu","year":"2020","journal-title":"Glia"},{"issue":"23","key":"10.1016\/j.jare.2024.08.016_b0105","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1182\/blood-2009-10-249540","article-title":"Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation","volume":"115","author":"Krawczyk","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jare.2024.08.016_b0110","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cmet.2012.04.023","article-title":"The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism","volume":"15","author":"Haschemi","year":"2012","journal-title":"Cell Metab"},{"issue":"8","key":"10.1016\/j.jare.2024.08.016_b0115","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1084\/jem.20132477","article-title":"Differential roles of microglia and monocytes in the inflamed central nervous system","volume":"211","author":"Yamasaki","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.jare.2024.08.016_b0120","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jare.2022.03.011","article-title":"Soluble Trem2 is a negative regulator of erythrophagocytosis after intracerebral hemorrhage in a CD36 receptor recycling manner","volume":"44","author":"Zhou","year":"2023","journal-title":"J Adv Res"},{"issue":"15","key":"10.1016\/j.jare.2024.08.016_b0125","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk2376","article-title":"Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms","volume":"8","author":"Bao","year":"2022","journal-title":"Sci Adv"},{"issue":"6","key":"10.1016\/j.jare.2024.08.016_b0130","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1161\/STROKEAHA.118.024578","article-title":"Enhancement of hematoma clearance With CD47 blocking antibody in experimental intracerebral hemorrhage","volume":"50","author":"Jing","year":"2019","journal-title":"Stroke"},{"issue":"51","key":"10.1016\/j.jare.2024.08.016_b0135","doi-asserted-by":"crossref","first-page":"32679","DOI":"10.1073\/pnas.2018497117","article-title":"IL-4\/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice","volume":"117","author":"Xu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.jare.2024.08.016_b0140","doi-asserted-by":"crossref","first-page":"E1738","DOI":"10.1073\/pnas.1525528113","article-title":"New tools for studying microglia in the mouse and human CNS","volume":"113","author":"Bennett","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"615","key":"10.1016\/j.jare.2024.08.016_b0145","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe5640","article-title":"Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases","volume":"13","author":"Xiang","year":"2021","journal-title":"Sci Transl Med"},{"issue":"7644","key":"10.1016\/j.jare.2024.08.016_b0150","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature21379","article-title":"Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism","volume":"543","author":"Pan","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0155","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12974-021-02201-3","article-title":"AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury","volume":"18","author":"Zhou","year":"2021","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0160","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13046-020-01807-4","article-title":"Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells","volume":"40","author":"Chen","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/neu.2009.1049","article-title":"Statistical parametric mapping and cluster counting analysis of [18F] FDG-PET imaging in traumatic brain injury","volume":"27","author":"Zhang","year":"2010","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jare.2024.08.016_b0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/3-211-32318-X_35","article-title":"Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study","volume":"95","author":"O'Connell","year":"2005","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.jare.2024.08.016_b0175","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jns.2016.08.042","article-title":"Brain glucose metabolism changes in Parkinson's disease patients with CHCHD2 mutation based on (18)F-FDG PET imaging","volume":"369","author":"Mao","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jare.2024.08.016_b0180","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neurobiolaging.2018.01.002","article-title":"Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation","volume":"65","author":"Apostolova","year":"2018","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.jare.2024.08.016_b0185","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.jare.2024.08.016_b0190","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41593-018-0296-9","article-title":"Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE","volume":"22","author":"Parhizkar","year":"2019","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0195","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/s41467-020-15267-z","article-title":"Microglial metabolic flexibility supports immune surveillance of the brain parenchyma","volume":"11","author":"Bernier","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0200","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13024-019-0305-9","article-title":"Glucose transporter 1 critically controls microglial activation through facilitating glycolysis","volume":"14","author":"Wang","year":"2019","journal-title":"Mol Neurodegener"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0205","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.radonc.2015.08.025","article-title":"The association of (18)F-FDG PET and glucose metabolism biomarkers GLUT1 and HK2 in p16 positive and negative head and neck squamous cell carcinomas","volume":"117","author":"Baschnagel","year":"2015","journal-title":"Radiother Oncol"},{"issue":"14","key":"10.1016\/j.jare.2024.08.016_b0210","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.7150\/thno.74848","article-title":"(18)F-FDG PET as an imaging biomarker for the response to FGFR-targeted therapy of cancer cells via FGFR-initiated mTOR\/HK2 axis","volume":"12","author":"Jiang","year":"2022","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.jare.2024.08.016_b0215","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/s42255-022-00707-5","article-title":"Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity","volume":"4","author":"Hu","year":"2022","journal-title":"Nat Metab"},{"issue":"16","key":"10.1016\/j.jare.2024.08.016_b0220","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1111\/febs.15327","article-title":"Glycolysis - a key player in the inflammatory response","volume":"287","author":"Soto-Heredero","year":"2020","journal-title":"FEBS J"},{"issue":"4","key":"10.1016\/j.jare.2024.08.016_b0225","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ni.2833","article-title":"TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation","volume":"15","author":"Everts","year":"2014","journal-title":"Nat Immunol"},{"issue":"3","key":"10.1016\/j.jare.2024.08.016_b0230","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2010.03.002","article-title":"VDAC, a multi-functional mitochondrial protein regulating cell life and death","volume":"31","author":"Shoshan-Barmatz","year":"2010","journal-title":"Mol Aspects Med"},{"issue":"3","key":"10.1016\/j.jare.2024.08.016_b0235","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10863-008-9148-8","article-title":"Regulation of hexokinase binding to VDAC","volume":"40","author":"Pastorino","year":"2008","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.jare.2024.08.016_b0240","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-cellbio-021820-101354","article-title":"Mitochondrial quality control and restraining innate immunity","volume":"36","author":"Moehlman","year":"2020","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"4","key":"10.1016\/j.jare.2024.08.016_b0245","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.1016\/j.jare.2024.08.016_b0250","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(10)70002-8","article-title":"Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis","volume":"9","author":"Tang","year":"2010","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.1016\/j.jare.2024.08.016_b0255","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3233\/JAD-150274","article-title":"Cerebral amyloid angiopathy-related microbleeds correlate with glucose metabolism and brain volume in Alzheimer's disease","volume":"48","author":"Samuraki","year":"2015","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"10.1016\/j.jare.2024.08.016_b0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186976","article-title":"Asymmetry of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities","volume":"12","author":"Park","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jare.2024.08.016_b0265","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1471-4159.1977.tb10649.x","article-title":"The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat","volume":"28","author":"Sokoloff","year":"1977","journal-title":"J Neurochem"},{"issue":"3\u20135","key":"10.1016\/j.jare.2024.08.016_b0270","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000111335","article-title":"Sites and mechanisms of function-related changes in energy metabolism in the nervous system","volume":"15","author":"Sokoloff","year":"1993","journal-title":"Dev Neurosci"},{"issue":"2","key":"10.1016\/j.jare.2024.08.016_b0275","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1023\/A:1022534709672","article-title":"Energetics of functional activation in neural tissues","volume":"24","author":"Sokoloff","year":"1999","journal-title":"Neurochem Res"},{"issue":"6","key":"10.1016\/j.jare.2024.08.016_b0280","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"47","key":"10.1016\/j.jare.2024.08.016_b0285","doi-asserted-by":"crossref","first-page":"14770","DOI":"10.1523\/JNEUROSCI.3669-09.2009","article-title":"Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve","volume":"29","author":"Cohen","year":"2009","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.jare.2024.08.016_b0290","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/glia.23271","article-title":"Bioenergetic regulation of microglia","volume":"66","author":"Ghosh","year":"2018","journal-title":"Glia"},{"issue":"Pt 12","key":"10.1016\/j.jare.2024.08.016_b0295","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1242\/jeb.00241","article-title":"Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function","volume":"206","author":"Wilson","year":"2003","journal-title":"J Exp Biol"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0300","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010234","article-title":"2-deoxy-d-glucose and its analogs: from diagnostic to therapeutic agents","volume":"21","author":"Pajak","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jare.2024.08.016_b0305","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949117","article-title":"Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca(2+) -dependent death of cancer cells","volume":"21","author":"Ciscato","year":"2020","journal-title":"EMBO Rep"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0310","doi-asserted-by":"crossref","first-page":"e005645","DOI":"10.1161\/JAHA.112.005645","article-title":"Extent of mitochondrial hexokinase II dissociation during ischemia correlates with mitochondrial cytochrome c release, reactive oxygen species production, and infarct size on reperfusion","volume":"2","author":"Pasdois","year":"2012","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.jare.2024.08.016_b0315","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cell.2016.05.076","article-title":"Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan","volume":"166","author":"Wolf","year":"2016","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jare.2024.08.016_b0320","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.cmet.2021.11.004","article-title":"Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis","volume":"33","author":"Hinrichsen","year":"2021","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.jare.2024.08.016_b0325","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0306-4522(92)90500-2","article-title":"Turnover of resident microglia in the normal adult mouse brain","volume":"48","author":"Lawson","year":"1992","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.jare.2024.08.016_b0330","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/glia.22394","article-title":"Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues","volume":"60","author":"Eyo","year":"2012","journal-title":"Glia"},{"issue":"11","key":"10.1016\/j.jare.2024.08.016_b0335","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/bies.201300084","article-title":"The Warburg effect then and now: from cancer to inflammatory diseases","volume":"35","author":"Palsson-McDermott","year":"2013","journal-title":"Bioessays"},{"issue":"6","key":"10.1016\/j.jare.2024.08.016_b0340","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1177\/0271678X16679170","article-title":"Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage","volume":"38","author":"Leclerc","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"10.1016\/j.jare.2024.08.016_b0345","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41467-019-08446-0","article-title":"Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury","volume":"10","author":"Bellver-Landete","year":"2019","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.jare.2024.08.016_b0350","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1523\/JNEUROSCI.3585-12.2013","article-title":"SPARC regulates microgliosis and functional recovery following cortical ischemia","volume":"33","author":"Lloyd-Burton","year":"2013","journal-title":"J Neurosci"},{"issue":"8","key":"10.1016\/j.jare.2024.08.016_b0355","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in acute ischemic and hemorrhagic stroke","volume":"23","author":"Alsbrook","year":"2023","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.jare.2024.08.016_b0360","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-3-211-09469-3_9","article-title":"Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin, and Src","volume":"105","author":"Sharp","year":"2008","journal-title":"Acta Neurochir Suppl"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322400359X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322400359X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:52:19Z","timestamp":1762599139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209012322400359X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":72,"alternative-id":["S209012322400359X"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.08.016","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired microglial glycolysis promotes inflammatory responses after intracerebral haemorrhage via HK2-dependent mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}