{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:45:29Z","timestamp":1785883529970,"version":"3.56.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2662025DKPY009"],"award-info":[{"award-number":["2662025DKPY009"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32025036"],"award-info":[{"award-number":["32025036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32430104"],"award-info":[{"award-number":["32430104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD04053"],"award-info":[{"award-number":["2023ZD04053"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1800204"],"award-info":[{"award-number":["2021YFD1800204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jare.2025.09.059","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:16:42Z","timestamp":1759796202000},"page":"1207-1222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment"],"prefix":"10.1016","volume":"85","author":[{"given":"Huimin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengsong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-3972","authenticated-orcid":false,"given":"Hongbo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jare.2025.09.059_b0005","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00705-020-04572-z","article-title":"Higher virulence of swine H1N2 influenza viruses containing avian-origin HA and 2009 pandemic PA and NP in pigs and mice","volume":"165","author":"Jang","year":"2020","journal-title":"Arch. Virol"},{"issue":"10","key":"10.1016\/j.jare.2025.09.059_b0010","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/vetsci10100599","article-title":"Seroprevalence of Swine Influenza a Virus (swIAV) infections in commercial farrow-to-finish pig farms in greece","volume":"10","author":"Papatsiros","year":"2023","journal-title":"Vet Sci"},{"key":"10.1016\/j.jare.2025.09.059_b0015","article-title":"Influenza a Virus in Swine: Epidemiology","volume":"7(647","author":"Mancera Gracia","year":"2020","journal-title":"Challenges and Vaccination Strategies Front Vet Sci"},{"issue":"20","key":"10.1016\/j.jare.2025.09.059_b0020","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.3390\/ani13203281","article-title":"An update in knowledge of pigs as the source of zoonotic pathogens","volume":"13","author":"Augustyniak","year":"2023","journal-title":"Animals (Basel)"},{"issue":"34","key":"10.1016\/j.jare.2025.09.059_b0025","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203919119","article-title":"A Eurasian avian-like H1N1 swine influenza reassortant virus became pathogenic and highly transmissible due to mutations in its PA gene","volume":"119","author":"Meng","year":"2022","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.jare.2025.09.059_b0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11427-022-2208-0","article-title":"Continued evolution of the Eurasian avian-like H1N1 swine influenza viruses in China","volume":"66","author":"Meng","year":"2023","journal-title":"Sci. China Life Sci."},{"issue":"11","key":"10.1016\/j.jare.2025.09.059_b0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001558","article-title":"Global mortality estimates for the 2009 Influenza Pandemic from the GLaMOR project: a modeling study","volume":"10","author":"Simonsen","year":"2013","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0040","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2466686","article-title":"Rapid surge of reassortant A(H1N1) influenza viruses in danish swine and their zoonotic potential","volume":"14","author":"Ryt-Hansen","year":"2025","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.jare.2025.09.059_b0045","article-title":"Major change in swine influenza virus diversity in France owing to emergence and widespread dissemination of a newly introduced H1N2 1C genotype in 2020","volume":"11(1):veae112","author":"Richard","year":"2025","journal-title":"Virus Evol."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12985-022-01794-2","article-title":"Human infection with a reassortant swine-origin influenza A(H1N2)v virus in Taiwan, 2021","volume":"19","author":"Yang","year":"2022","journal-title":"Virol. J."},{"issue":"3","key":"10.1016\/j.jare.2025.09.059_b0055","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2024.29.3.2400002","article-title":"A case of swine influenza A(H1N2)v in England, November 2023","volume":"29","author":"Cogdale","year":"2024","journal-title":"Euro Surveill."},{"issue":"25","key":"10.1016\/j.jare.2025.09.059_b0060","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1056\/NEJMoa0903812","article-title":"Triple-reassortant swine influenza a (H1) in humans in the United States, 2005-2009","volume":"360","author":"Shinde","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00705-019-04457-w","article-title":"Displacement of the Gent\/1999 human-like swine H1N2 influenza a virus lineage by novel H1N2 reassortants in Germany","volume":"165","author":"Zell","year":"2020","journal-title":"Arch. Virol"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0070","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00018-025-05611-1","article-title":"Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches","volume":"82","author":"Bonomini","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jare.2025.09.059_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvacx.2024.100452","article-title":"Outlining recent updates on influenza therapeutics and vaccines: a comprehensive review","volume":"17","author":"Malik","year":"2024","journal-title":"Vaccine X"},{"issue":"4","key":"10.1016\/j.jare.2025.09.059_b0080","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.apsb.2025.03.011","article-title":"Overview of host-directed antiviral targets for future research and drug development","volume":"15","author":"Gu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.jare.2025.09.059_b0085","doi-asserted-by":"crossref","first-page":"e00168","DOI":"10.1128\/CMR.00168-19","article-title":"Host-directed antiviral therapy","volume":"33","author":"Kumar","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jare.2025.09.059_b0090","article-title":"Entry of influenza a virus into host cells \u2014 recent progress and remaining challenges","volume":"48(23\u201329)","author":"Sempere Borau","year":"2021","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.jare.2025.09.059_b0095","article-title":"Hemagglutinin stability and its impact on influenza A virus infectivity, pathogenicity, and transmissibility in avians, and humans","volume":"13(5)","author":"Russell","year":"2021","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.jare.2025.09.059_b0100","doi-asserted-by":"crossref","first-page":"62a","DOI":"10.1016\/j.bpj.2024.11.404","article-title":"BPS2025 - investigating an HA-mediated mechanism of avian IAV host tropism with smFRET","volume":"124","author":"Unger","year":"2025","journal-title":"Biophys. J ."},{"issue":"2","key":"10.1016\/j.jare.2025.09.059_b0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.virs.2024.01.003","article-title":"C1QTNF5 is a novel attachment factor that facilitates the entry of influenza a virus","volume":"39","author":"Yu","year":"2024","journal-title":"Virol. Sin."},{"key":"10.1016\/j.jare.2025.09.059_b0110","article-title":"The Immunomodulatory CEA cell adhesion molecule 6 (CEACAM6\/CD66c) is a protein receptor for the influenza a virus","volume":"13(5)","author":"Rahman","year":"2021","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0115","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2020.10.009","article-title":"Advances in the development of entry inhibitors for sialic-acid-targeting viruses","volume":"26","author":"Heida","year":"2021","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0120","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41420-024-02180-3","article-title":"Biological function of sialic acid and sialylation in human health and disease","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Death Discov"},{"issue":"2","key":"10.1016\/j.jare.2025.09.059_b0125","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.celrep.2018.03.045","article-title":"Genome-wide CRISPR\/Cas9 screen identifies host factors essential for influenza virus replication","volume":"23","author":"Han","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jare.2025.09.059_b0130","article-title":"Apolipoprotein E mediates cell resistance to influenza virus infection","volume":"8(38):eabm6668","author":"Gao","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0135","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1038\/s41467-022-34111-0","article-title":"Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection","volume":"13","author":"Trimarco","year":"2022","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.jare.2025.09.059_b0140","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.celrep.2017.07.060","article-title":"A CRISPR activation screen identifies a pan-avian influenza virus inhibitory host factor","volume":"20","author":"Heaton","year":"2017","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.jare.2025.09.059_b0145","doi-asserted-by":"crossref","first-page":"e773","DOI":"10.1093\/cid\/ciab113","article-title":"DAS181 treatment of severe lower respiratory tract parainfluenza virus infection in immunocompromised patients: a phase 2 randomized","volume":"73","author":"Chemaly","year":"2021","journal-title":"Placebo-Controlled Study Clin Infect Dis"},{"key":"10.1016\/j.jare.2025.09.059_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2017.05.028","article-title":"Linear polysialoside outperforms dendritic analogs for inhibition of influenza virus infection invitro and invivo","volume":"138","author":"Bhatia","year":"2017","journal-title":"Biomaterials"},{"issue":"6663","key":"10.1016\/j.jare.2025.09.059_b0155","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/34432","article-title":"A serine\/threonine kinase gene defective in Peutz-Jeghers syndrome","volume":"391","author":"Hemminki","year":"1998","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jare.2025.09.059_b0160","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.tips.2025.06.008","article-title":"Targeting LKB1\/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance","volume":"46","author":"Minor","year":"2025","journal-title":"Trends Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.jare.2025.09.059_b0165","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.surg.2017.11.030","article-title":"Hepatitis B virus X protein represses LKB1 expression to promote tumor progression and poor postoperative outcome in hepatocellular carcinoma","volume":"163","author":"Wu","year":"2018","journal-title":"Surgery"},{"key":"10.1016\/j.jare.2025.09.059_b0170","article-title":"LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription","volume":"10(40)","author":"Tang","year":"2013","journal-title":"Retrovirology"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12985-023-02166-0","article-title":"DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK\/ERK\/mTOR signaling pathway to induce autophagy","volume":"20","author":"Wu","year":"2023","journal-title":"Virol. J."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0180","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1038\/s41467-020-18936-1","article-title":"CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0185","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41467-019-13965-x","article-title":"Genome-wide CRISPR screen identifies host dependency factors for influenza a virus infection","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jare.2025.09.059_b0190","article-title":"Variations in genome-wide RNAi screens: lessons from influenza research","volume":"5(2","author":"Chou","year":"2015","journal-title":"J Clin Bioinforma"},{"key":"10.1016\/j.jare.2025.09.059_b0195","article-title":"The role of STK11\/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression. Front Cell","volume":"12","author":"Kang","year":"2024","journal-title":"Dev. Biol."},{"issue":"3","key":"10.1016\/j.jare.2025.09.059_b0200","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s11427-023-2471-4","article-title":"M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes","volume":"67","author":"Hu","year":"2024","journal-title":"Sci. China Life Sci."},{"issue":"7","key":"10.1016\/j.jare.2025.09.059_b0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008656","article-title":"Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation","volume":"16","author":"Sieben","year":"2020","journal-title":"PLoS Pathog."},{"issue":"21","key":"10.1016\/j.jare.2025.09.059_b0210","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1021\/bi00447a018","article-title":"Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance study","volume":"28","author":"Sauter","year":"1989","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/j.jare.2025.09.059_b0215","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.bpj.2013.03.054","article-title":"Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutinin","volume":"104","author":"Gudheti","year":"2013","journal-title":"Biophys. J ."},{"issue":"7","key":"10.1016\/j.jare.2025.09.059_b0220","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1091\/mbc.E18-11-0715","article-title":"Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane","volume":"31","author":"Sil","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jare.2025.09.059_b0225","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-60761-376-3_4","article-title":"Jasplakinolide: an actin-specific reagent that promotes actin polymerization","volume":"586(71\u201387)","author":"Holzinger","year":"2009","journal-title":"Methods Mol. Biol."},{"issue":"7","key":"10.1016\/j.jare.2025.09.059_b0230","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3390\/cells10071831","article-title":"The RHO Family GTPases: Mechanisms of Regulation and Signaling","volume":"10","author":"Mosaddeghzadeh","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jare.2025.09.059_b0235","article-title":"Rho Family GTPases and Rho GEFs in glucose homeostasis","volume":"10(4)","author":"Machin","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0240","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cell.2020.10.028","article-title":"Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection","volume":"184","author":"Wei","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0245","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cell.2020.10.030","article-title":"Identification of required host factors for SARS-CoV-2 infection in human cells","volume":"184","author":"Daniloski","year":"2021","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jare.2025.09.059_b0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009055","article-title":"Identification of unrecognized host factors promoting HIV-1 latency","volume":"16","author":"Li","year":"2020","journal-title":"PLoS Pathog."},{"issue":"22","key":"10.1016\/j.jare.2025.09.059_b0255","doi-asserted-by":"crossref","first-page":"e00319","DOI":"10.1128\/JVI.00319-20","article-title":"Loss of the Nuclear Protein RTF2 enhances influenza virus replication","volume":"94","author":"Chia","year":"2020","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.jare.2025.09.059_b0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010141","article-title":"A genome-wide CRISPR\/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis","volume":"17","author":"Song","year":"2021","journal-title":"PLoS Pathog."},{"issue":"13","key":"10.1016\/j.jare.2025.09.059_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110559","article-title":"Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection","volume":"38","author":"Yi","year":"2022","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.jare.2025.09.059_b0270","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/carcin\/bgab104","article-title":"Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers","volume":"42","author":"Donnelly","year":"2021","journal-title":"Carcinogenesis"},{"issue":"9","key":"10.1016\/j.jare.2025.09.059_b0275","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00604-24","article-title":"LKB1 suppresses KSHV reactivation and promotes primary effusion lymphoma progression","volume":"98","author":"Li","year":"2024","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.jare.2025.09.059_b0280","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4269\/ajtmh.18-0761","article-title":"Significance of autophagy in dengue virus infection: a brief review","volume":"100","author":"Acharya","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"5","key":"10.1016\/j.jare.2025.09.059_b0285","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3390\/cells10051118","article-title":"Multifaceted Role of AMPK in Viral Infections","volume":"10","author":"Bhutta","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.jare.2025.09.059_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002661","article-title":"AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis","volume":"8","author":"Moser","year":"2012","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0295","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/imr.12119","article-title":"Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells","volume":"256","author":"Nayak","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jare.2025.09.059_b0300","article-title":"BAG6 supports stress fiber formation by preventing the ubiquitin-mediated degradation of RhoA","volume":"34(4):ar34","author":"Miyauchi","year":"2023","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jare.2025.09.059_b0305","article-title":"LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity","volume":"11(77)","author":"Xu","year":"2010","journal-title":"BMC Cell Biol."},{"issue":"30","key":"10.1016\/j.jare.2025.09.059_b0310","doi-asserted-by":"crossref","first-page":"29497","DOI":"10.18632\/oncotarget.4985","article-title":"Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho a activation","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jare.2025.09.059_b0315","article-title":"MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity","volume":"10(503):eaan3286","author":"Sand\u00ed","year":"2017","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0320","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1038\/s41467-022-31840-0","article-title":"Human-type sialic acid receptors contribute to avian influenza a virus binding and entry by hetero-multivalent interactions","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jare.2025.09.059_b0325","doi-asserted-by":"crossref","unstructured":"C. H. Fong, L. Lu, L. L. Chen, M. L. Yeung, A. J. Zhang, H. Zhao, et al. Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size. iScience 2022;25(4):104037. Doi: 10.1016\/j.isci.2022.104037.","DOI":"10.1016\/j.isci.2022.104037"},{"issue":"9","key":"10.1016\/j.jare.2025.09.059_b0330","doi-asserted-by":"crossref","first-page":"e01567","DOI":"10.1128\/JVI.01567-19","article-title":"Modified sialic acids on mucus and erythrocytes inhibit influenza A virus hemagglutinin and neuraminidase functions","volume":"94","author":"Barnard","year":"2020","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0335","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1038\/s41598-020-62074-z","article-title":"The human lung glycome reveals novel glycan ligands for influenza A virus","volume":"10","author":"Jia","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jare.2025.09.059_b0340","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tcb.2018.01.009","article-title":"Clustering on Membranes: Fluctuations and more","volume":"28","author":"Johannes","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.jare.2025.09.059_b0345","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tcb.2020.11.004","article-title":"Dynamic plasma membrane organization: a complex symphony","volume":"31","author":"van Deventer","year":"2021","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.jare.2025.09.059_b0350","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bpj.2022.12.015","article-title":"Lifetime of actin-dependent protein nanoclusters","volume":"122","author":"Sarkar","year":"2023","journal-title":"Biophys. J ."},{"issue":"4","key":"10.1016\/j.jare.2025.09.059_b0355","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.cell.2019.04.018","article-title":"The Lateral Organization and Mobility of Plasma Membrane Components","volume":"177","author":"Jacobson","year":"2019","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jare.2025.09.059_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2022.184093","article-title":"Refinement of singer-nicolson fluid-mosaic model by microscopy imaging: lipid rafts and actin-induced membrane compartmentalization","volume":"1865","author":"Suzuki","year":"2023","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"30","key":"10.1016\/j.jare.2025.09.059_b0365","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2123056119","article-title":"Active emulsions in living cell membranes driven by contractile stresses and transbilayer coupling","volume":"119","author":"Saha","year":"2022","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0370","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12964-024-01689-5","article-title":"LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors","volume":"22","author":"Trelford","year":"2024","journal-title":"Cell Commun. Signaling"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0375","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s42003-020-1092-0","article-title":"STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation","volume":"3","author":"Granado-Mart\u00ednez","year":"2020","journal-title":"Commun. Biol."},{"issue":"11","key":"10.1016\/j.jare.2025.09.059_b0380","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1080\/15548627.2021.1872187","article-title":"Crocetin promotes clearance of amyloid-\u03b2 by inducing autophagy via the STK11\/LKB1-mediated AMPK pathway","volume":"17","author":"Wani","year":"2021","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.jare.2025.09.059_b0385","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1158\/0008-5472.CAN-15-1439","article-title":"STK11\/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment","volume":"76","author":"Koyama","year":"2016","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.jare.2025.09.059_b0390","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.3390\/cells10113129","article-title":"STK11\/LKB1 modulation of the immune response in lung cancer: from biology to therapeutic impact","volume":"10","author":"Pons-Tostivint","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.jare.2025.09.059_b0395","doi-asserted-by":"crossref","first-page":"346","DOI":"10.5530\/ijper.55.2.72","article-title":"Targeted drug delivery system: advantages, carriers and strategies","volume":"55","author":"Prabahar","year":"2021","journal-title":"Indian Journal of Pharmaceutical Education and Research"},{"issue":"1","key":"10.1016\/j.jare.2025.09.059_b0400","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/jac\/dkae391","article-title":"Rapid viral suppression using integrase inhibitors during acute HIV-1 infection","volume":"80","author":"McKellar","year":"2025","journal-title":"J. Antimicrob. Chemother."},{"issue":"1400","key":"10.1016\/j.jare.2025.09.059_b0405","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1098\/rstb.2000.0639","article-title":"Transient antiretroviral treatment during acute simian immunodeficiency virus infection facilitates long-term control of the virus","volume":"355","author":"Wodarz","year":"2000","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225007635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225007635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:53:21Z","timestamp":1785880401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225007635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":81,"alternative-id":["S2090123225007635"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.09.059","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.09.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}