{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:16:09Z","timestamp":1792786569910,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873292"],"award-info":[{"award-number":["81873292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7252264"],"award-info":[{"award-number":["7252264"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Beijing Municipality"},{"DOI":"10.13039\/501100005893","name":"China Academy of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Collaborative Project of Science and Technology Innovation Project of China Academy of Traditional Chinese Medicine","award":["CI2023C072YLL"],"award-info":[{"award-number":["CI2023C072YLL"]}],"id":[{"id":"https:\/\/ror.org\/02a5vfy19","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jare.2025.05.052","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T19:22:07Z","timestamp":1748287327000},"page":"223-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Characterization of immune features and discovery of potential biomarkers for ankylosing spondylitis using deep plasma proteomics"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9090-2635","authenticated-orcid":false,"given":"Xiaohan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuening","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-922X","authenticated-orcid":false,"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9570","key":"10.1016\/j.jare.2025.05.052_b0005","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"Braun","year":"2007","journal-title":"Lancet (London, England)"},{"issue":"4","key":"10.1016\/j.jare.2025.05.052_b0010","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/rheumatology\/ket387","article-title":"Global prevalence of ankylosing spondylitis","volume":"53","author":"Dean","year":"2014","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.jare.2025.05.052_b0015","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00296-020-04537-0","article-title":"Prevalence of ankylosing spondylitis in a Chinese population: a systematic review and meta-analysis","volume":"40","author":"Zhao","year":"2020","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jare.2025.05.052_b0020","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.14956.1","article-title":"Recent advances in ankylosing spondylitis: understanding the disease and management","volume":"7","author":"Garcia-Montoya","year":"2018","journal-title":"F1000Res"},{"issue":"5","key":"10.1016\/j.jare.2025.05.052_b0025","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s10753-023-01834-1","article-title":"SPI1 regulates the progression of ankylosing spondylitis by modulating TLR5 via NF-\u03baB signaling","volume":"46","author":"Wenbo","year":"2023","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.jare.2025.05.052_b0030","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/acr.23851","article-title":"Impact of smoking in response to tumor necrosis factor inhibitors in axial spondyloarthritis: methodologic considerations for longitudinal observational studies","volume":"72","author":"Zhao","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"7","key":"10.1016\/j.jare.2025.05.052_b0035","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/rheumatology\/kez480","article-title":"How to calculate the ASDAS based on C-reactive protein without individual questions from the BASDAI: the BASDAI-based ASDAS formula","volume":"59","author":"Aranda-Valera","year":"2020","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.jare.2025.05.052_b0040","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/BOR.0000000000000588","article-title":"Measuring outcomes in ankylosing spondylitis: pearls and pitfalls","volume":"31","author":"Magrey","year":"2019","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.052_b0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/1756-185X.14008","article-title":"Development of a Bangla version of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI)","volume":"24","author":"Abdal","year":"2021","journal-title":"Int J Rheum Dis"},{"issue":"8","key":"10.1016\/j.jare.2025.05.052_b0050","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23343","article-title":"Association between C-reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty","volume":"34","author":"Xu","year":"2020","journal-title":"J Clin Lab Anal"},{"issue":"3","key":"10.1016\/j.jare.2025.05.052_b0055","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3899\/jrheum.170079","article-title":"Severity of sacroiliitis and erythrocyte sedimentation rate are associated with a low trabecular bone score in young male patients with ankylosing spondylitis","volume":"45","author":"Kang","year":"2018","journal-title":"J Rheumatol"},{"issue":"4","key":"10.1016\/j.jare.2025.05.052_b0060","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s40265-019-01075-3","article-title":"Secukinumab: a review in ankylosing spondylitis","volume":"79","author":"Blair","year":"2019","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.jare.2025.05.052_b0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10198-019-01110-w","article-title":"The value of persistence in treatment with subcutaneous TNF-alpha inhibitors for ankylosing spondylitis","volume":"21","author":"Svedbom","year":"2020","journal-title":"Eur J Health Econ"},{"issue":"9","key":"10.1016\/j.jare.2025.05.052_b0070","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/annrheumdis-2020-217927","article-title":"Paradoxical gastrointestinal effects of interleukin-17 blockers","volume":"79","author":"Fauny","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.jare.2025.05.052_b0075","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3897\/folmed.62.e39402","article-title":"Drug-neutralizing antibodies against TNF-\u03b1 blockers as biomarkers of therapy effect evaluation","volume":"62","author":"Kraev","year":"2020","journal-title":"Folia Med (Plovdiv)"},{"issue":"19","key":"10.1016\/j.jare.2025.05.052_b0080","doi-asserted-by":"crossref","first-page":"11561","DOI":"10.3390\/ijms231911561","article-title":"Practical significance of biomarkers in axial spondyloarthritis: updates on diagnosis, disease activity, and prognosis","volume":"23","author":"Diaconu","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.jare.2025.05.052_b0085","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1111\/1756-185X.13735","article-title":"Validity and reliability of the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with axial spondyloarthritis (axSpA) in Singapore","volume":"22","author":"Kwan","year":"2019","journal-title":"Int J Rheum Dis"},{"issue":"23\u201324","key":"10.1016\/j.jare.2025.05.052_b0090","article-title":"Targeted liquid chromatography-tandem mass spectrometry analysis of proteins: Basic principles, applications, and perspectives","volume":"21","author":"Kulyyassov","year":"2021","journal-title":"Proteomics"},{"issue":"4","key":"10.1016\/j.jare.2025.05.052_b0095","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1136\/annrheumdis-2011-200216","article-title":"High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis","volume":"71","author":"Heiland","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2025.05.052_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.620920","article-title":"The emerging roles of endocrine hormones in different arthritic disorders","volume":"12","author":"Bertoldo","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"10.1016\/j.jare.2025.05.052_b0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41584-022-00764-w","article-title":"Effects of targeted therapies on bone in rheumatic and musculoskeletal diseases","volume":"18","author":"So\u00f3s","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.jare.2025.05.052_b0110","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/ijms18040697","article-title":"Role and Function of A(2A) and A3 adenosine receptors in patients with ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis","volume":"18","author":"Ravani","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jare.2025.05.052_b0115","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1136\/annrheumdis-2012-203075","article-title":"The effect of two golimumab doses on radiographic progression in ankylosing spondylitis: results through 4 years of the GO-RAISE trial","volume":"73","author":"Braun","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.jare.2025.05.052_b0120","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrrheum.2013.93","article-title":"Spondyloarthritis: is it time to replace BASDAI with ASDAS?","volume":"9","author":"Machado","year":"2013","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.jare.2025.05.052_b0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/annrheumdis-2017-211734","article-title":"Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force","volume":"77","author":"Smolen","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2025.05.052_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341569","article-title":"Establishment and clinical application evaluations of a deep mining strategy of plasma proteomics based on nanomaterial protein coronas","volume":"1275","author":"Wang","year":"2023","journal-title":"Anal Chim Acta"},{"issue":"24","key":"10.1016\/j.jare.2025.05.052_b0135","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1111\/bph.12658","article-title":"Targeting Rho-GTPases in immune cell migration and inflammation","volume":"171","author":"Biro","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.jare.2025.05.052_b0140","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/annrheumdis-2020-218304","article-title":"Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo","volume":"80","author":"Menegatti","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"19","key":"10.1016\/j.jare.2025.05.052_b0145","doi-asserted-by":"crossref","first-page":"7702","DOI":"10.1021\/acs.analchem.3c00809","article-title":"Integrated proteomics and single-cell mass cytometry analysis dissects the immune landscape of ankylosing spondylitis","volume":"95","author":"Wang","year":"2023","journal-title":"Anal Chem"},{"issue":"11","key":"10.1016\/j.jare.2025.05.052_b0150","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1136\/annrheumdis-2019-215349","article-title":"Integrin and transcriptomic profiles identify a distinctive synovial CD8+ T cell subpopulation in spondyloarthritis","volume":"78","author":"Qaiyum","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"7\u20139","key":"10.1016\/j.jare.2025.05.052_b0155","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/ars.2021.0068","article-title":"Redox control of integrin-mediated hepatic inflammation in systemic autoimmunity","volume":"36","author":"Patel","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jare.2025.05.052_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106773","article-title":"Proteomic analysis of serum-derived extracellular vesicles in ankylosing spondylitis patients","volume":"87","author":"Huang","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2025.05.052_b0165","article-title":"Global proteomic analyses reveals abnormal immune regulation in patients with new onset ankylosing spondylitis","volume":"13","author":"Yu","year":"2022","journal-title":"Front Immunol"},{"issue":"32","key":"10.1016\/j.jare.2025.05.052_b0170","doi-asserted-by":"crossref","first-page":"20153","DOI":"10.1021\/acsomega.0c01776","article-title":"Quantitative proteomic analyses to reveal the key features of proteins in new onset ankylosing spondylitis patients","volume":"5","author":"Lu","year":"2020","journal-title":"ACS Omega"},{"issue":"2","key":"10.1016\/j.jare.2025.05.052_b0175","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1021\/acs.jproteome.9b00676","article-title":"Discovery of potential serum protein biomarkers in ankylosing spondylitis using tandem mass tag-based quantitative proteomics","volume":"19","author":"Liu","year":"2020","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jare.2025.05.052_b0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-immunol-092419-031130","article-title":"Age-associated B Cells","volume":"38","author":"Cancro","year":"2020","journal-title":"Annu Rev Immunol"},{"issue":"570","key":"10.1016\/j.jare.2025.05.052_b0185","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz5327","article-title":"Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis","volume":"12","author":"Kristyanto","year":"2020","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.jare.2025.05.052_b0190","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.jare.2025.05.052_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front Immunol"},{"issue":"24","key":"10.1016\/j.jare.2025.05.052_b0200","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000033985","article-title":"Genetic association between ankylosing spondylitis and major depressive disorders: shared pathways, protein networks and the key gene","volume":"102","author":"Dong","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jare.2025.05.052_b0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1227281","article-title":"STAT1 deficiency underlies a proinflammatory imprint of naive CD4(+) T cells in spondyloarthritis","volume":"14","author":"Cherqaoui","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.05.052_b0210","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.2147\/IJGM.S310677","article-title":"The value of serum amyloid A in the diagnosis and management of ankylosing spondylitis","volume":"14","author":"Hu","year":"2021","journal-title":"Int J Gen Med"},{"issue":"11","key":"10.1016\/j.jare.2025.05.052_b0215","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/art.24838","article-title":"Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis","volume":"61","author":"de Vries","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.jare.2025.05.052_b0220","first-page":"201","article-title":"Serum disease-associated proteins of ankylosing spondylitis: results of a preliminary study by comparative proteomics","volume":"28","author":"Li","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jare.2025.05.052_b0225","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fphar.2020.00231","article-title":"Circulating retinol-binding protein 4 as a possible biomarker of treatment response for ankylosing spondylitis: an array-based comparative study","volume":"11","author":"Wu","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.05.052_b0230","article-title":"Serum amyloid A in inflammatory rheumatic diseases: a compendious review of a renowned biomarker","volume":"11","author":"Sori\u0107 Hosman","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.05.052_b0235","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3389\/fimmu.2018.00708","article-title":"Multiplex cytokine analysis of aqueous humor in juvenile idiopathic arthritis-associated anterior uveitis with or without secondary glaucoma","volume":"9","author":"Bauer","year":"2018","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.jare.2025.05.052_b0240","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.joca.2018.05.017","article-title":"Inflammatory and oxidative stress biomarkers in alkaptonuria: data from the DevelopAKUre project","volume":"26","author":"Braconi","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.jare.2025.05.052_b0245","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cell.2019.11.026","article-title":"Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease","volume":"180","author":"Lee","year":"2020","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.jare.2025.05.052_b0250","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/art.41644","article-title":"Inflammasome activation in ankylosing spondylitis is associated with gut dysbiosis","volume":"73","author":"Guggino","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jare.2025.05.052_b0255","article-title":"Axial spondyloarthritis: new advances in diagnosis and management","volume":"372","author":"Ritchlin","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jare.2025.05.052_b0260","article-title":"Innate cells: the alternative source of IL-17 in axial and peripheral spondyloarthritis?","volume":"11","author":"Rosine","year":"2020","journal-title":"Front Immunol"},{"issue":"Suppl 2","key":"10.1016\/j.jare.2025.05.052_b0265","doi-asserted-by":"crossref","first-page":"ii116","DOI":"10.1136\/annrheumdis-2012-202371","article-title":"Effect of IL-17A blockade with secukinumab in autoimmune diseases","volume":"72","author":"Patel","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.jare.2025.05.052_b0270","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/gb-2007-8-5-215","article-title":"The integrins","volume":"8","author":"Takada","year":"2007","journal-title":"Genome Biol"},{"issue":"6","key":"10.1016\/j.jare.2025.05.052_b0275","first-page":"681","article-title":"Gut mucosal T cell lines from ankylosing spondylitis patients are enriched with alphaEbeta7 integrin","volume":"19","author":"Van Damme","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jare.2025.05.052_b0280","doi-asserted-by":"crossref","first-page":"e543","DOI":"10.1016\/j.wneu.2021.11.014","article-title":"Potential pathogenic genes and mechanism of ankylosing spondylitis: a study based on WGCNA and bioinformatics analysis","volume":"158","author":"Wu","year":"2022","journal-title":"World Neurosurg"},{"issue":"6","key":"10.1016\/j.jare.2025.05.052_b0285","first-page":"828","article-title":"Over-expression of talin 1 and integrin-linked kinase in PBMCs of patients with ankylosing spondylitis: a proteomic study","volume":"28","author":"Li","year":"2010","journal-title":"Clin Exp Rheumatol"},{"issue":"24","key":"10.1016\/j.jare.2025.05.052_b0290","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1038\/onc.2010.644","article-title":"Integrin-linked kinase regulates melanoma angiogenesis by activating NF-\u03baB\/interleukin-6 signaling pathway","volume":"30","author":"Wani","year":"2011","journal-title":"Oncogene"},{"issue":"5642","key":"10.1016\/j.jare.2025.05.052_b0295","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.1086652","article-title":"Talin binding to integrin beta tails: a final common step in integrin activation","volume":"302","author":"Tadokoro","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.05.052_b0300","doi-asserted-by":"crossref","first-page":"11966","DOI":"10.1038\/ncomms11966","article-title":"The mechanical response of talin","volume":"7","author":"Yao","year":"2016","journal-title":"Nat Commun"},{"issue":"1\u20133","key":"10.1016\/j.jare.2025.05.052_b0305","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0167-4781(02)00247-6","article-title":"Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1","volume":"1575","author":"Melchior","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jare.2025.05.052_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.01.044","article-title":"The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review","volume":"112","author":"Yan","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.jare.2025.05.052_b0315","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.119.315829","article-title":"Interleukin-10 deficiency alters endothelial progenitor cell-derived exosome reparative effect on myocardial repair via integrin-linked kinase enrichment","volume":"126","author":"Yue","year":"2020","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jare.2025.05.052_b0320","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nm1722","article-title":"Kindlin-3 is essential for integrin activation and platelet aggregation","volume":"14","author":"Moser","year":"2008","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.jare.2025.05.052_b0325","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1182\/blood-2008-06-163162","article-title":"Kindlin-3: a new gene involved in the pathogenesis of LAD-III","volume":"112","author":"Mory","year":"2008","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.jare.2025.05.052_b0330","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900594","article-title":"Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cells","volume":"3","author":"Bialkowska","year":"2019","journal-title":"Life Sci Alliance"},{"issue":"12","key":"10.1016\/j.jare.2025.05.052_b0335","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1136\/annrheumdis-2017-212819","article-title":"Simultaneous inhibition of \u03b14\/\u03b27 integrin and tumour necrosis factor-\u03b1 in concomitant spondyloarthritis and inflammatory bowel disease","volume":"77","author":"Richard","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.jare.2025.05.052_b0340","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1182\/blood.2019003446","article-title":"Kindlin-3 recruitment to the plasma membrane precedes high-affinity \u03b22-integrin and neutrophil arrest from rolling","volume":"137","author":"Wen","year":"2021","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jare.2025.05.052_b0345","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41413-021-00176-8","article-title":"PDGFR\u03b1 reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair","volume":"10","author":"Xu","year":"2022","journal-title":"Bone Res"},{"issue":"2","key":"10.1016\/j.jare.2025.05.052_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112456","article-title":"Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis","volume":"399","author":"Kerr","year":"2021","journal-title":"Exp Cell Res"},{"issue":"6637","key":"10.1016\/j.jare.2025.05.052_b0355","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg2482","article-title":"Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity","volume":"379","author":"Zhai","year":"2023","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.jare.2025.05.052_b0360","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1136\/annrheumdis-2016-209749","article-title":"Clinical efficacy of \u03b14 integrin block with natalizumab in ankylosing spondylitis","volume":"75","author":"Ciccia","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.jare.2025.05.052_b0365","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s12325-023-02732-6","article-title":"Safety of upadacitinib in immune-mediated inflammatory diseases: systematic literature review of indirect and direct treatment comparisons of randomized controlled trials","volume":"41","author":"Mysler","year":"2024","journal-title":"Adv Ther"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322500373X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209012322500373X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T01:20:58Z","timestamp":1772414458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209012322500373X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":73,"alternative-id":["S209012322500373X"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.052","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of immune features and discovery of potential biomarkers for ankylosing spondylitis using deep plasma proteomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.05.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}