{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:02:33Z","timestamp":1788631353182,"version":"build-2803163510"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271006"],"award-info":[{"award-number":["32271006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jare.2025.07.035","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T15:23:33Z","timestamp":1752938613000},"page":"429-448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids"],"prefix":"10.1016","volume":"82","author":[{"given":"Jing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangfang","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jare.2025.07.035_b0005","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13451","article-title":"MeCP2 prevents age-associated cognitive decline via restoring synaptic plasticity in a senescence-accelerated mouse model","volume":"20","author":"Huang","year":"2021","journal-title":"Aging Cell"},{"issue":"22","key":"10.1016\/j.jare.2025.07.035_h0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216249","article-title":"Diogenes, adenosinergic system and BDNF signalling changes as a cross-sectional feature of RTT: characterization of Mecp2 heterozygous mouse females","volume":"24","author":"Miranda-Lourenco","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jare.2025.07.035_h0015","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1093\/nar\/gkae051","article-title":"Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2","volume":"52","author":"Ortega-Alarcon","year":"2024","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0015","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00125-013-3072-0","article-title":"Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons","volume":"57","author":"Wang","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.jare.2025.07.035_h0025","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.743207","article-title":"MeCP2 epigenetic silencing of oprm1 gene in primary sensory neurons under neuropathic pain conditions","author":"Sun","year":"2021","journal-title":"Front Neurosci"},{"issue":"8","key":"10.1016\/j.jare.2025.07.035_h0030","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s12276-022-00790-4","article-title":"MeCP2 inhibits ischemic neuronal injury by enhancing methylation of the FOXO3a promoter to repress the SPRY2-ZEB1 axis","volume":"54","author":"Meng","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jare.2025.07.035_b0025","article-title":"Metabolic signatures differentiate rett syndrome from unaffected siblings","volume":"147","author":"Neul","year":"2020","journal-title":"Front Integr Neurosci"},{"issue":"9","key":"10.1016\/j.jare.2025.07.035_b0030","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/gim.2015.186","article-title":"Diagnostic exome sequencing provides a molecular diagnosis for a significant proportion of patients with epilepsy","volume":"18","author":"Helbig","year":"2016","journal-title":"Genet Med"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_h0045","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12967-016-0930-9","article-title":"New perspective in diagnostics of mitochondrial disorders: two years' experience with whole-exome sequencing at a national paediatric centre","volume":"14","author":"Pronicka","year":"2016","journal-title":"J Transl Med"},{"key":"10.1016\/j.jare.2025.07.035_h0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108790","article-title":"Impaired mitochondrial quality control in Rett Syndrome","author":"Crivellari","year":"2021","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.nbd.2012.06.007","article-title":"Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome","volume":"48","author":"Grosser","year":"2012","journal-title":"Neurobiol Dis"},{"issue":"4","key":"10.1016\/j.jare.2025.07.035_b0045","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.stem.2013.09.001","article-title":"Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons","volume":"13","author":"Li","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0050","doi-asserted-by":"crossref","first-page":"20565","DOI":"10.1038\/s41598-024-71040-y","article-title":"Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons","volume":"14","author":"Tomasello","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0055","first-page":"32","article-title":"Mitochondrial quality control in human health and disease","volume":"11","author":"Liu","year":"2024","journal-title":"Mil Med Res"},{"issue":"10","key":"10.1016\/j.jare.2025.07.035_b0060","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat Cell Biol"},{"issue":"12","key":"10.1016\/j.jare.2025.07.035_b0065","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1080\/15548627.2021.1907167","article-title":"The role of mitophagy in the regulation of mitochondrial energetic status in neurons","volume":"17","author":"Han","year":"2021","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.jare.2025.07.035_b0070","article-title":"Mitophagy: a new player in stem cell biology","volume":"9","author":"Cairns","year":"2020","journal-title":"Biology (Basel)"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0075","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41467-020-20679-y","article-title":"BNIP3L\/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects","volume":"12","author":"Choi","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jare.2025.07.035_b0080","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/15548627.2020.1728096","article-title":"Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease","volume":"17","author":"Franco-Iborra","year":"2021","journal-title":"Autophagy"},{"issue":"7722","key":"10.1016\/j.jare.2025.07.035_h0100","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.jare.2025.07.035_h0105","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1016\/j.molcel.2021.10.001","article-title":"Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy","volume":"81","author":"Ordureau","year":"2021","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.jare.2025.07.035_h0110","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s43587-022-00214-y","article-title":"Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in drosophila","volume":"2","author":"Schmid","year":"2022","journal-title":"Nat Aging"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0090","doi-asserted-by":"crossref","first-page":"12297","DOI":"10.1038\/s41598-017-12069-0","article-title":"Retention of mitochondria in mature human red blood cells as the result of autophagy impairment in Rett syndrome","volume":"7","author":"Sbardella","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.07.035_b0095","first-page":"15537","article-title":"Proteomic profiling reveals mitochondrial alterations in Rett syndrome","author":"Cicaloni","year":"2020","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"10.1016\/j.jare.2025.07.035_b0100","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1038\/s44321-024-00151-w","article-title":"Unraveling autophagic imbalances and therapeutic insights in Mecp2-deficient models","volume":"16","author":"Esposito","year":"2024","journal-title":"EMBO Mol Med"},{"issue":"7467","key":"10.1016\/j.jare.2025.07.035_b0105","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.jare.2025.07.035_b0110","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41582-022-00723-9","article-title":"Human cerebral organoids - a new tool for clinical neurology research","volume":"18","author":"Eichmuller","year":"2022","journal-title":"Nat Rev Neurol"},{"issue":"12","key":"10.1016\/j.jare.2025.07.035_b0115","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.neuron.2024.04.007","article-title":"MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons","volume":"112","author":"Liu","year":"2024","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.jare.2025.07.035_b0120","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat Methods"},{"issue":"5","key":"10.1016\/j.jare.2025.07.035_b0125","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nmeth.1593","article-title":"Chemically defined conditions for human iPSC derivation and culture","volume":"8","author":"Chen","year":"2011","journal-title":"Nat Methods"},{"issue":"11","key":"10.1016\/j.jare.2025.07.035_b0130","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat Protoc"},{"issue":"8","key":"10.1016\/j.jare.2025.07.035_b0135","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s11064-016-1918-9","article-title":"Generation of human embryonic stem cell line expressing zsGreen in cholinergic neurons using CRISPR\/Cas9 system","volume":"41","author":"Zhou","year":"2016","journal-title":"Neurochem Res"},{"issue":"10","key":"10.1016\/j.jare.2025.07.035_b0140","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/bioinformatics\/btu048","article-title":"Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases","volume":"30","author":"Bae","year":"2014","journal-title":"Bioinformatics"},{"issue":"7762","key":"10.1016\/j.jare.2025.07.035_b0145","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41586-019-1289-x","article-title":"Individual brain organoids reproducibly form cell diversity of the human cerebral cortex","volume":"570","author":"Velasco","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0150","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/s41467-021-22117-z","article-title":"Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome","volume":"12","author":"Inak","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0155","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"issue":"W1","key":"10.1016\/j.jare.2025.07.035_b0160","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"10.1016\/j.jare.2025.07.035_b0165","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.jare.2025.07.035_b0170","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1002\/imt2.36","article-title":"Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform","volume":"1","author":"Shen","year":"2022","journal-title":"Imeta"},{"issue":"2","key":"10.1016\/j.jare.2025.07.035_b0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_h0205","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/brain\/awac244","article-title":"Cerebral organoids containing an AUTS2 missense variant model microcephaly","volume":"146","author":"Fair","year":"2023","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.jare.2025.07.035_h0210","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/acn3.51799","article-title":"MeCP2 dysfunction prevents proper BMP signaling and neural progenitor expansion in brain organoid","volume":"10","author":"Hong","year":"2023","journal-title":"Ann Clin Transl Neurol"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0185","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1038\/s41467-023-39337-0","article-title":"Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviours via autophagy pathway","volume":"14","author":"Guo","year":"2023","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jare.2025.07.035_b0190","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.neuron.2013.05.020","article-title":"Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons","volume":"78","author":"Kim","year":"2013","journal-title":"Neuron"},{"issue":"33","key":"10.1016\/j.jare.2025.07.035_b0195","doi-asserted-by":"crossref","first-page":"E6952","DOI":"10.1073\/pnas.1618210114","article-title":"Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome","volume":"114","author":"Bhattacherjee","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.jare.2025.07.035_b0200","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41582-024-00955-x","article-title":"Neurofilaments as biomarkers in neurological disorders - towards clinical application","volume":"20","author":"Khalil","year":"2024","journal-title":"Nat Rev Neurol"},{"issue":"7","key":"10.1016\/j.jare.2025.07.035_b0205","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death","volume":"17","author":"D'Amelio","year":"2010","journal-title":"Cell Death Differ"},{"issue":"6505","key":"10.1016\/j.jare.2025.07.035_b0210","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.aba9760","article-title":"Mitochondrial dynamics in postmitotic cells regulate neurogenesis","volume":"369","author":"Iwata","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0215","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12967-024-05041-w","article-title":"Mitochondrial metabolism in neural stem cells and implications for neurodevelopmental and neurodegenerative diseases","volume":"22","author":"Garone","year":"2024","journal-title":"J Transl Med"},{"issue":"5","key":"10.1016\/j.jare.2025.07.035_b0220","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2012.10.005","article-title":"Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal","volume":"11","author":"Zhang","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"11","key":"10.1016\/j.jare.2025.07.035_b0225","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112490","article-title":"Stem cell metabolism: powering cell-based therapeutics","volume":"9","author":"Rigaud","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0230","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41467-019-13781-3","article-title":"Angus McQuibban, ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway","volume":"11","author":"Moskal","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.07.035_b0235","first-page":"8412","article-title":"Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1","author":"Vasconcelos","year":"2014","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"10.1016\/j.jare.2025.07.035_h0270","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4103\/1673-5374.248108","article-title":"Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias","volume":"14","author":"Mou","year":"2019","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jare.2025.07.035_h0275","article-title":"Mitochondrial behaviour in axon degeneration and regeneration","author":"Wang","year":"2021","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"10.1016\/j.jare.2025.07.035_b0245","doi-asserted-by":"crossref","first-page":"741","DOI":"10.4103\/1673-5374.322429","article-title":"Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases","volume":"17","author":"Ozgen","year":"2022","journal-title":"Neural Regen Res"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0250","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41419-021-04469-y","article-title":"BNIP3L\/NIX-mediated mitophagy: molecular mechanisms and implications for human disease","volume":"13","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jare.2025.07.035_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101191","article-title":"Defective mitophagy in Alzheimer's disease","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res Rev"},{"issue":"W1","key":"10.1016\/j.jare.2025.07.035_b0260","doi-asserted-by":"crossref","first-page":"W118","DOI":"10.1093\/nar\/gkaf389","article-title":"Variant-aware Cas-OFFinder: web-based in silico variant-aware potential off-target site identification for genome editing applications","volume":"53","author":"Mekonnen","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.jare.2025.07.035_b0265","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.stem.2020.02.002","article-title":"Sliced human cortical organoids for modelling distinct cortical layer formation","volume":"26","author":"Qian","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"7986","key":"10.1016\/j.jare.2025.07.035_b0270","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41586-023-06713-1","article-title":"Ginhoux, iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer","volume":"623","author":"Park","year":"2023","journal-title":"Nature"},{"issue":"7931","key":"10.1016\/j.jare.2025.07.035_b0275","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-022-05277-w","article-title":"Maturation and circuit integration of transplanted human cortical organoids","volume":"610","author":"Revah","year":"2022","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jare.2025.07.035_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109124","article-title":"MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signalling","volume":"35","author":"Nakashima","year":"2021","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0285","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s13287-022-03216-0","article-title":"KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCs","volume":"13","author":"Xu","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.jare.2025.07.035_b0290","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/mp.2017.86","article-title":"MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling","volume":"23","author":"Mellios","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"3","key":"10.1016\/j.jare.2025.07.035_b0295","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/joa.13055","article-title":"New insights into the development of the human cerebral cortex","volume":"235","author":"Molnar","year":"2019","journal-title":"J Anat"},{"issue":"6632","key":"10.1016\/j.jare.2025.07.035_b0300","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn4705","article-title":"Mitochondria metabolism sets the species-specific tempo of neuronal development","volume":"379","author":"Iwata","year":"2023","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jare.2025.07.035_b0305","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/s12276-022-00841-w","article-title":"Abeta-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation","volume":"54","author":"Kim","year":"2022","journal-title":"Exp Mol Med"},{"issue":"2","key":"10.1016\/j.jare.2025.07.035_b0310","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.stem.2016.04.015","article-title":"Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program","volume":"19","author":"Khacho","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.jare.2025.07.035_b0315","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.stem.2020.10.019","article-title":"ROS dynamics delineate functional states of hippocampal neural stem cells and link to their activity-dependent exit from quiescence","volume":"28","author":"Adusumilli","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jare.2025.07.035_b0320","first-page":"9525","article-title":"Calcium signalling: a common target in neurological disorders and neurogenesis","author":"Glaser","year":"2019","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0325","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1186\/s12967-023-04622-5","article-title":"Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome","volume":"21","author":"Musokhranova","year":"2023","journal-title":"J Transl Med"},{"issue":"13","key":"10.1016\/j.jare.2025.07.035_b0330","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136739","article-title":"Treatment with the bacterial toxin CNF1 selectively rescues cognitive and brain mitochondrial deficits in a female mouse model of Rett syndrome carrying a MeCP2-Null mutation","volume":"22","author":"Urbinati","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.07.035_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111942","article-title":"Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation","volume":"42","author":"Sun","year":"2023","journal-title":"Cell Rep"},{"issue":"24","key":"10.1016\/j.jare.2025.07.035_b0340","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1016\/j.molcel.2021.11.034","article-title":"Programmed autophagy prevents excess organelle baggage during neurogenesis","volume":"81","author":"Lazarou","year":"2021","journal-title":"Mol Cell"},{"issue":"8","key":"10.1016\/j.jare.2025.07.035_b0345","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41419-020-02836-9","article-title":"Dual effects of thyroid hormone on neurons and neurogenesis in traumatic brain injury","volume":"11","author":"Lin","year":"2020","journal-title":"Cell Death Dis"},{"issue":"10","key":"10.1016\/j.jare.2025.07.035_b0350","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102508","article-title":"Senescence phenomena and metabolic alteration in mesenchymal stromal cells from a mouse model of Rett syndrome","volume":"20","author":"Squillaro","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.07.035_b0355","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1507345","article-title":"Mechanisms of mitophagy and oxidative stress in cerebral ischemia-reperfusion vascular dementia, and Alzheimer's disease","author":"Lyu","year":"2024","journal-title":"Front Mol Neurosci"},{"issue":"7588","key":"10.1016\/j.jare.2025.07.035_b0360","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature16533","article-title":"Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2","volume":"530","author":"Liu","year":"2016","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jare.2025.07.035_b0365","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/j.1528-1167.2012.03501.x","article-title":"Electroclinical pattern in MECP2 duplication syndrome: eight new reported cases and review of literature","volume":"53","author":"Vignoli","year":"2012","journal-title":"Epilepsia"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225005600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225005600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:55:44Z","timestamp":1773640544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225005600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":80,"alternative-id":["S2090123225005600"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.035","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}