{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:13:39Z","timestamp":1788866019556,"version":"build-2803163510"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62072441"],"award-info":[{"award-number":["62072441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172240"],"award-info":[{"award-number":["82172240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32241028"],"award-info":[{"award-number":["32241028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61932018"],"award-info":[{"award-number":["61932018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070329"],"award-info":[{"award-number":["82070329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82025001"],"award-info":[{"award-number":["82025001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32241027"],"award-info":[{"award-number":["32241027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170456"],"award-info":[{"award-number":["82170456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170521"],"award-info":[{"award-number":["82170521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92469111"],"award-info":[{"award-number":["92469111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2025.05.013","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T19:31:51Z","timestamp":1746905511000},"page":"743-758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations"],"prefix":"10.1016","volume":"80","author":[{"given":"Wenliang","family":"Che","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasuer","family":"Alifu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zesong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-Fang","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.05.013_b0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41586-020-2179-y","article-title":"Structural basis of receptor recognition by SARS-CoV-2","volume":"581","author":"Shang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.05.013_b0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s41065-020-00168-4","article-title":"Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes","volume":"158","author":"Yang","year":"2021","journal-title":"Hereditas"},{"key":"10.1016\/j.jare.2025.05.013_b0015","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1001\/jamacardio.2020.3551","article-title":"Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases","volume":"5","author":"Lindner","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jare.2025.05.013_b0020","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3390\/biomedicines8120626","article-title":"Evidence of SARS-CoV-2 transcriptional activity in cardiomyocytes of COVID-19 patients without clinical signs of cardiac involvement","volume":"8","author":"Bulfamante","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.jare.2025.05.013_b0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijid.2021.08.015","article-title":"SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case","volume":"111","author":"Nakamura","year":"2021","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jare.2025.05.013_b0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2025.05.013_b0035","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/jamacardio.2020.1017","article-title":"Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19)","volume":"5","author":"Guo","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jare.2025.05.013_b0040","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"Jama"},{"key":"10.1016\/j.jare.2025.05.013_b0045","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.05.013_b0050","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41591-021-01283-z","article-title":"Post-acute COVID-19 syndrome","volume":"27","author":"Nalbandian","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.05.013_b0055","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0140-6736(22)01214-4","article-title":"Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study","volume":"400","author":"Ballering","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2025.05.013_b0060","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1161\/ATVBAHA.124.321001","article-title":"COVID-19 is a coronary artery disease risk equivalent and exhibits a genetic interaction with ABO blood type","volume":"44","author":"Hilser","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0065","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000001290","article-title":"Cardiac arrhythmias and autonomic dysfunction associated with COVID-19: a scientific statement from the American Heart Association","author":"Gopinathannair","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jare.2025.05.013_b0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41541-022-00526-5","article-title":"Association between BNT162b2 vaccination and reported incidence of post-COVID-19 symptoms: cross-sectional study 2020-21, Israel","volume":"7","author":"Kuodi","year":"2022","journal-title":"NPJ Vacc"},{"key":"10.1016\/j.jare.2025.05.013_b0075","article-title":"Cardiovascular disease and covid-19: A systematic review","volume":"54","author":"Krishna","year":"2024","journal-title":"Int J Cardiol Heart Vasc"},{"key":"10.1016\/j.jare.2025.05.013_b0080","doi-asserted-by":"crossref","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","article-title":"UniProt: the universal protein knowledgebase in 2023","volume":"51","author":"The UniProt Consortium","year":"2023","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.jare.2025.05.013_b0085","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/btu031","article-title":"InterProScan 5: genome-scale protein function classification","volume":"30","author":"Jones","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jare.2025.05.013_b0090","doi-asserted-by":"crossref","first-page":"D261","DOI":"10.1093\/nar\/gku1223","article-title":"Expanded microbial genome coverage and improved protein family annotation in the COG database","volume":"43","author":"Galperin","year":"2015","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.jare.2025.05.013_b0095","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.jare.2025.05.013_b0100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/jcp.2005.026443","article-title":"An approach to endomyocardial biopsy interpretation","volume":"59","author":"Cunningham","year":"2006","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jare.2025.05.013_b0105","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1038\/s41598-019-40250-0","article-title":"Myocardial lipofuscin accumulation in ageing and sudden cardiac death","volume":"9","author":"Kakimoto","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.05.013_b0110","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/1074248417725058","article-title":"Carvedilol inhibits matrix metalloproteinase-2 activation in experimental autoimmune myocarditis: possibilities of cardioprotective application","volume":"23","author":"Skrzypiec-Spring","year":"2018","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.jare.2025.05.013_b0115","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3390\/biom11101415","article-title":"HMG-CoA reductase inhibitor, simvastatin is effective in decreasing degree of myocarditis by inhibiting metalloproteinases activation","volume":"11","author":"Skrzypiec-Spring","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jare.2025.05.013_b0120","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0140-6736(11)60648-X","article-title":"Myocarditis","volume":"379","author":"Sagar","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2025.05.013_b0125","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.3390\/cimb45070385","article-title":"Structural analysis of mitochondria in cardiomyocytes: insights into bioenergetics and membrane remodeling","author":"Adams","year":"2023","journal-title":"Curr Issues Mole Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00428668","article-title":"Ultrastructural morphometric study on the rat heart after chronic ethanol feeding","volume":"389","author":"Mall","year":"1980","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"10.1016\/j.jare.2025.05.013_b0135","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1134\/S0006297915050132","article-title":"Morphometric examination of mitochondrial ultrastructure in aging cardiomyocytes","volume":"80","author":"El'darov","year":"2015","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.jare.2025.05.013_b0140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tice.2018.09.006","article-title":"Volume microscopy in biology: FIB-SEM tomography","volume":"57","author":"Kizilyaprak","year":"2019","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jare.2025.05.013_b0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s43586-022-00131-9","article-title":"Volume electron microscopy","volume":"2","author":"Peddie","year":"2022","journal-title":"Nat Rev Methods Primers"},{"key":"10.1016\/j.jare.2025.05.013_b0150","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/d41586-023-00178-y","article-title":"Seven technologies to watch in 2023","volume":"613","author":"Eisenstein","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.05.013_b0155","article-title":"MitoStructSeg: a comprehensive platform for mitochondrial structure segmentation and analysis","volume":"2024","author":"Wang","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.jare.2025.05.013_b0160","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s11684-022-0981-7","article-title":"Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn\/winter 2022 COVID-19 wave in Chinese mainland","volume":"17","author":"Lu","year":"2023","journal-title":"Front Med"},{"key":"10.1016\/j.jare.2025.05.013_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172084","article-title":"In vivo T2* weighted MRI visualizes cardiac lesions in murine models of acute and chronic viral myocarditis","volume":"12","author":"Helluy","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.05.013_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110091","article-title":"MG-132 attenuates cardiac deterioration of viral myocarditis via AMPK pathway","volume":"126","author":"Zhang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2025.05.013_b0175","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.1127895","article-title":"Evolution of the molecular machines for protein import into mitochondria","volume":"313","author":"Dolezal","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.05.013_b0180","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/348605a0","article-title":"A yeast mitochondrial outer membrane protein essential for protein import and cell viability","volume":"348","author":"Baker","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.05.013_b0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014507","article-title":"Mitochondrial function is required for secretion of DAF-28\/insulin in C. elegans","volume":"6","author":"Billing","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.05.013_b0190","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/j.bbadis.2017.07.031","article-title":"The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease","volume":"1863","author":"Zeitlow","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jare.2025.05.013_b0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0167-4889(02)00259-8","article-title":"Functions of outer membrane receptors in mitochondrial protein import","volume":"1592","author":"Endo","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jare.2025.05.013_b0200","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.124.5.637","article-title":"A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria","volume":"124","author":"Harkness","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0205","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe9403","article-title":"Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms","volume":"370","author":"Gordon","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.05.013_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tibs.2003.11.003","article-title":"The small Tim proteins and the twin Cx3C motif","volume":"29","author":"Koehler","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jare.2025.05.013_b0215","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jmb.2008.07.069","article-title":"The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23","volume":"382","author":"Beverly","year":"2008","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0220","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12967-023-04037-2","article-title":"Identification of Timm13 protein translocase of the mitochondrial inner membrane as a potential mediator of liver fibrosis based on bioinformatics and experimental verification","volume":"21","author":"Liao","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jare.2025.05.013_b0225","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.biocel.2009.12.024","article-title":"The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells","volume":"42","author":"Gallerne","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0230","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cell.2013.06.033","article-title":"Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation","volume":"154","author":"Qiu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jare.2025.05.013_b0235","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.1074\/jbc.M413816200","article-title":"Dissection of the mitochondrial import and assembly pathway for human Tom40","volume":"280","author":"Humphries","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2025.05.013_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.748156","article-title":"Samm50 promotes hypertrophy by regulating Pink1-dependent mitophagy signaling in neonatal cardiomyocytes","volume":"8","author":"Xu","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jare.2025.05.013_b0245","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31293","article-title":"Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes","volume":"239","author":"Shao","year":"2024","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jare.2025.05.013_b0250","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/1873-3468.12170","article-title":"SAMM50 affects mitochondrial morphology through the association of Drp1 in mammalian cells","volume":"590","author":"Liu","year":"2016","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jare.2025.05.013_b0255","doi-asserted-by":"crossref","first-page":"16064","DOI":"10.1038\/srep16064","article-title":"Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure","volume":"5","author":"Ding","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.05.013_b0260","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1128\/MCB.06388-11","article-title":"Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes","volume":"32","author":"Ott","year":"2012","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120213","article-title":"Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits","volume":"10","author":"Ott","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.05.013_b0270","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1091230","article-title":"ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease","volume":"304","author":"Lustbader","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.05.013_b0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/emmm.200900055","article-title":"A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival","volume":"2","author":"Rauschenberger","year":"2010","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jare.2025.05.013_b0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005779","article-title":"MPV17 loss causes deoxynucleotide insufficiency and slow DNA replication in mitochondria","volume":"12","author":"Dalla Rosa","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jare.2025.05.013_b0285","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1002\/j.1460-2075.1994.tb06842.x","article-title":"The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species","volume":"13","author":"Zwacka","year":"1994","journal-title":"Embo J"},{"key":"10.1016\/j.jare.2025.05.013_b0290","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/hmg\/ddn309","article-title":"Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice","volume":"18","author":"Viscomi","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jare.2025.05.013_b0295","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/hmg\/ddp581","article-title":"Sym1, the yeast ortholog of the MPV17 human disease protein, is a stress-induced bioenergetic and morphogenetic mitochondrial modulator","volume":"19","author":"Dallabona","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jare.2025.05.013_b0300","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41420-021-00630-w","article-title":"Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish","volume":"7","author":"Bian","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jare.2025.05.013_b0305","doi-asserted-by":"crossref","first-page":"24726","DOI":"10.1074\/jbc.274.35.24726","article-title":"Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform","volume":"274","author":"Petrakis","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2025.05.013_b0310","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/hmg\/6.6.935","article-title":"Molecular mechanisms in mitochondrial DNA depletion syndrome","volume":"6","author":"Taanman","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jare.2025.05.013_b0315","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1053\/jhep.2001.27664","article-title":"The hepatic mitochondrial DNA depletion syndrome: ultrastructural changes in liver biopsies","volume":"34","author":"Mandel","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jare.2025.05.013_b0320","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/adc.2008.139584","article-title":"Simultaneous detection of mitochondrial DNA depletion and single-exon deletion in the deoxyguanosine gene using array-based comparative genomic hybridisation","volume":"94","author":"Lee","year":"2009","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jare.2025.05.013_b0325","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41556-025-01620-1","article-title":"In situ architecture of the human prohibitin complex","volume":"27","author":"Lange","year":"2025","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0330","doi-asserted-by":"crossref","DOI":"10.3390\/cells8010071","article-title":"Prohibitins: a critical role in mitochondrial functions and implication in diseases","volume":"8","author":"Signorile","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jare.2025.05.013_b0335","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1101\/gad.460708","article-title":"Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria","volume":"22","author":"Merkwirth","year":"2008","journal-title":"Genes Dev"},{"key":"10.1016\/j.jare.2025.05.013_b0340","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12192-008-0086-5","article-title":"Prohibitin protects against oxidative stress-induced cell injury in cultured neonatal cardiomyocyte","volume":"14","author":"Liu","year":"2009","journal-title":"Cell Stress Chaperon"},{"key":"10.1016\/j.jare.2025.05.013_b0345","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019877","article-title":"Prohibitin-1 is a dynamically regulated blood protein with cardioprotective effects in sepsis","volume":"10","author":"Mattox","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jare.2025.05.013_b0350","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41598-022-26775-x","article-title":"Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy","volume":"13","author":"Alula","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.05.013_b0355","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2014.04.016","article-title":"DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling","volume":"20","author":"Richter-Dennerlein","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2025.05.013_b0360","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1126\/science.1175145","article-title":"Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+\/H+ antiporter","volume":"326","author":"Jiang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.05.013_b0365","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1242\/jcs.026625","article-title":"Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L","volume":"121","author":"Tamai","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jare.2025.05.013_b0370","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41580-021-00415-0","article-title":"The assembly, regulation and function of the mitochondrial respiratory chain","volume":"23","author":"Vercellino","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0375","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1046\/j.1432-1327.2000.01701.x","article-title":"Physiological functions of thioredoxin and thioredoxin reductase","volume":"267","author":"Arn\u00e9r","year":"2000","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jare.2025.05.013_b0380","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1128\/MCB.24.21.9414-9423.2004","article-title":"Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function","volume":"24","author":"Conrad","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0385","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-981-13-6260-6_15","article-title":"Aldehyde dehydrogenase 2 (ALDH2) and aging: is there a sensible link?","volume":"1193","author":"Wu","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0390","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12931-017-0554-5","article-title":"Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung","volume":"18","author":"Kuroda","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.jare.2025.05.013_b0395","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/jcp.25294","article-title":"Expression of muscle-specific ribosomal protein L3-like impairs Myotube growth","volume":"231","author":"Chaillou","year":"2016","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jare.2025.05.013_b0400","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.3390\/v13112263","article-title":"Common laboratory mice are susceptible to infection with the SARS-CoV-2 beta variant","volume":"13","author":"Kant","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jare.2025.05.013_b0405","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41421-022-00509-9","article-title":"Biparatopic antibody BA7208\/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5","volume":"9","author":"Wang","year":"2023","journal-title":"Cell Discov"},{"key":"10.1016\/j.jare.2025.05.013_b0410","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41392-022-00930-2","article-title":"Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jare.2025.05.013_b0415","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28846","article-title":"SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB\/c mice with severe lung histopathological damage","volume":"95","author":"Yu","year":"2023","journal-title":"J Med Virol"},{"key":"10.1016\/j.jare.2025.05.013_b0420","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41392-021-00747-5","article-title":"SARS-CoV-2 leads to myocardial injury in rhesus macaque","volume":"6","author":"Feng","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jare.2025.05.013_b0425","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1007\/s00392-021-01910-2","article-title":"SARS-CoV-2, myocardial injury and inflammation: insights from a large clinical and autopsy study","volume":"110","author":"Dal Ferro","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jare.2025.05.013_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2023.105636","article-title":"SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril","volume":"215","author":"Huang","year":"2023","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jare.2025.05.013_b0435","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41392-023-01368-w","article-title":"SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy","volume":"8","author":"Liang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jare.2025.05.013_b0440","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3390\/ijms26031367","article-title":"Impact of African-specific ACE2 polymorphisms on omicron BA.4\/5 RBD binding and allosteric communication within the ACE2-RBD protein complex","volume":"26","author":"Barozi","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.05.013_b0445","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.jacc.2022.02.003","volume":"79","author":"Gluckman","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jare.2025.05.013_b0450","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ejhf.2190","article-title":"Heart failure association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy","volume":"23","author":"Seferovi\u0107","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jare.2025.05.013_b0455","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1186\/s12967-023-04787-z","article-title":"Landscape of molecular crosstalk between SARS-CoV-2 infection and cardiovascular diseases: emphasis on mitochondrial dysfunction and immune-inflammation","volume":"21","author":"Dai","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jare.2025.05.013_b0460","first-page":"335","article-title":"Electron microscopic observation of human hypertrophied myocardium","volume":"23","author":"Kajihara","year":"1973","journal-title":"Acta Pathol Jpn"},{"key":"10.1016\/j.jare.2025.05.013_b0465","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1083\/jcb.16.3.611","article-title":"The ultrastructure of isolated and in situ human cardiac age pigment","volume":"16","author":"Malkoff","year":"1963","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jare.2025.05.013_b0470","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1046\/j.1432-1033.2002.02869.x","article-title":"The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis","volume":"269","author":"Brunk","year":"2002","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jare.2025.05.013_b0475","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq1533","article-title":"Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts","volume":"15","author":"Guarnieri","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jare.2025.05.013_b0480","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/jamacardio.2020.2136","article-title":"A game plan for the resumption of sport and exercise after coronavirus disease 2019 (COVID-19) infection","volume":"5","author":"Phelan","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jare.2025.05.013_b0485","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.jacc.2015.09.035","volume":"66","author":"Maron","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jare.2025.05.013_b0490","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/bmb\/ldad016","article-title":"Long COVID: what is known and what gaps need to be addressed","volume":"147","author":"Krishna","year":"2023","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jare.2025.05.013_b0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101019","article-title":"Characterizing long COVID in an international cohort: 7 months of symptoms and their impact","volume":"38","author":"Davis","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jare.2025.05.013_b0500","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/ene.15721","article-title":"Functional neurological disorder in people with long COVID: A systematic review","volume":"30","author":"Teodoro","year":"2023","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jare.2025.05.013_b0505","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41581-021-00487-3","article-title":"Long COVID and kidney disease","volume":"17","author":"Yende","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jare.2025.05.013_b0510","doi-asserted-by":"crossref","first-page":"485","DOI":"10.5501\/wjv.v11.i6.485","article-title":"Musculoskeletal complications in long COVID-19: A systematic review","volume":"11","author":"Swarnakar","year":"2022","journal-title":"World J Virol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225003066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225003066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:16:32Z","timestamp":1769822192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225003066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":102,"alternative-id":["S2090123225003066"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.013","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.08.18.24311961","asserted-by":"object"}]},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}