{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T21:12:40Z","timestamp":1794085960286,"version":"4.8.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z201100005520017"],"award-info":[{"award-number":["Z201100005520017"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z201100005520016"],"award-info":[{"award-number":["Z201100005520016"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20354"],"award-info":[{"award-number":["U20A20354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012149","name":"National Key Scientific Instrument and Equipment Development Projects of China","doi-asserted-by":"publisher","award":["81530036"],"award-info":[{"award-number":["81530036"]}],"id":[{"id":"10.13039\/501100012149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012149","name":"National Key Scientific Instrument and Equipment Development Projects of China","doi-asserted-by":"publisher","award":["31627803"],"award-info":[{"award-number":["31627803"]}],"id":[{"id":"10.13039\/501100012149","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jare.2025.08.012","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T08:34:39Z","timestamp":1755506079000},"page":"727-740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Proteomic signature of dementia risk in type 2 diabetes"],"prefix":"10.1016","volume":"83","author":[{"given":"Zhibo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuye","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuman","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-0336","authenticated-orcid":false,"given":"Jianping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.08.012_b0005","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1016\/j.cell.2024.06.029","article-title":"Diabetes mellitus-Progress and opportunities in the evolving epidemic","volume":"187","author":"Abel","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jare.2025.08.012_b0010","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S2213-8587(24)00158-X","article-title":"Call for effective therapies for preventing dementia in people with type 2 diabetes","volume":"12","author":"van Sloten","year":"2024","journal-title":"The Lancet Diabetes & Endocrinology"},{"key":"10.1016\/j.jare.2025.08.012_b0015","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3233\/JAD-190427","article-title":"Diabetes-Associated Dementia Risk and competing risk of death in the Three-City Study","volume":"71","author":"Frison","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jare.2025.08.012_b0020","doi-asserted-by":"crossref","first-page":"e661","DOI":"10.1016\/S2468-2667(20)30185-7","article-title":"Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study","volume":"5","author":"Jia","year":"2020","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jare.2025.08.012_b0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2147\/NDT.S189905","article-title":"Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment","volume":"15","author":"Albai","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.jare.2025.08.012_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194735","article-title":"Predicting dementia from primary care records: a systematic review and meta-analysis","volume":"13","author":"Ford","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.08.012_b0035","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S1474-4422(20)30139-3","article-title":"Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective","volume":"19","author":"Biessels","year":"2020","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.jare.2025.08.012_b0040","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrendo.2010.228","article-title":"Cognitive function, dementia and type 2 diabetes mellitus in the elderly","volume":"7","author":"Strachan","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2025.08.012_b0045","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.2337\/db13-1954","article-title":"Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease","volume":"63","author":"De Felice","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jare.2025.08.012_b0050","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41574-018-0048-7","article-title":"Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications","volume":"14","author":"Biessels","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2025.08.012_b0055","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.58149","article-title":"Alzheimer Disease Blood Biomarkers and Cognition among individuals with Diabetes and Overweight or Obesity","volume":"8","author":"Mielke","year":"2025","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jare.2025.08.012_b0060","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S2213-8587(13)70048-2","article-title":"Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: a cohort study","volume":"1","author":"Exalto","year":"2013","journal-title":"The Lancet Diabetes & Endocrinology"},{"key":"10.1016\/j.jare.2025.08.012_b0065","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/ene.13642","article-title":"Risk score prediction model for dementia in patients with type 2 diabetes","volume":"25","author":"Li","year":"2018","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jare.2025.08.012_b0070","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41591-019-0665-2","article-title":"Plasma protein patterns as comprehensive indicators of health","volume":"25","author":"Williams","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.08.012_b0075","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.08.012_b0080","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature01514","article-title":"Disease proteomics","volume":"422","author":"Hanash","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.08.012_b0085","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2337\/dc22-1830","article-title":"Proteomic Predictors of Incident Diabetes: results from the Atherosclerosis Risk in Communities (ARIC) study","volume":"46","author":"Rooney","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2025.08.012_b0090","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1038\/s41591-022-02055-z","article-title":"Proteomic signatures for identification of impaired glucose tolerance","volume":"28","author":"Carrasco-Zanini","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.08.012_b0095","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2337\/dc24-1696","article-title":"Large-Scale Plasma Proteomics Improves Prediction of Peripheral Artery Disease in individuals with Type 2 Diabetes: a prospective Cohort Study","volume":"48","author":"Yu","year":"2025","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2025.08.012_b0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12933-024-02143-z","article-title":"Association of plasma proteomics with incident coronary heart disease in individuals with and without type 2 diabetes: results from the population-based KORA study","volume":"23","author":"Luo","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jare.2025.08.012_b0105","doi-asserted-by":"crossref","DOI":"10.2337\/dc24-0290","article-title":"Large-Scale Proteomics Improve Prediction of Chronic Kidney Disease in people with Diabetes","author":"Ye","year":"2024","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2025.08.012_b0110","article-title":"Plasma Proteomics of Diabetic Kidney Disease among Asians with Younger-Onset Type 2 Diabetes","author":"Gurung","year":"2024","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jare.2025.08.012_b0115","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s43587-023-00565-0","article-title":"Plasma proteomic profiles predict future dementia in healthy adults","volume":"4","author":"Guo","year":"2024","journal-title":"Nat Aging"},{"key":"10.1016\/j.jare.2025.08.012_b0120","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/alz.12419","article-title":"Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies","volume":"18","author":"Lindbohm","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jare.2025.08.012_b0125","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s41586-025-08584-0","article-title":"Mass-spectrometry-based proteomics: from single cells to clinical applications","volume":"638","author":"Guo","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.08.012_b0130","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.08.012_b0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2337\/dc21-1512","article-title":"Association of a Healthy Lifestyle with All-Cause and Cause-Specific Mortality among Individuals with Type 2 Diabetes: a prospective Study in UK Biobank","volume":"45","author":"Han","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2025.08.012_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v077.i01","article-title":"ranger: a Fast Implementation of Random Forests for High Dimensional Data in C++ and R","volume":"77","author":"Wright","year":"2017","journal-title":"J Stat Softw"},{"key":"10.1016\/j.jare.2025.08.012_b0145","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41591-023-02790-x","article-title":"Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma","volume":"30","author":"Jiang","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.08.012_b0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.32614\/RJ-2014-008","article-title":"ROSE: a package for binary imbalanced learning","volume":"6","author":"Lunardon","year":"2014","journal-title":"The R Journal"},{"key":"10.1016\/j.jare.2025.08.012_b0155","first-page":"48","article-title":"Package \u2018caret\u2019","volume":"223","author":"Kuhn","year":"2020","journal-title":"The R Journal"},{"key":"10.1016\/j.jare.2025.08.012_b0160","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.jare.2025.08.012_b0165","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. the","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.jare.2025.08.012_b0170","first-page":"2013","article-title":"Package \u2018igraph\u2019","volume":"3","author":"Csardi","year":"2013","journal-title":"Last accessed"},{"key":"10.1016\/j.jare.2025.08.012_b0175","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biochi.2020.04.003","article-title":"EDA2R mediates podocyte injury in high glucose milieu","volume":"174","author":"Lan","year":"2020","journal-title":"Biochimie"},{"key":"10.1016\/j.jare.2025.08.012_b0180","doi-asserted-by":"crossref","unstructured":"Gong J, Williams DM, Scholes S, Assaad S, Bu F, Hayat S, et al. Unraveling the role of plasma proteins in dementia: insights from two cohort studies in the UK, with causal evidence from Mendelian randomization. medRxiv. 2024:2024.06.04.24308415.","DOI":"10.1101\/2024.06.04.24308415"},{"key":"10.1016\/j.jare.2025.08.012_b0185","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s11357-023-00764-y","article-title":"Plasma levels of neurology-related proteins are associated with cognitive performance in an older population with overweight\/obesity and metabolic syndrome","volume":"45","author":"Llaurador-Coll","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.jare.2025.08.012_b0190","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13024-020-00388-2","article-title":"Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach","volume":"15","author":"van Steenoven","year":"2020","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jare.2025.08.012_b0195","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/jnnp-2019-322493","article-title":"Neuronal pentraxin 2: a synapse-derived CSF biomarker in genetic frontotemporal dementia","volume":"91","author":"van der Ende","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jare.2025.08.012_b0200","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41398-024-02915-x","article-title":"The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses","volume":"14","author":"Walker","year":"2024","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jare.2025.08.012_b0205","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0165-6147(02)01899-0","article-title":"Carbonic anhydrase gating of attention: memory therapy and enhancement","volume":"23","author":"Sun","year":"2002","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jare.2025.08.012_b0210","doi-asserted-by":"crossref","first-page":"16035","DOI":"10.1038\/npjgenmed.2016.35","article-title":"Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers","volume":"1","author":"Pedersen","year":"2016","journal-title":"NPJ Genom Med"},{"key":"10.1016\/j.jare.2025.08.012_b0215","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13195-017-0320-4","article-title":"Rho GTPases as therapeutic targets in Alzheimer\u2019s disease","volume":"9","author":"Aguilar","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.jare.2025.08.012_b0220","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2024.6619","article-title":"Changes in Alzheimer Disease Blood Biomarkers and Associations with Incident All-Cause Dementia","author":"Lu","year":"2024","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jare.2025.08.012_b0225","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/jnnp-2018-318212","article-title":"Models for predicting risk of dementia: a systematic review","volume":"90","author":"Hou","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jare.2025.08.012_b0230","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf5681","article-title":"Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life","volume":"15","author":"Walker","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jare.2025.08.012_b0235","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-024-03164-7","article-title":"Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations","author":"Argentieri","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.08.012_b0240","doi-asserted-by":"crossref","first-page":"785","DOI":"10.7326\/M14-0737","volume":"161","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jare.2025.08.012_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2017.05.005","article-title":"Physical activity modifies the influence of apolipoprotein E \u03b54 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans","volume":"14","author":"Shih","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jare.2025.08.012_b0250","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.2337\/dc21-1597","article-title":"Changes in Physical activity and the risk of Dementia in patients with New-Onset Type 2 Diabetes: a Nationwide Cohort Study","volume":"45","author":"Yoo","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2025.08.012_b0255","article-title":"Opposite causal effects of type 2 diabetes and metformin on Alzheimer's disease","volume":"100129","author":"Liu","year":"2025","journal-title":"J Prev Alzheimers Dis"},{"key":"10.1016\/j.jare.2025.08.012_b0260","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.2337\/dc20-0892","article-title":"Metformin Use is Associated with Slowed Cognitive Decline and Reduced Incident Dementia in older adults with Type 2 Diabetes: the Sydney memory and Ageing Study","volume":"43","author":"Samaras","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2025.08.012_b0265","article-title":"Metformin use is associated with a reduced risk of cognitive impairment in adults with diabetes mellitus: a systematic review and meta-analysis","volume":"16","author":"Zhang","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jare.2025.08.012_b0270","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/alz.12161","article-title":"Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status","volume":"16","author":"Wu","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jare.2025.08.012_b0275","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S1474-4422(11)70188-0","article-title":"Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy","volume":"10","author":"Launer","year":"2011","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.jare.2025.08.012_b0280","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.963933","article-title":"Efficacy of intranasal insulin in improving cognition in mild cognitive impairment or dementia: a systematic review and meta-analysis","volume":"14","author":"Long","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jare.2025.08.012_b0285","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.2337\/dc23-0222","article-title":"Insulin Use in Type 2 Diabetes and the risk of Dementia: a Comparative Population-based Cohort Study","volume":"46","author":"Alkabbani","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jare.2025.08.012_b0290","unstructured":"Tang H, Donahoo WT, Svensson M, Shaaban CE, Smith G, Jaffee MS, et al. Heterogeneous treatment effects of sodium-glucose cotransporter 2 inhibitors on risk of dementia in people with type 2 diabetes: A population-based cohort study. Alzheimer's & Dementia.n\/a."},{"key":"10.1016\/j.jare.2025.08.012_b0295","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tem.2017.11.001","article-title":"JAK\/STAT\u2013emerging players in metabolism","volume":"29","author":"Dodington","year":"2018","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"10.1016\/j.jare.2025.08.012_b0300","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/ijms24010864","article-title":"The Role of the JAK\/STAT signaling pathway in the pathogenesis of alzheimer\u2019s disease: new potential treatment target","volume":"24","author":"Rusek","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.08.012_b0305","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9846312","article-title":"Therapeutic Targeting of the Proinflammatory IL-6-JAK\/STAT Signalling Pathways responsible for Vascular Restenosis in Type 2 Diabetes Mellitus","volume":"2019","author":"Moshapa","year":"2019","journal-title":"Cardiol Res Pract"},{"key":"10.1016\/j.jare.2025.08.012_b0310","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1523\/JNEUROSCI.3516-14.2015","article-title":"The JAK\/STAT3 Pathway is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases","volume":"35","author":"Ben Haim","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.jare.2025.08.012_b0315","series-title":"Chakrabarti S","first-page":"14","author":"Wang","year":"2023"},{"key":"10.1016\/j.jare.2025.08.012_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103246","article-title":"Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la\/KLF5 pathway","volume":"75","author":"Zhang","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2025.08.012_b0325","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12974-024-03166-9","article-title":"Herpes simplex virus 1 accelerates the progression of Alzheimer's disease by modulating microglial phagocytosis and activating NLRP3 pathway","volume":"21","author":"Wang","year":"2024","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.08.012_b0330","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-240073","article-title":"Analysis of the Association between Pathogen Exposure and the risk of Dementia","author":"Fu","year":"2024","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jare.2025.08.012_b0335","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41591-023-02729-2","article-title":"Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone","volume":"30","author":"Banerjee","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.08.012_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002266","article-title":"Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: a nontargeted metabolomic study","volume":"14","author":"Snowden","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.jare.2025.08.012_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-017-0277-3","article-title":"A novel Alzheimer\u2019s disease drug candidate targeting inflammation and fatty acid metabolism","volume":"9","author":"Daugherty","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.jare.2025.08.012_b0350","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/jama.2021.4001","article-title":"Association between Age at Diabetes Onset and subsequent risk of Dementia","volume":"325","author":"Barbiellini Amidei","year":"2021","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jare.2025.08.012_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101102","article-title":"GLP-1 receptor agonists in the treatment of type 2 diabetes\u2013state-of-the-art","volume":"46","author":"Nauck","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.jare.2025.08.012_b0360","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrendo.2011.243","article-title":"SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects","volume":"8","author":"Ferrannini","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2025.08.012_b0365","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225006010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225006010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:02:57Z","timestamp":1778835777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225006010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":73,"alternative-id":["S2090123225006010"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.08.012","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic signature of dementia risk in type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}