{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:56:36Z","timestamp":1790211396604,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002555","name":"Seoul Women's University","doi-asserted-by":"publisher","award":["2025-0184"],"award-info":[{"award-number":["2025-0184"]}],"id":[{"id":"10.13039\/501100002555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2023R1A2C1006827"],"award-info":[{"award-number":["2023R1A2C1006827"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2023- 00222997"],"award-info":[{"award-number":["RS-2023- 00222997"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NR076822"],"award-info":[{"award-number":["NR076822"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jare.2025.07.001","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:39:20Z","timestamp":1751582360000},"page":"1083-1098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Scutellarein attenuates cancer cachexia-induced muscle atrophy via targeted inhibition of the JAK\/STAT pathway"],"prefix":"10.1016","volume":"82","author":[{"given":"Heeju","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeyoung","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minju","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sieun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4962-0338","authenticated-orcid":false,"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiantao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonhee","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jin","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanguine","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.07.001_b0005","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.2147\/CMAR.S261585","article-title":"Cancer cachexia: definition, staging, and emerging treatments","author":"Ni","year":"2020","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.jare.2025.07.001_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tem.2024.12.005","article-title":"Systemic metabolic crosstalk as driver of cancer cachexia","author":"Wyart","year":"2025","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.jare.2025.07.001_b0015","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.tem.2021.03.007","article-title":"Cancer-mediated muscle cachexia: etiology and clinical management","volume":"32","author":"Siff","year":"2021","journal-title":"Trends Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.jare.2025.07.001_b0020","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis","volume":"14","author":"Argil\u00e9s","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jare.2025.07.001_b0025","first-page":"1569","article-title":"Diagnostic criteria of cancer cachexia: relation to quality of life, exercise capacity and survival in unselected palliative care patients","volume":"21","author":"Wallengren","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jare.2025.07.001_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1519278","article-title":"Muscle loss in cancer cachexia: what is the basis for nutritional support?","volume":"16","author":"Faiad","year":"2025","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.jare.2025.07.001_b0035","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3390\/cancers11091264","article-title":"Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle","volume":"11","author":"de Castro","year":"2019","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0040","article-title":"TNF\u2010\u03b1 and IFN\u2010s\u2010dependent muscle decay is linked to NF\u2010\u03baB\u2010and STAT\u20101\u03b1\u2010stimulated atrogin1 and MuRF1 genes in C2C12 myotubes","volume":"2013","author":"Pijet","year":"2013","journal-title":"Mediat Inflamm"},{"issue":"5","key":"10.1016\/j.jare.2025.07.001_b0045","doi-asserted-by":"crossref","first-page":"622","DOI":"10.15252\/emmm.201607052","article-title":"STAT 3 promotes IFN \u03b3\/TNF \u03b1\u2010induced muscle wasting in an NF\u2010\u03baB\u2010dependent and IL\u20106\u2010independent manner","volume":"9","author":"Ma","year":"2017","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jare.2025.07.001_b0050","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fnut.2020.00004","article-title":"Plasma lipid profile and systemic inflammation in patients with cancer cachexia","volume":"7","author":"Riccardi","year":"2020","journal-title":"Front Nutr"},{"issue":"11","key":"10.1016\/j.jare.2025.07.001_b0055","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/ijc.29620","article-title":"Tumor inoculation site affects the development of cancer cachexia and muscle wasting","volume":"137","author":"Matsuyama","year":"2015","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1016\/j.jare.2025.07.001_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022538","article-title":"STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia","volume":"6","author":"Bonetto","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jare.2025.07.001_b0065","doi-asserted-by":"crossref","first-page":"E410","DOI":"10.1152\/ajpendo.00039.2012","article-title":"JAK\/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia","volume":"303","author":"Bonetto","year":"2012","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jare.2025.07.001_b0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/rco2.24","article-title":"JAK inhibitors suppress cancer cachexia-associated anorexia and adipose wasting in mice","volume":"3","author":"Arora","year":"2020","journal-title":"JCSM Rapid Commun"},{"issue":"3","key":"10.1016\/j.jare.2025.07.001_b0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jare.2025.07.001_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109042","article-title":"Novel anti-obesity effect of scutellarein and potential underlying mechanism of actions","volume":"117","author":"Lin","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"10.1016\/j.jare.2025.07.001_b0085","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.3390\/molecules27123782","article-title":"Scutellarein inhibits LPS-induced inflammation through NF-\u03baB\/MAPKs signaling pathway in RAW264. 7 cells","volume":"27","author":"Park","year":"2022","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jare.2025.07.001_b0090","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4196\/kjpp.2015.19.5.441","article-title":"Scutellarein reduces inflammatory responses by inhibiting Src kinase activity","volume":"19","author":"Sung","year":"2015","journal-title":"Korean J Physiol Pharmacol"},{"issue":"2","key":"10.1016\/j.jare.2025.07.001_b0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"issue":"4","key":"10.1016\/j.jare.2025.07.001_b0100","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nmeth.1314","article-title":"SUnSET, a nonradioactive method to monitor protein synthesis","volume":"6","author":"Schmidt","year":"2009","journal-title":"Nat Methods"},{"key":"10.1016\/j.jare.2025.07.001_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129463","article-title":"Identifying Codium fragile extract components and their effects on muscle weight and exercise endurance","volume":"353","author":"Ahn","year":"2021","journal-title":"Food Chem"},{"key":"10.1016\/j.jare.2025.07.001_b0110","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2147\/JIR.S353489","article-title":"Role of JAK2\/STAT3 signaling pathway in the tumorigenesis, chemotherapy resistance, and treatment of solid tumors: a systemic review","author":"Mengie Ayele","year":"2022","journal-title":"J Inflamm Res"},{"issue":"2","key":"10.1016\/j.jare.2025.07.001_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188359","article-title":"Advances in cancer cachexia: intersection between affected organs, mediators, and pharmacological interventions","volume":"1873","author":"Siddiqui","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"7","key":"10.1016\/j.jare.2025.07.001_b0120","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1096\/fj.00-0463","article-title":"Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor\u2010\u03ba\u0392","volume":"15","author":"Langen","year":"2001","journal-title":"FASEB J"},{"issue":"14","key":"10.1016\/j.jare.2025.07.001_b0125","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1128\/MCB.05397-11","article-title":"Gamma interferon modulates myogenesis through the major histocompatibility complex class II transactivator, CIITA","volume":"31","author":"Londhe","year":"2011","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jare.2025.07.001_b0130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10911-008-9062-z","article-title":"Jak2\/Stat5 signaling in mammogenesis, breast cancer initiation and progression","volume":"13","author":"Wagner","year":"2008","journal-title":"J Mammary Gland Biol Neoplasia"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0135","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13395-022-00297-6","article-title":"The Myotube Analyzer: how to assess myogenic features in muscle stem cells","volume":"12","author":"No\u00eb","year":"2022","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.jare.2025.07.001_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-405943-6.00001-4","article-title":"Molecular and cellular regulation of skeletal myogenesis","volume":"110","author":"Comai","year":"2014","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.jare.2025.07.001_b0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semcdb.2017.11.010","article-title":"The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration","volume":"72","author":"Hern\u00e1ndez-Hern\u00e1ndez","year":"2017","journal-title":"Semin Cell Dev Biol"},{"issue":"6","key":"10.1016\/j.jare.2025.07.001_b0150","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Bodine","year":"2014","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"24","key":"10.1016\/j.jare.2025.07.001_b0155","doi-asserted-by":"crossref","DOI":"10.21037\/atm-20-7269","article-title":"Inhibition of IL-6\/JAK\/STAT3 pathway rescues denervation-induced skeletal muscle atrophy","volume":"8","author":"Huang","year":"2020","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jare.2025.07.001_b0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/112_2013_17","article-title":"The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli","volume":"166","author":"Goodman","year":"2014","journal-title":"Rev Physiol Biochem Pharmacol"},{"issue":"11","key":"10.1016\/j.jare.2025.07.001_b0165","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","article-title":"Akt\/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo","volume":"3","author":"Bodine","year":"2001","journal-title":"Nat Cell Biol"},{"issue":"7","key":"10.1016\/j.jare.2025.07.001_b0170","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and function of AMPK in physiology and diseases","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp Mol Med"},{"issue":"5","key":"10.1016\/j.jare.2025.07.001_b0175","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCRESAHA.109.206185","article-title":"Peroxisome proliferator-activated receptor \u03b4 is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart","volume":"106","author":"Wang","year":"2010","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0180","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrd4467","article-title":"Muscle wasting in disease: molecular mechanisms and promising therapies","volume":"14","author":"Cohen","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jare.2025.07.001_b0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2015.11.002","article-title":"Protein breakdown in cancer cachexia","volume":"54","author":"Sandri","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jare.2025.07.001_b0190","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.semcdb.2015.10.039","article-title":"Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia","volume":"54","author":"Tsoli","year":"2016","journal-title":"Semin Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.jare.2025.07.001_b0195","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","article-title":"Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria","volume":"151","author":"Fedorenko","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jare.2025.07.001_b0200","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s13539-011-0052-4","article-title":"Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass","volume":"3","author":"Sakuma","year":"2012","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"45","key":"10.1016\/j.jare.2025.07.001_b0205","doi-asserted-by":"crossref","first-page":"78300","DOI":"10.18632\/oncotarget.20962","article-title":"Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7","volume":"8","author":"Jang","year":"2017","journal-title":"Oncotarget"},{"issue":"16","key":"10.1016\/j.jare.2025.07.001_b0210","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1158\/1078-0432.CCR-16-0495","article-title":"Molecular pathways: cachexia signaling\u2014a targeted approach to cancer treatment","volume":"22","author":"Miyamoto","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.jare.2025.07.001_b0215","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3390\/antiox13060710","article-title":"Scutellarein suppresses the production of ROS and inflammatory mediators of LPS-activated bronchial epithelial cells and attenuates acute lung injury in mice","volume":"13","author":"Li","year":"2024","journal-title":"Antioxidants"},{"issue":"11","key":"10.1016\/j.jare.2025.07.001_b0220","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.3390\/ijms12118208","article-title":"Synthesis and bio-activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease","volume":"12","author":"Qian","year":"2011","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jare.2025.07.001_b0225","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/antiox11020224","article-title":"On the scavenging ability of scutellarein against the OOH radical in water and lipid-like environments: a theoretical study","volume":"11","author":"Spiegel","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jare.2025.07.001_b0230","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.biopha.2018.09.024","article-title":"Scutellarein selectively targets multiple myeloma cells by increasing mitochondrial superoxide production and activating intrinsic apoptosis pathway","volume":"109","author":"Shi","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0235","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3892\/ijmm.2014.1997","article-title":"Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo","volume":"35","author":"Shi","year":"2015","journal-title":"Int J Mol Med"},{"issue":"10","key":"10.1016\/j.jare.2025.07.001_b0240","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22870","article-title":"Scutellarein induces apoptosis and inhibits proliferation, migration, and invasion in ovarian cancer via inhibition of EZH2\/FOXO1 signaling","volume":"35","author":"Lang","year":"2021","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10020-025-01246-x","article-title":"JAK2\/STAT3\/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction","volume":"31","author":"Peng","year":"2025","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0250","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s11658-023-00521-1","article-title":"The regulatory relationship between transcription factor STAT3 and noncoding RNA","volume":"29","author":"Liu","year":"2024","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0255","first-page":"47","article-title":"Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis","volume":"12","author":"Richardson","year":"2023","journal-title":"Eurodegener"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0260","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1182\/asheducation-2009.1.636","article-title":"Therapeutic potential of JAK2 inhibitors","volume":"2009","author":"Verstovsek","year":"2009","journal-title":"Am Soc Hematol Educ Program"},{"issue":"4","key":"10.1016\/j.jare.2025.07.001_b0265","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.semcdb.2008.07.002","article-title":"JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies","volume":"19","author":"Vainchenker","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jare.2025.07.001_b0270","doi-asserted-by":"crossref","first-page":"82","DOI":"10.12688\/f1000research.13167.1","article-title":"JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders","volume":"7","author":"Vainchenker","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.jare.2025.07.001_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-12-568","article-title":"Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer","volume":"12","author":"Suzumura","year":"2012","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.jare.2025.07.001_b0280","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJMoa1713137","article-title":"Osimertinib in untreated EGFR-mutated advanced non\u2013small-cell lung cancer","volume":"378","author":"Soria","year":"2018","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.jare.2025.07.001_b0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijo.2021.5270","article-title":"Mechanisms and management of 3rd\u2011generation EGFR\u2011TKI resistance in advanced non\u2011small cell lung cancer","volume":"59","author":"He","year":"2021","journal-title":"Int J Oncol"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0290","doi-asserted-by":"crossref","first-page":"13430","DOI":"10.1038\/s41598-024-64226-x","article-title":"Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2\/STAT3 signalling pathway","volume":"14","author":"Duan","year":"2024","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jare.2025.07.001_b0295","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1111\/jcmm.14169","article-title":"Scutellarin inhibits proliferation and invasion of hepatocellular carcinoma cells via down\u2010regulation of JAK2\/STAT3 pathway","volume":"23","author":"Liu","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0300","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.1038\/s41598-023-33156-5","article-title":"Network pharmacology to explore the mechanism of scutellarin in the treatment of brain ischaemia and experimental verification of JAK2\/STAT3 signalling pathway","volume":"13","author":"Jia","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jare.2025.07.001_b0305","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12967-025-06155-5","article-title":"IFN-\u03b3-mediated inhibition of JAK\/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis","volume":"23","author":"Wang","year":"2025","journal-title":"J Transl Med"},{"issue":"3","key":"10.1016\/j.jare.2025.07.001_b0310","first-page":"24","article-title":"Bioactive compounds in functional food and their role as therapeutics","volume":"4","author":"Mondal","year":"2021","journal-title":"Bioact Compd Health Dis"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225004990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225004990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:46:09Z","timestamp":1773355569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225004990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":62,"alternative-id":["S2090123225004990"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.001","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scutellarein attenuates cancer cachexia-induced muscle atrophy via targeted inhibition of the JAK\/STAT pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}