{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:16:53Z","timestamp":1790612213341,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304424"],"award-info":[{"award-number":["82304424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ4081"],"award-info":[{"award-number":["2024JJ4081"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jare.2025.04.006","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:18:13Z","timestamp":1744150693000},"page":"783-799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion"],"prefix":"10.1016","volume":"79","author":[{"given":"Junyong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinYan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihe","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuxing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimiao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.jare.2025.04.006_b0005","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.3748\/wjg.v29.i18.2747","article-title":"Current trends in acute pancreatitis: Diagnostic and therapeutic challenges","volume":"29","author":"Zerem","year":"2023","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.jare.2025.04.006_b0010","doi-asserted-by":"crossref","DOI":"10.1097\/MPA.0000000000002259","article-title":"Acute pancreatitis: Current clinical approaches, molecular pathophysiology, and potential therapeutics","volume":"52","author":"Wiley","year":"2023","journal-title":"Pancreas"},{"issue":"10","key":"10.1016\/j.jare.2025.04.006_b0015","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41419-023-06216-x","article-title":"Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1\u03b1\/HO-1 mediated ferroptosis","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.jare.2025.04.006_b0020","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.7150\/ijbs.84494","article-title":"Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with anxa2 to restore the antioxidative activity of prdx1","volume":"20","author":"He","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"5","key":"10.1016\/j.jare.2025.04.006_b0025","doi-asserted-by":"crossref","first-page":"953","DOI":"10.47391\/JPMA.9280","article-title":"Acute pancreatitis: A narrative review","volume":"74","author":"Sohail","year":"2024","journal-title":"JPMA J Pak Med Assoc"},{"issue":"7","key":"10.1016\/j.jare.2025.04.006_b0030","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1053\/j.gastro.2018.11.082","article-title":"Acute pancreatitis: A multifaceted set of organelle and cellular interactions","volume":"156","author":"Habtezion","year":"2019","journal-title":"Gastroenterology"},{"issue":"30","key":"10.1016\/j.jare.2025.04.006_b0035","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s10020-024-00826-7","article-title":"The role of interleukin-22 in severe acute pancreatitis","volume":"15","author":"Yang","year":"2024","journal-title":"Mol Med"},{"issue":"2","key":"10.1016\/j.jare.2025.04.006_b0040","first-page":"271","article-title":"Nutrition therapy in critically ill patients with severe acute pancreatitis","volume":"39","author":"Sun","year":"2024","journal-title":"Nutr Clin Pract Off Publ Am Soc Parenter Enter Nutr"},{"issue":"3","key":"10.1016\/j.jare.2025.04.006_b0045","doi-asserted-by":"crossref","first-page":"419","DOI":"10.14309\/ajg.0000000000002645","article-title":"American college of gastroenterology guidelines: Management of acute pancreatitis","volume":"119","author":"Tenner","year":"2024","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jare.2025.04.006_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2024.10.030","article-title":"Practical management of severe acute pancreatitis","volume":"133","author":"Hamesch","year":"2025","journal-title":"Eur J Intern Med"},{"issue":"24","key":"10.1016\/j.jare.2025.04.006_b0055","first-page":"6026","article-title":"Polyphenols and microbiota modulation: Insights from swine and other animal models for human therapeutic strategies","volume":"29","author":"Anghel","year":"2024","journal-title":"Mol Basel Switz"},{"key":"10.1016\/j.jare.2025.04.006_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109488","article-title":"Polyphenols as potential preventers of osteoporosis: A comprehensive review on antioxidant and anti-inflammatory effects, molecular mechanisms, and signal pathways in bone metabolism","volume":"123","author":"Su","year":"2024","journal-title":"J Nutr Biochem"},{"issue":"1","key":"10.1016\/j.jare.2025.04.006_b0065","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12951-024-02439-y","article-title":"The mitochondria-targeted kaempferol nanoparticle ameliorates severe acute pancreatitis","volume":"22","author":"Wen","year":"2024","journal-title":"J Nanobiotechnology"},{"issue":"2","key":"10.1016\/j.jare.2025.04.006_b0070","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10787-024-01584-y","article-title":"Therapeutic potential of plant polyphenols in acute pancreatitis","volume":"33","author":"Niu","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"6","key":"10.1016\/j.jare.2025.04.006_b0075","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/ptr.7850","article-title":"Research progress of proanthocyanidins and anthocyanidins","volume":"37","author":"Zhao","year":"2023","journal-title":"Phytother Res PTR"},{"issue":"19","key":"10.1016\/j.jare.2025.04.006_b0080","doi-asserted-by":"crossref","first-page":"18732","DOI":"10.1021\/acsnano.3c01940","article-title":"Microenvironment-responsive metal-phenolic nanozyme release platform with antibacterial, ROS scavenging, and osteogenesis for periodontitis","volume":"17","author":"Xu","year":"2023","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.jare.2025.04.006_b0085","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1021\/acsmaterialslett.3c00906","article-title":"Natural metal polyphenol nanozyme: Free radical scavenging and antioxidation for the treatment of acute kidney injury","volume":"5","author":"Yuan","year":"2023","journal-title":"ACS Mater Lett"},{"issue":"1","key":"10.1016\/j.jare.2025.04.006_b0090","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12951-024-02802-z","article-title":"Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis","volume":"22","author":"Zhu","year":"2024","journal-title":"J Nanobiotechnology"},{"issue":"11","key":"10.1016\/j.jare.2025.04.006_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202208571","article-title":"Mitochondrial\u2010targeted delivery of polyphenol\u2010mediated antioxidases complexes against pyroptosis and inflammatory diseases","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv Mater"},{"issue":"24","key":"10.1016\/j.jare.2025.04.006_b0100","doi-asserted-by":"crossref","first-page":"24593","DOI":"10.1021\/acsnano.3c10212","article-title":"Advanced generation therapeutics: Biomimetic nanodelivery system for tumor immunotherapy","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jare.2025.04.006_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123220","article-title":"Coaxial electrostatic spray-based preparation of localization missile liposomes on a microfluidic chip for targeted treatment of triple-negative breast cancer","volume":"643","author":"Wang","year":"2023","journal-title":"Int J Pharm"},{"key":"10.1016\/j.jare.2025.04.006_b0110","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.actbio.2019.10.022","article-title":"Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer","volume":"101","author":"Li","year":"2020","journal-title":"Acta Biomater"},{"issue":"10","key":"10.1016\/j.jare.2025.04.006_b0115","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1007\/s13346-021-01110-5","article-title":"Recent progress of macrophage vesicle-based drug delivery systems","volume":"12","author":"Xu","year":"2022","journal-title":"Drug Deliv Transl Res"},{"issue":"33","key":"10.1016\/j.jare.2025.04.006_b0120","article-title":"Genetically engineered membrane-coated nanoparticles forenhanced prostate-specific membrane antigen targeting and ferroptosis treatment of castration-resistant prostate cancer","volume":"11","author":"Li","year":"2024","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"issue":"2","key":"10.1016\/j.jare.2025.04.006_b0125","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3390\/antiox14020208","article-title":"Oxidative mechanism of peyronie\u2019s disease and effectiveness of pentoxifylline in the therapeutic management: A narrative review","volume":"14","author":"Paulis","year":"2025","journal-title":"Antioxid Basel Switz"},{"issue":"1","key":"10.1016\/j.jare.2025.04.006_b0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/MPA.0b013e3181612d19","article-title":"Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis","volume":"37","author":"De Campos","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.jare.2025.04.006_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105940","article-title":"Macrophages-derived p38\u03b1 promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy","volume":"77","author":"Fan","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2025.04.006_b0140","doi-asserted-by":"crossref","unstructured":"Karki R, Lee S, Mall R, Pandian N, Wang Y, Sharma BR, et al. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection. Sci Immunol. 2022 Aug 26;7(74):eabo6294.","DOI":"10.1126\/sciimmunol.abo6294"},{"issue":"5","key":"10.1016\/j.jare.2025.04.006_b0145","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0039-6060(96)80271-6","article-title":"Therapeutic efficacy of an antineutrophil monoclonal antibody, Urge-8, against acute necrotizing pancreatitis in rats","volume":"119","author":"Han","year":"1996","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.jare.2025.04.006_b0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archsurg.1995.01430010095020","article-title":"Anti-Neutrophil Antibody Attenuates the Severity of Acute Lung Injury in Rats With Experimental Acute Pancreatitis","volume":"130","author":"Inoue","year":"1995","journal-title":"Arch Surg"},{"issue":"8","key":"10.1016\/j.jare.2025.04.006_b0155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.jare.2025.04.006_b0160","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gutjnl-2022-327448","article-title":"Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis","volume":"72","author":"Glaubitz","year":"2023","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jare.2025.04.006_b0165","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/j.gastro.2019.09.040","article-title":"NLRP3 inflammasome regulates development of systemic inflammatory response and compensatory anti-inflammatory response syndromes in mice with acute pancreatitis","volume":"158","author":"Sendler","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jare.2025.04.006_b0170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/biom14010059","article-title":"The interaction of microbiome and pancreas in acute pancreatitis","volume":"14","author":"Zhang","year":"2023","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.jare.2025.04.006_b0175","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/s44318-024-00067-8","article-title":"Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice","volume":"43","author":"Kaurani","year":"2024","journal-title":"EMBO J"},{"issue":"11","key":"10.1016\/j.jare.2025.04.006_b0180","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1242\/jcs.045278","article-title":"Blocking \u03b2-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells","volume":"122","author":"Gu","year":"2009","journal-title":"J Cell Sci"},{"issue":"7","key":"10.1016\/j.jare.2025.04.006_b0185","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/s41418-017-0041-z","article-title":"Type I IFN operates pyroptosis and necroptosis during multidrug-resistant a. baumannii infection","volume":"25","author":"Li","year":"2018","journal-title":"Cell Death Differ"},{"issue":"4","key":"10.1016\/j.jare.2025.04.006_b0190","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pan.2016.05.001","article-title":"NF-\u03baB in acute pancreatitis: Mechanisms and therapeutic potential","volume":"16","author":"Jakkampudi","year":"2016","journal-title":"Pancreatology"},{"issue":"7\u20138","key":"10.1016\/j.jare.2025.04.006_b0195","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10495-018-1464-9","article-title":"Gastrointestinal microecology: A crucial and potential target in acute pancreatitis","volume":"23","author":"Cen","year":"2018","journal-title":"Apoptosis"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:57:32Z","timestamp":1778835452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225002255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"alternative-id":["S2090123225002255"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.006","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}