{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:21:51Z","timestamp":1786382511009,"version":"build-2736575974"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["ZK[2022]505"],"award-info":[{"award-number":["ZK[2022]505"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Province Science and Technology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Province Department of Education","doi-asserted-by":"publisher","award":["Qian-jiao-ji (2023)071"],"award-info":[{"award-number":["Qian-jiao-ji (2023)071"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160139"],"award-info":[{"award-number":["32160139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2025.04.017","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:32:20Z","timestamp":1744623140000},"page":"991-1007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Gastrodin enhances stress resilience through promoting Wnt\/\u03b2-Catenin-dependent neurogenesis"],"prefix":"10.1016","volume":"80","author":[{"given":"Haili","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9306-6261","authenticated-orcid":false,"given":"Pei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-e","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-6229","authenticated-orcid":false,"given":"Zili","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-827X","authenticated-orcid":false,"given":"Jinqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.04.017_b0005","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neubiorev.2017.08.019","article-title":"Treatment resistant depression: a multi-scale, systems biology approach","volume":"84","author":"Akil","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jare.2025.04.017_b0010","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-050098","article-title":"Effect of repetitive transcranial magnetic stimulation on patients with severe depression: a study protocol for systematic review and meta-analysis of randomised clinical trials","volume":"11","author":"Han","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.jare.2025.04.017_b0015","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(21)02141-3","article-title":"Time for united action on depression: a Lancet-World Psychiatric Association Commission","volume":"399","author":"Herrman","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2025.04.017_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101805","article-title":"Major depression and the biological hallmarks of aging","volume":"83","author":"Lorenzo","year":"2023","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jare.2025.04.017_b0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-psych-122216-011613","article-title":"Depression's unholy trinity: dysregulated stress, immunity, and the microbiome","volume":"71","author":"Cruz-Pereira","year":"2020","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.jare.2025.04.017_b0030","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.04.017_b0035","doi-asserted-by":"crossref","unstructured":"M. Daly, E. Robinson Depression and anxiety during COVID-19, Lancet 399 (2022) 518. doi: 10.1016\/S0140-6736(22)00187-8.","DOI":"10.1016\/S0140-6736(22)00187-8"},{"key":"10.1016\/j.jare.2025.04.017_b0040","first-page":"e5","article-title":"Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention","author":"Charney","year":"2004","journal-title":"Sci STKE"},{"key":"10.1016\/j.jare.2025.04.017_b0045","doi-asserted-by":"crossref","unstructured":"F. VanMeter, D. Cicchetti Resilience, Handb Clin Neurol 173 (2020) 67-73. doi: 10.1016\/B978-0-444-64150-2.00008-3.","DOI":"10.1016\/B978-0-444-64150-2.00008-3"},{"key":"10.1016\/j.jare.2025.04.017_b0050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.biopsych.2018.08.020","article-title":"Alpha (1)- and beta (3)-adrenergic receptor-mediated mesolimbic homeostatic plasticity confers resilience to social stress in susceptible mice","volume":"85","author":"Zhang","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jare.2025.04.017_b0055","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1751-9004.2011.00379.x","article-title":"Resilience in the context of chronic stress and health in adults","volume":"5","author":"Schetter","year":"2011","journal-title":"Soc Personal Psychol Compass"},{"key":"10.1016\/j.jare.2025.04.017_b0060","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s13311-017-0527-x","article-title":"Neural substrates of depression and resilience","volume":"14","author":"Han","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jare.2025.04.017_b0065","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.biopsych.2019.04.011","article-title":"Neurobiology of resilience: interface between mind and body","volume":"86","author":"Cathomas","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jare.2025.04.017_b0070","doi-asserted-by":"crossref","first-page":"e1101","DOI":"10.1038\/tp.2017.68","article-title":"Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioral and biological changes relevant to depression","volume":"7","author":"Egeland","year":"2017","journal-title":"Transl Psychiatr"},{"key":"10.1016\/j.jare.2025.04.017_b0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.conb.2014.08.012","article-title":"The current state of the neurogenic theory of depression and anxiety","volume":"30","author":"Miller","year":"2015","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.jare.2025.04.017_b0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pnpbp.2015.02.001","article-title":"Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation","volume":"60","author":"Fenton","year":"2015","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jare.2025.04.017_b0085","article-title":"Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice","volume":"18","author":"Sachs","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.jare.2025.04.017_b0090","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7150\/thno.81067","article-title":"Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jare.2025.04.017_b0095","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/mp.2010.34","article-title":"Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress","volume":"15","author":"Schloesser","year":"2010","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.jare.2025.04.017_b0100","article-title":"Effect of exercise for depression: systematic review and network meta-analysis of randomized controlled trials","volume":"384","author":"Noetel","year":"2024","journal-title":"BMJ-British Medical Journal"},{"key":"10.1016\/j.jare.2025.04.017_b0105","article-title":"PDGF-BB-dependent neurogenesis buffers depressive-like behaviors by inhibition of GABAergic projection from medial septum to dentate gyrus","volume":"10","author":"Li","year":"2023","journal-title":"Adv Sci"},{"key":"10.1016\/j.jare.2025.04.017_b0110","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1007\/s12035-015-9197-z","article-title":"Bisphenol-a mediated inhibition of hippocampal neurogenesis attenuated by curcumin via canonical Wnt pathway","volume":"53","author":"Tiwari","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jare.2025.04.017_b0115","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/ptr.8178","article-title":"Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signaling and neurogenesis after cerebral ischemia","volume":"38","author":"Lai","year":"2024","journal-title":"Phytother Res"},{"key":"10.1016\/j.jare.2025.04.017_b0120","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/aps.2014.156","article-title":"Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K\/Akt pathway","volume":"36","author":"Liu","year":"2015","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jare.2025.04.017_b0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aca.2007.03.035","article-title":"Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat","volume":"590","author":"Lin","year":"2007","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.jare.2025.04.017_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.112885","article-title":"Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood-stasis migraine model by blood-brain microdialysis method","volume":"177","author":"Mi","year":"2020","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.jare.2025.04.017_b0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fphar.2018.00024","article-title":"A review on central nervous system effects of gastrodin","volume":"9","author":"Liu","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.04.017_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153576","article-title":"Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation","volume":"87","author":"Hsu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jare.2025.04.017_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105171","article-title":"Gastrodin promotes hippocampal neurogenesis via PDE9-cGMP-PKG pathway in mice following cerebral ischemia","volume":"150","author":"Xiao","year":"2021","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jare.2025.04.017_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179540","article-title":"Gastrodin, a promising natural small molecule for the treatment of central nervous system disorders, and its recent progress in synthesis, pharmacology and pharmacokinetics","volume":"25","author":"Dai","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.04.017_b0155","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1002\/glia.23878","article-title":"Priming of microglia with IFN-gamma impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects","volume":"68","author":"Zhang","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.jare.2025.04.017_b0160","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jtcme.2021.08.013","article-title":"Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: involvement of the monoaminergic system","volume":"12","author":"Sabrina","year":"2022","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.jare.2025.04.017_b0165","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/mp.2013.155","article-title":"Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis","volume":"19","author":"Kreisel","year":"2014","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.jare.2025.04.017_b0170","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/hipo.20718","article-title":"Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression","volume":"20","author":"Chen","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.jare.2025.04.017_b0175","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jare.2022.02.015","article-title":"A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt\/beta-catenin signaling","volume":"43","author":"Tao","year":"2023","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2025.04.017_b0180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41419-024-06621-w","article-title":"Nuclear receptor NURR1 functions to promote stemness and epithelial-mesenchymal transition in prostate cancer via its targeting of Wnt\/beta-catenin signaling pathway","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jare.2025.04.017_b0185","doi-asserted-by":"crossref","DOI":"10.1177\/2040622320962648","article-title":"Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of beta-catenin and beta-catenin-mediated transcription","volume":"11","author":"Chen","year":"2020","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1016\/j.jare.2025.04.017_b0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2017.07.012","article-title":"Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice","volume":"66","author":"Zhang","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jare.2025.04.017_b0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The open field test for measuring locomotor activity and anxiety-like behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jare.2025.04.017_b0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0014-2999(91)90125-A","article-title":"Utility of an elevated plus-maze for dissociation of amnesic and behavioral effects of drugs in mice","volume":"194","author":"Itoh","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jare.2025.04.017_b0205","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1248\/bpb.31.1109","article-title":"Antidepressant-like effects of psoralen isolated from the seeds of Psoralea corylifolia in the mouse forced swimming test","volume":"31","author":"Xu","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jare.2025.04.017_b0210","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jare.2025.04.017_b0215","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nm.3162","article-title":"Astrocyte-derived ATP modulates depressive-like behaviors","volume":"19","author":"Cao","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.04.017_b0220","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/mp.2014.96","article-title":"Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility","volume":"20","author":"Nasca","year":"2015","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.jare.2025.04.017_b0225","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1073858420939034","article-title":"Neural stem cell niche and adult neurogenesis","volume":"27","author":"Li","year":"2021","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jare.2025.04.017_b0230","doi-asserted-by":"crossref","first-page":"12625","DOI":"10.1080\/21655979.2022.2076499","article-title":"Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase\/protein kinase B\/nuclear factor erythroid 2-related factor 2 (PI3K\/AKT\/Nrf2) signaling pathway","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.jare.2025.04.017_b0235","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12974-022-02478-y","article-title":"Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-gamma pathway","volume":"19","author":"Jiang","year":"2022","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.jare.2025.04.017_b0240","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1038\/npp.2015.85","article-title":"Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors","volume":"40","author":"Hill","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jare.2025.04.017_b0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41380-018-0036-2","article-title":"The role of adult hippocampal neurogenesis in brain health and disease","volume":"24","author":"Toda","year":"2019","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.jare.2025.04.017_b0250","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1210\/jc.2019-00749","article-title":"Hippocampal volume, cognitive functions, depression, anxiety, and quality of life in patients with cushing syndrome","volume":"104","author":"Frimodt-Moller","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jare.2025.04.017_b0255","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1523\/JNEUROSCI.3632-07.2008","article-title":"Hen Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells","volume":"28","author":"Wang","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.jare.2025.04.017_b0260","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1111\/cns.14196","article-title":"Akebia saponin D acts via the PPAR-gamma pathway to reprogram pro-neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jare.2025.04.017_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.680903","article-title":"Ginsenoside Rb1 produces antidepressant-like effects in a chronic social defeat stress model of depression through the BDNF-Trkb signaling pathway","volume":"12","author":"Jiang","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.04.017_b0270","article-title":"Niuhuang Qingxin Wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating TrkB\/ERK\/CREB signaling pathway in chronic restraint stress or corticosterone challenge mice","volume":"14","author":"Du","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.04.017_b0275","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/1073858410397054","article-title":"Roecklein The aging hippocampus: interactions between exercise, depression, and BDNF","volume":"18","author":"Erickson","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jare.2025.04.017_b0280","article-title":"IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis","volume":"7","author":"Zhang","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2025.04.017_b0285","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwad248","article-title":"Luo Neurogenesis in primates versus rodents and the value of non-human primate models","volume":"10","author":"Zhang","year":"2023","journal-title":"Natl Sci Rev"},{"key":"10.1016\/j.jare.2025.04.017_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2023.102693","article-title":"Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis","volume":"79","author":"Li","year":"2023","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.jare.2025.04.017_b0295","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/cncr.28003","article-title":"Predictors of depression in breast cancer patients treated with radiation: role of prior chemotherapy and nuclear factor kappa B","volume":"119","author":"Torres","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.jare.2025.04.017_b0300","doi-asserted-by":"crossref","first-page":"e892","DOI":"10.1038\/tp.2016.122","article-title":"The antidepressant roles of Wnt2 and Wnt3 in stress-induced depression-like behaviors","volume":"6","author":"Zhou","year":"2016","journal-title":"Transl Psychiatr"},{"key":"10.1016\/j.jare.2025.04.017_b0305","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41419-022-04784-y","article-title":"Simvastatin rescues memory and granule cell maturation through the Wnt\/beta-catenin signaling pathway in a mouse model of Alzheimer's disease","volume":"13","author":"Tong","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jare.2025.04.017_b0310","article-title":"Chronic intermittent hypobaric hypoxia restores hippocampus function and rescues cognitive impairments in chronic epileptic rats via wnt\/beta-catenin signaling","volume":"13","author":"Sun","year":"2020","journal-title":"Front Molec Neurosci"},{"key":"10.1016\/j.jare.2025.04.017_b0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20463\/jenb.2018.0009","article-title":"Chang Regular exercise and creatine supplementation prevent chronic mild stress-induced decrease in hippocampal neurogenesis via Wnt\/GSK3beta\/beta-catenin pathway","volume":"22","author":"Leem","year":"2018","journal-title":"J Exerc Nutrition Biochem"},{"key":"10.1016\/j.jare.2025.04.017_b0320","article-title":"Shi Gastrodin improves cognitive dysfunction in REM sleep-deprived rats by regulating TLR4\/NF-kappaB and Wnt\/beta-catenin signaling pathways","volume":"13","author":"Liu","year":"2023","journal-title":"BrainSci"},{"key":"10.1016\/j.jare.2025.04.017_b0325","doi-asserted-by":"crossref","DOI":"10.3390\/nu12061805","article-title":"Ji Effects of gastrodin against lead-induced brain injury in mice associated with the Wnt\/Nrf2 pathway","volume":"12","author":"Liu","year":"2020","journal-title":"Nutrients"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:49:04Z","timestamp":1769806144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225002619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":65,"alternative-id":["S2090123225002619"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.017","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrodin enhances stress resilience through promoting Wnt\/\u03b2-Catenin-dependent neurogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}