{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:53:40Z","timestamp":1788386020198,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009103","name":"Education Department of Shaanxi Province","doi-asserted-by":"publisher","award":["24JK0351"],"award-info":[{"award-number":["24JK0351"]}],"id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32425045"],"award-info":[{"award-number":["32425045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012270","name":"Shaanxi Key Science and Technology Innovation Team Project","doi-asserted-by":"publisher","award":["21JP020"],"award-info":[{"award-number":["21JP020"]}],"id":[{"id":"10.13039\/501100012270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jare.2025.02.017","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T12:10:24Z","timestamp":1739967024000},"page":"517-531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Toxicological mechanisms of carbon polymers in accelerating cognitive decline in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"78","author":[{"given":"Zihe","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongning","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.02.017_b0005","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1093\/brain\/awad303","article-title":"Microbiota from Alzheimer\u2019s patients induce deficits in cognition and hippocampal neurogenesis","volume":"146","author":"Grabrucker","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.jare.2025.02.017_b0010","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2025.02.017_b0015","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/alz.12421","article-title":"Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: a randomized trial","volume":"18","author":"Hoscheidt","year":"2022","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.jare.2025.02.017_b0020","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jamaneurol.2022.4397","article-title":"Association between consumption of ultraprocessed foods and cognitive decline","volume":"80","author":"Gomes Gon\u00e7alves","year":"2023","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jare.2025.02.017_b0025","doi-asserted-by":"crossref","first-page":"e1056","DOI":"10.1212\/WNL.0000000000200871","article-title":"Association of ultra-processed food consumption with risk of dementia: a prospective cohort study","volume":"99","author":"Li","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.jare.2025.02.017_b0030","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1474-4422(04)00878-6","article-title":"Dietary factors and Alzheimer's disease","volume":"3","author":"Luchsinger","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jare.2025.02.017_b0035","article-title":"High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation","volume":"120","author":"Wang","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jare.2025.02.017_b0040","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41575-024-00893-5","article-title":"Ultra-processed foods and food additives in gut health and disease","volume":"21","author":"Whelan","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2025.02.017_b0045","unstructured":"Diet, nutrition and the prevention of chronic diseases: Report of a WHO\/FAO expert consultation. Geneva, World Health Organization, 2003."},{"key":"10.1016\/j.jare.2025.02.017_b0050","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1176\/appi.ajp.2009.09060881","article-title":"Association of western and traditional diets with depression and anxiety in women","volume":"167","author":"Jacka","year":"2010","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jare.2025.02.017_b0055","first-page":"1","article-title":"The relationship between acrylamide and neurodegenerative diseases: gut microbiota as a new intermediate cue","author":"Xu","year":"2024","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jare.2025.02.017_b0060","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/1541-4337.12880","article-title":"Dietary cholesterol oxidation products: perspectives linking food processing and storage with health implications","volume":"21","author":"Liu","year":"2022","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"10.1016\/j.jare.2025.02.017_b0065","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.tifs.2021.07.023","article-title":"Modern techniques efficacy on tofu processing: a review","volume":"116","author":"Ali","year":"2021","journal-title":"Trends Food Sci Technol"},{"key":"10.1016\/j.jare.2025.02.017_b0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cofs.2016.10.003","article-title":"Rheological and thermal behavior of food matrices during processing and storage: relevance for textural and nutritional quality of food","volume":"9","author":"Renzetti","year":"2016","journal-title":"Curr Opin Food Sci"},{"key":"10.1016\/j.jare.2025.02.017_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133416","article-title":"Maillard reaction chemistry in formation of critical intermediates and flavour compounds and their antioxidant properties","volume":"393","author":"Shakoor","year":"2022","journal-title":"Food Chem"},{"key":"10.1016\/j.jare.2025.02.017_b0080","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1039\/C9FO00383E","article-title":"Insights into melanoidin conversion into fluorescent nanoparticles in the Maillard reaction","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct"},{"key":"10.1016\/j.jare.2025.02.017_b0085","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1021\/acs.jafc.5b04216","article-title":"Fluorescent nanoparticles from several commercial beverages: Their properties and potential application for bioimaging","volume":"63","author":"Liao","year":"2015","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jare.2025.02.017_b0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.etap.2015.11.012","article-title":"The presence of carbon nanostructures in bakery products induces metabolic stress in human mesenchymal stem cells through CYP1A and p53 gene expression","volume":"41","author":"Al-Hadi","year":"2016","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.jare.2025.02.017_b0095","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1039\/C8FO01159A","article-title":"Bio-distribution and interaction with dopamine of fluorescent nanodots from roasted chicken","volume":"9","author":"Song","year":"2018","journal-title":"Food Funct"},{"key":"10.1016\/j.jare.2025.02.017_b0100","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1021\/acsnano.3c01005","article-title":"Foodborne carbon dot exposure induces insulin resistance through gut microbiota dysbiosis and damaged intestinal mucus layer","volume":"17","author":"Zhang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jare.2025.02.017_b0105","doi-asserted-by":"crossref","first-page":"12263","DOI":"10.1021\/acsami.3c17656","article-title":"Foodborne carbon dots aggravate high-fat-diet-induced glucose homeostasis imbalance by disrupting the gut-liver axis","volume":"16","author":"Zhang","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jare.2025.02.017_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127832","article-title":"Effects of fluorescent carbon dots from the baked lamb on energy and lipid metabolism","volume":"338","author":"Zhang","year":"2021","journal-title":"Food Chem"},{"key":"10.1016\/j.jare.2025.02.017_b0115","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41467-023-35828-2","article-title":"Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme","volume":"14","author":"Gao","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.02.017_b0120","article-title":"Red emissive carbon dot superoxide dismutase nanozyme for bioimaging and ameliorating acute lung injury","volume":"33","author":"Liu","year":"2023","journal-title":"Adv Funct Materials"},{"key":"10.1016\/j.jare.2025.02.017_b0125","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.1021\/acsami.6b13954","article-title":"Drug-derived bright and color-tunable N-doped carbon dots for cell imaging and sensitive detection of Fe3+ in living cells","volume":"9","author":"Song","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jare.2025.02.017_b0130","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1021\/nn100561e","article-title":"Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality","volume":"4","author":"Oh","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.jare.2025.02.017_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101530","article-title":"Carbon dots supported single Fe atom nanozyme for drug-resistant glioblastoma therapy by activating autophagy-lysosome pathway","volume":"45","author":"Muhammad","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.jare.2025.02.017_b0140","doi-asserted-by":"crossref","first-page":"8458","DOI":"10.1039\/C9NR01678C","article-title":"Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells","volume":"11","author":"Liu","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.jare.2025.02.017_b0145","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ijdevneu.2008.05.006","article-title":"Golgi apparatus and neurodegenerative diseases","volume":"26","author":"Fan","year":"2008","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.jare.2025.02.017_b0150","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","article-title":"Mitochondria in health, disease, and aging","volume":"103","author":"Harrington","year":"2023","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2025.02.017_b0155","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12951-022-01576-6","article-title":"Biologically synthesized black ginger-selenium nanoparticle induces apoptosis and autophagy of AGS gastric cancer cells by suppressing the PI3K\/Akt\/mTOR signaling pathway","volume":"20","author":"Wang","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.jare.2025.02.017_b0160","article-title":"Chrysin ameliorates influenza virus infection in the upper airways by repressing virus-induced cell cycle arrest and mitochondria-dependent apoptosis","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.02.017_b0165","doi-asserted-by":"crossref","first-page":"e9982","DOI":"10.15252\/emmm.201809982","article-title":"Chlorambucil targets BRCA1\/2-deficient tumours and counteracts PARP inhibitor resistance","volume":"11","author":"Tacconi","year":"2019","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jare.2025.02.017_b0170","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3390\/cancers11121947","article-title":"A stilbenoid isorhapontigenin as a potential anti-cancer agent against breast cancer through inhibiting sphingosine kinases\/tubulin stabilization","volume":"11","author":"Subedi","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.jare.2025.02.017_b0175","doi-asserted-by":"crossref","first-page":"451","DOI":"10.4161\/cbt.19589","article-title":"Cyclin dependent kinases in cancer","volume":"13","author":"Canavese","year":"2012","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.jare.2025.02.017_b0180","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrm3420","article-title":"DNA damage checkpoints in stem cells, ageing and cancer","volume":"13","author":"Sperka","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jare.2025.02.017_b0185","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3892\/ijo.2017.3836","article-title":"Crude extract and solvent fractions of Calystegia soldanella induce G1 and Sphase arrest of the cell cycle in HepG2 cells","volume":"50","author":"Lee","year":"2017","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jare.2025.02.017_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.959967","article-title":"An integrated bioinformatic investigation of mitochondrial energy metabolism genes in colon adenocarcinoma followed by preliminary validation of CPT2 in tumor immune infiltration","volume":"13","author":"Cao","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.02.017_b0195","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/s41467-018-03903-8","article-title":"In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy","volume":"9","author":"Fan","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.02.017_b0200","doi-asserted-by":"crossref","first-page":"9224","DOI":"10.1002\/anie.201712469","article-title":"Carbon nanozymes: Enzymatic properties, catalytic mechanism, and applications","volume":"57","author":"Sun","year":"2018","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.jare.2025.02.017_b0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.aad0832","article-title":"Active sites of nitrogen-doped carbon materials for oxygen reduction reaction clarified using model catalysts","volume":"351","author":"Guo","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.02.017_b0210","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102034118","article-title":"HMGB1 released from nociceptors mediates inflammation","volume":"118","author":"Yang","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jare.2025.02.017_b0215","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12974-016-0670-z","article-title":"HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer\u2019s disease","volume":"13","author":"Festoff","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.02.017_b0220","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbi.2019.09.003","article-title":"CXCR7: A key neuroprotective molecule against alarmin HMGB1 mediated CNS pathophysiology and subsequent memory impairment","volume":"82","author":"Das","year":"2019","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jare.2025.02.017_b0225","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbi.2019.07.026","article-title":"IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease","volume":"81","author":"Liu","year":"2019","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jare.2025.02.017_b0230","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12974-023-02884-w","article-title":"RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling","volume":"20","author":"Yin","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.02.017_b0235","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jare.2025.02.017_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101907","article-title":"The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases","volume":"87","author":"Possemato","year":"2023","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jare.2025.02.017_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101645","article-title":"Roles of forkhead box O (FoxO) transcription factors in neurodegenerative diseases: a panoramic view","volume":"181","author":"Hu","year":"2019","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jare.2025.02.017_b0250","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S1474-4422(20)30231-3","article-title":"Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches","volume":"19","author":"Kellar","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jare.2025.02.017_b0255","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2282790","article-title":"Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP\/PS1 mice","volume":"15","author":"Qian","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jare.2025.02.017_b0260","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.devcel.2021.03.034","article-title":"Lipid metabolism and lipid signals in aging and longevity","volume":"56","author":"Mutlu","year":"2021","journal-title":"Dev Cell"},{"key":"10.1016\/j.jare.2025.02.017_b0265","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ajhg.2019.08.006","article-title":"Loss of SMPD4 causes a developmental disorder characterized by microcephaly and congenital arthrogryposis","volume":"105","author":"Magini","year":"2019","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jare.2025.02.017_b0270","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67452","article-title":"SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B","volume":"10","author":"Fan","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.jare.2025.02.017_b0275","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nm.3466","article-title":"Plasma phospholipids identify antecedent memory impairment in older adults","volume":"20","author":"Mapstone","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.02.017_b0280","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-201420","article-title":"Serum phosphatidylethanolamine and lysophosphatidylethanolamine levels differentiate Alzheimer\u2019s Disease from controls and predict progression from mild cognitive impairment","volume":"80","author":"Llano","year":"2021","journal-title":"J Alzheimer's Dis"},{"key":"10.1016\/j.jare.2025.02.017_b0285","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1388-1981(99)00188-2","article-title":"Anionic phospholipids, interfacial binding and the regulation of cell functions","volume":"1483","author":"Buckland","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jare.2025.02.017_b0290","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20082293","article-title":"Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2\/EP4 receptor signaling","volume":"206","author":"Boniface","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jare.2025.02.017_b0295","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1073\/pnas.1801609115","article-title":"Acetyl-l-carnitine deficiency in patients with major depressive disorder","volume":"115","author":"Nasca","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jare.2025.02.017_b0300","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.molcel.2011.01.002","article-title":"Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction","volume":"41","author":"Hallows","year":"2011","journal-title":"Mol Cell"},{"key":"10.1016\/j.jare.2025.02.017_b0305","doi-asserted-by":"crossref","first-page":"15965","DOI":"10.1038\/ncomms15965","article-title":"Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism","volume":"8","author":"Biancur","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.02.017_b0310","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chom.2017.06.007","article-title":"Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation","volume":"22","author":"Wlodarska","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jare.2025.02.017_b0315","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0893-133X(98)00005-0","article-title":"Effect of mental stress on plasma homovanillic acid in healthy human subjects","volume":"19","author":"Sumiyoshi","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jare.2025.02.017_b0320","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.cmet.2011.04.007","article-title":"Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis","volume":"13","author":"Zhang","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2025.02.017_b0325","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1105\/tpc.113.118018","article-title":"The importance of cardiolipin synthase for mitochondrial ultrastructure, respiratory function, plant development, and stress responses in Arabidopsis","volume":"25","author":"Pineau","year":"2013","journal-title":"Plant Cell"},{"key":"10.1016\/j.jare.2025.02.017_b0330","doi-asserted-by":"crossref","DOI":"10.1002\/alz.037201","article-title":"Using anxiety as a sex-specific neuropsychiatric biomarker of Alzheimer\u2019s disease","volume":"16","author":"Hunsberger","year":"2020","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.jare.2025.02.017_b0335","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41582-018-0013-z","article-title":"Tau-targeting therapies for Alzheimer disease","volume":"14","author":"Congdon","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jare.2025.02.017_b0340","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41580-018-0060-8","article-title":"A new era for understanding amyloid structures and disease","volume":"19","author":"Iadanza","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jare.2025.02.017_b0345","doi-asserted-by":"crossref","DOI":"10.1002\/alz.077471","article-title":"A\u03b2 accumulation associated with executive function decline and tau accumulation associated with memory decline in cognitively normal older people","volume":"19","author":"Chen","year":"2023","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.jare.2025.02.017_b0350","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-024-02790-2","article-title":"Inflammatory aspects of Alzheimer\u2019s disease","volume":"148","author":"Botella Lucena","year":"2024","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jare.2025.02.017_b0355","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nri3705","article-title":"Innate immune activation in neurodegenerative disease","volume":"14","author":"Heneka","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2025.02.017_b0360","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-\u03b2 and tau in Alzheimer\u2019s disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jare.2025.02.017_b0365","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.7150\/ijbs.57078","article-title":"Interaction between A\u03b2 and tau in the pathogenesis of Alzheimer's disease","volume":"17","author":"Zhang","year":"2021","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jare.2025.02.017_b0370","doi-asserted-by":"crossref","DOI":"10.1002\/alz.047266","article-title":"AR1001 ameliorates Alzheimer\u2019s disease pathology and symptoms by multi-mechanisms","volume":"16","author":"Kang","year":"2020","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.jare.2025.02.017_b0375","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1186\/1750-1326-7-S1-S26","article-title":"Neuroprotective effect of Curcumin involved in increasing the protein levels of UCP2 and inhibiting oxidative stress induced by chronic cerebral ischemia in vitro","volume":"7","author":"Gao","year":"2012","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jare.2025.02.017_b0380","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","article-title":"Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus","volume":"17","author":"Bettcher","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jare.2025.02.017_b0385","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8928530","article-title":"ATP induces disruption of tight junction proteins via IL-1 beta-dependent MMP-9 activation of human blood-brain barrier in vitro","volume":"2016","author":"Yang","year":"2016","journal-title":"Neural Plast"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225001158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225001158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:22:12Z","timestamp":1766157732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225001158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":77,"alternative-id":["S2090123225001158"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.02.017","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicological mechanisms of carbon polymers in accelerating cognitive decline in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}