{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:12:53Z","timestamp":1792613573074,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017623","name":"Zhejiang Provincial Outstanding Youth Science Foundation","doi-asserted-by":"publisher","award":["LR23H250001"],"award-info":[{"award-number":["LR23H250001"]}],"id":[{"id":"10.13039\/501100017623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201430"],"award-info":[{"award-number":["82201430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2025.04.043","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:05:29Z","timestamp":1745928329000},"page":"671-682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus"],"prefix":"10.1016","volume":"80","author":[{"given":"Yuqi","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingquan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingze","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Bartas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayeon","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjian","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiannan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemmings","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Beier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoule","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.04.043_b0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM196507152730301","article-title":"Symptomatic occult hydrocephalus with \u201cnormal\u201d cerebrospinal-fluid pressure.a treatable syndrome","volume":"273","author":"Adams","year":"1965","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jare.2025.04.043_b0010","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.wneu.2015.07.005","article-title":"Epidemiology of idiopathic normal pressure hydrocephalus: a systematic review of the literature","volume":"84","author":"Martin-Laez","year":"2015","journal-title":"World Neurosurg"},{"issue":"10","key":"10.1016\/j.jare.2025.04.043_b0015","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s00701-013-1835-5","article-title":"Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus","volume":"155","author":"Toma","year":"2013","journal-title":"Acta Neurochir"},{"issue":"15","key":"10.1016\/j.jare.2025.04.043_b0020","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1212\/WNL.0b013e31828c2fda","article-title":"Idiopathic normal-pressure hydrocephalus: pathophysiology and diagnosis by CSF biomarkers","volume":"80","author":"Jeppsson","year":"2013","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.jare.2025.04.043_b0025","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1136\/jnnp-2019-320826","article-title":"CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics","volume":"90","author":"Jeppsson","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"10.1016\/j.jare.2025.04.043_b0030","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00702-018-1842-z","article-title":"Cerebrospinal fluid biomarkers profile of idiopathic normal pressure hydrocephalus","volume":"125","author":"Schirinzi","year":"2018","journal-title":"J Neural Transm (Vienna)"},{"issue":"6","key":"10.1016\/j.jare.2025.04.043_b0035","article-title":"Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson\u2019s disease","volume":"3","author":"Karayel","year":"2022","journal-title":"Cell Rep Med"},{"issue":"43","key":"10.1016\/j.jare.2025.04.043_b0040","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz9360","article-title":"Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer\u2019s disease","volume":"6","author":"Higginbotham","year":"2020","journal-title":"Sci Adv"},{"issue":"9","key":"10.1016\/j.jare.2025.04.043_b0045","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.7150\/thno.31144","article-title":"In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine","volume":"9","author":"Xu","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0050","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and Metabolomic Characterization of COVID-19 Patient Sera","volume":"182","author":"Shen","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0055","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41421-022-00441-y","article-title":"Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding","volume":"8","author":"Tang","year":"2022","journal-title":"Cell Discov"},{"issue":"2","key":"10.1016\/j.jare.2025.04.043_b0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2176\/nmc.st.2020-0292","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus (Third Edition): endorsed by the Japanese society of normal pressure hydrocephalus","volume":"61","author":"Nakajima","year":"2021","journal-title":"Neurologia medico-chirurgica"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0065","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1227\/01.NEU.0000363408.69856.B8","article-title":"Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients","volume":"66","author":"Eide","year":"2010","journal-title":"Neurosurgery"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0070","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000111149","article-title":"Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus","volume":"25","author":"Kubo","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"11","key":"10.1016\/j.jare.2025.04.043_b0080","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910427","article-title":"Plasma Proteome Profiling to detect and avoid sample-related biases in biomarker studies","volume":"11","author":"Geyer","year":"2019","journal-title":"EMBO Mol Med"},{"issue":"D1","key":"10.1016\/j.jare.2025.04.043_b0085","doi-asserted-by":"crossref","first-page":"D721","DOI":"10.1093\/nar\/gky900","article-title":"CellMarker: a manually curated resource of cell markers in human and mouse","volume":"47","author":"Zhang","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.jare.2025.04.043_b0090","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v046.i11","article-title":"Fast r functions for robust correlations and hierarchical clustering","volume":"46","author":"Langfelder","year":"2012","journal-title":"J Stat Softw"},{"issue":"6","key":"10.1016\/j.jare.2025.04.043_b0095","doi-asserted-by":"crossref","first-page":"e9356","DOI":"10.15252\/msb.20199356","article-title":"Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer\u2019s disease","volume":"16","author":"Bader","year":"2020","journal-title":"Mol Syst Biol"},{"issue":"4","key":"10.1016\/j.jare.2025.04.043_b0100","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ana.25847","article-title":"Normal pressure hydrocephalus associated with Alzheimer\u2019s Disease","volume":"88","author":"Muller-Schmitz","year":"2020","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12987-021-00289-6","article-title":"Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus","volume":"18","author":"Lolansen","year":"2021","journal-title":"Fluids Barriers of the CNS"},{"issue":"5","key":"10.1016\/j.jare.2025.04.043_b0110","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2020.09.020","article-title":"Inflammation of the embryonic choroid plexus barrier following maternal immune activation","volume":"55","author":"Cui","year":"2020","journal-title":"Dev Cell"},{"issue":"3","key":"10.1016\/j.jare.2025.04.043_b0115","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7150\/thno.44364","article-title":"CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain","volume":"11","author":"Mai","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0120","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12987-024-00561-5","article-title":"Molecular signatures of normal pressure hydrocephalus: a large-scale proteomic analysis of cerebrospinal fluid","volume":"21","author":"Kamalian","year":"2024","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jare.2025.04.043_b0125","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.arr.2018.07.004","article-title":"Towards frailty biomarkers: candidates from genes and pathways regulated in aging and age-related diseases","volume":"47","author":"Cardoso","year":"2018","journal-title":"Ageing Res Rev"},{"issue":"7","key":"10.1016\/j.jare.2025.04.043_b0130","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1212\/WNL.0000000000002369","article-title":"Vascular factors in suspected normal pressure hydrocephalus: a population-based study","volume":"86","author":"Jaraj","year":"2016","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12987-022-00306-2","article-title":"Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus","volume":"19","author":"Braun","year":"2022","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"10.1016\/j.jare.2025.04.043_b0140","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1212\/WNL.50.4.1122","article-title":"CSF neurofilament and glial fibrillary acidic protein in normal pressure hydrocephalus","volume":"50","author":"Tullberg","year":"1998","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jare.2025.04.043_b0145","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013249","article-title":"Deletions in CWH43 cause idiopathic normal pressure hydrocephalus","volume":"13","author":"Yang","year":"2021","journal-title":"EMBO Mol Med"},{"issue":"4","key":"10.1016\/j.jare.2025.04.043_b0150","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809695","article-title":"NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer\u2019s disease","volume":"11","author":"Brummer","year":"2019","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer\u2019s disease: advances in genetics, pathophysiology, and therapeutic approaches","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"The Lancet Neurology"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/alz.12166","article-title":"Blood neuro-exosomal synaptic proteins predict Alzheimer\u2019s disease at the asymptomatic stage","volume":"17","author":"Jia","year":"2021","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.jare.2025.04.043_b0165","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1073\/pnas.1916715117","article-title":"LINGO1 is a regulatory subunit of large conductance, Ca(2+)-activated potassium channels","volume":"117","author":"Dudem","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"10.1016\/j.jare.2025.04.043_b0170","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/mds.25819","article-title":"Increased LINGO1 in the cerebellum of essential tremor patients","volume":"29","author":"Delay","year":"2014","journal-title":"Mov Disord"},{"issue":"7","key":"10.1016\/j.jare.2025.04.043_b0175","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1007\/s00701-022-05154-5","article-title":"Cerebrospinal fluid and venous biomarkers of shunt-responsive idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis","volume":"164","author":"Thavarajasingam","year":"2022","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.jare.2025.04.043_b0180","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"10.1016\/j.jare.2025.04.043_b0185","doi-asserted-by":"crossref","first-page":"859","DOI":"10.14348\/molcells.2015.0098","article-title":"Identification and epigenetic analysis of a maternally imprinted gene qpct","volume":"38","author":"Guo","year":"2015","journal-title":"Mol Cells"},{"issue":"4","key":"10.1016\/j.jare.2025.04.043_b0190","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.drudis.2022.01.016","article-title":"Challenges and hopes for Alzheimer\u2019s disease","volume":"27","author":"Tatulian","year":"2022","journal-title":"Drug Discov Today"},{"issue":"3","key":"10.1016\/j.jare.2025.04.043_b0195","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00401-021-02349-5","article-title":"A glutaminyl cyclase-catalyzed \u03b1-synuclein modification identified in human synucleinopathies","volume":"142","author":"Hartlage-R\u00fcbsamen","year":"2021","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.jare.2025.04.043_b0200","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nchembio.1790","article-title":"siRNA screen identifies QPCT as a druggable target for Huntington\u2019s disease","volume":"11","author":"Jimenez-Sanchez","year":"2015","journal-title":"Nat Chem Biol"},{"issue":"9","key":"10.1016\/j.jare.2025.04.043_b0205","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/emmm.201100158","article-title":"The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions","volume":"3","author":"Cynis","year":"2011","journal-title":"EMBO Mol Med"},{"issue":"3","key":"10.1016\/j.jare.2025.04.043_b0210","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0305-0491(92)90019-N","article-title":"Expression of retinol-binding protein mRNA in mammalian choroid plexus","volume":"101","author":"Duan","year":"1992","journal-title":"Comp Biochem Physiol B: Comp Biochem"},{"key":"10.1016\/j.jare.2025.04.043_b0215","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1128\/MCB.06193-11","article-title":"Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism","volume":"32","author":"Norseen","year":"2012","journal-title":"Mol Cel Biol"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0220","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12987-023-00440-5","article-title":"Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus","volume":"20","author":"Weiner","year":"2023","journal-title":"Fluids Barriers CNS"},{"issue":"551","key":"10.1016\/j.jare.2025.04.043_b0225","article-title":"Single-cell RNA sequencing unveils the communications between malignant T and myeloid cells contributing to tumor growth and immunosuppression in cutaneous T-cell lymphoma","volume":"28","author":"Du","year":"2022","journal-title":"Cancer Lett"},{"issue":"11","key":"10.1016\/j.jare.2025.04.043_b0230","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2147\/CIA.S105769","article-title":"Genes associated with Alzheimer\u2019s disease: an overview and current status","volume":"17","author":"Giri","year":"2016","journal-title":"Clin Interv Aging"},{"issue":"2","key":"10.1016\/j.jare.2025.04.043_b0235","first-page":"6","article-title":"Olfactomedin proteins: central players in development and disease","volume":"26","author":"Anholt","year":"2014","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jare.2025.04.043_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110028","article-title":"The role of the extracellular matrix protein TGFBI in cancer","volume":"84","author":"Corona","year":"2021","journal-title":"Cell Signal"},{"issue":"15","key":"10.1016\/j.jare.2025.04.043_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158034","article-title":"Novel insight in idiopathic normal pressure hydrocephalus (iNPH) biomarker discovery in CSF","volume":"22","author":"Torretta","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.04.043_b0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12987-021-00256-1","article-title":"Lumbar and ventricular CSF concentrations of extracellular matrix proteins before and after shunt surgery in idiopathic normal pressure hydrocephalus","volume":"18","author":"Minta","year":"2021","journal-title":"Fluids Barriers CNS"},{"issue":"5","key":"10.1016\/j.jare.2025.04.043_b0255","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1080\/15513815.2021.1982091","article-title":"B4GAT1 gene associated congenital muscular dystrophy presenting with recurrent severe ventriculomegaly: case report and review of literature","volume":"41","author":"Lallar","year":"2022","journal-title":"Fetal Pediatr Pathol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225002875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:46:51Z","timestamp":1769824011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225002875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"alternative-id":["S2090123225002875"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.043","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.04.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}