{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:46:58Z","timestamp":1794491218397,"version":"4.9.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3906600"],"award-info":[{"award-number":["2023YFB3906600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102797"],"award-info":[{"award-number":["82102797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370538"],"award-info":[{"award-number":["82370538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170549"],"award-info":[{"award-number":["82170549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jare.2025.03.058","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T13:00:02Z","timestamp":1743598802000},"page":"393-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production"],"prefix":"10.1016","volume":"79","author":[{"given":"Xiangyun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.03.058_b0005","doi-asserted-by":"crossref","unstructured":"Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46-54.e42; quiz e30. doi:10.1053\/j.gastro.2011.10.001.","DOI":"10.1053\/j.gastro.2011.10.001"},{"issue":"10401","key":"10.1016\/j.jare.2025.03.058_b0010","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jare.2025.03.058_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/j.gastro.2024.05.036","article-title":"Targeting the interleukin 23 pathway in inflammatory bowel disease","volume":"168","author":"Bourgonje","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jare.2025.03.058_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115263","article-title":"Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins","volume":"165","author":"Malaekeh-Nikouei","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"10.1016\/j.jare.2025.03.058_b0025","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1158\/1940-6207.CAPR-10-0186","article-title":"Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial","volume":"3","author":"Hosono","year":"2010","journal-title":"Cancer Prev Res (Phila)"},{"issue":"3","key":"10.1016\/j.jare.2025.03.058_b0030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/15384047.2018.1529108","article-title":"Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice","volume":"20","author":"Wang","year":"2019","journal-title":"Cancer Biol Ther"},{"issue":"6","key":"10.1016\/j.jare.2025.03.058_b0035","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/ibd\/izad283","article-title":"2'-Hydroxycinnamaldehyde alleviates intestinal inflammation by attenuating intestinal mucosal barrier damage via directly inhibiting STAT3","volume":"30","author":"Chen","year":"2024","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.jare.2025.03.058_b0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12943-020-01258-7","article-title":"Targeting STAT3 in cancer immunotherapy","volume":"19","author":"Zou","year":"2020","journal-title":"Mol Cancer"},{"issue":"12","key":"10.1016\/j.jare.2025.03.058_b0045","doi-asserted-by":"crossref","first-page":"11528","DOI":"10.1074\/jbc.M413930200","article-title":"Activation of Stat3 sequence-specific DNA binding and transcription by p300\/CREB-binding protein-mediated acetylation","volume":"280","author":"Wang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2025.03.058_b0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bcp.2017.05.006","article-title":"Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation","volume":"138","author":"Wang","year":"2017","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.jare.2025.03.058_b0055","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.molcel.2016.12.002","article-title":"Lysyl Oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation","volume":"65","author":"Ma","year":"2017","journal-title":"Mol Cell"},{"issue":"4","key":"10.1016\/j.jare.2025.03.058_b0060","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.celrep.2017.04.004","article-title":"Sirtuin-1 activation controls tumor growth by impeding Th17 differentiation via STAT3 deacetylation","volume":"19","author":"Limagne","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.jare.2025.03.058_b0065","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","article-title":"Acetyl-CoA and the regulation of metabolism: mechanisms and consequences","volume":"33","author":"Shi","year":"2015","journal-title":"Curr Opin Cell Biol"},{"issue":"9","key":"10.1016\/j.jare.2025.03.058_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110870","article-title":"Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids","volume":"39","author":"Li","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.jare.2025.03.058_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111942","article-title":"The Chinese herbal formulae (Yitangkang) exerts an antidiabetic effect through the regulation of substance metabolism and energy metabolism in type 2 diabetic rats","volume":"239","author":"Han","year":"2019","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10.1016\/j.jare.2025.03.058_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13880209.2019.1687527","article-title":"Effects of Fuzheng Huayu recipe on entecavir pharmacokinetics in normal and dimethylnitrosamine-induced hepatic fibrosis rats","volume":"58","author":"Yang","year":"2020","journal-title":"Pharm Biol"},{"issue":"1","key":"10.1016\/j.jare.2025.03.058_b0085","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12974-021-02342-5","article-title":"MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model","volume":"18","author":"Wen","year":"2021","journal-title":"J Neuroinflammation"},{"issue":"3","key":"10.1016\/j.jare.2025.03.058_b0090","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1530\/JME-14-0065","article-title":"Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling","volume":"53","author":"Shi","year":"2014","journal-title":"J Mol Endocrinol"},{"issue":"7","key":"10.1016\/j.jare.2025.03.058_b0095","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.7150\/ijbs.94548","article-title":"Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway","volume":"20","author":"Lan","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"30","key":"10.1016\/j.jare.2025.03.058_b0100","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.3748\/wjg.v28.i30.4053","article-title":"Gut microbiota, inflammatory bowel disease and colorectal cancer","volume":"28","author":"Quaglio","year":"2022","journal-title":"World J Gastroenterol"},{"issue":"13","key":"10.1016\/j.jare.2025.03.058_b0105","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.7150\/ijbs.74304","article-title":"P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6\/STAT3 Pathway","volume":"18","author":"Wu","year":"2022","journal-title":"Int J Biol Sci"},{"issue":"5707","key":"10.1016\/j.jare.2025.03.058_b0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1105166","article-title":"Stat3 dimerization regulated by reversible acetylation of a single lysine residue","volume":"307","author":"Yuan","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jare.2025.03.058_b0115","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cell.2018.08.040","article-title":"Acetate production from glucose and coupling to mitochondrial metabolism in mammals","volume":"175","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jare.2025.03.058_b0120","article-title":"Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota","volume":"15","author":"Wang","year":"2024","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.jare.2025.03.058_b0125","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/JOE-21-0194","article-title":"Metformin as an anti-inflammatory agent: a short review","volume":"251","author":"Kristuefi","year":"2021","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jare.2025.03.058_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110262","article-title":"Metformin activates the PI3K\/AKT\/BDNF axis to attenuate postoperative cognitive dysfunction","volume":"265","author":"Wu","year":"2025","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.jare.2025.03.058_b0135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12974-024-03313-2","article-title":"Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine","volume":"21","author":"Fan","year":"2024","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.03.058_b0140","article-title":"Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-\u043d\u00b6B\/MLCK pathway","volume":"e0200624","author":"Li","year":"2024","journal-title":"Microbiol Spectr"},{"issue":"2","key":"10.1016\/j.jare.2025.03.058_b0145","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00248-019-01400-z","article-title":"Identification of novel butyrate- and acetate-oxidizing bacteria in butyrate-fed mesophilic anaerobic chemostats by DNA-based stable isotope probing","volume":"79","author":"Yi","year":"2020","journal-title":"Microb Ecol"},{"issue":"11","key":"10.1016\/j.jare.2025.03.058_b0150","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00636-24","article-title":"Bacteroides vesicles promote functional alterations in the gut microbiota composition","volume":"12","author":"Shagaleeva","year":"2024","journal-title":"Microbiol Spectr"},{"issue":"5","key":"10.1016\/j.jare.2025.03.058_b0155","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s42255-024-01037-4","article-title":"Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc","volume":"6","author":"Wang","year":"2024","journal-title":"Nat Metab"},{"issue":"14","key":"10.1016\/j.jare.2025.03.058_b0160","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117112119","article-title":"HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation","volume":"119","author":"Cheung","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2025.03.058_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112541","article-title":"Repurposing metformin as adjuvant therapy in patients with ulcerative colitis treated with mesalamine: A randomized controlled double-blinded study","volume":"138","author":"El-Haggar","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"7829","key":"10.1016\/j.jare.2025.03.058_b0170","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2799-2","article-title":"A STAT3 palmitoylation cycle promotes T(H)17 differentiation and colitis","volume":"586","author":"Zhang","year":"2020","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jare.2025.03.058_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102202","article-title":"Perspectives regarding the intersections between STAT3 and oxidative metabolism in cancer","volume":"9","author":"Chun","year":"2020","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.jare.2025.03.058_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9080956","article-title":"The roles of post-translational modifications in STAT3 biological activities and functions","volume":"9","author":"Tesoriere","year":"2021","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.jare.2025.03.058_b0185","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41401-021-00744-y","article-title":"A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis","volume":"43","author":"Ren","year":"2022","journal-title":"Acta Pharmacol Sin"},{"issue":"13","key":"10.1016\/j.jare.2025.03.058_b0190","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1093\/hmg\/ddu059","article-title":"Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation","volume":"23","author":"Pougovkina","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"12","key":"10.1016\/j.jare.2025.03.058_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115015","article-title":"Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma","volume":"43","author":"Wang","year":"2024","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.jare.2025.03.058_b0200","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s13046-019-1391-9","article-title":"ACLY facilitates colon cancer cell metastasis by CTNNB1","volume":"38","author":"Wen","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jare.2025.03.058_b0205","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1038\/s41467-022-31725-2","article-title":"Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5(+) intestinal stem cell function","volume":"13","author":"Li","year":"2022","journal-title":"Nat Commun"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:16:24Z","timestamp":1768450584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225002188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"alternative-id":["S2090123225002188"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.03.058","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.03.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}