{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:34:37Z","timestamp":1789727677164,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3501701"],"award-info":[{"award-number":["2022YFC3501701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374065"],"award-info":[{"award-number":["82374065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074043"],"award-info":[{"award-number":["82074043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["24ZR1466500"],"award-info":[{"award-number":["24ZR1466500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2023YZZ02"],"award-info":[{"award-number":["2023YZZ02"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2025.04.028","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T18:26:39Z","timestamp":1745087199000},"page":"577-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated \u03b2-catenin\/Id2\/MBP signaling axis in oligodendrocyte precursor cells"],"prefix":"10.1016","volume":"80","author":[{"given":"Jinfeng","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-5341","authenticated-orcid":false,"given":"Xiaojun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jare.2025.04.028_b0005","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/glia.24441","article-title":"Regulation of lipid synthesis in myelin modulates neural activity and is required for motor learning","volume":"71","author":"Kato","year":"2023","journal-title":"Glia"},{"issue":"8017","key":"10.1016\/j.jare.2025.04.028_b0010","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/s41586-024-07525-7","article-title":"Myelin plasticity in theventral tegmental area is required for opioid reward","volume":"630","author":"Yal\u00e7\u0131n","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jare.2025.04.028_b0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00018-024-05222-2","article-title":"Functional myelin in cognition and neurodevelopmental disorders","volume":"81","author":"Khelfaoui","year":"2024","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.04.028_b0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tins.2023.11.003","article-title":"White matter injury across neurodegenerative disease","volume":"47","author":"Festa","year":"2024","journal-title":"Trends Neurosci"},{"issue":"7","key":"10.1016\/j.jare.2025.04.028_b0025","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41593-023-01366-9","article-title":"Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease","volume":"26","author":"Sch\u00e4ffner","year":"2023","journal-title":"Nat Neurosci"},{"issue":"21","key":"10.1016\/j.jare.2025.04.028_b0030","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.neuron.2022.09.023","article-title":"CNS remyelination and inflammation: from basic mechanisms to therapeutic opportunities","volume":"110","author":"Franklin","year":"2022","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.jare.2025.04.028_b0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/13524585241226830","article-title":"Effectiveness of immunotherapies in relapsing myelin oligodendrocyte glycoprotein antibody-associated disease","volume":"30","author":"Bilodeau","year":"2024","journal-title":"Mult Scler"},{"issue":"6","key":"10.1016\/j.jare.2025.04.028_b0040","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041358","article-title":"Regulators of oligodendrocyte differentiation","volume":"16","author":"Emery","year":"2024","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"12","key":"10.1016\/j.jare.2025.04.028_b0045","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1177\/0271678X241260100","article-title":"Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke","volume":"44","author":"Wang","year":"2024","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jare.2025.04.028_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154309","article-title":"Ginsenoside Rg1 promotes remyelination and functional recovery in demyelinating disease by enhancing oligodendrocyte precursor cells-mediated myelin repair","volume":"106","author":"Liu","year":"2022","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jare.2025.04.028_b0055","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00441-021-03539-z","article-title":"P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke","volume":"387","author":"Deshpande","year":"2022","journal-title":"Cell Tissue Res"},{"issue":"8","key":"10.1016\/j.jare.2025.04.028_b0060","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1111\/ejn.15810","article-title":"P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases","volume":"56","author":"Xiong","year":"2022","journal-title":"Eur J Neurosci"},{"issue":"10","key":"10.1016\/j.jare.2025.04.028_b0065","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/glia.24430","article-title":"Oligodendrocyte progenitor development from the postnatal rat subventricular zone is regulated by the p75 neurotrophin receptor","volume":"71","author":"Joshi","year":"2023","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.jare.2025.04.028_b0070","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12264-022-00936-4","article-title":"Elevated levels of naturally-occurring autoantibodies against the extracellular domain of p75NTR aggravate the pathology of alzheimer's disease","volume":"39","author":"He","year":"2023","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.jare.2025.04.028_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2022.102264","article-title":"Research on the function of the Cend1 regulatory mechanism on p75NTR signaling in spinal cord injury","volume":"95","author":"Chen","year":"2022","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.jare.2025.04.028_b0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-020-1708-9","article-title":"Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis","volume":"17","author":"Delivanoglou","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"8","key":"10.1016\/j.jare.2025.04.028_b0085","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.1007\/s12035-017-0841-7","article-title":"p75NTR and TROY: uncharted roles of nogo receptor complex in experimental autoimmune encephalomyelitis","volume":"55","author":"Theotokis","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"2","key":"10.1016\/j.jare.2025.04.028_b0090","doi-asserted-by":"crossref","first-page":"715","DOI":"10.7150\/thno.51390","article-title":"Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis","volume":"11","author":"Hu","year":"2021","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.jare.2025.04.028_b0095","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.tips.2021.06.006","article-title":"In vivo functions of p75(NTR): challenges and opportunities for an emerging therapeutic target","volume":"42","author":"Malik","year":"2021","journal-title":"Trends Pharmacol Sci"},{"issue":"11","key":"10.1016\/j.jare.2025.04.028_b0100","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1080\/01616412.2024.2376310","article-title":"High-intensity interval training stimulates remyelination via the Wnt\/\u03b2-catenin pathway in cuprizone-induced demyelination mouse model","volume":"46","author":"Chen","year":"2024","journal-title":"Neurol Res"},{"issue":"19\u201320","key":"10.1016\/j.jare.2025.04.028_b0105","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1007\/s00018-021-03927-2","article-title":"DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation","volume":"78","author":"Tiane","year":"2021","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.04.028_b0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00726-021-03111-7","article-title":"Multiple sclerosis and myelin basic protein: insights into protein disorder and disease","volume":"54","author":"Martinsen","year":"2022","journal-title":"Amino Acids"},{"key":"10.1016\/j.jare.2025.04.028_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110556","article-title":"Quercetin prevents the ferroptosis of OPCs by inhibiting the Id2\/transferrin pathway","volume":"381","author":"Wang","year":"2023","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jare.2025.04.028_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112610","article-title":"Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders","volume":"146","author":"Kabir","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2025.04.028_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111729","article-title":"Mechanistic insights and perspectives involved in neuroprotective action of quercetin","volume":"140","author":"Grewal","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2025.04.028_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153385","article-title":"Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK\/AKT\/NF\u03baB signaling pathway","volume":"80","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jare.2025.04.028_b0135","article-title":"Astragaloside II ameliorated podocyte injury and mitochondrial dysfunction in streptozotocin-induced diabetic rats","volume":"12","author":"Su","year":"2021","journal-title":"Front Pharmacol"},{"issue":"11","key":"10.1016\/j.jare.2025.04.028_b0140","first-page":"7074","article-title":"Astragaloside II alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo","volume":"11","author":"Qiao","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jare.2025.04.028_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175992","article-title":"Astragaloside IV against Alzheimer's disease via microglia-mediated neuroinflammation using network pharmacology and experimental validation","volume":"957","author":"Bao","year":"2023","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"10.1016\/j.jare.2025.04.028_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076495","article-title":"Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.04.028_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115622","article-title":"Total astragalosides promote oligodendrocyte precursor cell differentiation and enhance remyelination in cuprizone-induced mice through suppression of Wnt\/\u03b2-catenin signaling pathway","volume":"298","author":"Yuan","year":"2022","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.jare.2025.04.028_b0160","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3390\/ijms25031445","article-title":"How to use the cuprizone model to study de- and remyelination","volume":"25","author":"Kipp","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.04.028_b0165","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1002\/cpcb.49","article-title":"Using acutely dissociated and purified oligodendrocyte precursor cells for high-throughput drug screening to identify compounds that promote oligodendrocyte differentiation","volume":"79","author":"Lariosa-Willingham","year":"2018","journal-title":"Curr Protoc Cell Biol"},{"issue":"5","key":"10.1016\/j.jare.2025.04.028_b0170","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.apsb.2024.02.003","article-title":"Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery","volume":"14","author":"Qian","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jare.2025.04.028_b0175","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jare.2024.02.008","article-title":"Valerenic acid attenuates pathological myocardial hypertrophy by promoting the utilization of multiple substrates in the mitochondrial energy metabolism","volume":"68","author":"Liu","year":"2025","journal-title":"J Adv Res"},{"issue":"4","key":"10.1016\/j.jare.2025.04.028_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112293","article-title":"Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination","volume":"42","author":"Hou","year":"2023","journal-title":"Cell Rep"},{"issue":"5","key":"10.1016\/j.jare.2025.04.028_b0185","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.3390\/ijms24054596","article-title":"Demyelinating diseases: from molecular mechanisms to therapeutic strategies","volume":"24","author":"Bernardo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.04.028_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1169786","article-title":"Brain region dependent molecular signatures and myelin repair following chronic demyelination","volume":"17","author":"Samtani","year":"2023","journal-title":"Front Cell Neurosci"},{"issue":"10","key":"10.1016\/j.jare.2025.04.028_b0195","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1007\/s12031-022-02059-x","article-title":"Ursolic acid enhances myelin repair in adult mice brains and stimulates exhausted oligodendrocyte progenitors to remyelinate","volume":"72","author":"Honarvar","year":"2022","journal-title":"J Mol Neurosci"},{"issue":"3","key":"10.1016\/j.jare.2025.04.028_b0200","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1515\/revneuro-2023-0081","article-title":"The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies","volume":"35","author":"Parrilla","year":"2024","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.jare.2025.04.028_b0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2020.09.009","article-title":"Revisiting remyelination: towards a consensus on the regeneration of CNS myelin","volume":"116","author":"Franklin","year":"2021","journal-title":"Semin Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.jare.2025.04.028_b0210","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13218","article-title":"Automated analysis of gray matter damage in aged mice reveals impaired remyelination in the cuprizone model","volume":"34","author":"Gingele","year":"2024","journal-title":"Brain Pathol"},{"issue":"5","key":"10.1016\/j.jare.2025.04.028_b0215","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1001\/jamaneurol.2022.0489","article-title":"Association of maintenance intravenous immunoglobulin with prevention of relapse in adult myelin oligodendrocyte glycoprotein antibody-associated disease","volume":"79","author":"Chen","year":"2022","journal-title":"JAMA Neurol"},{"issue":"9","key":"10.1016\/j.jare.2025.04.028_b0220","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41589-022-01115-2","article-title":"The landscape of targets and lead molecules for remyelination","volume":"18","author":"Caprariello","year":"2022","journal-title":"Nat Chem Biol"},{"issue":"9","key":"10.1016\/j.jare.2025.04.028_b0225","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1007\/s11064-023-03946-4","article-title":"Effects of curcumin on axon growth and myelin sheath formation in an in vitro model","volume":"48","author":"Yang","year":"2023","journal-title":"Neurochem Res"},{"issue":"2","key":"10.1016\/j.jare.2025.04.028_b0230","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jgr.2022.09.005","article-title":"Korean Red Ginseng and Rb1 facilitate remyelination after cuprizone diet-induced demyelination","volume":"47","author":"Kwon","year":"2023","journal-title":"J Ginseng Res"},{"issue":"1","key":"10.1016\/j.jare.2025.04.028_b0235","doi-asserted-by":"crossref","first-page":"19723","DOI":"10.1038\/s41598-023-46541-x","article-title":"Resveratrol improves the prognosis of rats after spinal cord injury by inhibiting mitogen-activated protein kinases signaling pathway","volume":"13","author":"Kan","year":"2023","journal-title":"Sci Rep"},{"issue":"46","key":"10.1016\/j.jare.2025.04.028_b0240","doi-asserted-by":"crossref","first-page":"17924","DOI":"10.1021\/acs.jafc.3c05405","article-title":"Study on the biotransformation and activities of astragalosides from Astragali Radix in vitro and in vivo","volume":"71","author":"Song","year":"2023","journal-title":"J Agric Food Chem"},{"issue":"12","key":"10.1016\/j.jare.2025.04.028_b0245","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1523\/JNEUROSCI.1341-21.2022","article-title":"ADAM17 regulates p75(NTR)-mediated fibrinolysis and nerve remyelination","volume":"42","author":"Pellegatta","year":"2022","journal-title":"J Neurosci"},{"issue":"9","key":"10.1016\/j.jare.2025.04.028_b0250","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1093\/nar\/gkaa218","article-title":"Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation","volume":"48","author":"Wedel","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.jare.2025.04.028_b0255","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s10787-023-01406-7","article-title":"Hexahydrocurcumin attenuated demyelination and improved cognitive impairment in chronic cerebral hypoperfusion rats","volume":"32","author":"Jearjaroen","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jare.2025.04.028_b0260","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1237458","article-title":"Cholinergic neurodegeneration and cholesterol metabolism dysregulation by constitutive p75(NTR) signaling in the p75(exonIII)-KO mice","volume":"16","author":"Comaposada-Bar\u00f3","year":"2023","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"10.1016\/j.jare.2025.04.028_b0265","doi-asserted-by":"crossref","first-page":"536","DOI":"10.4103\/1673-5374.380873","article-title":"Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?","volume":"19","author":"Jourdi","year":"2024","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jare.2025.04.028_b0270","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ijbiomac.2022.11.078","article-title":"p75NTR enhances cognitive dysfunction in a mouse Alzheimer's disease model by inhibiting microRNA-210-3p-mediated PCYT2 through activation of NF-\u03baB","volume":"225","author":"Wei","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"10.1016\/j.jare.2025.04.028_b0275","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1007\/s12035-023-03727-8","article-title":"The molecular pathway of p75 neurotrophin receptor (p75NTR) in Parkinson's disease: the way of new inroads","volume":"61","author":"Ali","year":"2024","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jare.2025.04.028_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2023.102375","article-title":"Solifenacin promotes remyelination in cuprizone mouse model by inhibiting the Wnt\/\u03b2-catenin signaling pathway","volume":"136","author":"Xu","year":"2024","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.jare.2025.04.028_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106315","article-title":"G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation","volume":"187","author":"Boccazzi","year":"2023","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jare.2025.04.028_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2022.577876","article-title":"Matrine inhibits the Wnt3a\/\u03b2-catenin\/TCF7L2 signaling pathway in experimental autoimmune encephalomyelitis","volume":"367","author":"Ma","year":"2022","journal-title":"J Neuroimmunol"},{"issue":"1","key":"10.1016\/j.jare.2025.04.028_b0295","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40478-019-0657-y","article-title":"Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth","volume":"7","author":"Cerles","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.jare.2025.04.028_b0300","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.914153","article-title":"Clemastine promotes differentiation of oligodendrocyte progenitor cells through the activation of ERK1\/2 via muscarinic receptors after spinal cord injury","volume":"13","author":"Tong","year":"2022","journal-title":"Front Pharmacol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:16:10Z","timestamp":1769822170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225002735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":60,"alternative-id":["S2090123225002735"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.028","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated \u03b2-catenin\/Id2\/MBP signaling axis in oligodendrocyte precursor cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}