{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:26:14Z","timestamp":1792805174908,"version":"4.5.0"},"reference-count":168,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["SL2023A04J02637"],"award-info":[{"award-number":["SL2023A04J02637"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970930"],"award-info":[{"award-number":["81970930"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jare.2024.08.019","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T18:49:36Z","timestamp":1723920576000},"page":"443-458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine"],"prefix":"10.1016","volume":"73","author":[{"given":"Weiqi","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiliang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2024.08.019_b0005","first-page":"109","article-title":"Homeostatic medicine: new strategy and concept of health maintenance as well as diagnosis and treatment of diseases","volume":"58","author":"Qin","year":"2023","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.jare.2024.08.019_b0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s44194-022-00016-9","article-title":"Homeostatic medicine: a strategy for exploring health and disease","volume":"1","author":"Wang","year":"2022","journal-title":"Curr Med (Cham)"},{"key":"10.1016\/j.jare.2024.08.019_b0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41368-022-00163-7","article-title":"Oral microbiota in human systematic diseases","volume":"14","author":"Peng","year":"2022","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.jare.2024.08.019_b0020","first-page":"11","article-title":"Progress in oral microbiome related to oral and systemic diseases: an update","author":"Lee","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.jare.2024.08.019_b0025","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jare.2024.08.019_b0030","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1152\/physrev.00036.2016","article-title":"Osteoimmunology: the conceptual framework unifying the immune and skeletal systems","volume":"97","author":"Okamoto","year":"2017","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2024.08.019_b0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tem.2017.11.008","article-title":"The metabolic microenvironment steers bone tissue regeneration","volume":"29","author":"Loeffler","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jare.2024.08.019_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.751503","article-title":"Oral osteomicrobiology: the role of oral microbiota in alveolar bone homeostasis","volume":"11","author":"Cheng","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0045","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41413-023-00257-w","article-title":"New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis","volume":"11","author":"Hasco\u00ebt","year":"2023","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2024.08.019_b0050","article-title":"Bidirectional relationship between osteoarthritis and periodontitis: a population-based cohort study over a 15-year follow-up","volume":"13","author":"Ma","year":"2022","journal-title":"Front Immunol"},{"issue":"89","key":"10.1016\/j.jare.2024.08.019_b0055","first-page":"99","article-title":"Osteoporosis and periodontal diseases \u2013 An update on their association and mechanistic links","volume":"2022","author":"Yu","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1186\/s12879-022-07573-2","article-title":"Femoral osteomyelitis caused by oral anaerobic bacteria with mixed bacteremia of Campylobacter rectus and Parvimonas micra in a chronic periodontitis patient: a case report","volume":"22","author":"Itoh","year":"2022","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jare.2024.08.019_b0065","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","article-title":"Oral microbiome: Unveiling the fundamentals","volume":"23","author":"Deo","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"key":"10.1016\/j.jare.2024.08.019_b0070","doi-asserted-by":"crossref","first-page":"e024263","DOI":"10.1136\/bmjopen-2018-024263","article-title":"Cohort profile: the Buffalo OsteoPerio microbiome prospective cohort study","volume":"8","author":"Banack","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.jare.2024.08.019_b0075","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fmicb.2018.00302","article-title":"Conceptual perspectives: bacterial antimicrobial peptide induction as a novel strategy for symbiosis with the human host","volume":"9","author":"Ghosh","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0080","doi-asserted-by":"crossref","first-page":"1005992","DOI":"10.3389\/fimmu.2022.1005992","article-title":"Multi-omics analysis reveals the effects of microbiota on oral homeostasis","volume":"13","author":"Long","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2024.08.019_b0085","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3389\/fcimb.2017.00291","article-title":"Opportunistic pathogen porphyromonas gingivalis modulates danger signal ATP-mediated antibacterial NOX2 pathways in primary epithelial cells","volume":"7","author":"Roberts","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0090","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/s41385-018-0014-7","article-title":"Activation of Notch-1 in oral epithelial cells by P. gingivalis triggers the expression of the antimicrobial protein PLA2-IIA","volume":"11","author":"Al-Attar","year":"2018","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jare.2024.08.019_b0095","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","article-title":"Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement","volume":"10","author":"Hajishengallis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jare.2024.08.019_b0100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/JPER.21-0144","article-title":"Porphyromonas gingivalis outer membrane vesicles inhibit the invasion of Fusobacterium nucleatum into oral epithelial cells by downregulating FadA and FomA","volume":"93","author":"Zhang","year":"2022","journal-title":"J Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0105","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.3390\/nu14122426","article-title":"A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System\u2019s Response during Periodontitis","volume":"14","author":"Santonocito","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jare.2024.08.019_b0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/dj9050051","article-title":"The impact of sport training on oral health in athletes","volume":"9","author":"Tripodi","year":"2021","journal-title":"Dent J (Basel)"},{"key":"10.1016\/j.jare.2024.08.019_b0115","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1136\/jech-2019-212474","article-title":"Cigarette smoking and oral microbiota in low-income and African-American populations","volume":"73","author":"Yang","year":"2019","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.jare.2024.08.019_b0120","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1097\/CM9.0000000000001825","article-title":"Alterations in the oral microbiome in HIV infection: causes, effects and potential interventions","volume":"134","author":"Li","year":"2021","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jare.2024.08.019_b0125","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/ismej.2014.28","article-title":"Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients","volume":"8","author":"Li","year":"2014","journal-title":"ISME J"},{"key":"10.1016\/j.jare.2024.08.019_b0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00011-020-01418-x","article-title":"Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss","volume":"70","author":"Chang","year":"2021","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jare.2024.08.019_b0135","doi-asserted-by":"crossref","DOI":"10.1038\/ni.2604","article-title":"Compartmentalized and systemic control of tissue immunity by commensals","volume":"14","author":"Belkaid","year":"2013","journal-title":"Nat Immunol"},{"issue":"69","key":"10.1016\/j.jare.2024.08.019_b0140","first-page":"18","article-title":"Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis","volume":"2015","author":"Roberts","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/osi2.1078","article-title":"Role of osteoclasts in oral homeostasis and jawbone diseases","volume":"18","author":"Omi","year":"2020","journal-title":"Oral Sci Int"},{"key":"10.1016\/j.jare.2024.08.019_b0150","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/0022034516685711","article-title":"MicroRNAs and Periodontal Homeostasis","volume":"96","author":"Luan","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0155","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/0022034514540173","article-title":"Impact of the oral commensal flora on alveolar bone homeostasis","volume":"93","author":"Irie","year":"2014","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0160","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3390\/molecules23071517","article-title":"Commensal Microbiota Enhance Both Osteoclast and Osteoblast Activities","volume":"23","author":"Uchida","year":"2018","journal-title":"Molecules"},{"issue":"86","key":"10.1016\/j.jare.2024.08.019_b0165","first-page":"157","article-title":"Maintaining homeostatic control of periodontal bone tissue","volume":"2021","author":"Hathaway-Schrader","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0170","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41374-021-00697-0","article-title":"Commensal gut bacterium critically regulates alveolar bone homeostasis","volume":"102","author":"Hathaway-Schrader","year":"2022","journal-title":"Lab Invest"},{"key":"10.1016\/j.jare.2024.08.019_b0175","first-page":"7","article-title":"Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice","author":"Hathaway-Schrader","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jare.2024.08.019_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.714366","article-title":"Tetracycline, an appropriate reagent for measuring bone-formation activity in the murine model of the streptococcus mutans-induced bone loss","volume":"11","author":"Hirohashi","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0185","doi-asserted-by":"crossref","first-page":"fuab039","DOI":"10.1093\/femsre\/fuab039","article-title":"Metabolites of the oral microbiome: important mediators of multikingdom interactions","volume":"46","author":"Barbour","year":"2022","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.jare.2024.08.019_b0190","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jbmr.5650110303","article-title":"Nitric oxide and bone","volume":"11","author":"Evans","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2024.08.019_b0195","doi-asserted-by":"crossref","first-page":"e88645","DOI":"10.1371\/journal.pone.0088645","article-title":"Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis","volume":"9","author":"Hyde","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2024.08.019_b0200","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.niox.2008.08.003","article-title":"The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash","volume":"19","author":"Govoni","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jare.2024.08.019_b0205","doi-asserted-by":"crossref","first-page":"e13395","DOI":"10.1111\/cpr.13395","article-title":"Dietary nitrate improves jaw bone remodelling in zoledronate-treated mice","volume":"56","author":"Pan","year":"2023","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jare.2024.08.019_b0210","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1607235113","article-title":"Gut microbiota induce IGF-1 and promote bone formation and growth","volume":"113","author":"Yan","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2024.08.019_b0215","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/omi.12322","article-title":"A double-edged sword: Role of butyrate in the oral cavity and the gut","volume":"36","author":"Guan","year":"2021","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.tim.2024.05.006","article-title":"Unraveling host regulation of gut microbiota through the epigenome-microbiome axis","author":"Pepke","year":"2024","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jaut.2017.03.009","article-title":"Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases","volume":"83","author":"Chen","year":"2017","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jare.2024.08.019_b0230","doi-asserted-by":"crossref","first-page":"2022407","DOI":"10.1080\/19490976.2021.2022407","article-title":"Epigenetic regulation by gut microbiota","volume":"14","author":"Woo","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jare.2024.08.019_b0235","doi-asserted-by":"crossref","first-page":"2146160","DOI":"10.1155\/2020\/2146160","article-title":"Global Prevalence of Periodontal Disease and Lack of Its Surveillance","volume":"2020","author":"Nazir","year":"2020","journal-title":"ScientificWorldJournal"},{"issue":"38","key":"10.1016\/j.jare.2024.08.019_b0240","first-page":"135","article-title":"Periodontal microbial ecology","volume":"2005","author":"Socransky","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0245","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.2041-1014.2012.00663.x","article-title":"Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","volume":"27","author":"Hajishengallis","year":"2012","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0250","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jare.2024.08.019_b0255","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2024.08.019_b0260","doi-asserted-by":"crossref","first-page":"e22015","DOI":"10.1096\/fj.202101169R","article-title":"Antimicrobial-induced oral dysbiosis exacerbates naturally occurring alveolar bone loss","volume":"35","author":"Swanson","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.jare.2024.08.019_b0265","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/0022034520918536","article-title":"A new era for the oral microbiome","volume":"99","author":"Jakubovics","year":"2020","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0270","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1186\/s12864-016-3254-5","article-title":"Integrated metagenomic data analysis demonstrates that a loss of diversity in oral microbiota is associated with periodontitis","volume":"18","author":"Ai","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jare.2024.08.019_b0275","doi-asserted-by":"crossref","unstructured":"Yama K, Nishimoto Y, Kumagai K, Jo R, Harada M, Maruyama Y, et al. Dysbiosis of oral microbiome persists after dental treatment-induced remission of periodontal disease and dental caries. mSystems 2023;8:e0068323. doi: 10.1128\/msystems.00683-23.","DOI":"10.1128\/msystems.00683-23"},{"key":"10.1016\/j.jare.2024.08.019_b0280","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.3390\/ijms20184541","article-title":"Linkage of periodontitis and rheumatoid arthritis: current evidence and potential biological interactions","volume":"20","author":"de Molon","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2024.08.019_b0285","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1128\/IAI.68.10.6012-6026.2000","article-title":"Reverse transcriptase-PCR analysis of bacterial rRNA for detection and characterization of bacterial species in arthritis synovial tissue","volume":"68","author":"Kempsell","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.jare.2024.08.019_b0290","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1600-051X.2009.01496.x","article-title":"Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients","volume":"36","author":"Martinez-Martinez","year":"2009","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0295","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/RHU.0b013e3182500c95","article-title":"Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints","volume":"18","author":"T\u00e9moin","year":"2012","journal-title":"J Clin Rheumatol"},{"key":"10.1016\/j.jare.2024.08.019_b0300","first-page":"656","article-title":"Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs","volume":"24","author":"Moen","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jare.2024.08.019_b0305","doi-asserted-by":"crossref","first-page":"e1003627","DOI":"10.1371\/journal.ppat.1003627","article-title":"Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)","volume":"9","author":"Maresz","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jare.2024.08.019_b0310","doi-asserted-by":"crossref","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"Konig","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jare.2024.08.019_b0315","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/art.40227","article-title":"Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis","volume":"69","author":"Schwenzer","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jare.2024.08.019_b0320","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1002\/art.34539","article-title":"Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis","volume":"64","author":"Scher","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jare.2024.08.019_b0325","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1038\/s41598-019-44674-6","article-title":"Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients","volume":"9","author":"Corr\u00eaa","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.08.019_b0330","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1002\/art.41780","article-title":"Differences in the oral microbiome in patients with early rheumatoid arthritis and individuals at risk of rheumatoid arthritis compared to healthy individuals","volume":"73","author":"Kroese","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jare.2024.08.019_b0335","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/annrheumdis-2020-216972","article-title":"Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis","volume":"80","author":"Cheng","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2024.08.019_b0340","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fcimb.2019.00475","article-title":"Oral microbiota perturbations are linked to high risk for rheumatoid arthritis","volume":"9","author":"Tong","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0345","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jare.2024.08.019_b0350","article-title":"Oral-gut microbiota and arthritis: is there an evidence-based axis?","volume":"8","author":"Lorenzo","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jare.2024.08.019_b0355","doi-asserted-by":"crossref","first-page":"17126","DOI":"10.1038\/s41598-018-35473-6","article-title":"Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening","volume":"8","author":"Chen","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.08.019_b0360","doi-asserted-by":"crossref","first-page":"14305","DOI":"10.1038\/s41598-018-32675-w","article-title":"Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.08.019_b0365","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v2i0.5784","article-title":"Rheumatoid arthritis and the role of oral bacteria","volume":"2","author":"Loyola-Rodriguez","year":"2010","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0370","doi-asserted-by":"crossref","first-page":"e2348","DOI":"10.1097\/MD.0000000000002348","article-title":"The impact of oral hygiene maintenance on the association between periodontitis and osteoporosis: a nationwide population-based cross sectional study","volume":"95","author":"Huang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jare.2024.08.019_b0375","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/jre.12464","article-title":"Patients with chronic periodontitis present increased risk for osteoporosis: a population-based cohort study in Taiwan","volume":"52","author":"Mau","year":"2017","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jare.2024.08.019_b0380","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/odi.13531","article-title":"Associations between osteoporosis and risk of periodontitis: a pooled analysis of observational studies","volume":"27","author":"Xu","year":"2021","journal-title":"Oral Dis"},{"key":"10.1016\/j.jare.2024.08.019_b0385","article-title":"Salivary microbiota of periodontitis aggravates bone loss in ovariectomized rats","volume":"12","author":"Wang","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0390","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1902\/jop.2015.150365","article-title":"Oral Microbiota, Periodontal Status, and Osteoporosis in Postmenopausal Females","volume":"87","author":"Hern\u00e1ndez-Vigueras","year":"2016","journal-title":"J Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0395","doi-asserted-by":"crossref","unstructured":"X W, M Z, T Z, Q W, G L, J D. Flourishing Antibacterial Strategies for Osteomyelitis Therapy. Advanced Science (Weinheim, Baden-Wurttemberg, Germany) 2023;10. doi: 10.1002\/advs.202206154.","DOI":"10.1002\/advs.202206154"},{"key":"10.1016\/j.jare.2024.08.019_b0400","first-page":"19","article-title":"Streptococcus anginosus and phalangeal osteomyelitis: an unusual presentation","volume":"10","author":"Ribeiro","year":"2020","journal-title":"J Orthop Case Rep"},{"key":"10.1016\/j.jare.2024.08.019_b0405","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2334-12-161","article-title":"Osteomyelitis of a long bone due to Fusobacterium nucleatum and Actinomyces meyeri in an immunocompetent adult: a case report and literature review","volume":"12","author":"Lee","year":"2012","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jare.2024.08.019_b0410","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00393-021-01035-x","article-title":"Results from a pilot study on the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis","volume":"82","author":"Zeus","year":"2023","journal-title":"Z Rheumatol"},{"key":"10.1016\/j.jare.2024.08.019_b0415","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/0022034520926126","article-title":"Inflammatory networks linking oral microbiome with systemic health and disease","volume":"99","author":"Kleinstein","year":"2020","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0420","doi-asserted-by":"crossref","unstructured":"Parahitiyawa NB, Jin LJ, Leung WK, Yam WC, Samaranayake LP. Microbiology of odontogenic bacteremia: beyond endocarditis. Clin Microbiol Rev 2009;22:46\u201364, Table of Contents. doi: 10.1128\/CMR.00028-08.","DOI":"10.1128\/CMR.00028-08"},{"key":"10.1016\/j.jare.2024.08.019_b0425","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-051X.2006.00924.x","article-title":"Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation","volume":"33","author":"Forner","year":"2006","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0430","doi-asserted-by":"crossref","first-page":"e1651158","DOI":"10.1080\/21688370.2019.1651158","article-title":"Gingival epithelial barrier: regulation by beneficial and harmful microbes","volume":"7","author":"Takahashi","year":"2019","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jare.2024.08.019_b0435","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1177\/0022034519865184","article-title":"Porphyromonas gingivalis Impairs oral epithelial barrier through targeting GRHL2","volume":"98","author":"Chen","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0440","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/jre.12388","article-title":"Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-\u03b1, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1","volume":"52","author":"Damgaard","year":"2017","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jare.2024.08.019_b0445","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1371\/journal.ppat.0020076","article-title":"Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection","volume":"2","author":"Mydel","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jare.2024.08.019_b0450","doi-asserted-by":"crossref","unstructured":"Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009;22:240\u201373, Table of Contents. doi: 10.1128\/CMR.00046-08.","DOI":"10.1128\/CMR.00046-08"},{"key":"10.1016\/j.jare.2024.08.019_b0455","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.joca.2016.05.008","article-title":"Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation","volume":"24","author":"Huang","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jare.2024.08.019_b0460","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1399-302X.2007.00415.x","article-title":"An acute injection of Porphyromonas gingivalis lipopolysaccharide modulates the OPG\/RANKL system and interleukin-6 in an ovariectomized mouse model","volume":"23","author":"Lu","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jare.2024.08.019_b0465","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13075-016-1056-4","article-title":"Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice","volume":"18","author":"Chukkapalli","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jare.2024.08.019_b0470","first-page":"427066","article-title":"Biological properties of extracellular vesicles and their physiological functions","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jare.2024.08.019_b0475","doi-asserted-by":"crossref","first-page":"e12157","DOI":"10.1002\/jev2.12157","article-title":"Extracellular vesicles derived from the periodontal pathogen Filifactor alocis induce systemic bone loss through Toll-like receptor 2","volume":"10","author":"Kim","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jare.2024.08.019_b0480","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.chom.2023.03.018","article-title":"Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles","volume":"31","author":"Hong","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jare.2024.08.019_b0485","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41575-021-00488-4","article-title":"The role of oral bacteria in inflammatory bowel disease","volume":"18","author":"Read","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2024.08.019_b0490","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1177\/00220345211049781","article-title":"Periodontitis salivary microbiota worsens colitis","volume":"101","author":"Qian","year":"2022","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0495","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13075-020-02348-z","article-title":"Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model","volume":"22","author":"Hamamoto","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jare.2024.08.019_b0500","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41368-022-00212-1","article-title":"Systemic antibiotics increase microbiota pathogenicity and oral bone loss","volume":"15","author":"Yuan","year":"2023","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.jare.2024.08.019_b0505","doi-asserted-by":"crossref","first-page":"2110194","DOI":"10.1080\/20002297.2022.2110194","article-title":"Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice","volume":"14","author":"Yamazaki","year":"2022","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0510","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.752708","article-title":"Gut-bone axis: a non-negligible contributor to periodontitis","volume":"11","author":"Jia","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0515","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3390\/nu12020574","article-title":"Gut-joint axis: the role of physical exercise on gut microbiota modulation in older people with osteoarthritis","volume":"12","author":"de Sire","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jare.2024.08.019_b0520","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2024.08.019_b0525","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1038\/s41598-017-07196-7","article-title":"Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system","volume":"7","author":"Sato","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.08.019_b0530","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/jcpe.13708","article-title":"Periodontitis may impair the homeostasis of systemic bone through regulation of gut microbiota in ApoE-\/- mice","volume":"49","author":"Li","year":"2022","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0535","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1177\/00220345211009449","article-title":"Gut Microbiota May Mediate the Influence of Periodontitis on Prediabetes","volume":"100","author":"Li","year":"2021","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0540","doi-asserted-by":"crossref","first-page":"eabm1511","DOI":"10.1126\/sciadv.abm1511","article-title":"Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis","volume":"8","author":"He","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2024.08.019_b0545","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ismej.2012.174","article-title":"The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation","volume":"7","author":"Abusleme","year":"2013","journal-title":"ISME J"},{"key":"10.1016\/j.jare.2024.08.019_b0550","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1038\/srep04828","article-title":"Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota","volume":"4","author":"Arimatsu","year":"2014","journal-title":"Sci Rep"},{"issue":"89","key":"10.1016\/j.jare.2024.08.019_b0555","first-page":"99","article-title":"Osteoporosis and periodontal diseases - An update on their association and mechanistic links","volume":"2022","author":"Yu","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0560","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/annrheumdis-2018-213697","article-title":"Porphyromonas gingivalis experimentally induces periodontis and an anti-CCP2-associated arthritis in the rat","volume":"78","author":"Courbon","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2024.08.019_b0565","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/jbmr.1973","article-title":"Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation","volume":"28","author":"Kim","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2024.08.019_b0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(03)00841-2","article-title":"Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology","volume":"321","author":"Nanes","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.jare.2024.08.019_b0575","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bone.2015.11.014","article-title":"Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice","volume":"83","author":"Anbinder","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.jare.2024.08.019_b0580","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41467-018-03147-6","article-title":"Host defense against oral microbiota by bone-damaging T cells","volume":"9","author":"Tsukasaki","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2024.08.019_b0585","doi-asserted-by":"crossref","first-page":"e460","DOI":"10.1038\/emm.2017.301","article-title":"Interrupting oral infection of Porphyromonas gingivalis with anti-FimA antibody attenuates bacterial dissemination to the arthritic joint and improves experimental arthritis","volume":"50","author":"Jeong","year":"2018","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jare.2024.08.019_b0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121158","article-title":"Immunomodulatory effects exerted by extracellular vesicles from Staphylococcus epidermidis and Staphylococcus aureus isolated from bone-anchored prostheses","volume":"278","author":"Zaborowska","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2024.08.019_b0595","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.815638","article-title":"Outer membrane vesicles from fusobacterium nucleatum switch m0-like macrophages toward the m1 phenotype to destroy periodontal tissues in mice","volume":"13","author":"Chen","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0600","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jare.2024.08.019_b0605","doi-asserted-by":"crossref","first-page":"e92368","DOI":"10.1371\/journal.pone.0092368","article-title":"Probiotics protect mice from ovariectomy-induced cortical bone loss","volume":"9","author":"Ohlsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2024.08.019_b0610","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/cpr.12173","article-title":"Porphyromonas gingivalis lipopolysaccharides regulate functions of bone marrow mesenchymal stem cells","volume":"48","author":"Tang","year":"2015","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jare.2024.08.019_b0615","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1634\/stemcells.2007-0454","article-title":"Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling","volume":"26","author":"Liotta","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jare.2024.08.019_b0620","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/scrt456","article-title":"Lipopolysaccharide differentially affects the osteogenic differentiation of periodontal ligament stem cells and bone marrow mesenchymal stem cells through Toll-like receptor 4 mediated nuclear factor \u03baB pathway","volume":"5","author":"Li","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jare.2024.08.019_b0625","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2121-9-52","article-title":"Prolonged exposure to bacterial toxins downregulated expression of toll-like receptors in mesenchymal stromal cell-derived osteoprogenitors","volume":"9","author":"Mo","year":"2008","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.jare.2024.08.019_b0630","doi-asserted-by":"crossref","first-page":"e13442","DOI":"10.7717\/peerj.13442","article-title":"Lipopolysaccharide-activated macrophages regulate the osteogenic differentiation of bone marrow mesenchymal stem cells through exosomes","volume":"10","author":"Song","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.jare.2024.08.019_b0635","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/omi.12307","article-title":"Filifactor alocis-derived extracellular vesicles inhibit osteogenesis through TLR2 signaling","volume":"35","author":"Song","year":"2020","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jare.2024.08.019_b0640","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.3390\/ijms23116316","article-title":"Cartilage homeostasis and osteoarthritis","volume":"23","author":"Fujii","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2024.08.019_b0645","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/jre.13064","article-title":"Effect of osteoarthritis on alveolar bone loss in experimental periodontitis in rats","volume":"58","author":"Al Bayaty","year":"2023","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jare.2024.08.019_b0650","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1136\/ard.2008.102392","article-title":"Effects of Porphyromonas gingivalis on cell cycle progression and apoptosis of primary human chondrocytes","volume":"68","author":"Pischon","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2024.08.019_b0655","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00223-010-9389-5","article-title":"Induced apoptosis of chondrocytes by Porphyromonas gingivalis as a possible pathway for cartilage loss in rheumatoid arthritis","volume":"87","author":"R\u00f6hner","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jare.2024.08.019_b0660","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2008.06.061","article-title":"Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13","volume":"373","author":"Sakurai","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jare.2024.08.019_b0665","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1194\/jlr.M400278-JLR200","article-title":"Structures and biological activity of phosphorylated dihydroceramides of Porphyromonas gingivalis","volume":"45","author":"Nichols","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jare.2024.08.019_b0670","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/03008207.2012.657308","article-title":"The impact of Porphyromonas gingivalis lipids on apoptosis of primary human chondrocytes","volume":"53","author":"R\u00f6hner","year":"2012","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jare.2024.08.019_b0675","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.micinf.2010.05.011","article-title":"Porphyromonas gingivalis invades osteoblasts and inhibits bone formation","volume":"12","author":"Zhang","year":"2010","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jare.2024.08.019_b0680","doi-asserted-by":"crossref","first-page":"14239","DOI":"10.1038\/s41598-022-18412-4","article-title":"Effects of extracellular vesicles derived from oral bacteria on osteoclast differentiation and activation","volume":"12","author":"Kim","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.08.019_b0685","doi-asserted-by":"crossref","first-page":"19257","DOI":"10.1038\/s41598-019-55595-9","article-title":"IL-36\u03b3 is a pivotal inflammatory player in periodontitis-associated bone loss","volume":"9","author":"Cloitre","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2024.08.019_b0690","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1472-6831-14-89","article-title":"Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model","volume":"14","author":"Zhang","year":"2014","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jare.2024.08.019_b0695","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1902\/jop.2011.110315","article-title":"Combined effects of hydrogen sulfide and lipopolysaccharide on osteoclast differentiation in rats","volume":"83","author":"Irie","year":"2012","journal-title":"J Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0700","doi-asserted-by":"crossref","first-page":"15621","DOI":"10.1074\/jbc.M113.520510","article-title":"Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-\u03b1 and interleukin-1\u03b2 but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain","volume":"289","author":"Akiyama","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2024.08.019_b0705","doi-asserted-by":"crossref","first-page":"20147","DOI":"10.1074\/jbc.M115.655787","article-title":"Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-\u03baB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts","volume":"290","author":"Kassem","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2024.08.019_b0710","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.bbalip.2017.01.008","article-title":"Phosphoglycerol dihydroceramide, a distinctive ceramide produced by Porphyromonas gingivalis, promotes RANKL-induced osteoclastogenesis by acting on non-muscle myosin II-A (Myh9), an osteoclast cell fusion regulatory factor","volume":"1862","author":"Kanzaki","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.jare.2024.08.019_b0715","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1111\/jcmm.17299","article-title":"Crosstalk between dihydroceramides produced by Porphyromonas gingivalis and host lysosomal cathepsin B in the promotion of osteoclastogenesis","volume":"26","author":"Duarte","year":"2022","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jare.2024.08.019_b0720","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.4049\/jimmunol.177.3.1879","article-title":"Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation","volume":"177","author":"Inada","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jare.2024.08.019_b0725","article-title":"Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus","volume":"5","author":"Shen","year":"2024","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.jare.2024.08.019_b0730","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/annrheumdis-2020-219009","article-title":"Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in mice","volume":"80","author":"Moentadj","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2024.08.019_b0735","doi-asserted-by":"crossref","first-page":"1010368","DOI":"10.3389\/fimmu.2022.1010368","article-title":"The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2024.08.019_b0740","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/0022034517742139","article-title":"Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis","volume":"97","author":"Rosier","year":"2018","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0745","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1902\/jop.2016.160217","article-title":"Benefits of Bifidobacterium animalis subsp. lactis Probiotic in Experimental Periodontitis","volume":"88","author":"Oliveira","year":"2017","journal-title":"J Periodontol"},{"key":"10.1016\/j.jare.2024.08.019_b0750","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrrheum.2016.68","article-title":"The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions","volume":"12","author":"Abdollahi-Roodsaz","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jare.2024.08.019_b0755","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41413-023-00264-x","article-title":"Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis","volume":"11","author":"Lyu","year":"2023","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2024.08.019_b0760","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1172\/JCI86062","article-title":"Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics","volume":"126","author":"Li","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2024.08.019_b0765","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1007\/s12602-020-09735-7","article-title":"Probiotic composition and chondroitin sulfate regulate TLR-2\/4-mediated NF-\u03baB inflammatory pathway and cartilage metabolism in experimental osteoarthritis","volume":"13","author":"Korotkyi","year":"2021","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.jare.2024.08.019_b0770","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jcp.24340","article-title":"Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice","volume":"228","author":"McCabe","year":"2013","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jare.2024.08.019_b0775","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3390\/microorganisms9040673","article-title":"Probiotic propionibacterium freudenreichii MJ2 enhances osteoblast differentiation and mineralization by increasing the OPG\/RANKL Ratio","volume":"9","author":"Yeom","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.jare.2024.08.019_b0780","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-022-00932-0","article-title":"The secretion profile of mesenchymal stem cells and potential applications in treating human diseases","volume":"7","author":"Han","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jare.2024.08.019_b0785","first-page":"326","article-title":"Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis","volume":"22","author":"Tian","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2024.08.019_b0790","doi-asserted-by":"crossref","first-page":"eabe0083","DOI":"10.1126\/sciadv.abe0083","article-title":"Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis","volume":"7","author":"You","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2024.08.019_b0795","doi-asserted-by":"crossref","first-page":"e12152","DOI":"10.1002\/jev2.12152","article-title":"Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p","volume":"10","author":"Lee","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jare.2024.08.019_b0800","doi-asserted-by":"crossref","first-page":"798","DOI":"10.21037\/atm-21-1838","article-title":"Exosomes derived from cyclic mechanical stretch-exposed bone marrow mesenchymal stem cells inhibit RANKL-induced osteoclastogenesis through the NF-\u03baB signaling pathway","volume":"9","author":"Xiao","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jare.2024.08.019_b0805","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13287-020-1569-2","article-title":"Balanced oral pathogenic bacteria and probiotics promoted wound healing via maintaining mesenchymal stem cell homeostasis","volume":"11","author":"Han","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jare.2024.08.019_b0810","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/stem.2762","article-title":"Ecological balance of oral microbiota is required to maintain oral mesenchymal stem cell homeostasis","volume":"36","author":"Su","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.jare.2024.08.019_b0815","doi-asserted-by":"crossref","first-page":"e0260433","DOI":"10.1371\/journal.pone.0260433","article-title":"Development and characterization of an oral microbiome transplant among Australians for the treatment of dental caries and periodontal disease: a study protocol","volume":"16","author":"Nath","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2024.08.019_b0820","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/0022034521995423","article-title":"Oral microbiota transplant in dogs with naturally occurring periodontitis","volume":"100","author":"Beikler","year":"2021","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2024.08.019_b0825","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1016\/j.csbj.2021.10.028","article-title":"Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice","volume":"19","author":"Xiao","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.jare.2024.08.019_b0830","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12967-023-03995-x","article-title":"The oral microbiome in autoimmune diseases: friend or foe?","volume":"21","author":"Huang","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jare.2024.08.019_b0835","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jot.2022.08.003","article-title":"Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function","volume":"37","author":"Zhang","year":"2022","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jare.2024.08.019_b0840","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/s41591-023-02502-5","article-title":"Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine","volume":"29","author":"Tobias","year":"2023","journal-title":"Nat Med"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322400362X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322400362X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:53:56Z","timestamp":1762599236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209012322400362X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":168,"alternative-id":["S209012322400362X"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2024.08.019","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2024.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}