{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T07:00:05Z","timestamp":1794466805094,"version":"4.9.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072746"],"award-info":[{"award-number":["32072746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024NC-YBXM-092"],"award-info":[{"award-number":["2024NC-YBXM-092"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2025.04.023","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T09:57:46Z","timestamp":1745143066000},"page":"197-218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip"],"prefix":"10.1016","volume":"80","author":[{"given":"Lei","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xina","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.04.023_b0005","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3390\/ijms17122032","article-title":"Ghrelin attenuates intestinal barrier dysfunction following intracerebral hemorrhage in mice","volume":"17","author":"Cheng","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.04.023_b0010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40168-023-01491-4","article-title":"Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial","volume":"11","author":"Zaccaria","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.jare.2025.04.023_b0015","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp Mol Med"},{"issue":"Suppl","key":"10.1016\/j.jare.2025.04.023_b0020","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/MCG.0b013e31826ae849","article-title":"The gut barrier: new acquisitions and therapeutic approaches","volume":"46","author":"Scaldaferri","year":"2012","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jare.2025.04.023_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104248","article-title":"New insights in intestinal oxidative stress damage and the health intervention effects of nutrients: a review","volume":"75","author":"Wang","year":"2020","journal-title":"J Funct Foods"},{"key":"10.1016\/j.jare.2025.04.023_b0030","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3390\/foods12020262","article-title":"The molecular mechanism of yam polysaccharide protected H(2)O(2)-induced oxidative damage in IEC-6 cells","volume":"12","author":"Shen","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.jare.2025.04.023_b0035","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202102952","article-title":"Effects of docetaxel injection and docetaxel micelles on the intestinal barrier and intestinal microbiota","volume":"8","author":"Liu","year":"2021","journal-title":"Adv Sci"},{"key":"10.1016\/j.jare.2025.04.023_b0040","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.3390\/antiox11102002","article-title":"Acidifiers attenuate diquat-induced oxidative stress and inflammatory responses by regulating NF-\u03baB\/MAPK\/COX-2 pathways in IPEC-J2 cells","volume":"11","author":"Xu","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jare.2025.04.023_b0045","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/j.gastro.2017.09.010","article-title":"Deficiency of the mitochondrial NAD kinase causes stress-induced hepatic steatosis in mice","volume":"154","author":"Zhang","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jare.2025.04.023_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101364","article-title":"The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways","volume":"28","author":"He","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2025.04.023_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.12287","article-title":"Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging","volume":"14","author":"Ziegler","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.jare.2025.04.023_b0060","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2025.04.023_b0065","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.04.023_b0070","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.3390\/biomedicines11051388","article-title":"The influence of gut microbiota on oxidative stress and the immune system","volume":"11","author":"Kunst","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jare.2025.04.023_b0075","article-title":"Inflammatory and microbiota-related regulation of the intestinal epithelial barrier","volume":"8","author":"Barbara","year":"2021","journal-title":"Front Nutr"},{"key":"10.1016\/j.jare.2025.04.023_b0080","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1172\/JCI43653","article-title":"Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans","volume":"120","author":"Schoenmakers","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2025.04.023_b0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2018.05.066","article-title":"Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease","volume":"127","author":"Short","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jare.2025.04.023_b0090","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7478523","article-title":"Supplementation of micronutrient selenium in metabolic diseases: its role as an antioxidant","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jare.2025.04.023_b0095","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12951-017-0252-y","article-title":"Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-\u03baB mediated hyper inflammation","volume":"15","author":"Zhu","year":"2017","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.jare.2025.04.023_b0100","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1021\/acscentsci.8b00112","article-title":"Selenium-encoded isotopic signature targeted profiling","volume":"4","author":"Gao","year":"2018","journal-title":"ACS Cent Sci"},{"key":"10.1016\/j.jare.2025.04.023_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102242","article-title":"Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status","volume":"50","author":"Demircan","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2025.04.023_b0110","doi-asserted-by":"crossref","first-page":"14053","DOI":"10.1021\/acsnano.3c04344","article-title":"Translational selenium nanoparticles to attenuate allergic dermatitis through Nrf2-Keap1-driven activation of selenoproteins","volume":"17","author":"Xie","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jare.2025.04.023_b0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12951-022-01754-6","article-title":"Protective effect of spore oil-functionalized nano-selenium system on cisplatin-induced nephrotoxicity by regulating oxidative stress-mediated pathways and activating immune response","volume":"21","author":"Liu","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.jare.2025.04.023_b0120","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1002\/etc.1995","article-title":"Subacute toxicity of nano-selenium compared to other selenium species in mice","volume":"31","author":"Benko","year":"2012","journal-title":"Environ Toxicol Chem"},{"key":"10.1016\/j.jare.2025.04.023_b0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41538-022-00145-3","article-title":"Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction","volume":"6","author":"Qiao","year":"2022","journal-title":"npj Sci Food"},{"key":"10.1016\/j.jare.2025.04.023_b0130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40580-022-00299-6","article-title":"Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip","volume":"9","author":"Jeon","year":"2022","journal-title":"Nano Converg"},{"key":"10.1016\/j.jare.2025.04.023_b0135","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3390\/bios13010136","article-title":"Microfluidic gut-on-a-chip: fundamentals and challenges","volume":"13","author":"Thomas","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.jare.2025.04.023_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120196","article-title":"Gut-on-a-chip: current progress and future opportunities","volume":"255","author":"Ashammakhi","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2025.04.023_b0145","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/17425255.2024.2365254","article-title":"Bioengineered human gut-on-a-chip for advancing non-clinical pharmaco-toxicology","volume":"20","author":"Shin","year":"2024","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.jare.2025.04.023_b0150","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.carbpol.2018.04.110","article-title":"Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized by Lactobacillus casei ATCC 393","volume":"195","author":"Xu","year":"2018","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.jare.2025.04.023_b0155","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00659-23","article-title":"Selenite bioremediation by food-grade probiotic lactobacillus casei ATCC 393: insights from proteomics analysis","volume":"11","author":"Qiao","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jare.2025.04.023_b0160","doi-asserted-by":"crossref","first-page":"9083","DOI":"10.7150\/thno.46467","article-title":"Lentinan-functionalized selenium nanoparticles target tumor cell mitochondria via TLR4\/TRAF3\/MFN1 pathway","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jare.2025.04.023_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10717544.2018.1556359","article-title":"Galactose-modified selenium nanoparticles for targeted delivery of doxorubicin to hepatocellular carcinoma","volume":"26","author":"Xia","year":"2019","journal-title":"Drug Deliv"},{"key":"10.1016\/j.jare.2025.04.023_b0170","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41565-021-00858-8","article-title":"Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics","volume":"16","author":"Rennick","year":"2021","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.jare.2025.04.023_b0175","doi-asserted-by":"crossref","first-page":"12193","DOI":"10.1021\/jacs.3c02179","article-title":"Oral Hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota","volume":"145","author":"Ouyang","year":"2023","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jare.2025.04.023_b0180","doi-asserted-by":"crossref","first-page":"E10539","DOI":"10.1073\/pnas.1810819115","article-title":"Intestinal barrier dysfunction orchestrates the onset of inflammatory host-microbiome cross-talk in a human gut inflammation-on-a-chip","volume":"115","author":"Shin","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.jare.2025.04.023_b0185","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2013.137","article-title":"Microfabrication of human organs-on-chips","volume":"8","author":"Huh","year":"2013","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jare.2025.04.023_b0190","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12951-022-01273-4","article-title":"Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NF\u03baB P65 signaling pathway after spinal cord injury","volume":"20","author":"Liu","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.jare.2025.04.023_b0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.aninu.2023.08.003","article-title":"Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets","volume":"15","author":"Qiao","year":"2023","journal-title":"Anim Nutr"},{"key":"10.1016\/j.jare.2025.04.023_b0200","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201910566","article-title":"Nanocarrier-mediated cytosolic delivery of biopharmaceuticals","volume":"30","author":"He","year":"2020","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.jare.2025.04.023_b0205","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3390\/pharmaceutics12040371","article-title":"Endocytosis: the nanoparticle and submicron nanocompounds gateway into the cell","volume":"12","author":"Manzanares","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jare.2025.04.023_b0210","first-page":"1330","article-title":"Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma","volume":"6","author":"Xia","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2025.04.023_b0215","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41598-018-19598-2","article-title":"Fast and effective mitochondrial delivery of \u03c9-Rhodamine-B-polysulfobetaine-PEG copolymers","volume":"8","author":"Morimoto","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.04.023_b0220","doi-asserted-by":"crossref","first-page":"28694","DOI":"10.1038\/srep28694","article-title":"White spot syndrome virus entry is dependent on multiple endocytic routes and strongly facilitated by Cq-GABARAP in a CME-dependent manner","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.04.023_b0225","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3390\/molecules22081240","article-title":"Enhanced uptake of Fe3O4 nanoparticles by intestinal epithelial cells in a state of inflammation","volume":"22","author":"Zhou","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jare.2025.04.023_b0230","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-nutr-071714-034250","article-title":"Regulation of selenium metabolism and transport","volume":"35","author":"Burk","year":"2015","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jare.2025.04.023_b0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02784430","article-title":"Selenium metabolism and bioavailability","volume":"54","author":"Daniels","year":"1996","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.jare.2025.04.023_b0240","article-title":"Translational nanotherapeutics reprograms immune microenvironment in malignant pleural effusion of lung adenocarcinoma","volume":"10","author":"Song","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.jare.2025.04.023_b0245","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.tibtech.2023.01.004","article-title":"Organs-on-chips: a decade of innovation","volume":"41","author":"Strelez","year":"2023","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.jare.2025.04.023_b0250","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3389\/fphys.2018.01584","article-title":"Intestinal in vitro and ex vivo models to study host-microbiome interactions and acute stressors","volume":"9","author":"Pearce","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.jare.2025.04.023_b0255","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.vetmic.2011.10.017","article-title":"Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations","volume":"156","author":"Brosnahan","year":"2012","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.jare.2025.04.023_b0260","unstructured":"Vergauwen H. The IPEC-J2 Cell Line. In The Impact of Food Bioactives on Health: In vitro and ex vivo models. Edited by Verhoeckx K, Cotter P, L\u00f3pez-Exp\u00f3sito I, Kleiveland C, Lea T, Mackie A, Requena T, Swiatecka D, Wichers H. Cham (CH): Springer. Copyright 2015, The Author(s). 2015: 125-34."},{"key":"10.1016\/j.jare.2025.04.023_b0265","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41575-020-0331-7","article-title":"Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD","volume":"17","author":"Kudelka","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2025.04.023_b0270","first-page":"9106","article-title":"Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice","volume":"20","author":"Zhang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jare.2025.04.023_b0275","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.coph.2015.11.005","article-title":"Mast cells and inflammatory bowel disease","volume":"25","author":"Boeckxstaens","year":"2015","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jare.2025.04.023_b0280","doi-asserted-by":"crossref","first-page":"31936","DOI":"10.1074\/jbc.M506338200","article-title":"Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins","volume":"280","author":"Jacob","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2025.04.023_b0285","doi-asserted-by":"crossref","first-page":"22381","DOI":"10.1073\/pnas.0906372106","article-title":"Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase\/Mcpt4-dependent mechanism","volume":"106","author":"Groschwitz","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.jare.2025.04.023_b0290","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41467-017-02536-7","article-title":"Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney","volume":"9","author":"Festa","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.04.023_b0295","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/cancers11050647","article-title":"The role of AMP-activated protein kinase as a potential target of treatment of hepatocellular carcinoma","volume":"11","author":"Jiang","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jare.2025.04.023_b0300","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.2147\/DDDT.S442154","article-title":"The role of AMPK signaling in ulcerative colitis","volume":"17","author":"Yuan","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.jare.2025.04.023_b0305","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3389\/fphar.2018.00761","article-title":"Activating AMPK to restore tight junction assembly in intestinal epithelium and to attenuate experimental colitis by metformin","volume":"9","author":"Chen","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.04.023_b0310","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2012.12.016","article-title":"Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy","volume":"152","author":"Kim","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jare.2025.04.023_b0315","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1080\/15548627.2016.1191857","article-title":"PRKAA\/AMPK restricts HBV replication through promotion of autophagic degradation","volume":"12","author":"Xie","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jare.2025.04.023_b0320","first-page":"503","article-title":"Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation","volume":"161","author":"Sadatomi","year":"2017","journal-title":"J Biochem"},{"key":"10.1016\/j.jare.2025.04.023_b0325","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nm.4153","article-title":"NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages","volume":"22","author":"Moon","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.04.023_b0330","doi-asserted-by":"crossref","first-page":"23193","DOI":"10.18632\/aging.203611","article-title":"Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK\/Nrf2\/NLRP3 inflammasome","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jare.2025.04.023_b0335","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molimm.2018.09.010","article-title":"The role of mitochondria in NLRP3 inflammasome activation","volume":"103","author":"Liu","year":"2018","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jare.2025.04.023_b0340","article-title":"Escherichia coli K88 activates NLRP3 inflammasome-mediated pyroptosis in vitro and in vivo","volume":"38","author":"Cheng","year":"2024","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.jare.2025.04.023_b0345","doi-asserted-by":"crossref","first-page":"e00099","DOI":"10.1128\/MCB.00099-20","article-title":"The molecular mechanisms regulating the KEAP1-NRF2 pathway","volume":"40","author":"Baird","year":"2020","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jare.2025.04.023_b0350","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.2147\/JIR.S467882","article-title":"Targeting the AMPK\/Nrf2 pathway: a novel therapeutic approach for acute lung injury","volume":"17","author":"Huang","year":"2024","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jare.2025.04.023_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110483","article-title":"Selenium nanoparticles: properties, preparation methods, and therapeutic applications","volume":"378","author":"Xiao","year":"2023","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jare.2025.04.023_b0360","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3390\/nano13030424","article-title":"Biogenic selenium nanoparticles in biomedical sciences: properties, current trends, novel opportunities and emerging challenges in theranostic nanomedicine","volume":"13","author":"Zambonino","year":"2023","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jare.2025.04.023_b0365","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s11033-024-09598-z","article-title":"Recent advances in the therapeutic applications of selenium nanoparticles","volume":"51","author":"Ansari","year":"2024","journal-title":"Mol Biol Rep"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322500267X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322500267X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:39:44Z","timestamp":1769805584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209012322500267X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":73,"alternative-id":["S209012322500267X"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.023","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}