{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:19:02Z","timestamp":1791361142844,"version":"4.3.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470548"],"award-info":[{"award-number":["82470548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270555"],"award-info":[{"award-number":["82270555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100572"],"award-info":[{"award-number":["82100572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2023YFC2507300"],"award-info":[{"award-number":["2023YFC2507300"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012956"],"award-info":[{"award-number":["2024A1515012956"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013032"],"award-info":[{"award-number":["2024A1515013032"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M653228"],"award-info":[{"award-number":["2019M653228"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jare.2025.07.002","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T13:00:36Z","timestamp":1751634036000},"page":"751-764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial growth factor receptor 2 pathway in inflammatory bowel disease"],"prefix":"10.1016","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3569-7541","authenticated-orcid":false,"given":"Gaoshi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-1484","authenticated-orcid":false,"given":"Shuhui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rirong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn's disease, nature reviews","volume":"6","author":"Roda","year":"2020","journal-title":"Disease Primers"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis, Nature reviews","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Disease primers"},{"key":"10.1016\/j.jare.2025.07.002_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2023.07.001","article-title":"Recent advances in the treatment of IBD: targets, mechanisms and related therapies","volume":"71\u201372","author":"Liu","year":"2023","journal-title":"Cytokine Growth Fact Rev"},{"issue":"10","key":"10.1016\/j.jare.2025.07.002_b0020","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/ueg2.12305","article-title":"Landscape of new drugs and targets in inflammatory bowel disease","volume":"10","author":"Vieujean","year":"2022","journal-title":"United European Gastroenterol J"},{"issue":"6","key":"10.1016\/j.jare.2025.07.002_b0025","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/MOG.0b013e328365d37c","article-title":"Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease","volume":"29","author":"D'Alessio","year":"2013","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.jare.2025.07.002_b0030","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.2147\/JIR.S414891","article-title":"Interaction between blood vasculatures and lymphatic vasculatures during inflammation","volume":"16","author":"Wang","year":"2023","journal-title":"J Inflamm Res"},{"issue":"27","key":"10.1016\/j.jare.2025.07.002_b0035","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology of inflammatory bowel diseases","volume":"383","author":"Chang","year":"2020","journal-title":"New England J Med"},{"issue":"7","key":"10.1016\/j.jare.2025.07.002_b0040","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1053\/j.gastro.2006.03.054","article-title":"Angiogenesis as a novel component of inflammatory bowel disease pathogenesis","volume":"130","author":"Danese","year":"2006","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.jare.2025.07.002_b0045","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1136\/gut.2010.207480","article-title":"Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'brothers in arms'","volume":"60","author":"Danese","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jare.2025.07.002_b0050","article-title":"Angiogenesis in inflammatory bowel disease","volume":"2015","author":"Alkim","year":"2015","journal-title":"Int J Inflamm"},{"issue":"6","key":"10.1016\/j.jare.2025.07.002_b0055","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2353\/ajpath.2008.070593","article-title":"Multiple pathogenic roles of microvasculature in inflammatory bowel disease: a Jack of all trades","volume":"172","author":"Deban","year":"2008","journal-title":"Am J Pathol"},{"issue":"2","key":"10.1016\/j.jare.2025.07.002_b0060","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1053\/j.gastro.2008.12.029","article-title":"Is inflammatory bowel disease a vascular disease? Targeting angiogenesis improves chronic inflammation in inflammatory bowel disease","volume":"136","author":"Binion","year":"2009","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.jare.2025.07.002_b0065","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s10495-017-1396-9","article-title":"Structural aspects of transglutaminase 2: functional, structural, and regulatory diversity","volume":"22","author":"Lee","year":"2017","journal-title":"Apopt Int J Program Cell Death"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1152\/physrev.00003.2023","article-title":"Tissue transglutaminase: a multifunctional and multisite regulator in health and disease","volume":"104","author":"Yao","year":"2024","journal-title":"Physiol Rev"},{"issue":"5","key":"10.1016\/j.jare.2025.07.002_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052797","article-title":"The role of transglutaminase 2 in cancer: an update","volume":"25","author":"Zaltron","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.jare.2025.07.002_b0080","doi-asserted-by":"crossref","first-page":"e3032","DOI":"10.1038\/cddis.2017.399","article-title":"The functional relationship between transglutaminase 2 and transforming growth factor \u03b21 in the regulation of angiogenesis and endothelial-mesenchymal transition","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis"},{"issue":"14","key":"10.1016\/j.jare.2025.07.002_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21145042","article-title":"Transglutaminase 2-mediated p53 depletion promotes angiogenesis by increasing HIF-1\u03b1-p300 binding in renal cell carcinoma","volume":"21","author":"Lee","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.xphs.2020.11.001","article-title":"Proteomics-informed identification of luminal targets for in situ diagnosis of inflammatory bowel disease","volume":"110","author":"Asad","year":"2021","journal-title":"J Pharm Sci"},{"issue":"3","key":"10.1016\/j.jare.2025.07.002_b0095","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/labinvest.2010.186","article-title":"Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease","volume":"91","author":"Elli","year":"2011","journal-title":"Laborat Invest; A J Technical Methods Pathol"},{"issue":"11","key":"10.1016\/j.jare.2025.07.002_b0100","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1038\/emm.2016.95","article-title":"Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis","volume":"48","author":"Jeong","year":"2016","journal-title":"Exp Mol Med"},{"issue":"6","key":"10.1016\/j.jare.2025.07.002_b0105","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and Ileo-anal pouch disorders","volume":"11","author":"Magro","year":"2017","journal-title":"J Crohns Colitis"},{"issue":"7","key":"10.1016\/j.jare.2025.07.002_b0110","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/gut.30.7.983","article-title":"Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Groupe d'Etudes Th\u00e9rapeutiques des Affections Inflammatoires du Tube Digestif (GETAID)","volume":"30","author":"Mary","year":"1989","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","article-title":"3rd European evidence-based consensus on the diagnosis and management of Crohn's disease 2016: Part 1: diagnosis and medical management","volume":"11","author":"Gomoll\u00f3n","year":"2017","journal-title":"J Crohns Colitis"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0120","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1038\/s41467-023-38785-y","article-title":"Express analyst: a unified platform for RNA-sequencing analysis in non-model species","volume":"14","author":"Liu","year":"2023","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.jare.2025.07.002_b0125","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cell.2019.08.008","article-title":"Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy","volume":"178","author":"Martin","year":"2019","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jare.2025.07.002_b0130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/ibd\/izac201","article-title":"Assessing cellular and transcriptional diversity of Ileal Mucosa among treatment-Na\u00efve and treated Crohn's disease","volume":"29","author":"Maddipatla","year":"2023","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0135","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1038\/s41467-023-40156-6","article-title":"Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease","volume":"14","author":"Garrido-Trigo","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0140","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1038\/s41467-023-39173-2","article-title":"Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis","volume":"14","author":"Du","year":"2023","journal-title":"Nat Commun"},{"issue":"13","key":"10.1016\/j.jare.2025.07.002_b0145","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"43","key":"10.1016\/j.jare.2025.07.002_b0150","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J Open Source Soft"},{"issue":"7","key":"10.1016\/j.jare.2025.07.002_b0155","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"issue":"6","key":"10.1016\/j.jare.2025.07.002_b0160","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1053\/gast.1997.v112.pm9178682","article-title":"Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease","volume":"112","author":"Binion","year":"1997","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0165","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.1038\/s41467-024-50048-y","article-title":"Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.jare.2025.07.002_b0170","first-page":"559","article-title":"Strategies for targeting cytokines in inflammatory bowel disease","volume":"24","author":"Neurath","year":"2024","journal-title":"Nat RevImmunol."},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10456-017-9583-4","article-title":"Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions","volume":"21","author":"Sajib","year":"2018","journal-title":"Angiogenesis"},{"issue":"6","key":"10.1016\/j.jare.2025.07.002_b0180","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/MIB.0000000000000791","article-title":"The role of the mesentery in crohn's disease: the contributions of nerves, vessels, lymphatics, and fat to the pathogenesis and disease course","volume":"22","author":"Li","year":"2016","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0185","doi-asserted-by":"crossref","first-page":"G5","DOI":"10.1152\/ajpgi.00107.2007","article-title":"Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues","volume":"293","author":"Chidlow","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7","key":"10.1016\/j.jare.2025.07.002_b0190","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jare.2025.07.002_b0195","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.191.4.603","article-title":"The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase","volume":"191","author":"Arentz-Hansen","year":"2000","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0200","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa2032441","article-title":"A randomized trial of a transglutaminase 2 inhibitor for celiac disease","volume":"385","author":"Schuppan","year":"2021","journal-title":"New Engl J Med"},{"issue":"9","key":"10.1016\/j.jare.2025.07.002_b0205","doi-asserted-by":"crossref","first-page":"e808","DOI":"10.1038\/cddis.2013.318","article-title":"A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis","volume":"4","author":"Wang","year":"2013","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.jare.2025.07.002_b0210","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2008.09.064","article-title":"VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis","volume":"136","author":"Scaldaferri","year":"2009","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.jare.2025.07.002_b0215","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm.2016.87","article-title":"Mechanisms and regulation of endothelial VEGF receptor signalling","volume":"17","author":"Simons","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"10.1016\/j.jare.2025.07.002_b0220","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1136\/gut.2008.152496","article-title":"Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition","volume":"57","author":"Binion","year":"2008","journal-title":"Gut"},{"issue":"D1","key":"10.1016\/j.jare.2025.07.002_b0225","doi-asserted-by":"crossref","first-page":"D104","DOI":"10.1093\/nar\/gkaa1057","article-title":"GTRD: an integrated view of transcription regulation","volume":"49","author":"Kolmykov","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jare.2025.07.002_b0230","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jss.2013.04.026","article-title":"Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis","volume":"184","author":"Knod","year":"2013","journal-title":"J Surg Res"},{"issue":"5","key":"10.1016\/j.jare.2025.07.002_b0235","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/gut.2006.112524","article-title":"Bevacizumab and postponed suture leakages after surgery for ulcerative colitis and rectal cancer","volume":"56","author":"Adenis","year":"2007","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.jare.2025.07.002_b0240","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/annonc\/mdn566","article-title":"Acute exacerbation of hemorrhagic rectocolitis during antiangiogenic therapy with sunitinib and sorafenib","volume":"19","author":"Loriot","year":"2008","journal-title":"Ann Oncol: Off J Eur Soc Med Oncol"},{"issue":"5","key":"10.1016\/j.jare.2025.07.002_b0245","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): determining Therapeutic Goals for Treat-to-Target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"issue":"19","key":"10.1016\/j.jare.2025.07.002_b0250","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12196292","article-title":"Benefits and challenges of treat-to-target in inflammatory bowel disease","volume":"12","author":"West","year":"2023","journal-title":"J Clin Med"},{"issue":"12","key":"10.1016\/j.jare.2025.07.002_b0255","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1136\/gutjnl-2021-326562","article-title":"Recent advances in clinical practice: advances in cross-sectional imaging in inflammatory bowel disease","volume":"71","author":"Rimola","year":"2022","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.jare.2025.07.002_b0260","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11051408","article-title":"The utility of faecal calprotectin, lactoferrin and other faecal biomarkers in discriminating endoscopic activity in Crohn's disease: a systematic review and meta-analysis","volume":"11","author":"Bohra","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jare.2025.07.002_b0265","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.imlet.2022.05.005","article-title":"Overexpression of pigment epithelium-derived factor in breast cancer cell-derived exosomes induces M1 polarization in macrophages","volume":"248","author":"Moradi-Chaleshtori","year":"2022","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jare.2025.07.002_b0270","doi-asserted-by":"crossref","first-page":"14206","DOI":"10.1038\/ncomms14206","article-title":"Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity","volume":"8","author":"Hernandez-Fernaud","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225005004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225005004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:58:09Z","timestamp":1778835489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225005004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":54,"alternative-id":["S2090123225005004"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.002","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial growth factor receptor 2 pathway in inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}