{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:12:21Z","timestamp":1789085541974,"version":"build-2803163510"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-LZX0038"],"award-info":[{"award-number":["CSTB2022NSCQ-LZX0038"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-JQX0035"],"award-info":[{"award-number":["CSTB2023NSCQ-JQX0035"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022nscq-msx0916"],"award-info":[{"award-number":["CSTB2022nscq-msx0916"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022nscq-msx0830"],"award-info":[{"award-number":["CSTB2022nscq-msx0830"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001378"],"award-info":[{"award-number":["82001378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571663"],"award-info":[{"award-number":["82571663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202804"],"award-info":[{"award-number":["82202804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271497"],"award-info":[{"award-number":["82271497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jare.2025.10.076","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:09:14Z","timestamp":1762214954000},"page":"527-541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of general anesthetics on seizure termination, mortality, and neurological prognosis in a rat model of pediatric refractory status epilepticus: A comparative randomized controlled study"],"prefix":"10.1016","volume":"86","author":[{"given":"Bo","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9531","key":"10.1016\/j.jare.2025.10.076_b0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(06)69043-0","article-title":"Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study","volume":"368","author":"Chin","year":"2006","journal-title":"Lancet"},{"issue":"Pt 10","key":"10.1016\/j.jare.2025.10.076_b0010","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1093\/brain\/awr239","article-title":"North London Epilepsy Research N. Death within 8 years after childhood convulsive status epilepticus: a population-based study","volume":"134","author":"Pujar","year":"2011","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.jare.2025.10.076_b0015","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1474-4422(06)70546-4","article-title":"Outcome of paediatric convulsive status epilepticus: a systematic review","volume":"5","author":"Raspall-Chaure","year":"2006","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12028-012-9695-z","article-title":"Guidelines for the evaluation and management of status epilepticus","volume":"17","author":"Brophy","year":"2012","journal-title":"Neurocrit Care"},{"issue":"6","key":"10.1016\/j.jare.2025.10.076_b0025","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1474-4422(15)00042-3","article-title":"Status epilepticus in adults","volume":"14","author":"Betjemann","year":"2015","journal-title":"Lancet Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.jare.2025.10.076_b0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/anae.15606","article-title":"Management of status epilepticus: a narrative review","volume":"77","author":"Migdady","year":"2022","journal-title":"Anaesthesia"},{"issue":"9","key":"10.1016\/j.jare.2025.10.076_b0035","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1097\/CCM.0b013e3182591ff1","article-title":"Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation","volume":"40","author":"Kowalski","year":"2012","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1016\/j.jare.2025.10.076_b0040","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1212\/WNL.0000000000000009","article-title":"Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study","volume":"82","author":"Sutter","year":"2014","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jare.2025.10.076_b0045","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/CCM.0000000000000881","article-title":"Status epilepticus: impact of therapeutic coma on outcome","volume":"43","author":"Marchi","year":"2015","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.jare.2025.10.076_b0050","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2131\/jts.41.627","article-title":"Persistent neuronal apoptosis and synaptic loss induced by multiple but not single exposure of propofol contribute to long-term cognitive dysfunction in neonatal rats","volume":"41","author":"Chen","year":"2016","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.jare.2025.10.076_b0055","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijdevneu.2016.10.002","article-title":"Etanercept, an inhibitor of TNF-a, prevents propofol-induced neurotoxicity in the developing brain","volume":"55","author":"Chen","year":"2016","journal-title":"Int J Dev Neurosci"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0060","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1213\/ANE.0000000000006233","article-title":"Consequences of general anesthesia in infancy on behavior and brain structure","volume":"136","author":"Salaun","year":"2023","journal-title":"Anesth Analg"},{"issue":"9","key":"10.1016\/j.jare.2025.10.076_b0065","doi-asserted-by":"crossref","first-page":"18284","DOI":"10.3390\/ijms140918284","article-title":"Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions","volume":"14","author":"Reddy","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jare.2025.10.076_b0070","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0920-1211(02)00085-2","article-title":"Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus","volume":"50","author":"Jones","year":"2002","journal-title":"Epilepsy Res"},{"issue":"10","key":"10.1016\/j.jare.2025.10.076_b0075","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1113\/JP270056","article-title":"In vivo evaluation of the dentate gate theory in epilepsy","volume":"593","author":"Krook-Magnuson","year":"2015","journal-title":"J Physiol"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0080","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s13311-019-00815-3","article-title":"HMGB1 is a therapeutic target and biomarker in diazepam-refractory status epilepticus with wide time window","volume":"17","author":"Zhao","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"8","key":"10.1016\/j.jare.2025.10.076_b0085","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1046\/j.1528-1157.2003.62402.x","article-title":"Diazepam terminates brief but not prolonged seizures in young, Na\u00a8\u0131ve rats","volume":"44","author":"Goodkin","year":"2003","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0090","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.eplepsyres.2008.07.007","article-title":"Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus","volume":"82","author":"Bankstahl","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jare.2025.10.076_b0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2012.11.002","article-title":"Stiripentol is anticonvulsant by potentiating GABAergic transmission in a model of benzodiazepine-refractory status epilepticus","volume":"67","author":"Grosenbaugh","year":"2013","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.jare.2025.10.076_b0100","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/EJA.0000000000000128","article-title":"Impact of propofol anaesthesia on cytokine expression profiles in the developing rat brain: a randomised placebo-controlled experimental in-vivo study","volume":"32","author":"Kargaran","year":"2015","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.jare.2025.10.076_b0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijdevneu.2015.04.002","article-title":"Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt","volume":"45","author":"Osterop","year":"2015","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.jare.2025.10.076_b0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2013.03.036","article-title":"Anticonvulsant effect of dexmedetomidine in a rat model of self-sustaining status epilepticus with prolonged amygdala stimulation","volume":"543","author":"Kan","year":"2013","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0115","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1528-1167.2007.01384.x","article-title":"A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation","volume":"49","author":"Martin","year":"2007","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.jare.2025.10.076_b0120","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/epi4.12545","article-title":"Sevoflurane as bridge therapy for plasma exchange and Anakinra in febrile infection-related epilepsy syndrome","volume":"6","author":"L'Erario","year":"2021","journal-title":"Epilepsia Open"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12974-022-02528-5","article-title":"Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor","volume":"19","author":"Chen","year":"2022","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0130","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.apmr.2018.05.036","article-title":"Development of Composite Scores for the TBI-QOL","volume":"101","author":"Tyner","year":"2020","journal-title":"Arch Phys Med Rehabil"},{"issue":"9","key":"10.1016\/j.jare.2025.10.076_b0135","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/epi.13480","article-title":"Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits","volume":"57","author":"Niquet","year":"2016","journal-title":"Epilepsia"},{"issue":"Pt 8","key":"10.1016\/j.jare.2025.10.076_b0140","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1093\/brain\/aws176","article-title":"Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy","volume":"135","author":"Barkas","year":"2012","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0145","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00004647-199902000-00011","article-title":"Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats","volume":"19","author":"Fernandes","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"10.1016\/j.jare.2025.10.076_b0150","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1055\/s-0040-1719076","article-title":"Status epilepticus-work-up and management in children","volume":"40","author":"Barcia Aguilar","year":"2020","journal-title":"Semin Neurol"},{"key":"10.1016\/j.jare.2025.10.076_b0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jocn.2019.03.050","article-title":"A school-aged boy with super-refractory status epilepticus secondary to cortical dysplasia treated with dexmedetomidine","volume":"64","author":"Malta","year":"2019","journal-title":"J Clin Neurosci"},{"issue":"11","key":"10.1016\/j.jare.2025.10.076_b0160","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s12630-020-01753-x","article-title":"The effect of dexmedetomidine on status epilepticus in a patient with anti-NMDA receptor encephalitis","volume":"67","author":"Coluzzi","year":"2020","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.jare.2025.10.076_b0165","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuro.2020.03.007","article-title":"Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats","volume":"79","author":"Dunn","year":"2020","journal-title":"Neurotoxicology"},{"issue":"21","key":"10.1016\/j.jare.2025.10.076_b0170","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra021261","article-title":"Mechanisms of actions of inhaled anesthetics","volume":"348","author":"Campagna","year":"2003","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0175","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/0929867003375335","article-title":"Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery","volume":"7","author":"Trapani","year":"2000","journal-title":"Curr Med Chem"},{"issue":"10","key":"10.1016\/j.jare.2025.10.076_b0180","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.3426-07.2008","article-title":"Subunit-specific trafficking of GABA(A) receptors during status epilepticus","volume":"28","author":"Goodkin","year":"2008","journal-title":"J Neurosci"},{"issue":"7","key":"10.1016\/j.jare.2025.10.076_b0185","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41582-022-00664-3","article-title":"Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus","volume":"18","author":"Burman","year":"2022","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0190","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/bja\/aev226","article-title":"Dexmedetomidine: review, update, and future considerations of paediatric perioperative and periprocedural applications and limitations","volume":"115","author":"Mahmoud","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jare.2025.10.076_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2018.01.010","article-title":"Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus","volume":"141","author":"McCarren","year":"2018","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jare.2025.10.076_b0200","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuropharm.2018.05.015","article-title":"Mechanisms underlying anticonvulsant and proconvulsant actions of norepinephrine","volume":"137","author":"Ghasemi","year":"2018","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0205","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40981-019-0234-1","article-title":"Dexmedetomidine administration in a patient with status epilepticus under color density spectral array monitoring","volume":"5","author":"Obara","year":"2019","journal-title":"JA Clin Rep"},{"key":"10.1016\/j.jare.2025.10.076_b0210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.seizure.2024.01.013","article-title":"Ketamine in the treatment of refractory and super-refractory status epilepticus: Experience from two centres","volume":"117","author":"Garcia-Ruiz","year":"2024","journal-title":"Seizure"},{"issue":"12","key":"10.1016\/j.jare.2025.10.076_b0215","doi-asserted-by":"crossref","first-page":"e1227","DOI":"10.1212\/WNL.0000000000200889","article-title":"Ketamine for management of neonatal and pediatric refractory status epilepticus","volume":"99","author":"Jacobwitz","year":"2022","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jare.2025.10.076_b0220","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s40263-018-0519-3","article-title":"Antidepressant efficacy and tolerability of ketamine and esketamine: a critical review","volume":"32","author":"Molero","year":"2018","journal-title":"CNS Drugs"},{"issue":"2\u20133","key":"10.1016\/j.jare.2025.10.076_b0225","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0920-1211(00)00175-3","article-title":"Ketamine controls prolonged status epilepticus","volume":"42","author":"Borris","year":"2000","journal-title":"Epilepsy Res"},{"issue":"24","key":"10.1016\/j.jare.2025.10.076_b0230","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1212\/WNL.0b013e318278b685","article-title":"Efficacy and safety of ketamine in refractory status epilepticus in children","volume":"79","author":"Rosati","year":"2012","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.jare.2025.10.076_b0235","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s40263-018-0569-6","article-title":"Ketamine for refractory status epilepticus: a systematic review","volume":"32","author":"Rosati","year":"2018","journal-title":"CNS Drugs"},{"issue":"9","key":"10.1016\/j.jare.2025.10.076_b0240","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S2213-2600(14)70171-7","article-title":"Respiratory infections in patients undergoing mechanical ventilation","volume":"2","author":"Rello","year":"2014","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0245","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pediatrneurol.2014.03.006","article-title":"Use of ketamine in a newborn with refractory status epilepticus: a case report","volume":"51","author":"Tarocco","year":"2014","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jare.2025.10.076_b0250","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.seizure.2018.08.002","article-title":"Pathophysiology of convulsive status epilepticus","volume":"68","author":"Sanchez Fernandez","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.jare.2025.10.076_b0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2017.04.019","article-title":"Simultaneous triple therapy for the treatment of status epilepticus","volume":"104","author":"Niquet","year":"2017","journal-title":"Neurobiol Dis"},{"issue":"1\u20132","key":"10.1016\/j.jare.2025.10.076_b0260","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","article-title":"Trajectories of brain development: point of vulnerability or window of opportunity?","volume":"27","author":"Andersen","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jare.2025.10.076_b0265","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1749-6632.2009.05173.x","article-title":"Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain","volume":"1199","author":"Rizzi","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"Suppl 3","key":"10.1016\/j.jare.2025.10.076_b0270","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/ehp.00108s3511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ Health Perspect"},{"issue":"14","key":"10.1016\/j.jare.2025.10.076_b0275","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1523\/JNEUROSCI.19-14-06157.1999","article-title":"5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze","volume":"19","author":"Malleret","year":"1999","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/nlme.2001.4040","article-title":"Fischer 344 and wistar rats differ in anxiety and habituation but not in water maze performance","volume":"78","author":"Bert","year":"2002","journal-title":"Neurobiol Learn Mem"},{"issue":"10","key":"10.1016\/j.jare.2025.10.076_b0285","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S1474-4422(04)00881-6","article-title":"Susceptibility of immature and adult brains to seizure effects","volume":"3","author":"Haut","year":"2004","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.1016\/j.jare.2025.10.076_b0290","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1046\/j.1528-1157.2002.17802.x","article-title":"Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model","volume":"43","author":"Roch","year":"2002","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.jare.2025.10.076_b0295","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1993.tb02123.x","article-title":"Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting","volume":"34","author":"Mello","year":"1993","journal-title":"Epilepsia"},{"issue":"Pt B","key":"10.1016\/j.jare.2025.10.076_b0300","article-title":"Early polytherapy for benzodiazepine-refractory status epilepticus","volume":"101","author":"Niquet","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"6","key":"10.1016\/j.jare.2025.10.076_b0305","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuro.2011.05.006","article-title":"Diet composition modifies the toxicity of repeated soman exposure in rats","volume":"32","author":"Langston","year":"2011","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0310","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0306-4522(01)00047-1","article-title":"Locomotor activity induced by the non-competitive N-methyl-D-aspartate antagonist, MK-801: role of nucleus accumbens efferent pathways","volume":"104","author":"Leonibus","year":"2001","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.jare.2025.10.076_b0315","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41583-019-0213-6","article-title":"Perirhinal circuits for memory processing","volume":"20","author":"Miyashita","year":"2019","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0320","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/cjn.2014.121","article-title":"Modern inhalational anesthetics for refractory status epilepticus","volume":"42","author":"Zeiler","year":"2015","journal-title":"Can J Neurol Sci"},{"issue":"5","key":"10.1016\/j.jare.2025.10.076_b0325","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1213\/ane.0b013e3181852595","article-title":"The howling cortex: seizures and general anesthetic drugs","volume":"107","author":"Voss","year":"2008","journal-title":"Anesth Analg"},{"issue":"4","key":"10.1016\/j.jare.2025.10.076_b0330","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10877-017-0055-6","article-title":"Inhaled anesthetic agent sedation in the ICU and trace gas concentrations: a review","volume":"32","author":"Herzog-Niescery","year":"2018","journal-title":"J Clin Monit Comput"},{"issue":"1","key":"10.1016\/j.jare.2025.10.076_b0335","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/bja\/aer132","article-title":"Malignant hyperthermia: pharmacology of triggering","volume":"107","author":"Hopkins","year":"2011","journal-title":"Br J Anaesth"},{"issue":"2","key":"10.1016\/j.jare.2025.10.076_b0340","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S2352-4642(17)30174-8","article-title":"Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study","volume":"2","author":"Pujar","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.jare.2025.10.076_b0345","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.seizure.2018.08.021","article-title":"The burden of pediatric status epilepticus: Epidemiology, morbidity, mortality, and costs","volume":"68","author":"Gurcharran","year":"2019","journal-title":"Seizure"},{"issue":"3","key":"10.1016\/j.jare.2025.10.076_b0350","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/1531-8249(200003)47:3<336::AID-ANA9>3.0.CO;2-W","article-title":"Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term","volume":"47","author":"Dube","year":"2000","journal-title":"Ann Neurol"},{"issue":"11","key":"10.1016\/j.jare.2025.10.076_b0355","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1523\/JNEUROSCI.22-11-04591.2002","article-title":"Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner","volume":"22","author":"Brewster","year":"2002","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.jare.2025.10.076_b0360","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/cpmo.17","article-title":"Methodological Considerations for Optimizing and Validating Behavioral Assays","volume":"6","author":"Sukoff Rizzo","year":"2016","journal-title":"Curr Protoc Mouse Biol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225008720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225008720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:46:39Z","timestamp":1789083999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225008720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":72,"alternative-id":["S2090123225008720"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.10.076","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of general anesthetics on seizure termination, mortality, and neurological prognosis in a rat model of pediatric refractory status epilepticus: A comparative randomized controlled study","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.10.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}