{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:28:51Z","timestamp":1791804531480,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515012002"],"award-info":[{"award-number":["2024A1515012002"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102520"],"award-info":[{"award-number":["82102520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071341"],"award-info":[{"award-number":["32071341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52202358"],"award-info":[{"award-number":["52202358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202741"],"award-info":[{"award-number":["82202741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2025.05.025","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T19:18:45Z","timestamp":1747163925000},"page":"411-422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of Notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1\/Akt signaling"],"prefix":"10.1016","volume":"80","author":[{"given":"Bizhi","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongcheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuzhi","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.jare.2025.05.025_b0005","doi-asserted-by":"crossref","first-page":"16773","DOI":"10.1039\/D3RA01700A","article-title":"Self-healing hydrogels for bone defect repair","volume":"13","author":"Li","year":"2023","journal-title":"RSC Adv"},{"key":"10.1016\/j.jare.2025.05.025_b0010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.actbio.2023.12.014","article-title":"Biocompatibility and osteogenic potential of choline phosphate chitosan coated biodegradable Zn1Mg","volume":"175","author":"Zhong","year":"2024","journal-title":"Acta Biomater"},{"issue":"10","key":"10.1016\/j.jare.2025.05.025_b0015","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41551-021-00810-0","article-title":"Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity","volume":"6","author":"Freedman","year":"2022","journal-title":"Nat Biomed Eng"},{"issue":"11","key":"10.1016\/j.jare.2025.05.025_b0020","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.3390\/ma16114117","article-title":"Bone grafts in dental medicine: an overview of autografts, allografts and synthetic materials","volume":"16","author":"Ferraz","year":"2023","journal-title":"Materials (Basel)"},{"issue":"23","key":"10.1016\/j.jare.2025.05.025_b0025","article-title":"Aptamer-functionalized hydrogels promote bone healing by selectively recruiting endogenous bone marrow mesenchymal stem cells","volume":"7","author":"Gong","year":"2023","journal-title":"Mater Today Biol"},{"issue":"14","key":"10.1016\/j.jare.2025.05.025_b0030","doi-asserted-by":"crossref","first-page":"17543","DOI":"10.1021\/acsami.2c23107","article-title":"Drug-delivery nanoplatform with synergistic regulation of angiogenesis-osteogenesis coupling for promoting vascularized bone regeneration","volume":"15","author":"Li","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jare.2025.05.025_b0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-981-15-3262-7_3","article-title":"Injectable in situ-forming hydrogels for protein and peptide delivery","volume":"1250","author":"Park","year":"2020","journal-title":"Adv Exp Med Biol"},{"issue":"18","key":"10.1016\/j.jare.2025.05.025_b0040","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1039\/D4MH00398E","article-title":"Injectable hydrogels for bone regeneration with tunable degradability via peptide chirality modification","volume":"11","author":"Chen","year":"2024","journal-title":"Mater Horiz"},{"issue":"12","key":"10.1016\/j.jare.2025.05.025_b0045","first-page":"327","article-title":"Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering","volume":"26","author":"Xue","year":"2021","journal-title":"Bioact Mater"},{"issue":"2","key":"10.1016\/j.jare.2025.05.025_b0050","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1039\/D0NR07406C","article-title":"Injectable, self-healing mesoporous silica nanocomposite hydrogels with improved mechanical properties","volume":"13","author":"Zengin","year":"2021","journal-title":"Nanoscale"},{"issue":"307","key":"10.1016\/j.jare.2025.05.025_b0055","article-title":"High-stretchable, self-healing, self-adhesive, self-extinguishing, low-temperature tolerant starch-based gel and its application in stimuli-responsiveness","volume":"1","author":"Zhao","year":"2023","journal-title":"Carbohydr Polym"},{"issue":"21","key":"10.1016\/j.jare.2025.05.025_b0060","first-page":"97","article-title":"Black phosphorus nanosheets-enabled DNA hydrogel integrating 3D-printed scaffold for promoting vascularized bone regeneration","volume":"17","author":"Miao","year":"2022","journal-title":"Bioact Mater"},{"issue":"11","key":"10.1016\/j.jare.2025.05.025_b0065","first-page":"641","article-title":"Notoginsenoside R1: A systematic review of its pharmacological properties","volume":"74","author":"Guo","year":"2019","journal-title":"Pharmazie"},{"issue":"6","key":"10.1016\/j.jare.2025.05.025_b0070","first-page":"6012","article-title":"Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats","volume":"14","author":"Zou","year":"2017","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.jare.2025.05.025_b0075","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1080\/21691401.2019.1671434","article-title":"Notoginsenoside R1 alleviates high glucose-evoked damage in RSC96 cells through down-regulation of miR-503","volume":"47","author":"Wang","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"2020","key":"10.1016\/j.jare.2025.05.025_b0080","article-title":"Panax notoginseng saponins prevent bone loss by promoting angiogenesis in an osteoporotic mouse model","volume":"14","author":"Hu","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jare.2025.05.025_b0085","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.intimp.2017.03.018","article-title":"Notoginsenoside R1 suppresses wear particle-induced osteolysis and RANKL mediated osteoclastogenesis in vivo and in vitro","volume":"47","author":"Zhao","year":"2017","journal-title":"Int Immunopharmacol"},{"issue":"16","key":"10.1016\/j.jare.2025.05.025_b0090","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.2147\/DDDT.S387004","article-title":"Notoginsenoside R1 promotes proliferation and osteogenic differentiation of hPDLSCs via Wnt\/\u03b2-catenin signaling pathway","volume":"23","author":"Han","year":"2022","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"10.1016\/j.jare.2025.05.025_b0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/iep.12494","article-title":"Notoginsenoside R1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ER\u03b1\/GSK-3\u03b2\/\u03b2-catenin signalling pathway","volume":"105","author":"Lu","year":"2024","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.jare.2025.05.025_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153302","article-title":"Notoginsenoside R1 activates the Ang2\/Tie2 pathway to promote angiogenesis","volume":"78","author":"Zhong","year":"2020","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jare.2025.05.025_b0105","article-title":"Double-network DNA macroporous hydrogel enables aptamer-directed cell recruitment to accelerate bone healing","volume":"11","author":"Miao","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"6","key":"10.1016\/j.jare.2025.05.025_b0110","first-page":"1839","article-title":"Simultaneous incorporation of PTH (1-34) and nano-hydroxyapatite into Chitosan\/Alginate Hydrogels for efficient bone regeneration","volume":"6","author":"Zou","year":"2020","journal-title":"Bioact Mater"},{"issue":"122","key":"10.1016\/j.jare.2025.05.025_b0115","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.actbio.2020.12.031","article-title":"Notoginsenoside R1 functionalized gelatin hydrogels to promote reparative dentinogenesis","volume":"1","author":"Wang","year":"2021","journal-title":"Acta Biomater"},{"issue":"9","key":"10.1016\/j.jare.2025.05.025_b0120","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.2147\/IJN.S72555","article-title":"Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration","volume":"1","author":"Cai","year":"2014","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"10.1016\/j.jare.2025.05.025_b0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41368-021-00132-6","article-title":"Construction of hollow polydopamine nanoparticle-based drug sustainable release system and its application in bone regeneration","volume":"13","author":"Wang","year":"2021","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.jare.2025.05.025_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110470","article-title":"Anti-ischemia\/reperfusion injury effects of notoginsenoside R1 on small molecule metabolism in rat brain after ischemic stroke as visualized by MALDI-MS imaging","volume":"129","author":"Zhu","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"10.1016\/j.jare.2025.05.025_b0135","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/jcb.30344","article-title":"Molecular mechanism of VEGF and its role in pathological angiogenesis","volume":"123","author":"Ahmad","year":"2022","journal-title":"J Cell Biochem"},{"issue":"2","key":"10.1016\/j.jare.2025.05.025_b0140","first-page":"455","article-title":"Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis","volume":"59","author":"Melincovici","year":"2018","journal-title":"Rom J Morphol Embryol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.025_b0145","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1186\/s12967-022-03841-6","article-title":"KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation","volume":"20","author":"Jia","year":"2022","journal-title":"J Transl Med"},{"issue":"3","key":"10.1016\/j.jare.2025.05.025_b0150","article-title":"Controllable adaptive molybdate-oligosaccharide nanoparticles regulate M2 macrophage mitochondrial function and promote angiogenesis via PI3K\/HIF-1\u03b1\/VEGF pathway to accelerate diabetic wound healing","volume":"13","author":"Huang","year":"2024","journal-title":"Adv Healthc Mater"},{"issue":"5","key":"10.1016\/j.jare.2025.05.025_b0155","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3390\/pharmaceutics15051334","article-title":"Hydrogel drug delivery systems for bone regeneration","volume":"15","author":"Bai","year":"2023","journal-title":"Pharmaceutics"},{"issue":"Pt 1","key":"10.1016\/j.jare.2025.05.025_b0160","article-title":"Programmed release of vascular endothelial growth factor and exosome from injectable chitosan nanofibrous microsphere-based PLGA-PEG-PLGA hydrogel for enhanced bone regeneration","volume":"253","author":"Han","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jare.2025.05.025_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2024.213848","article-title":"A composite hydrogel loaded with the processed pyritum promotes bone repair via stimulate the osteogenic differentiation of BMSCs","volume":"160","author":"Zhu","year":"2024","journal-title":"Biomater Adv"},{"issue":"149","key":"10.1016\/j.jare.2025.05.025_b0170","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.actbio.2022.07.014","article-title":"Robust coupling of angiogenesis and osteogenesis by VEGF-decorated matrices for bone regeneration","volume":"1","author":"Burger","year":"2022","journal-title":"Acta Biomater"},{"issue":"884","key":"10.1016\/j.jare.2025.05.025_b0175","article-title":"Salidroside improves angiogenesis-osteogenesis coupling by regulating the HIF-1\u03b1\/VEGF signalling pathway in the bone environment","volume":"5","author":"Guo","year":"2020","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"10.1016\/j.jare.2025.05.025_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003537","article-title":"Osteoclasts control osteoblast chemotaxis via PDGF-BB\/PDGF receptor beta signaling","volume":"3","author":"Sanchez-Fernandez","year":"2008","journal-title":"PLoS One"},{"issue":"7492","key":"10.1016\/j.jare.2025.05.025_b0185","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.jare.2025.05.025_b0190","article-title":"Recent advancement in vascularized tissue-engineered bone based on materials design and modification","volume":"11","author":"Liu","year":"2023","journal-title":"Mater Today Biol"},{"issue":"8","key":"10.1016\/j.jare.2025.05.025_b0195","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ajpath.2019.05.005","article-title":"Notch Signaling in Osteogenesis, Osteoclastogenesis, and Angiogenesis","volume":"189","author":"Luo","year":"2019","journal-title":"Am J Pathol"},{"issue":"7492","key":"10.1016\/j.jare.2025.05.025_b0200","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature13146","article-title":"Endothelial Notch activity promotes angiogenesis and osteogenesis in bone","volume":"507","author":"Ramasamy","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jare.2025.05.025_b0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12032-016-0747-7","article-title":"Notch-1 signaling activates NF-\u03baB in human breast carcinoma MDA-MB-231 cells via PP2A-dependent AKT pathway","volume":"33","author":"Li","year":"2016","journal-title":"Med Oncol"},{"key":"10.1016\/j.jare.2025.05.025_b0210","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2018.09.031","article-title":"Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells","volume":"440\u2013441","author":"Xiao","year":"2019","journal-title":"Cancer Lett"},{"issue":"8","key":"10.1016\/j.jare.2025.05.025_b0215","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/onc.2016.275","article-title":"DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia","volume":"36","author":"Hu","year":"2017","journal-title":"Oncogene"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225003431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225003431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:37:48Z","timestamp":1769805468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225003431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":43,"alternative-id":["S2090123225003431"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.025","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of Notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1\/Akt signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}