{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:40:05Z","timestamp":1792813205307,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["ZDXK202252"],"award-info":[{"award-number":["ZDXK202252"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["32372443"],"award-info":[{"award-number":["32372443"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2023HWYQ-017"],"award-info":[{"award-number":["2023HWYQ-017"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH192"],"award-info":[{"award-number":["ZR2023MH192"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jare.2025.01.020","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T19:26:59Z","timestamp":1736796419000},"page":"155-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish"],"prefix":"10.1016","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-1173","authenticated-orcid":false,"given":"Ruike","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.01.020_b0005","first-page":"1279","article-title":"Mycotoxins affecting animals, foods, humans, and plants: types, occurrence, toxicities, action mechanisms","volume":"10","author":"Awuchi","year":"2021","journal-title":"Prevent Detox Strategies-A Revisit Foods"},{"issue":"10","key":"10.1016\/j.jare.2025.01.020_b0010","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.3390\/molecules29102280","article-title":"A highly sensitive and group-specific enzyme-linked immunosorbent assay (ELISA) for the detection of AFB(1) in agriculture and aquiculture products","volume":"29","author":"Cao","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.jare.2025.01.020_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133916","article-title":"The potential for reducing aflatoxin B1 contamination of stored peanuts by soil disinfection","volume":"469","author":"Guo","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2025.01.020_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172323","article-title":"Prevalence and concentration of mycotoxins in bovine feed and feed components: a global systematic review and meta-analysis","volume":"929","author":"Chhaya","year":"2024","journal-title":"Sci Total Environ"},{"issue":"1","key":"10.1016\/j.jare.2025.01.020_b0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/toxins11010054","article-title":"Regional Sub-Saharan Africa total diet study in Benin, Cameroon, Mali and Nigeria reveals the presence of 164 mycotoxins and other secondary metabolites in foods","volume":"11","author":"Ingenbleek","year":"2019","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jare.2025.01.020_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134822","article-title":"Aflatoxin B1-induced liver pyroptosis is mediated by disturbing the gut microbial metabolites: the roles of pipecolic acid and norepinephrine","volume":"474","author":"Ye","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2025.01.020_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164436","article-title":"Obesity promotes fumonisin B1 hepatotoxicity","volume":"891","author":"Dopavogui","year":"2023","journal-title":"Sci Total Environ"},{"issue":"6390","key":"10.1016\/j.jare.2025.01.020_b0040","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.aap7999","article-title":"Worldwide emergence of resistance to antifungal drugs challenges human health and food security","volume":"360","author":"Fisher","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.01.020_b0045","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.foodchem.2016.09.180","article-title":"Mycotoxin and fungicide residues in wheat grains from fungicide-treated plants measured by a validated LC-MS method","volume":"220","author":"Da","year":"2017","journal-title":"Food Chem"},{"key":"10.1016\/j.jare.2025.01.020_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122545","article-title":"Microbial degradation of two highly persistent fluorinated fungicides - epoxiconazole and fludioxonil","volume":"394","author":"Alexandrino","year":"2020","journal-title":"J Hazard Mater"},{"issue":"11","key":"10.1016\/j.jare.2025.01.020_b0055","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1080\/03601234.2020.1807262","article-title":"Validation and expanded uncertainty determination of pesticides in water; and their survey on paddy rice irrigation water from Argentina","volume":"55","author":"Medina","year":"2020","journal-title":"J Environ Sci Health B"},{"key":"10.1016\/j.jare.2025.01.020_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123422","article-title":"Comprehensive multiresidue chromatographic methods for monitoring pesticides in agricultural areas and corresponding plant protection zones","volume":"344","author":"Pszczolinska","year":"2024","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jare.2025.01.020_b0065","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.chemosphere.2019.03.140","article-title":"The effects of hexaconazole and epoxiconazole enantiomers on metabolic profile following exposure to zebrafish (Danio rerio) as well as the histopathological changes","volume":"226","author":"Jia","year":"2019","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.jare.2025.01.020_b0070","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000371837","article-title":"Changes in Gut Microbiota May Be Early Signs of Liver Toxicity Induced by Epoxiconazole in Rats","volume":"60","author":"Xu","year":"2014","journal-title":"Chemotherapy"},{"key":"10.1016\/j.jare.2025.01.020_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109952","article-title":"Epoxiconazole alters the histology and transcriptome of mouse liver in a transgenerational pattern","volume":"360","author":"Le Corre","year":"2022","journal-title":"Chem Biol Interact"},{"issue":"17","key":"10.1016\/j.jare.2025.01.020_b0080","doi-asserted-by":"crossref","first-page":"17535","DOI":"10.1007\/s11356-019-05022-3","article-title":"Oxidative stress, genotoxicity, biochemical and histopathological modifications induced by epoxiconazole in liver and kidney of Wistar rats","volume":"26","author":"Hamdi","year":"2019","journal-title":"Environ Sci Pollut Res Int"},{"issue":"Suppl 1","key":"10.1016\/j.jare.2025.01.020_b0085","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/toxsci\/kfq283","article-title":"Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology","volume":"120","author":"Kensler","year":"2011","journal-title":"Toxicol Sci"},{"issue":"28","key":"10.1016\/j.jare.2025.01.020_b0090","doi-asserted-by":"crossref","first-page":"10787","DOI":"10.1021\/acs.jafc.3c02617","article-title":"Aflatoxin B(1) induces inflammatory liver injury via gut microbiota in mice","volume":"71","author":"Ye","year":"2023","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jare.2025.01.020_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171973","article-title":"Protective effect of selenomethionine on rabbit testicular injury induced by Aflatoxin B1","volume":"927","author":"Zhang","year":"2024","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jare.2025.01.020_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114976","article-title":"Effect of zearalenone on aflatoxin B1-induced intestinal and ovarian toxicity in pregnant and lactating rats","volume":"258","author":"Wu","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jare.2025.01.020_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114599","article-title":"Transgenerational toxicity induced by maternal AFB(1) exposure in Caenorhabditis elegans associated with underlying epigenetic regulations","volume":"187","author":"Zhou","year":"2024","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jare.2025.01.020_b0110","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tox.2015.08.001","article-title":"Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats","volume":"336","author":"Tanaka","year":"2015","journal-title":"Toxicology"},{"issue":"26","key":"10.1016\/j.jare.2025.01.020_b0115","doi-asserted-by":"crossref","first-page":"17267","DOI":"10.1021\/acsnano.4c04901","article-title":"Lipid nanoparticular codelivery system for enhanced antitumor effects by ferroptosis-apoptosis synergistic with programmed cell death-ligand 1 downregulation","volume":"18","author":"Cao","year":"2024","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.jare.2025.01.020_b0120","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: role of lipid peroxidation, iron and ferritinophagy","volume":"1861","author":"Latunde-Dada","year":"2017","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"3","key":"10.1016\/j.jare.2025.01.020_b0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jare.2025.01.020_b0130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jare.2025.01.020_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106275","article-title":"Self-recovery study of fluoride-induced ferroptosis in the liver of zebrafish (Danio rerio)","volume":"251","author":"Wu","year":"2022","journal-title":"Aquat Toxicol"},{"issue":"8","key":"10.1016\/j.jare.2025.01.020_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18646","article-title":"Fluoride-induced apoptosis in non-skeletal tissues of experimental animals: A systematic review and meta-analysis","volume":"9","author":"Angwa","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jare.2025.01.020_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.765973","article-title":"Inhibition of the anti-apoptotic Bcl-2 family by BH3 mimetics sensitize the mitochondrial permeability transition pore through Bax and Bak","volume":"9","author":"Patel","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.jare.2025.01.020_b0150","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1080\/1028415X.2020.1840035","article-title":"Neuroprotective effects of natural compounds on neurotoxin-induced oxidative stress and cell apoptosis","volume":"25","author":"Chen","year":"2022","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.jare.2025.01.020_b0155","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.redox.2017.03.007","article-title":"BID links ferroptosis to mitochondrial cell death pathways","volume":"12","author":"Neitemeier","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2025.01.020_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114105","article-title":"Combined toxic effects of fludioxonil and triadimefon on embryonic development of zebrafish (Danio rerio)","volume":"260","author":"Wang","year":"2020","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jare.2025.01.020_b0165","article-title":"OECD guidelines for the testing of chemicals. Fish, Acute Toxicity","author":"OECD","year":"2019","journal-title":"TEST"},{"key":"10.1016\/j.jare.2025.01.020_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.115911","article-title":"Pond mitigation in dissolved and particulate pesticide transfers: Influence of storm events and seasonality (Aurade agricultural catchment, SW-France)","volume":"320","author":"Chaumet","year":"2022","journal-title":"J Environ Manage"},{"key":"10.1016\/j.jare.2025.01.020_b0175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.foodcont.2011.06.007","article-title":"Aflatoxin B1 in maize harvested over 3 years in Iran","volume":"23","author":"Karami-Osboo","year":"2012","journal-title":"Food Control"},{"issue":"17","key":"10.1016\/j.jare.2025.01.020_b0180","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jare.2025.01.020_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129644","article-title":"Transgenerational effects of co-exposure to cadmium and carbofuran on zebrafish based on biochemical and transcriptomic analyses","volume":"439","author":"Wang","year":"2022","journal-title":"J Hazard Mater"},{"issue":"12","key":"10.1016\/j.jare.2025.01.020_b0190","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"5","key":"10.1016\/j.jare.2025.01.020_b0195","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.jare.2025.01.020_b0200","doi-asserted-by":"crossref","unstructured":"Whittaker RH. EVOLUTION AND MEASUREMENT OF SPECIESDIVERSITY. Taxon 1972; 21 (2-3): 213-51. org\/10.2307\/1218190.","DOI":"10.2307\/1218190"},{"issue":"2","key":"10.1016\/j.jare.2025.01.020_b0205","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1574-6941.2007.00375.x","article-title":"Multivariate analyses in microbial ecology","volume":"62","author":"Ramette","year":"2007","journal-title":"FEMS Microbiol Ecol"},{"issue":"6","key":"10.1016\/j.jare.2025.01.020_b0210","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"issue":"7402","key":"10.1016\/j.jare.2025.01.020_b0215","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.01.020_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174710","article-title":"Synergistic risk in the gut and liver: Insights into the toxic mechanisms and molecular interactions of combined exposure to triazophos and fenvalerate in zebrafish","volume":"948","author":"An","year":"2024","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jare.2025.01.020_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112380","article-title":"Peiminine ameliorates Crohn's disease-like colitis by enhancing the function of the intestinal epithelial barrier through Nrf2\/HO1 signal","volume":"136","author":"Qiu","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.jare.2025.01.020_b0230","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/imr.12567","article-title":"Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease","volume":"279","author":"Pickard","year":"2017","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jare.2025.01.020_b0235","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1367047","article-title":"Black tea preserves intestinal homeostasis through balancing barriers and microbiota in mice","volume":"11","author":"Shi","year":"2024","journal-title":"Front Nutr"},{"issue":"2","key":"10.1016\/j.jare.2025.01.020_b0240","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12812","article-title":"Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota\/intestinal FXR\/liver TLR4 signaling axis in mice","volume":"73","author":"Liu","year":"2022","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jare.2025.01.020_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173285","article-title":"Polystyrene nanoplastics exacerbate aflatoxin B1-induced hepatic injuries by modulating the gut-liver axis","volume":"935","author":"Zhang","year":"2024","journal-title":"Sci Total Environ"},{"issue":"4","key":"10.1016\/j.jare.2025.01.020_b0250","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3390\/metabo13040522","article-title":"Oral Exposure to Epoxiconazole Disturbed the Gut Micro-Environment and Metabolic Profiling in Male Mice","volume":"13","author":"Weng","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jare.2025.01.020_b0255","doi-asserted-by":"crossref","unstructured":"Wang J, Lv L, An X, Zhang C, Tang T, Sun Y, et al. Combined effects of different-sized microplastics and fluindapyr on earthworm: bioaccumulation, oxidative stress, histopathological responses and gut microbiota. Environ Pollut 2024:125478. 10.1016\/j.envpol.2024.125478.","DOI":"10.2139\/ssrn.4788436"},{"key":"10.1016\/j.jare.2025.01.020_b0260","article-title":"Combined effects of polyvinyl chloride or polypropylene microplastics with cadmium on the intestine of zebrafish at environmentally relevant concentrations","volume":"954","author":"Li","year":"2024","journal-title":"Sci Total Environ"},{"issue":"6","key":"10.1016\/j.jare.2025.01.020_b0265","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41422-022-00645-7","article-title":"Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons","volume":"32","author":"Zhu","year":"2022","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.jare.2025.01.020_b0270","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1990827","article-title":"Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease","volume":"13","author":"Markandey","year":"2021","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.jare.2025.01.020_b0275","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/gutjnl-2020-321747","article-title":"Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health","volume":"70","author":"Fassarella","year":"2021","journal-title":"Gut"},{"issue":"18","key":"10.1016\/j.jare.2025.01.020_b0280","doi-asserted-by":"crossref","first-page":"14066","DOI":"10.3390\/ijms241814066","article-title":"Unfolded Protein Response Signaling in Liver Disorders: A 2023 Updated Review","volume":"24","author":"Shreya","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"237","key":"10.1016\/j.jare.2025.01.020_b0285","article-title":"Spirulina platensis ameliorates hepatic oxidative stress and DNA damage induced by aflatoxin B1 in rats","volume":"2024","author":"Altyar","year":"2024","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.jare.2025.01.020_b0290","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41419-020-2618-6","article-title":"TGF-beta1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells","volume":"11","author":"Kim","year":"2020","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.jare.2025.01.020_b0295","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/antiox12040819","article-title":"Total Flavonoids of Rhizoma Drynariae Mitigates Aflatoxin B1-Induced Liver Toxicity in Chickens via Microbiota-Gut-Liver Axis Interaction Mechanisms","volume":"12","author":"Huang","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jare.2025.01.020_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123021","article-title":"New insights into endocrine reproductive toxicity of Microcystis aeruginosa combined with ammonia exposure in zebrafish","volume":"342","author":"Ou-Yang","year":"2024","journal-title":"Environ Pollut"},{"issue":"6","key":"10.1016\/j.jare.2025.01.020_b0305","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/00071660701713534","article-title":"Studies on production performance and toxin residues in tissues and eggs of layer chickens fed on diets with various concentrations of aflatoxin AFB1","volume":"48","author":"Pandey","year":"2007","journal-title":"Br Poult Sci"},{"issue":"4","key":"10.1016\/j.jare.2025.01.020_b0310","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12543","article-title":"Melatonin protects in vitro matured porcine oocytes from toxicity of Aflatoxin B1","volume":"66","author":"Cheng","year":"2019","journal-title":"J Pineal Res"},{"issue":"3","key":"10.1016\/j.jare.2025.01.020_b0315","doi-asserted-by":"crossref","first-page":"e4011","DOI":"10.1002\/cbf.4011","article-title":"A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes","volume":"42","author":"Zamanian","year":"2024","journal-title":"Cell Biochem Funct"},{"issue":"10","key":"10.1016\/j.jare.2025.01.020_b0320","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1007\/s12035-023-03433-5","article-title":"A Review on Caspases: Key Regulators of Biological Activities and Apoptosis","volume":"60","author":"Sahoo","year":"2023","journal-title":"Mol Neurobiol"},{"issue":"6","key":"10.1016\/j.jare.2025.01.020_b0325","article-title":"Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens","volume":"103","author":"Hao","year":"2024","journal-title":"Poult Sci"},{"key":"10.1016\/j.jare.2025.01.020_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142388","article-title":"Mechanistic insights into the parental co-exposure of T-2 toxin and epoxiconazole on the F1 generation of zebrafish (Danio rerio)","volume":"361","author":"Wang","year":"2024","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.jare.2025.01.020_b0335","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msae170","article-title":"Epigenetics Research in Evolutionary Biology: Perspectives on Timescales and Mechanisms","volume":"41","author":"Yi","year":"2024","journal-title":"Mol Biol Evol"},{"issue":"1","key":"10.1016\/j.jare.2025.01.020_b0340","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/dnares\/dsx039","article-title":"Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens","volume":"25","author":"Ouyang","year":"2018","journal-title":"DNA Res"},{"key":"10.1016\/j.jare.2025.01.020_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.115108","article-title":"Impact of hexafluoropropylene oxide trimer acid (HFPO-TA) on sex differentiation after exposures during different development stages of zebrafish (Danio rerio)","volume":"194","author":"Dong","year":"2024","journal-title":"Food Chem Toxicol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225000396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225000396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:19:51Z","timestamp":1766157591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225000396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":69,"alternative-id":["S2090123225000396"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.01.020","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}