{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:31:21Z","timestamp":1786991481796,"version":"build-2736575974"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1311300"],"award-info":[{"award-number":["2018YFC1311300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["82400281"],"award-info":[{"award-number":["82400281"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530012"],"award-info":[{"award-number":["81530012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20269"],"award-info":[{"award-number":["U22A20269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jare.2025.09.018","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T15:49:27Z","timestamp":1757519367000},"page":"717-735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["SAMHD1 promotes cardiac repair post myocardial infarction by targeting NR4a1 to regulate macrophage metabolic reprogramming"],"prefix":"10.1016","volume":"84","author":[{"given":"Yu-Lan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yang","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Ming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Peng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-3169","authenticated-orcid":false,"given":"Qi-Zhu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.09.018_b0005","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1606915","article-title":"Acute myocardial infarction","volume":"376","author":"Anderson","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jare.2025.09.018_b0010","article-title":"Effects of sacubitril\/valsartan on cardiac reverse remodeling and cardiac resynchronization in patients with acute myocardial infarction","volume":"9","author":"Yang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jare.2025.09.018_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116093","article-title":"Salidroside attenuates myocardial ischemia\/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission","volume":"448","author":"Tian","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jare.2025.09.018_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2022.04.005","article-title":"Role of circular RNA in myocardial ischemia and ageing-related diseases","volume":"65","author":"Gao","year":"2022","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jare.2025.09.018_b0025","article-title":"Metformin-enhanced cardiac AMP-activated protein kinase\/atrogin-1 pathways inhibit charged multivesicular body protein 2B accumulation in ischemia-reperfusion injury","volume":"8","author":"Li","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jare.2025.09.018_b0030","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.amjcard.2021.04.019","article-title":"New heart failure after myocardial infarction (from the national cardiovascular data registries [NCDR] linked with all-payer claims)","volume":"151","author":"Faridi","year":"2021","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jare.2025.09.018_b0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: incidence and predictors","volume":"8","author":"Jen\u010da","year":"2021","journal-title":"ESC Heart Failure"},{"key":"10.1016\/j.jare.2025.09.018_b0040","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/eurheartj\/ehi352","article-title":"Heart failure on admission and the risk of stroke following acute myocardial infarction: the VALIANT registry","volume":"26","author":"Szummer","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jare.2025.09.018_b0045","first-page":"99","article-title":"Myocardial infarct inflammation","volume":"19","author":"Visan","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jare.2025.09.018_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102384","article-title":"Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction","volume":"54","author":"Li","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2025.09.018_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113377","article-title":"Macrophage-derived VEGF-C reduces cardiac inflammation and prevents heart dysfunction in CVB3-induced viral myocarditis via remodeling cardiac lymphatic vessels","volume":"143","author":"Chen","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2025.09.018_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41569-024-01114-x","article-title":"The spleen in ischaemic heart disease","author":"Heusch","year":"2025","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jare.2025.09.018_b0065","doi-asserted-by":"crossref","first-page":"419","DOI":"10.31083\/j.rcm2511419","article-title":"The role of cardiac macrophages in inflammation and fibrosis after myocardial ischemia-reperfusion","volume":"25","author":"Jin","year":"2024","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.jare.2025.09.018_b0070","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41586-024-08008-5","article-title":"Targeting immune-fibroblast cell communication in heart failure","volume":"635","author":"Amrute","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jare.2025.09.018_b0075","doi-asserted-by":"crossref","unstructured":"H. Tan, Y. Song, J. Chen, N. Zhang, Q. Wang, Q. Li et al., Platelet-like fusogenic liposome-mediated targeting delivery of mir-21 improves myocardial remodeling by reprogramming macrophages post myocardial ischemia-reperfusion injury, Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 8(2021)e2100787. doi:10.1002\/advs.202100787.","DOI":"10.1002\/advs.202100787"},{"key":"10.1016\/j.jare.2025.09.018_b0080","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1161\/CIRCULATIONAHA.121.057549","article-title":"Cardiac resident macrophage-derived legumain improves cardiac repair by promoting clearance and degradation of apoptotic cardiomyocytes after myocardial infarction","volume":"145","author":"Jia","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jare.2025.09.018_b0085","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/eurheartj\/eht331","article-title":"Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir","volume":"35","author":"van der Laan","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jare.2025.09.018_b0090","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41569-022-00823-5","article-title":"Macrophages in cardiac remodelling after myocardial infarction","volume":"20","author":"Yap","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jare.2025.09.018_b0095","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s10753-021-01467-2","article-title":"New insights and novel therapeutic potentials for macrophages in myocardial infarction","volume":"44","author":"Zhang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.jare.2025.09.018_b0100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fcvm.2019.00042","article-title":"Immunometabolism of phagocytes and relationships to cardiac repair","volume":"6","author":"Zhang","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jare.2025.09.018_b0105","doi-asserted-by":"crossref","unstructured":"Kong Y, Zhang Q, S. Wang, R. Li, C. Fu, Q. Wei, Mitochondrial metabolism regulated macrophage phenotype in myocardial infarction, Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 180(2024)117494. doi:10.1016\/j.biopha.2024.117494.","DOI":"10.1016\/j.biopha.2024.117494"},{"key":"10.1016\/j.jare.2025.09.018_b0110","doi-asserted-by":"crossref","unstructured":"Mouton AJ, DeLeon-Pennell KY, O. J. Rivera Gonzalez, E. R. Flynn, T. C. Freeman, J. J. Saucerman et al., Mapping macrophage polarization over the myocardial infarction time continuum, Basic Res Cardiol 113(2018)26. doi:10.1007\/s00395-018-0686-x.","DOI":"10.1007\/s00395-018-0686-x"},{"key":"10.1016\/j.jare.2025.09.018_b0115","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1161\/CIRCULATIONAHA.123.065506","article-title":"Targeting NPM1 epigenetically promotes postinfarction cardiac repair by reprogramming reparative macrophage metabolism","volume":"149","author":"Zhang","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jare.2025.09.018_b0120","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159498","article-title":"Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction","volume":"133","author":"Cai","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2025.09.018_b0125","article-title":"Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism","author":"Levesque","year":"2024","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jare.2025.09.018_b0130","doi-asserted-by":"crossref","unstructured":"Guo H, Yang W, H. Li, J. Yang, Y. Huang, Y. Tang et al., The SAMHD1-MX2 axis restricts HIV-1 infection at postviral DNA synthesis, mBio. 15(2024)e0136324. doi:10.1128\/mbio.01363-24.","DOI":"10.1128\/mbio.01363-24"},{"key":"10.1016\/j.jare.2025.09.018_b0135","doi-asserted-by":"crossref","unstructured":"Shao J, Wang W, S. Li, G. Yin, L. Han, X. Wang et al., Nuclear Overexpression of SAMHD1 Induces M phase stalling in hepatoma cells and suppresses HCC progression by interacting with the cohesin complex, Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 12(2025)e2411988. doi:10.1002\/advs.202411988.","DOI":"10.1002\/advs.202411988"},{"key":"10.1016\/j.jare.2025.09.018_b0140","first-page":"189","article-title":"SAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer","volume":"47","author":"Guti\u00e9rrez-Chamorro","year":"2024","journal-title":"Cell Oncol (Dordrecht, Netherlands)"},{"key":"10.1016\/j.jare.2025.09.018_b0145","doi-asserted-by":"crossref","unstructured":"Yang H, Cheung PH, L. Wu, SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway, bioRxiv : the preprint server for biology. (2025). doi:10.1101\/2025.01.08.632057.","DOI":"10.1101\/2025.01.08.632057"},{"key":"10.1016\/j.jare.2025.09.018_b0150","article-title":"SAMHD1 attenuates acute inflammation by maintaining mitochondrial function in macrophages via interaction with VDAC1","volume":"24","author":"Xu","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.09.018_b0155","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/s41598-022-26556-6","article-title":"Transcriptome-wide analysis reveals the coregulation of RNA-binding proteins and alternative splicing genes in the development of atherosclerosis","volume":"13","author":"Wang","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.09.018_b0160","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12872-023-03666-1","article-title":"Construction and evaluation of immune-related diagnostic model in patients with heart failure caused by idiopathic dilated cardiomyopathy","volume":"24","author":"Xu","year":"2024","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.jare.2025.09.018_b0165","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1038\/s41467-024-48970-2","article-title":"Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5\/NR4a1 axis","volume":"15","author":"Ma","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.09.018_b0170","doi-asserted-by":"crossref","first-page":"400","DOI":"10.7150\/ijbs.104680","article-title":"Nuclear receptor 4A1 regulates mitochondrial homeostasis in cardiac post-ischemic injury by controlling mitochondrial fission 1 protein-mediated fragmentation and parkin-dependent mitophagy","volume":"21","author":"Ye","year":"2025","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jare.2025.09.018_b0175","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1111\/bph.16378","article-title":"A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages","volume":"181","author":"Ji","year":"2024","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jare.2025.09.018_b0180","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.immuni.2023.03.003","article-title":"The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome","volume":"56","author":"Zhu","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jare.2025.09.018_b0185","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40035-025-00487-4","article-title":"Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT\/GSK-3\u03b2 axis","volume":"14","author":"Lei","year":"2025","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.jare.2025.09.018_b0190","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCRESAHA.123.324023","article-title":"RNF149 destabilizes IFNGR1 in macrophages to favor postinfarction cardiac repair","volume":"135","author":"Huang","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.jare.2025.09.018_b0195","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCULATIONAHA.123.065603","article-title":"USP28 serves as a key suppressor of mitochondrial morphofunctional defects and cardiac dysfunction in the diabetic heart","volume":"149","author":"Xie","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jare.2025.09.018_b0200","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1038\/s41467-023-40639-6","article-title":"IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice","volume":"14","author":"Ma","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.09.018_b0205","doi-asserted-by":"crossref","unstructured":"Hu T, Wu Q, Q. Yao, J. Yu, K. Jiang, Y. Wan et al., PRDM16 exerts critical role in myocardial metabolism and energetics in type 2 diabetes induced cardiomyopathy, Metab: Clin Exp. 146(2023)155658. doi:10.1016\/j.metabol.2023.155658.","DOI":"10.1016\/j.metabol.2023.155658"},{"key":"10.1016\/j.jare.2025.09.018_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2025.03.004","article-title":"Gang of 3: how the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation","author":"P\u00e5lsson-McDermott","year":"2025","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2025.09.018_b0215","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1038\/s41467-021-26295-8","article-title":"Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62\/SQSTM1 condensates","volume":"12","author":"Peng","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.09.018_b0220","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1038\/s41467-024-51736-5","article-title":"Lipid synthesis, triggered by PPAR\u03b3 T166 dephosphorylation, sustains reparative function of macrophages during tissue repair","volume":"15","author":"Zuo","year":"2024","journal-title":"Nat Commun"},{"issue":"2020","key":"10.1016\/j.jare.2025.09.018_b0225","doi-asserted-by":"crossref","first-page":"27412","DOI":"10.1073\/pnas.2002997117","article-title":"Blocking PPAR\u03b3 interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression","volume":"117","author":"Yang","year":"2020","journal-title":"PNAS"},{"key":"10.1016\/j.jare.2025.09.018_b0230","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/CIRCULATIONAHA.124.070368","article-title":"Immunomodulatory therapy for ischemic heart disease","volume":"150","author":"Zhao","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jare.2025.09.018_b0235","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/CIRCRESAHA.123.324114","article-title":"Macrophage-expressed coagulation factor VII promotes adverse cardiac remodeling","volume":"135","author":"Garlapati","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.jare.2025.09.018_b0240","doi-asserted-by":"crossref","DOI":"10.1172\/JCI175297","article-title":"Single-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repair","volume":"134","author":"Fu","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2025.09.018_b0245","doi-asserted-by":"crossref","unstructured":"Kanuri B, Sreejit G, P. Biswas, A. J. Murphy, P. R. Nagareddy, Macrophage heterogeneity in myocardial infarction: evolution and implications for diverse therapeutic approaches, iScience. 27(2024)110274. doi:10.1016\/j.isci.2024.110274.","DOI":"10.1016\/j.isci.2024.110274"},{"key":"10.1016\/j.jare.2025.09.018_b0250","doi-asserted-by":"crossref","unstructured":"Weinberger T, M. Denise, M. Joppich, M. Fischer, C. Garcia Rodriguez, K. Kumaraswami et al., Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia, eLife. 12(2024). doi:10.7554\/eLife.89377.","DOI":"10.7554\/eLife.89377.4"},{"key":"10.1016\/j.jare.2025.09.018_b0255","doi-asserted-by":"crossref","unstructured":"Zhang X, Fang Y, X. Qin, Y. Zhang, B. Kang, L. Zhong et al., The role of MCPIP1 in macrophage polarization and cardiac function post-myocardial infarction, Adv Sci (Weinheim, Baden-Wurttemberg, Germany). (2025)e2500747. doi:10.1002\/advs.202500747.","DOI":"10.1002\/advs.202500747"},{"key":"10.1016\/j.jare.2025.09.018_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102909","article-title":"miR-182\/183-Rasa1 axis induced macrophage polarization and redox regulation promotes repair after ischemic cardiac injury","volume":"67","author":"Yang","year":"2023","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2025.09.018_b0265","first-page":"719","article-title":"Peptide amphiphiles alleviate myocardial endoplasmic reticulum stress to enhance cardiomyocyte-macrophage communication and promote macrophage M2 polarization, Journal of controlled release : official journal of the Controlled Release","volume":"378","author":"Guo","year":"2025","journal-title":"Society"},{"key":"10.1016\/j.jare.2025.09.018_b0270","doi-asserted-by":"crossref","first-page":"17395","DOI":"10.1074\/jbc.RA119.009167","article-title":"Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion","volume":"294","author":"Blythe","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2025.09.018_b0275","article-title":"Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF \u03b2\/Smad activation and cardiac fibrosis induced by angiotensin II","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.09.018_b0280","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41467-019-14263-2","article-title":"Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair","volume":"11","author":"Sim\u00f5es","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2025.09.018_b0285","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1016\/j.jacc.2019.10.036","article-title":"Transition of macrophages to fibroblast-like cells in healing myocardial infarction","volume":"74","author":"Haider","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jare.2025.09.018_b0290","article-title":"ADAM8 deficiency in macrophages promotes cardiac repair after myocardial infarction via ANXA2-mTOR-autophagy pathway","author":"Ji","year":"2024","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2025.09.018_b0295","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/cvr\/cvn292","article-title":"Post-infarct remodelling: contribution of wound healing and inflammation","volume":"81","author":"Frantz","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jare.2025.09.018_b0300","doi-asserted-by":"crossref","first-page":"13440","DOI":"10.1111\/jcmm.15969","article-title":"Calhex231 ameliorates myocardial fibrosis post myocardial infarction in rats through the autophagy-NLRP3 inflammasome pathway in macrophages","volume":"24","author":"Liu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jare.2025.09.018_b0305","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2174\/1389450118666171031115025","article-title":"Macrophage polarization as a therapeutic target in myocardial infarction","volume":"19","author":"Cheng","year":"2018","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.jare.2025.09.018_b0310","doi-asserted-by":"crossref","first-page":"29583","DOI":"10.3390\/ijms161226187","article-title":"Modulators of macrophage polarization influence healing of the infarcted myocardium","volume":"16","author":"ter Horst","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.09.018_b0315","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jare.2025.09.018_b0320","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJMoa1809798","article-title":"Low-dose methotrexate for the prevention of atherosclerotic events","volume":"380","author":"Ridker","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jare.2025.09.018_b0325","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJMoa2405922","article-title":"Colchicine in acute myocardial infarction","volume":"392","author":"Jolly","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jare.2025.09.018_b0330","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2021.02.049","article-title":"Randomized trial of interleukin-6 receptor inhibition in patients with acute ST-segment elevation myocardial infarction","volume":"77","author":"Broch","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jare.2025.09.018_b0335","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jare.2025.09.018_b0340","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/CIRCULATIONAHA.120.050771","article-title":"Colchicine in patients with acute coronary syndrome: the Australian COPS randomized clinical trial","volume":"142","author":"Tong","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jare.2025.09.018_b0345","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1007718","article-title":"Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis","volume":"13","author":"An","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.09.018_b0350","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jsbmb.2015.04.016","article-title":"Nuclear receptor 4A (NR4A) family - orphans no more","volume":"157","author":"Safe","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jare.2025.09.018_b0355","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00018-024-05513-8","article-title":"The orphan nuclear receptor Nr4a1 contributes to interstitial cardiac fibrosis via modulation of cardiac fibroblast and macrophage phenotype","volume":"81","author":"Widiapradja","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jare.2025.09.018_b0360","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s10753-023-01926-y","article-title":"SLAMF7 promotes foam cell formation of macrophage by suppressing NR4A1 expression during carotid atherosclerosis","volume":"47","author":"Yuan","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.jare.2025.09.018_b0365","article-title":"Kallistatin\/Serpina3c inhibits cardiac fibrosis after myocardial infarction by regulating glycolysis via Nr4a1 activation","volume":"1868","author":"Ji","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Disease"},{"key":"10.1016\/j.jare.2025.09.018_b0370","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41392-021-00542-2","article-title":"FGF1(\u0394HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK\/Nur77 suppression","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jare.2025.09.018_b0375","article-title":"Molecular mechanism of NR4A1\/MDM2\/P53 signaling pathway regulation inducing ferroptosis in renal tubular epithelial cells involved in the progression of renal ischemia-reperfusion injury, Biochimica et biophysica acta","volume":"1870","author":"Lin","year":"2024","journal-title":"Mol Basis Dis"},{"key":"10.1016\/j.jare.2025.09.018_b0380","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nm1471","article-title":"NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism","volume":"12","author":"Pei","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2025.09.018_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111742","article-title":"NR4A1 promotes oxidative stresses after myocardial ischemia reperfusion injury in aged mice","volume":"162","author":"Peng","year":"2022","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jare.2025.09.018_b0390","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/s12931-024-03064-x","article-title":"Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPAR\u03b3\/HO-1","volume":"25","author":"Feng","year":"2024","journal-title":"Respir Res"},{"key":"10.1016\/j.jare.2025.09.018_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156192","article-title":"Inhibition of colorectal cancer aggressiveness by Oleanolic acid through Nur77 degradation","volume":"135","author":"Deng","year":"2024","journal-title":"Phytomed : Int J Phytotherapy Phytopharmacol"},{"key":"10.1016\/j.jare.2025.09.018_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.01.041","article-title":"Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction","author":"Boteanu","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2025.09.018_b0405","first-page":"273","article-title":"Injection of ROS-responsive hydrogel loaded with IL-1\u03b2-targeted nanobody for ameliorating myocardial infarction","volume":"46","author":"Wang","year":"2025","journal-title":"Bioact Mater"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225007015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225007015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T21:07:35Z","timestamp":1780261655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225007015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":81,"alternative-id":["S2090123225007015"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.09.018","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SAMHD1 promotes cardiac repair post myocardial infarction by targeting NR4a1 to regulate macrophage metabolic reprogramming","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}