{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:22:32Z","timestamp":1793247752269,"version":"4.5.0"},"reference-count":262,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018607","name":"Henan Province Science and Technology Innovation Talent Program","doi-asserted-by":"publisher","award":["SYLYC2023092"],"award-info":[{"award-number":["SYLYC2023092"]}],"id":[{"id":"10.13039\/501100018607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32161143021"],"award-info":[{"award-number":["32161143021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271410"],"award-info":[{"award-number":["81271410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Henan Province Natural Science Foundation","doi-asserted-by":"publisher","award":["182300410313"],"award-info":[{"award-number":["182300410313"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2025.05.034","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T19:21:28Z","timestamp":1747423288000},"page":"451-474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Beyond the Brain: Exploring the multi-organ axes in Parkinson\u2019s disease pathogenesis"],"prefix":"10.1016","volume":"80","author":[{"given":"Tingting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0005","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3390\/ijms25021131","article-title":"Dopamine Signaling in Substantia Nigra and Its Impact on Locomotor Function-Not a New Concept, but Neglected Reality","volume":"25","author":"Salvatore","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0010","article-title":"Deciphering the Roles of Metformin in Alzheimer's Disease: A Snapshot","volume":"27","author":"Liao","year":"2022","journal-title":"Front Pharmacol"},{"issue":"14","key":"10.1016\/j.jare.2025.05.034_b0015","article-title":"Exploring the Pharmacological Potential of Metformin for Neurodegenerative Diseases","volume":"26","author":"Du","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"207","key":"10.1016\/j.jare.2025.05.034_b0020","article-title":"Exploring the dual character of metformin in Alzheimer's disease","volume":"1","author":"Ning","year":"2022","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b0025","doi-asserted-by":"crossref","first-page":"132","DOI":"10.31083\/j.jin2205132","article-title":"Pain in Parkinson's Disease: Pathophysiology, Classification and Treatment","volume":"22","author":"Cattaneo","year":"2023","journal-title":"J Integr Neurosci"},{"issue":"29","key":"10.1016\/j.jare.2025.05.034_b0030","doi-asserted-by":"crossref","first-page":"9816","DOI":"10.1080\/10408398.2022.2076064","article-title":"Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases","volume":"63","author":"Li","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jare.2025.05.034_b0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuint.2018.01.006","article-title":"Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model","volume":"114","author":"Wang","year":"2018","journal-title":"Neurochem Int"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b0040","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1474-4422(15)00007-1","article-title":"Gastrointestinal dysfunction in Parkinson's disease","volume":"14","author":"Fasano","year":"2015","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13024-018-0257-5","article-title":"Inoculation of \u03b1-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve","volume":"13","author":"Uemura","year":"2018","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jare.2025.05.034_b0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2016.08.019","article-title":"Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls","volume":"32","author":"Unger","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.jare.2025.05.034_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105744","article-title":"Evidence for immune system alterations in peripheral biological fluids in Parkinson's disease","volume":"170","author":"Bartl","year":"2022","journal-title":"Neurobiol Dis"},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b0060","article-title":"The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson's Disease: A Pilot Study","volume":"30","author":"Lu","year":"2021","journal-title":"Front Nutr"},{"issue":"24","key":"10.1016\/j.jare.2025.05.034_b0065","first-page":"00320","article-title":"The liver-brain axis in metabolic dysfunction-associated steatotic liver disease","volume":"S2468\u20131253","author":"Mikkelsen","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b0070","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.32604\/biocell.2024.051518","article-title":"The pathogenesis of parkinson\u2019s disease and crosstalk with other diseases","volume":"48","author":"Liu","year":"2024","journal-title":"Biocell"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0075","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3390\/ijms25021294","article-title":"From the Gut to the Brain: The Role of Enteric Glial Cells and Their Involvement in the Pathogenesis of Parkinson's Disease","volume":"25","author":"Montalb\u00e1n-Rodr\u00edguez","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b0080","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1039\/D1FO03888E","article-title":"Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut-brain axis","volume":"13","author":"Xia","year":"2022","journal-title":"Food Funct"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0085","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1158\/0008-5472.CAN-19-3184","article-title":"Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor Macrophages","volume":"80","author":"Liu","year":"2020","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0090","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.immuni.2022.12.017","article-title":"Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity","volume":"56","author":"Cao","year":"2023","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b0095","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/qjmed\/hcy154","article-title":"Neuroimmune regulation of lung infection and inflammation","volume":"112","author":"Huang","year":"2019","journal-title":"QJM"},{"issue":"16","key":"10.1016\/j.jare.2025.05.034_b0100","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2147\/COPD.S290363","article-title":"Neurological and Psychiatric Comorbidities in Chronic Obstructive Pulmonary Disease","volume":"3","author":"Puteikis","year":"2021","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.jare.2025.05.034_b0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cyto.2019.02.016","article-title":"The proinflammatory effects of chronic excessive exercise","volume":"119","author":"da Rocha","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.jare.2025.05.034_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.155903","article-title":"Pathological interplay of NF-\u03baB and M1 macrophages in chronic inflammatory lung diseases","volume":"269","author":"Alanazi","year":"2025","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.jare.2025.05.034_b0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jocn.2023.11.019","article-title":"Association of liver fibrosis with cognitive decline in Parkinson's disease","volume":"119","author":"Zolin","year":"2024","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.jare.2025.05.034_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105190","article-title":"Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain injuries","volume":"160","author":"D\u00e9saubry","year":"2020","journal-title":"Pharmacol Res"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0125","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.3390\/ijms22126479","article-title":"The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection","volume":"22","author":"Burtscher","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"23","key":"10.1016\/j.jare.2025.05.034_b0130","doi-asserted-by":"crossref","first-page":"12842","DOI":"10.3390\/ijms252312842","article-title":"Unraveling the Bone-Brain Axis: A New Frontier in Parkinson's Disease Research","volume":"25","author":"Liu","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.05.034_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106396","article-title":"Natural history of lung function over one year in patients with Parkinson's disease","volume":"182","author":"Kaminsky","year":"2021","journal-title":"Respir Med"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0140","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/jnnp.52.3.329","article-title":"Pulmonary function in Parkinson's disease","volume":"52","author":"Hovestadt","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0145","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-0037-1602839","article-title":"Longitudinal Changes in Speech Breathing in Older Adults with and without Parkinson's Disease","volume":"38","author":"Huber","year":"2017","journal-title":"Semin Speech Lang"},{"key":"10.1016\/j.jare.2025.05.034_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2024.107801","article-title":"Dyspnea in Parkinson's disease","author":"Jain","year":"2024","journal-title":"Respir Med"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b0155","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3390\/brainsci11050595","article-title":"Respiratory Dysfunctions in Parkinson's Disease Patients","volume":"11","author":"Docu Axelerad","year":"2021","journal-title":"Brain Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00455-015-9671-9","article-title":"Dysphagia in Parkinson's Disease","volume":"31","author":"Suttrup","year":"2016","journal-title":"Dysphagia"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0165","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/brainsci12020143","article-title":"Parkinson's Disease in Light of the COVID-19 Pandemic","volume":"12","author":"Drelich-Zbroja","year":"2022","journal-title":"Brain Sci"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0095-4543(21)00251-7","article-title":"Respiratory dysfunction in Parkinson's disease","volume":"4","author":"MacIntosh","year":"1977","journal-title":"Prim Care"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0175","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1378\/chest.124.3.1009","article-title":"Impaired efficacy of cough in patients with Parkinson disease","volume":"124","author":"Ebihara","year":"2003","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0180","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1164\/ajrccm\/138.2.266","article-title":"Respiratory muscle dysfunction in Parkinson's disease","volume":"138","author":"Tzelepis","year":"1988","journal-title":"Am Rev Respir Dis"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b0185","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00204-010-0525-9","article-title":"Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes","volume":"84","author":"Sriram","year":"2010","journal-title":"Arch Toxicol"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0190","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0272-5231(21)00964-3","article-title":"Respiratory dysfunction in Parkinson's disease. P","volume":"15","author":"Brown","year":"1994","journal-title":"Clin Chest Med"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0195","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13054-018-1979-z","article-title":"Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants","volume":"22","author":"Jansen","year":"2018","journal-title":"Crit Care"},{"issue":"1\u20133","key":"10.1016\/j.jare.2025.05.034_b0200","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejphar.2004.07.025","article-title":"Acetylcholine: a novel regulator of airway smooth muscle remodelling?","volume":"500","author":"Gosens","year":"2004","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0205","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1002\/jmv.28061","article-title":"Lung-brain axis: Metabolomics and pathological changes in lungs and brain of respiratory syncytial virus-infected mice","volume":"94","author":"Mao","year":"2022","journal-title":"J Med Virol"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0263021","article-title":"Microglia-secreted TNF-\u03b1 affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors","volume":"18","author":"Wenker","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.05.034_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105376","article-title":"The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies","volume":"158","author":"Amin","year":"2022","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jare.2025.05.034_b0220","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1749-6632.2000.tb05426.x","article-title":"Cytokine activation of the HPA axis","volume":"917","author":"Dunn","year":"2000","journal-title":"Ann N Y Acad Sci"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0225","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1023\/A:1020720722209","article-title":"Molecular mechanisms of actions of interleukin-6 on the brain, with special reference to serotonin and the hypothalamo-pituitary-adrenocortical axis","volume":"24","author":"Barkhudaryan","year":"1999","journal-title":"Neurochem Res"},{"issue":"11","key":"10.1016\/j.jare.2025.05.034_b0230","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/iub.1685","article-title":"6-Hydroxydopamine induces brain vascular endothelial inflammation","volume":"69","author":"Fu","year":"2017","journal-title":"IUBMB Life"},{"issue":"45","key":"10.1016\/j.jare.2025.05.034_b0235","article-title":"Lung Immune Cell Niches and the Discovery of New Cell Subtypes","volume":"11","author":"Shan","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0240","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s10571-022-01238-z","article-title":"Functional Two-Way Crosstalk Between Brain and Lung: The Brain-Lung Axis","volume":"43","author":"Li","year":"2023","journal-title":"Cell Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0245","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.4110\/in.2024.24.e20","article-title":"The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)","volume":"24","author":"Park","year":"2024","journal-title":"Immune Netw"},{"issue":"Pt 3","key":"10.1016\/j.jare.2025.05.034_b0250","article-title":"Peripheral (lung-to-brain) exposure to diesel particulate matter induces oxidative stress and increased markers for systemic inflammation","volume":"231","author":"Pradhan","year":"2023","journal-title":"Environ Res"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0255","doi-asserted-by":"crossref","first-page":"00165","DOI":"10.1183\/23120541.00165-2020","article-title":"Respiratory dysfunction in Parkinson's disease: a narrative review","volume":"6","author":"D'Arrigo","year":"2020","journal-title":"ERJ Open Res"},{"issue":"11","key":"10.1016\/j.jare.2025.05.034_b0260","doi-asserted-by":"crossref","first-page":"L962","DOI":"10.1152\/ajplung.00073.2014","article-title":"Mitochondria in lung biology and pathology: more than just a powerhouse","volume":"306","author":"Schumacker","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"Suppl 1","key":"10.1016\/j.jare.2025.05.034_b0265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/1440-1681.12764","article-title":"The mobility of mitochondria: Intercellular trafficking in health and disease","volume":"44","author":"Berridge","year":"2017","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"3\u20134","key":"10.1016\/j.jare.2025.05.034_b0270","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10495-022-01799-w","article-title":"Mild hypothermia alleviates oxygen-glucose deprivation\/reperfusion-induced apoptosis by inhibiting ROS generation, improving mitochondrial dysfunction and regulating DNA damage repair pathway in PC12 cells","volume":"28","author":"Zhou","year":"2023","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0275","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.brainresrev.2007.10.011","article-title":"Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?","volume":"57","author":"Morale","year":"2008","journal-title":"Brain Res Rev"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b0280","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1074\/jbc.M112.402123","article-title":"Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease","volume":"288","author":"Bajpai","year":"2013","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b0285","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/00207454.2017.1403916","article-title":"Prooxidant-antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease","volume":"128","author":"Mileti\u0107","year":"2018","journal-title":"Int J Neurosci"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0290","first-page":"63","article-title":"Correlation between Hypovitaminosis D and Nutritional Status with The Severity of Clinical Symptoms And Impaired Cognitive Function in Patients with Parkinson's Disease","volume":"30","author":"Lien","year":"2021","journal-title":"Acta Neurol Taiwan"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0295","article-title":"Iron status influences mitochondrial disease progression in Complex I-deficient mice","volume":"17","author":"Kelly","year":"2023","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0300","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s10646-023-02714-y","article-title":"Ecotoxicology of the herbicide paraquat: effects on wildlife and knowledge gaps","volume":"32","author":"Donaher","year":"2023","journal-title":"Ecotoxicology"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b0305","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1034\/j.1600-0773.2000.pto870608.x","article-title":"Hepatic disposition of neurotoxins and pesticides","volume":"87","author":"Yang","year":"2000","journal-title":"Pharmacol Toxicol"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0310","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0013-9351(03)00109-9","article-title":"Effect of manganese chloride exposure on liver and brain mitochondria function in rats","volume":"93","author":"Zhang","year":"2003","journal-title":"Environ Res"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0315","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/10715760290021270","article-title":"Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1)","volume":"36","author":"Chan","year":"2002","journal-title":"Free Radic Res"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0320","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF01797916","article-title":"Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease","volume":"14","author":"Williams","year":"1991","journal-title":"J Inherit Metab Dis"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0325","first-page":"187","article-title":"The detoxification enzyme systems","volume":"3","author":"Liska","year":"1998","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.jare.2025.05.034_b0330","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012\u2013. Levodopa. 2021 Oct 25."},{"key":"10.1016\/j.jare.2025.05.034_b0335","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012\u2013. Pergolide. 2017 Jul 20."},{"key":"10.1016\/j.jare.2025.05.034_b0340","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012\u2013. Ropinirole. 2017 Jul 21."},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0345","doi-asserted-by":"crossref","first-page":"19272","DOI":"10.1038\/s41598-023-44142-2","article-title":"Safety comparisons among monoamine oxidase inhibitors against Parkinson's disease using FDA adverse event reporting system","volume":"13","author":"Asano","year":"2023","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0350","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/j.1440-1746.2008.05456.x","article-title":"Uncoupling of sympathetic nervous system and hypothalamic-pituitary-adrenal axis in cirrhosis","volume":"23","author":"Wiest","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2025.05.034_b0355","series-title":"In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing","article-title":"Jul 10","author":"Willman","year":"2023"},{"key":"10.1016\/j.jare.2025.05.034_b0360","doi-asserted-by":"crossref","unstructured":"Fox SH, Katzenschlager R, Lim SY, Barton B, de Bie RMA, Seppi K, Coelho M, Sampaio C; Movement Disorder Society Evidence-Based Medicine Committee. International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson's disease. Mov Disord. 2018 Aug;33(8):1248-1266. doi: 10.1002\/mds.27372. Epub 2018 Mar 23. Erratum in: Mov Disord. 2018 Dec;33(12):1992.","DOI":"10.1002\/mds.27372"},{"key":"10.1016\/j.jare.2025.05.034_b0365","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012\u2013. Parkinson Disease Agents. 2021 Oct 25."},{"key":"10.1016\/j.jare.2025.05.034_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.therap.2018.02.004","article-title":"Safety data and withdrawal of hepatotoxic drugs","author":"Babai","year":"2021","journal-title":"Therapie"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0375","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4321\/S1130-01082012000400002","article-title":"Drug dosage recommendations in patients with chronic liver disease","volume":"104","author":"Peri\u00e1\u00f1ez-P\u00e1rraga","year":"2012","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.jare.2025.05.034_b0380","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012\u2013. Rotigotine. 2017 Jul 21."},{"key":"10.1016\/j.jare.2025.05.034_b0385","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012\u2013. Safinamide. 2019 Apr 8."},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b0390","article-title":"The Added Value of Patient Engagement in Early Dialogue at EMA: Scientific Advice as a Case Study","volume":"20","author":"Murphy","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jare.2025.05.034_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2024.103981","article-title":"Glutathione S-transferase: A keystone in Parkinson's disease pathogenesis and therapy","volume":"132","author":"Padhan","year":"2025","journal-title":"Mol Cell Neurosci"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0400","first-page":"1207","article-title":"The effect of low dose amphetamine in rotenone-induced toxicity in a mice model of Parkinson's disease","volume":"23","author":"Abdel-Salam","year":"2020","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0405","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1139\/y88-063","article-title":"Effects of 6-hydroxydopamine on oxidative phosphorylation of mitochondria from rat striatum, cortex, and liver","volume":"66","author":"Thakar","year":"1988","journal-title":"Can J Physiol Pharmacol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0410","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40478-021-01136-3","article-title":"Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease","volume":"9","author":"Reyes","year":"2021","journal-title":"Acta Neuropathol Commun"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0415","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.medcli.2024.04.022","article-title":"Parkinsonism in liver diseases or dysfunction","volume":"163","author":"Li","year":"2024","journal-title":"Med Clin (Barc)"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0420","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/1073858420943180","article-title":"\u03b1-Synuclein in Parkinson's Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role?","volume":"27","author":"Zheng","year":"2021","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jare.2025.05.034_b0425","doi-asserted-by":"crossref","DOI":"10.1067\/j.cpradiol.2015.03.004","article-title":"Neurologic Manifestations of Chronic Liver Disease and Liver Cirrhosis","author":"Sureka","year":"2015","journal-title":"Curr Probl Diagn Radiol"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b0430","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"361","key":"10.1016\/j.jare.2025.05.034_b0435","article-title":"The involvement of JAK\/STAT signaling pathway in the treatment of Parkinson's disease","volume":"15","author":"Lashgari","year":"2021","journal-title":"J Neuroimmunol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0440","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s43556-023-00151-1","article-title":"JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions","volume":"4","author":"Sarapultsev","year":"2023","journal-title":"Mol Biomed"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0445","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41575-018-0075-9","article-title":"Wnt-\u03b2-catenin signalling in liver development, health and disease","volume":"16","author":"Perugorria","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"13","key":"10.1016\/j.jare.2025.05.034_b0450","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-pathol-020117-044010","article-title":"Wnt\/\u03b2-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology","volume":"24","author":"Russell","year":"2018","journal-title":"Annu Rev Pathol"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0455","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13101","article-title":"Parkinson's disease, aging and adult neurogenesis: Wnt\/\u03b2-catenin signalling as the key to unlock the mystery of endogenous brain repair","volume":"19","author":"Marchetti","year":"2020","journal-title":"Aging Cell"},{"issue":"16","key":"10.1016\/j.jare.2025.05.034_b0460","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.3390\/ijms23169196","article-title":"mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease","volume":"23","author":"Feng","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12017-016-8417-7","article-title":"mTOR Signaling in Parkinson's Disease","volume":"19","author":"Lan","year":"2017","journal-title":"Neuromolecular Med"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b0470","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s11011-015-9747-0","article-title":"The concept of \u201cthe inflamed brain\u201d in acute liver failure: mechanisms and new therapeutic opportunities","volume":"31","author":"Butterworth","year":"2016","journal-title":"Metab Brain Dis"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0475","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13522","article-title":"\u03b1-synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease","volume":"20","author":"Tu","year":"2021","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b0480","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/jnc.12672","article-title":"Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons","volume":"129","author":"Shen","year":"2014","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0485","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12974-024-03125-4","article-title":"Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice","volume":"21","author":"Li","year":"2024","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0490","doi-asserted-by":"crossref","DOI":"10.1111\/gtc.13185","article-title":"Rapamycin Abrogates Aggregation of Human \u03b1-Synuclein Expressed in Fission Yeast via an Autophagy-Independent Mechanism","volume":"30","author":"Sugimoto","year":"2025","journal-title":"Genes Cells"},{"key":"10.1016\/j.jare.2025.05.034_b0495","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add0499","article-title":"Enhanced mTORC1 signaling and protein synthesis in pathologic \u03b1-synuclein cellular and animal models of Parkinson's disease","author":"Khan","year":"2023","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0500","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12883-024-03596-1","article-title":"Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol","volume":"24","author":"Svensson","year":"2024","journal-title":"BMC Neurol"},{"issue":"1\u20132","key":"10.1016\/j.jare.2025.05.034_b0505","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-510X(02)00079-5","article-title":"Abnormalities of rate-corrected QT intervals in Parkinson's disease-a comparison with multiple system atrophy and progressive supranuclear palsy","volume":"199","author":"Deguchi","year":"2002","journal-title":"J Neurol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0510","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/mds.27836","article-title":"Understanding the links between cardiovascular disease and Parkinson's disease","volume":"35","author":"Potashkin","year":"2020","journal-title":"Mov Disord"},{"key":"10.1016\/j.jare.2025.05.034_b0515","article-title":"Brain-heart axis\u2013Review Article","author":"Manea","year":"2015","journal-title":"J Med Life"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0520","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41531-022-00323-w","article-title":"Heart-brain synchronization breakdown in Parkinson's disease","volume":"8","author":"Iniguez","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0525","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/hrt.38.9.897","article-title":"'Incessant' tachycardias in Wolff-Parkinson-White syndrome. II: Role of atypical cycle length dependency and nodal-his escape beats in initiating reciprocating tachycardias","volume":"38","author":"Coumel","year":"1976","journal-title":"Br Heart J"},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b0530","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.parkreldis.2014.04.007","article-title":"Cardiovascular effects of levodopa in Parkinson's disease","volume":"20","author":"Noack","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0535","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3892\/br.2023.1607","article-title":"Parkinson's disease and cardiovascular involvement: Edifying insights (Review)","volume":"18","author":"Grosu","year":"2023","journal-title":"Biomed Rep"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b0540","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.acvd.2013.02.003","article-title":"Drug-induced valvular heart disease: an update","volume":"106","author":"Andrejak","year":"2013","journal-title":"Arch Cardiovasc Dis"},{"issue":"10","key":"10.1016\/j.jare.2025.05.034_b0545","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00702-024-02828-5","article-title":"Therapeutic drug monitoring in Parkinson's disease","volume":"131","author":"M\u00fcller","year":"2024","journal-title":"J Neural Transm (Vienna)"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0550","doi-asserted-by":"crossref","first-page":"H260","DOI":"10.1152\/ajpheart.01208.2006","article-title":"Calf venous compliance in multiple system atrophy","volume":"293","author":"Lipp","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"s1","key":"10.1016\/j.jare.2025.05.034_b0555","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.3233\/JPD-202036","article-title":"Management of Orthostatic Hypotension in Parkinson's Disease","volume":"10","author":"Fanciulli","year":"2020","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.jare.2025.05.034_b0560","doi-asserted-by":"crossref","DOI":"10.4103\/aian.aian_476_22","article-title":"Neurogenic Supine Hypertension and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease","author":"Kapoor","year":"2023","journal-title":"Ann Indian Acad Neurol"},{"issue":"22","key":"10.1016\/j.jare.2025.05.034_b0565","doi-asserted-by":"crossref","first-page":"12467","DOI":"10.3390\/ijms252212467","article-title":"Effect of Oxidative Stress on Mitochondrial Damage and Repair in Heart Disease and Ischemic Events","volume":"25","author":"Kowalczyk","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0570","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1532-0456(02)00116-3","article-title":"Brain antioxidant regulation in mammals and anoxia-tolerant reptiles: balanced for neuroprotection and neuromodulation","volume":"133","author":"Rice","year":"2002","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0575","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16110","article-title":"Parkinso\u0144s disease cardiovascular symptoms: A new complex functional and structural insight","volume":"31","author":"Kincl","year":"2024","journal-title":"Eur J Neurol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0580","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s11658-023-00491-4","article-title":"Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction","volume":"28","author":"Zuo","year":"2023","journal-title":"Cell Mol Biol Lett"},{"issue":"10","key":"10.1016\/j.jare.2025.05.034_b0585","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/s41593-024-01746-9","article-title":"VEGF-A-mediated venous endothelial cell proliferation results in neoangiogenesis during neuroinflammation","volume":"27","author":"Shahriar","year":"2024","journal-title":"Nat Neurosci"},{"issue":"10","key":"10.1016\/j.jare.2025.05.034_b0590","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/mds.28129","article-title":"Subclinical Cardiac Microdamage, Motor Severity, and Cognition in Parkinson's Disease","volume":"35","author":"Choe","year":"2020","journal-title":"Mov Disord"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0595","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bbrc.2006.09.034","article-title":"ANP inhibits LPS-induced stimulation of rat microglial cells by suppressing NF-kappaB and AP-1 activations","volume":"350","author":"Moriyama","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b0600","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/cells9040865","article-title":"Revisiting the Role of Neurotrophic Factors in Inflammation","volume":"9","author":"Morel","year":"2020","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.jare.2025.05.034_b0605","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.3390\/biomedicines12102387","article-title":"Cognitive Impairment and Synaptic Dysfunction in Cardiovascular Disorders: The New Frontiers of the Heart-Brain Axis","volume":"12","author":"Soda","year":"2024","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b0610","doi-asserted-by":"crossref","first-page":"H2264","DOI":"10.1152\/ajpheart.01072.2003","article-title":"Acute myocardial infarction induces hypothalamic cytokine synthesis","volume":"286","author":"Francis","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"15","key":"10.1016\/j.jare.2025.05.034_b0615","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases","volume":"25","author":"Wang","year":"2022","journal-title":"J Inflamm Res"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0620","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12974-021-02332-7","article-title":"Biologic TNF-\u03b1 inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy","volume":"18","author":"Ou","year":"2021","journal-title":"J Neuroinflammation"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b0625","doi-asserted-by":"crossref","DOI":"10.2174\/1573403X17666210202102210","article-title":"Atrial Natriuretic Peptide: Structure, Function, and Physiological Effects: A Narrative Review","volume":"17","author":"Rao","year":"2021","journal-title":"Curr Cardiol Rev"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b0630","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3390\/jcm9072265","article-title":"Natriuretic Peptides, Cognitive Impairment and Dementia: An Intriguing Pathogenic Link with Implications in Hypertension","volume":"9","author":"Gallo","year":"2020","journal-title":"J Clin Med"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0635","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"13","key":"10.1016\/j.jare.2025.05.034_b0640","article-title":"Role of Nrf2 in Parkinson's Disease: Toward New Perspectives","volume":"24","author":"Yang","year":"2022","journal-title":"Front Pharmacol"},{"issue":"Pt 3","key":"10.1016\/j.jare.2025.05.034_b0645","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/brain\/awm302","article-title":"Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease","volume":"131","author":"Orimo","year":"2008","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b0650","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1474-4422(20)30136-8","article-title":"Safety and immunogenicity of the \u03b1-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial","volume":"19","author":"Volc","year":"2020","journal-title":"Lancet Neurol"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b0655","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.4103\/1673-5374.387972","article-title":"A \u201cmessenger zone hypothesis\u201d based on the visual three-dimensional spatial distribution of motoneurons innervating deep limb muscles","volume":"19","author":"Huang","year":"2024","journal-title":"Neural Regen Res"},{"issue":"6695","key":"10.1016\/j.jare.2025.05.034_b0660","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1126\/science.adj8533","article-title":"Brain-muscle communication prevents muscle aging by maintaining daily physiology","volume":"384","author":"Kumar","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.05.034_b0665","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2024.105412","article-title":"Unveiling the muscle-brain axis: A bidirectional mendelian randomization study investigating the causal relationship between sarcopenia-related traits and brain aging","volume":"123","author":"Li","year":"2024","journal-title":"Arch Gerontol Geriatr"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0670","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.23736\/S0022-4707.20.10884-3","article-title":"Myokines: a descriptive review","volume":"60","author":"Barbalho","year":"2020","journal-title":"J Sports Med Phys Fitness"},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b0675","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat Rev Endocrinol"},{"issue":"4\u20136","key":"10.1016\/j.jare.2025.05.034_b0680","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.brainresbull.2007.03.010","article-title":"Muscle proprioceptive feedback and spinal networks","volume":"73","author":"Windhorst","year":"2007","journal-title":"Brain Res Bull"},{"issue":"197","key":"10.1016\/j.jare.2025.05.034_b0685","article-title":"How does the skeletal muscle communicate with the brain in health and disease?","volume":"1","author":"Isaac","year":"2021","journal-title":"Neuropharmacology"},{"issue":"357","key":"10.1016\/j.jare.2025.05.034_b0690","article-title":"Irisin's emerging role in Parkinson's disease research: A review from molecular mechanisms to therapeutic prospects","volume":"15","author":"Qiu","year":"2024","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0695","article-title":"Effects of nordic walking exercise on gait, motor\/non-motor symptoms, and serum brain-derived neurotrophic factor in individuals with Parkinson's disease","volume":"14","author":"Harro","year":"2022","journal-title":"Front Rehabil Sci"},{"key":"10.1016\/j.jare.2025.05.034_b0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.humov.2019.102513","article-title":"Gait, balance, mobility and muscle strength in people with anxiety compared to healthy individuals","volume":"67","author":"Feldman","year":"2019","journal-title":"Hum Mov Sci"},{"issue":"1\u20132","key":"10.1016\/j.jare.2025.05.034_b0705","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.mce.2006.03.017","article-title":"The p38 MAPK signaling pathway: a major regulator of skeletal muscle development","volume":"252","author":"Keren","year":"2006","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b0710","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ceca.2010.11.009","article-title":"Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation","volume":"49","author":"Wiegert","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jare.2025.05.034_b0715","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110906","article-title":"Aerobic exercise modulates the striatal Erk\/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease","volume":"209","author":"Zhou","year":"2024","journal-title":"Brain Res Bull"},{"issue":"310","key":"10.1016\/j.jare.2025.05.034_b0720","article-title":"Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model","volume":"1","author":"Sayed","year":"2022","journal-title":"Life Sci"},{"key":"10.1016\/j.jare.2025.05.034_b0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105807","article-title":"Skeletal muscle atrophy: From mechanisms to treatments","volume":"172","author":"Yin","year":"2021","journal-title":"Pharmacol Res"},{"issue":"10","key":"10.1016\/j.jare.2025.05.034_b0730","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fphys.2019.00500","article-title":"The JAK\/STAT Pathway in Skeletal Muscle Pathophysiology","volume":"30","author":"Moresi","year":"2019","journal-title":"Front Physiol"},{"issue":"230","key":"10.1016\/j.jare.2025.05.034_b0735","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.freeradbiomed.2025.01.053","article-title":"Skeletal muscle innervation: Reactive oxygen species as regulators of neuromuscular junction dynamics and motor unit remodeling","volume":"16","author":"Guzman","year":"2025","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0740","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.apsb.2024.10.004","article-title":"Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications","volume":"15","author":"Dash","year":"2025","journal-title":"Acta Pharm Sin B"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0745","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12640-017-9804-z","article-title":"Neuromelanin in Parkinson's Disease: from Fenton Reaction to Calcium Signaling","volume":"33","author":"Kn\u00f6rle","year":"2018","journal-title":"Neurotox Res"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0750","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2174\/1874467208666150507105105","article-title":"Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging","volume":"8","author":"Santulli","year":"2015","journal-title":"Curr Mol Pharmacol"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b0755","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/jcsm.13290","article-title":"Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy","volume":"14","author":"Zhang","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0760","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/JPD-225108","article-title":"Temporal Muscle Thickness Correlates with Sarcopenia in Parkinson's Disease","volume":"13","author":"Peball","year":"2023","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.jare.2025.05.034_b0765","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.freeradbiomed.2024.01.036","article-title":"Exercise couples mitochondrial function with skeletal muscle fiber type via ROS-mediated epigenetic modification","volume":"213","author":"Li","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0770","doi-asserted-by":"crossref","first-page":"C844","DOI":"10.1152\/ajpcell.00402.2005","article-title":"Type II skeletal myofibers possess unique properties that potentiate mitochondrial H(2)O(2) generation","volume":"290","author":"Anderson","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jare.2025.05.034_b0775","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108750","article-title":"Lycopene increases the proportion of slow-twitch muscle fiber by AMPK signaling to improve muscle anti-fatigue ability","volume":"94","author":"Wen","year":"2021","journal-title":"J Nutr Biochem"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0780","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1475-097X.2010.00973.x","article-title":"Higher proportion of fast-twitch (type II) muscle fibres in idiopathic inflammatory myopathies - evident in chronic but not in untreated newly diagnosed patients","volume":"31","author":"Loell","year":"2011","journal-title":"Clin Physiol Funct Imaging"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0785","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.3390\/biomedicines10123228","article-title":"Exercise-Boosted Mitochondrial Remodeling in Parkinson's Disease","volume":"10","author":"Maga\u00f1a","year":"2022","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b0790","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3389\/fpsyg.2016.00780","article-title":"Deficits in the Mimicry of Facial Expressions in Parkinson's Disease","volume":"7","author":"Livingstone","year":"2016","journal-title":"Front Psychol"},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b0795","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1007\/s00415-024-12488-w","article-title":"Neck rigidity: a pitfall for video head-impulse tests in Parkinson's disease","volume":"271","author":"Woo","year":"2024","journal-title":"J Neurol"},{"key":"10.1016\/j.jare.2025.05.034_b0800","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.parkreldis.2018.06.020","article-title":"Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson's disease","volume":"56","author":"Tan","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.jare.2025.05.034_b0805","doi-asserted-by":"crossref","unstructured":"Fujimoto K. Dropped head in Parkinson's disease. J Neurol. 2006 Dec;253 Suppl 7:VII21-26.","DOI":"10.1007\/s00415-006-7006-3"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0810","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/17446651.2020.1756772","article-title":"Parkinson's disease and osteoporosis: basic and clinical implications","volume":"15","author":"Figueroa","year":"2020","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"45","key":"10.1016\/j.jare.2025.05.034_b0815","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000040061","article-title":"Causal effects of Parkinson's disease on the risk of osteoporosis: A two-sample Mendelian randomization study","volume":"103","author":"Huang","year":"2024","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0820","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00296-008-0632-6","article-title":"Prevalence and risk factors of osteoporosis in patients with Parkinson's disease","volume":"28","author":"Bezza","year":"2008","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jare.2025.05.034_b0825","doi-asserted-by":"crossref","unstructured":"Ma C, Yu R, Li J, Xiao E, Guo J, Wang X, Li G, Liu P. Cross-sectional study and bioinformatics analysis to reveal the correlations of osteoporosis in patients with Parkinson's disease. Exp Gerontol. 2023 Mar;173:112111. doi: 10.1016\/j.exger.2023.112111. Epub 2023 Feb 2. Erratum in: Exp Gerontol. 2023 Jul;178:112205.","DOI":"10.1016\/j.exger.2023.112205"},{"issue":"363","key":"10.1016\/j.jare.2025.05.034_b0830","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.taap.2018.12.003","article-title":"Bone loss in MPTP mouse model of Parkinson's disease is triggered by decreased osteoblastogenesis and increased osteoclastogenesis","volume":"15","author":"Ali","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0835","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13578-021-00702-5","volume":"11","author":"Xiong","year":"2021","journal-title":"Parkinson's in the bone Cell Biosci"},{"issue":"10","key":"10.1016\/j.jare.2025.05.034_b0840","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1084\/jem.20171320","article-title":"Gpr158 mediates osteocalcin's regulation of cognition","volume":"214","author":"Khrimian","year":"2017","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0845","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40168-020-00988-6","article-title":"Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson's disease","volume":"9","author":"Hou","year":"2021","journal-title":"Microbiome"},{"issue":"13","key":"10.1016\/j.jare.2025.05.034_b0850","article-title":"Bone-Derived Factors as Potential Biomarkers for Parkinson's Disease","volume":"24","author":"Lin","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jare.2025.05.034_b0855","series-title":"Parkinson\u2019s disease and osteocalcin pilot study: Is there a protective role of bone in neurodegeneration?","author":"Nordvig","year":"2020"},{"issue":"18","key":"10.1016\/j.jare.2025.05.034_b0860","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1016\/j.cell.2023.07.023","article-title":"The projection-specific signals that establish functionally segregated dopaminergic synapses","volume":"186","author":"Terauchi","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.jare.2025.05.034_b0865","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105805","article-title":"The promise of the TGF-\u03b2 superfamily as a therapeutic target for Parkinson's disease","volume":"171","author":"Karampetsou","year":"2022","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0870","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.etap.2004.12.053","article-title":"Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration","volume":"19","author":"Erikson","year":"2005","journal-title":"Environ Toxicol Pharmacol"},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b0875","doi-asserted-by":"crossref","first-page":"56","DOI":"10.17116\/jnevro202212208156","article-title":"Vitamin D i drugie pokazateli kal'tsii-fosfornogo obmena kak vozmozhnye prediktory bolezni Parkinsona [Vitamin D and other indicators of calcium-phosphorus metabolism as possible predictors of Parkinson's disease]","volume":"122","author":"Novotnij","year":"2022","journal-title":"Zh Nevrol Psikhiatr Im S S Korsakova"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0880","doi-asserted-by":"crossref","first-page":"10656","DOI":"10.1007\/s12035-024-04227-z","article-title":"Unraveling the Intricacies of OPG\/RANKL\/RANK Biology and Its Implications in Neurological Disorders-A Comprehensive Literature Review","volume":"61","author":"Freeman","year":"2024","journal-title":"Mol Neurobiol"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0885","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5312\/wjo.v3.i9.142","article-title":"RANKL-RANK interaction in immune regulatory systems","volume":"3","author":"Akiyama","year":"2012","journal-title":"World J Orthop"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0890","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/cells11010132","article-title":"Regulation of TNF-Induced Osteoclast Differentiation","volume":"11","author":"Yao","year":"2021","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.jare.2025.05.034_b0895","doi-asserted-by":"crossref","first-page":"14915","DOI":"10.3390\/ijms241914915","article-title":"Inflammatory Blood Biomarkers Are Associated with Long-Term Clinical Disease Severity in Parkinson's Disease","volume":"24","author":"Hepp","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1\u20134","key":"10.1016\/j.jare.2025.05.034_b0900","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000464244","article-title":"Implicating Receptor Activator of NF-\u03baB (RANK)\/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli","volume":"39","author":"Kichev","year":"2017","journal-title":"Dev Neurosci"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b0905","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys"},{"issue":"10","key":"10.1016\/j.jare.2025.05.034_b0910","doi-asserted-by":"crossref","first-page":"749","DOI":"10.14348\/molcells.2022.0058","article-title":"PARK2 Induces Osteoclastogenesis through Activation of the NF-\u03baB Pathway","volume":"45","author":"Hong","year":"2022","journal-title":"Mol Cells"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b0915","article-title":"GPR37 and its neuroprotective mechanisms: bridging osteocalcin signaling and brain function","volume":"20","author":"Bian","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0920","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s43587-024-00791-0","article-title":"A primary cilia-autophagy axis in hippocampal neurons is essential to maintain cognitive resilience","volume":"5","author":"Rivagorda","year":"2025","journal-title":"Nat Aging"},{"issue":"Pt 1","key":"10.1016\/j.jare.2025.05.034_b0925","article-title":"Curcumin activates the Wnt\/\u03b2-catenin signaling pathway to alleviate hippocampal neurogenesis abnormalities caused by intermittent hypoxia: A study based on network pharmacology and experimental verification","volume":"143","author":"He","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0930","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41413-025-00404-5","article-title":"Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials","volume":"13","author":"Yu","year":"2025","journal-title":"Bone Res"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b0935","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut microbiota are related to Parkinson's disease and clinical phenotype","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov Disord"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0940","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13024-024-00766-0","article-title":"Gut-first Parkinson's disease is encoded by gut dysbiome","volume":"19","author":"Munoz-Pinto","year":"2024","journal-title":"Mol Neurodegener"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0945","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/mds.29620","article-title":"Erythrocytic \u03b1-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease","volume":"39","author":"Yang","year":"2024","journal-title":"Mov Disord"},{"issue":"16","key":"10.1016\/j.jare.2025.05.034_b0950","article-title":"Ambroxol attenuates detrimental effect of LPS-induced glia-mediated neuroinflammation, oxidative stress, and cognitive dysfunction in mice brain","volume":"6","author":"Ullah","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.05.034_b0955","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103092","article-title":"Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS\/RNS: Relevance to Parkinson's disease and therapeutic implications","volume":"71","author":"Kalyanaraman","year":"2024","journal-title":"Redox Biol"},{"issue":"18","key":"10.1016\/j.jare.2025.05.034_b0960","article-title":"Roseburia hominis Alleviates Neuroinflammation via Short-Chain Fatty Acids through Histone Deacetylase Inhibition","volume":"66","author":"Song","year":"2022","journal-title":"Mol Nutr Food Res"},{"issue":"14","key":"10.1016\/j.jare.2025.05.034_b0965","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.3390\/jcm13144130","article-title":"The Brain-Gut Axis, an Important Player in Alzheimer and Parkinson Disease: A Narrative Review","volume":"13","author":"Caradonna","year":"2024","journal-title":"J Clin Med"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0970","article-title":"A gut bacterial amyloid promotes \u03b1-synuclein aggregation and motor impairment in mice","volume":"11","author":"Sampson","year":"2020","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0975","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-019-1528-y","article-title":"Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson's disease","volume":"16","author":"Lin","year":"2019","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0980","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3892\/etm.2021.10974","article-title":"Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons","volume":"23","author":"Zhang","year":"2022","journal-title":"Exp Ther Med"},{"issue":"371","key":"10.1016\/j.jare.2025.05.034_b0985","article-title":"The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation","volume":"15","author":"Serna-Rodr\u00edguez","year":"2022","journal-title":"J Neuroimmunol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b0990","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13041-025-01179-w","article-title":"Sodium butyrate attenuates microglia-mediated neuroinflammation by modulating the TLR4\/MyD88\/NF-\u03baB pathway and microbiome-gut-brain axis in cardiac arrest mice","volume":"18","author":"Sun","year":"2025","journal-title":"Mol Brain"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b0995","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.apsb.2021.03.020","article-title":"Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4\/MyD88\/NF-\u03baB pathway through microbiota-gut-brain axis","volume":"11","author":"Zhao","year":"2021","journal-title":"Acta Pharm Sin B"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b1000","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41423-020-00585-5","article-title":"The aryl hydrocarbon receptor and the gut-brain axis","volume":"18","author":"Barroso","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jare.2025.05.034_b1005","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127858","article-title":"Gut microbiota modulates neurotransmitter and gut-brain signaling","volume":"287","author":"Qu","year":"2024","journal-title":"Microbiol Res"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b1010","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1055\/s-0043-1771457","article-title":"Constipation in Parkinson's Disease","volume":"43","author":"Quigley","year":"2023","journal-title":"Semin Neurol"},{"issue":"11","key":"10.1016\/j.jare.2025.05.034_b1015","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/bbb\/zbad115","article-title":"Antidepressant properties of voluntary exercise mediated by gut microbiota","volume":"87","author":"Watanabe","year":"2023","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jare.2025.05.034_b1020","doi-asserted-by":"crossref","unstructured":"Singh J, Vanlallawmzuali, Singh A, Biswal S, Zomuansangi R, Lalbiaktluangi C, Singh BP, Singh PK, Vellingiri B, Iyer M, Ram H, Udey B, Yadav MK. Microbiota-brain axis: Exploring the role of gut microbiota in psychiatric disorders - A comprehensive review. Asian J Psychiatr. 2024 Jul;97:104068.","DOI":"10.1016\/j.ajp.2024.104068"},{"issue":"15","key":"10.1016\/j.jare.2025.05.034_b1025","article-title":"Effect of BF839\u2009+\u2009earthworm protein supplement on motor and some non-motor symptoms of Parkinson's disease: a randomized clinical trial","volume":"6","author":"Zeng","year":"2024","journal-title":"Front Neurol"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b1030","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3390\/nu13062099","article-title":"Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders","volume":"13","author":"Chen","year":"2021","journal-title":"Nutrients"},{"issue":"14","key":"10.1016\/j.jare.2025.05.034_b1035","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.3390\/nu15143258","article-title":"The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components","volume":"15","author":"Xiong","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20180794","article-title":"Microbiome-microglia connections via the gut-brain axis","volume":"216","author":"Abdel-Haq","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/j.jare.2025.05.034_b1045","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2020.101340","article-title":"Sleep, circadian rhythm, and gut microbiota","volume":"53","author":"Matenchuk","year":"2020","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.jare.2025.05.034_b1050","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2022.101691","article-title":"The microbiota-gut-brain axis in sleep disorders","volume":"65","author":"Wang","year":"2022","journal-title":"Sleep Med Rev"},{"issue":"71","key":"10.1016\/j.jare.2025.05.034_b1055","article-title":"Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson's disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial","volume":"27","author":"Bruggeman","year":"2024","journal-title":"EClinicalMedicine"},{"issue":"13","key":"10.1016\/j.jare.2025.05.034_b1060","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.3390\/nu16132041","article-title":"Gut-Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on \u03b1-Synuclein in Parkinson's Disease","volume":"16","author":"Riegelman","year":"2024","journal-title":"Nutrients"},{"issue":"402","key":"10.1016\/j.jare.2025.05.034_b1065","article-title":"The positive correlation of antioxidant activity and prebiotic effect about oat phenolic compounds","volume":"15","author":"Zhang","year":"2023","journal-title":"Food Chem"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b1070","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3390\/antiox11040755","article-title":"The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease","volume":"11","author":"Lian","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1075","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s12882-024-03824-3","article-title":"NaHS protects brain, heart, and lungs as remote organs from renal ischemia\/reperfusion-induced oxidative stress in male and female rats","volume":"25","author":"Saberi","year":"2024","journal-title":"BMC Nephrol"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b1080","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3350\/cmh.2020.0174","article-title":"Liver-lung axes in alcohol-related liver disease","volume":"26","author":"Arteel","year":"2020","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1085","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41522-022-00352-6","article-title":"Host-microbiome interactions: Gut-Liver axis and its connection with other organs","volume":"8","author":"Anand","year":"2022","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1090","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jhep.2022.01.003","article-title":"Gut liver muscle brain axis: A comprehensive viewpoint on prognosis in cirrhosis","volume":"77","author":"Ridola","year":"2022","journal-title":"J Hepatol"},{"issue":"14","key":"10.1016\/j.jare.2025.05.034_b1095","article-title":"Liver-bone crosstalk in non-alcoholic fatty liver disease: Clinical implications and underlying pathophysiology","volume":"10","author":"Zhao","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b1100","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1165\/rcmb.2014-0195OC","article-title":"The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia","volume":"53","author":"Hilliard","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b1105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000343990","article-title":"Exercise limitations by the oxygen delivery and utilization systems in aging and disease: coordinated adaptation and deadaptation of the lung-heart muscle axis - a mini-review","volume":"59","author":"Burtscher","year":"2013","journal-title":"Gerontology"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b1110","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1378\/chest.10-2397","article-title":"Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: operation of a lung\/bone marrow axis","volume":"139","author":"Holt","year":"2011","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.11005\/jbm.2014.21.1.29","article-title":"Interaction between Muscle and Bone","volume":"21","author":"Kaji","year":"2014","journal-title":"J Bone Metab"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b1120","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fendo.2018.00351","article-title":"FGF23 in Cardiovascular Disease: Innocent Bystander or Active Mediator?","volume":"27","author":"St\u00f6hr","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"10.1016\/j.jare.2025.05.034_b1125","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.3390\/jpm12071108","article-title":"Concomitant Brain Injury and Spinal Cord Injury Management Strategies: A Narrative Review","volume":"12","author":"Valbuena Valecillos","year":"2022","journal-title":"J Pers Med"},{"issue":"37","key":"10.1016\/j.jare.2025.05.034_b1130","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.3748\/wjg.v21.i37.10609","article-title":"Brain-gut-microbiota axis in Parkinson's disease","volume":"21","author":"Mulak","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b1135","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10571-021-01066-7","article-title":"The Gut-Brain Axis: Two Ways Signaling in Parkinson's Disease","volume":"42","author":"Dogra","year":"2022","journal-title":"Cell Mol Neurobiol"},{"issue":"8","key":"10.1016\/j.jare.2025.05.034_b1140","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.3390\/ijms22084052","article-title":"Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders","volume":"22","author":"Nay","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.jare.2025.05.034_b1145","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.3390\/ijms21124306","article-title":"Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress","volume":"21","author":"Hahad","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.05.034_b1150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2018.04.031","article-title":"Cardiac abnormalities in Parkinson's disease and Parkinsonism","volume":"53","author":"Scorza","year":"2018","journal-title":"J Clin Neurosci"},{"issue":"3","key":"10.1016\/j.jare.2025.05.034_b1155","doi-asserted-by":"crossref","DOI":"10.1177\/03000605241237880","article-title":"Bone involvement in the early stages of Parkinson's disease: a case-control study","volume":"52","author":"Liguori","year":"2024","journal-title":"J Int Med Res"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1160","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/s41598-023-29534-8","article-title":"Effects of an incentive spirometer versus a threshold inspiratory muscle trainer on lung functions in Parkinson's disease patients: a randomized trial","volume":"13","author":"Mohammed Yusuf","year":"2023","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b1165","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.3390\/ijerph20042925","article-title":"The Effects of Resistance Exercise on the Cardiorespiratory Tissue of Rats with Parkinson's Disease","volume":"20","author":"Moreira","year":"2023","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b1170","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3390\/ijms19061689","article-title":"Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson's Disease","volume":"19","author":"Caputi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.05.034_b1175","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jare.2022.10.013","article-title":"Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment","volume":"50","author":"Salim","year":"2023","journal-title":"J Adv Res"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41531-022-00295-x","article-title":"Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management","volume":"8","author":"Warnecke","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b1185","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3390\/cells12050770","article-title":"Okadaic Acid Activates JAK\/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells","volume":"12","author":"Wuerger","year":"2023","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b1190","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/TA.0000000000000602","article-title":"Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting JAK\/STAT signaling pathway in rats","volume":"78","author":"Song","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jare.2025.05.034_b1195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155419","article-title":"Dahuang-Wumei decoction protects against hepatic encephalopathy in mice: Behavioural, biochemical, and molecular evidence","volume":"128","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jare.2025.05.034_b1200","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neurobiolaging.2018.03.021","article-title":"Evidence of Wnt\/\u03b2-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease","volume":"67","author":"Dengler-Crish","year":"2018","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jare.2025.05.034_b1205","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2023.09.001","article-title":"Irisin as an agent for protecting against osteoporosis: A review of the current mechanisms and pathways","volume":"62","author":"Hu","year":"2024","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2025.05.034_b1210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jceh.2021.08.028","article-title":"Fatigue in Cirrhosis","author":"Bhandari","year":"2022","journal-title":"J Clin Exp Hepatol"},{"issue":"45","key":"10.1016\/j.jare.2025.05.034_b1215","doi-asserted-by":"crossref","first-page":"25118","DOI":"10.1021\/acs.jafc.4c07035","article-title":"Apple Polyphenol Extracts Attenuated Depressive-Like Behaviors of High-Sucrose Diet Feeding Mice by Farnesoid X Receptor-Mediated Modulation of Bile Acid Circulation within the Liver-Gut-Brain Axis","volume":"72","author":"Xie","year":"2024","journal-title":"J Agric Food Chem"},{"issue":"1\u20133","key":"10.1016\/j.jare.2025.05.034_b1220","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jad.2010.09.002","article-title":"Plasma ANP and BNP during exercise in patients with major depressive disorder and in healthy controls","volume":"129","author":"Wis\u00e9n","year":"2011","journal-title":"J Affect Disord"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1225","first-page":"5","article-title":"Effects of natriuretic peptides upon hypothalamo-pituitary-adrenocortical system activity and anxiety behaviour","volume":"108","author":"Wiedemann","year":"2000","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.jare.2025.05.034_b1230","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154044","article-title":"The pathogenesis and treatment mechanism of Parkinson's disease from the perspective of traditional Chinese medicine","volume":"100","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"issue":"31","key":"10.1016\/j.jare.2025.05.034_b1235","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1080\/10408398.2022.2084600","article-title":"Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review","volume":"63","author":"Alugoju","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jare.2025.05.034_b1240","doi-asserted-by":"crossref","unstructured":"Hallbeck M, Ekmark-Lew\u00e9n S, Kahle PJ, Ingelsson M, Reyes JF. Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease. iScience. 2024 Nov 23;27(12):111448.","DOI":"10.1016\/j.isci.2024.111448"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b1245","first-page":"297","article-title":"Autophagy\u2013a basic mechanism and a potential role for neurodegeneration","volume":"43","author":"Bursch","year":"2005","journal-title":"Folia Neuropathol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1250","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41392-023-01353-3","article-title":"Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions","volume":"8","author":"Dong-Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b1255","doi-asserted-by":"crossref","first-page":"106","DOI":"10.14802\/jmd.21085","article-title":"Fecal Calprotectin in Parkinson's Disease and Multiple System Atrophy","volume":"15","author":"Hor","year":"2022","journal-title":"J Mov Disord"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b1260","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/0972753120960265","article-title":"Effect of Disease Severity on Respiratory Impedance in Parkinson's Disease","volume":"27","author":"Sampath","year":"2020","journal-title":"Ann Neurosci"},{"key":"10.1016\/j.jare.2025.05.034_b1265","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cotox.2017.10.003","article-title":"ROLE OF CYTOCHROME P450S IN THE GENERATION AND METABOLISM OF REACTIVE OXYGEN SPECIES","volume":"7","author":"Veith","year":"2018","journal-title":"Curr Opin Toxicol"},{"issue":"2","key":"10.1016\/j.jare.2025.05.034_b1270","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jare.2025.05.034_b1275","article-title":"Bone-Derived Modulators That Regulate Brain Function: Emerging Therapeutic Targets for Neurological Disorders","volume":"10","author":"Chen","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1280","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/19768354.2018.1487334","article-title":"Lithium chloride promotes proliferation of neural stem cells in vitro, possibly by triggering the Wnt signaling pathway","volume":"23","author":"Zhang","year":"2018","journal-title":"Anim Cells Syst (Seoul)"},{"issue":"4","key":"10.1016\/j.jare.2025.05.034_b1285","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1513\/pats.200707-096ET","article-title":"Inhaled and systemic corticosteroids in chronic obstructive pulmonary disease","volume":"5","author":"Falk","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"15","key":"10.1016\/j.jare.2025.05.034_b1290","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.3390\/nu16152476","article-title":"Nebulized Glutathione as a Key Antioxidant for the Treatment of Oxidative Stress in Neurodegenerative Conditions","volume":"16","author":"Lana","year":"2024","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.jare.2025.05.034_b1295","first-page":"509","article-title":"Nesiritide: past, present, and future","volume":"53","author":"Burger","year":"2005","journal-title":"Minerva Cardioangiol"},{"issue":"5","key":"10.1016\/j.jare.2025.05.034_b1300","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/jnc.15260","article-title":"Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses A\u03b2 production and related pathology in a mouse model of Alzheimer's disease","volume":"156","author":"Yuede","year":"2021","journal-title":"J Neurochem"},{"issue":"498","key":"10.1016\/j.jare.2025.05.034_b1305","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuroscience.2022.07.018","article-title":"Irisin: A promising treatment for neurodegenerative diseases","volume":"21","author":"Qi","year":"2022","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jare.2025.05.034_b1310","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00415-024-12770-x","article-title":"An update on immune-based alpha-synuclein trials in Parkinson's disease","volume":"272","author":"Alfaidi","year":"2024","journal-title":"J Neurol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225003522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225003522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:44:53Z","timestamp":1769805893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225003522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":262,"alternative-id":["S2090123225003522"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.034","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond the Brain: Exploring the multi-organ axes in Parkinson\u2019s disease pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}