{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:03:57Z","timestamp":1787868237675,"version":"build-2784847793"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTC2021jscx-gksb-N0020"],"award-info":[{"award-number":["CSTC2021jscx-gksb-N0020"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2021ZD0201802"],"award-info":[{"award-number":["2021ZD0201802"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jare.2025.07.054","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T22:26:31Z","timestamp":1754432791000},"page":"287-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Fingernail-based metabolomics reveals a stepwise decline in dodecanoic acid associated with Alzheimer\u2019s disease progression"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7071-5931","authenticated-orcid":false,"given":"Wenbo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangjing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuhan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9425-2967","authenticated-orcid":false,"given":"Yang","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.07.054_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110022","article-title":"Metabolomic signatures of lead exposure in the VA normative aging study","volume":"190","author":"Kelly","year":"2020","journal-title":"Environ Res"},{"key":"10.1016\/j.jare.2025.07.054_b0010","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jchromb.2015.08.044","article-title":"Human nails metabolite analysis: a rapid and simple method for quantification of uric acid in human fingernail by high-performance liquid chromatography with UV-detection","volume":"1002","author":"Li","year":"2015","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"2","key":"10.1016\/j.jare.2025.07.054_b0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/10408363.2021.1991882","article-title":"Biomarkers of disease in human nails: a comprehensive review","volume":"59","author":"Jaramillo Ortiz","year":"2022","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"2","key":"10.1016\/j.jare.2025.07.054_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20021273","article-title":"Identification of Alzheimer's disease by imaging: a comprehensive review","volume":"20","author":"T","year":"2023","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"10.1016\/j.jare.2025.07.054_b0025","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/brain\/awac407","article-title":"Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration","volume":"146","author":"Gonzalez-Ortiz","year":"2023","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.jare.2025.07.054_b0030","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1002\/alz.13318","article-title":"Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease","volume":"19","author":"Yakoub","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jare.2025.07.054_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101987","article-title":"Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives","volume":"89","author":"Lista","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"10","key":"10.1016\/j.jare.2025.07.054_b0040","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF01726910","article-title":"Increased fructose-lysine of nail protein in diabetic patients","volume":"62","author":"Oimomi","year":"1984","journal-title":"Klin Wochenschr"},{"issue":"8","key":"10.1016\/j.jare.2025.07.054_b0045","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/bmc.3687","article-title":"Uric acid quantification in fingernail of gout patients and healthy volunteers using HPLC-UV","volume":"30","author":"Li","year":"2016","journal-title":"Biomed Chromatograp: BMC"},{"issue":"3","key":"10.1016\/j.jare.2025.07.054_b0050","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.biopsycho.2011.05.007","article-title":"Dehydroepiandrosterone in nails of infants: a potential biomarker of intrauterine responses to maternal stress","volume":"87","author":"Tegethoff","year":"2011","journal-title":"Biol Psychol"},{"issue":"3","key":"10.1016\/j.jare.2025.07.054_b0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"3","key":"10.1016\/j.jare.2025.07.054_b0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jare.2025.07.054_b0065","unstructured":"Center KADR. CDR\u00ae Scoring Table. Available at https:\/\/knightadrcwustledu\/professionals-clinicians\/cdr-dementia-staging-instrument\/cdr-scoring-table\/. 2015."},{"issue":"10","key":"10.1016\/j.jare.2025.07.054_b0070","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/nprot.2010.108","article-title":"Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry","volume":"5","author":"Smart","year":"2010","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.jare.2025.07.054_b0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41522-019-0086-5","article-title":"A metabolomic study of the effect of Candida albicans glutamate dehydrogenase deletion on growth and morphogenesis","volume":"5","author":"Han","year":"2019","journal-title":"npj Biofilms Microbiomes"},{"issue":"19","key":"10.1016\/j.jare.2025.07.054_b0080","first-page":"2573","article-title":"Normalization of peak intensities in bottom-up MS-based proteomics using singular value decomposition","volume":"25","author":"Karpievitch","year":"2009","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"1","key":"10.1016\/j.jare.2025.07.054_b0085","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12916-025-03920-7","article-title":"Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury","volume":"23","author":"Huang","year":"2025","journal-title":"BMC Med"},{"issue":"5","key":"10.1016\/j.jare.2025.07.054_b0090","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41422-022-00614-0","article-title":"Comprehensive metabolomics expands precision medicine for triple-negative breast cancer","volume":"32","author":"Xiao","year":"2022","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.jare.2025.07.054_b0095","doi-asserted-by":"crossref","first-page":"16393","DOI":"10.1038\/s41598-025-01161-5","article-title":"Application of interpretable machine learning algorithms to predict macroangiopathy risk in Chinese patients with type 2 diabetes mellitus","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jare.2025.07.054_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0007114515001452","article-title":"The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action","volume":"114","author":"Fernando","year":"2015","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1016\/j.jare.2025.07.054_b0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13195-024-01430-x","article-title":"Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer's astrocytes","volume":"16","author":"Zhang","year":"2024","journal-title":"Alzheimers Res Ther"},{"issue":"9","key":"10.1016\/j.jare.2025.07.054_b0110","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1021\/acs.jproteome.1c00290","article-title":"Metabolic profiling of neocortical tissue discriminates Alzheimer's disease from mild cognitive impairment, high pathology controls, and normal controls","volume":"20","author":"Jasbi","year":"2021","journal-title":"J Proteome Res"},{"issue":"2","key":"10.1016\/j.jare.2025.07.054_b0115","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3233\/JAD-230291","article-title":"Periodontal status and saliva metabolic signature in patients with Alzheimer's disease","volume":"95","author":"Yang","year":"2023","journal-title":"J Alzheimer's Dis: JAD"},{"issue":"3","key":"10.1016\/j.jare.2025.07.054_b0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1871527320666210405141123","article-title":"Dietary nutrients and prevention of Alzheimer's disease","volume":"21","author":"Chauhan","year":"2022","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"4","key":"10.1016\/j.jare.2025.07.054_b0125","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3349\/ymj.2023.0119","article-title":"Effect of dietary habits on Alzheimer's disease progression","volume":"65","author":"Ahn","year":"2024","journal-title":"Yonsei Med J"},{"issue":"1","key":"10.1016\/j.jare.2025.07.054_b0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s44324-024-00016-3","article-title":"Serum and CSF metabolomics analysis shows mediterranean ketogenic diet mitigates risk factors of Alzheimer's disease","volume":"2","author":"Schweickart","year":"2024","journal-title":"npj Metab Health Dis"},{"issue":"6","key":"10.1016\/j.jare.2025.07.054_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/nu15061429","article-title":"Dietary fats and cognitive status in Italian middle-old adults","volume":"15","author":"Currenti","year":"2023","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.jare.2025.07.054_b0140","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s11064-018-2587-7","article-title":"Lauric acid alleviates neuroinflammatory responses by activated microglia: involvement of the GPR40-dependent pathway","volume":"43","author":"Nishimura","year":"2018","journal-title":"Neurochem Res"},{"issue":"8","key":"10.1016\/j.jare.2025.07.054_b0145","doi-asserted-by":"crossref","first-page":"693","DOI":"10.5650\/jos.ess16069","article-title":"Lauric acid stimulates ketone body production in the KT-5 astrocyte cell line","volume":"65","author":"Nonaka","year":"2016","journal-title":"J Oleo Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.07.054_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108572","article-title":"ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism","volume":"34","author":"Qi","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.jare.2025.07.054_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101043","article-title":"Blood fatty acids in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review","volume":"60","author":"Hosseini","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jare.2025.07.054_b0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molmet.2019.08.010","article-title":"Clinical and lifestyle related factors influencing whole blood metabolite levels - a comparative analysis of three large cohorts","volume":"29","author":"Beuchel","year":"2019","journal-title":"Mol Metab"},{"issue":"3","key":"10.1016\/j.jare.2025.07.054_b0165","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s12551-023-01069-2","article-title":"Quantitative analysis of human hairs and nails","volume":"15","author":"Bali","year":"2023","journal-title":"Biophys Rev"},{"issue":"6","key":"10.1016\/j.jare.2025.07.054_b0170","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1007\/s12559-024-10346-5","article-title":"Diagnostic potential of eye movements in Alzheimer\u2019s disease via a multiclass machine learning model","volume":"16","author":"Song","year":"2024","journal-title":"Cogn Comput"},{"key":"10.1016\/j.jare.2025.07.054_b0175","article-title":"A comprehensive review of computer-aided diagnosis of major mental and neurological disorders and suicide: a biostatistical perspective on data mining","volume":"11","author":"Mansourian","year":"2021","journal-title":"Diagnostics (Basel, Switzerland)"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225005843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225005843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:25:51Z","timestamp":1776885951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225005843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":35,"alternative-id":["S2090123225005843"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.054","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fingernail-based metabolomics reveals a stepwise decline in dodecanoic acid associated with Alzheimer\u2019s disease progression","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.07.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}