{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:10:12Z","timestamp":1789085412377,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2022ZDLSF02-01"],"award-info":[{"award-number":["2022ZDLSF02-01"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270420"],"award-info":[{"award-number":["82270420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22205173"],"award-info":[{"award-number":["22205173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241204"],"award-info":[{"award-number":["82241204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21674085"],"award-info":[{"award-number":["21674085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0504402"],"award-info":[{"award-number":["2023ZD0504402"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013149","name":"Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012270","name":"Shaanxi Key Science and Technology Innovation Team Project","doi-asserted-by":"publisher","award":["2024RS-CXTD-81"],"award-info":[{"award-number":["2024RS-CXTD-81"]}],"id":[{"id":"10.13039\/501100012270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jare.2025.11.028","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:46:50Z","timestamp":1763538410000},"page":"605-619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["SIRT3-activating, biodegradable poly-honokiol with high drug loading for thoracic aortic dissection therapy"],"prefix":"10.1016","volume":"86","author":[{"given":"Xi\u2019nan","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longteng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjie","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jare.2025.11.028_b0005","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00395-024-01053-1","article-title":"Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections","volume":"119","author":"Ganizada","year":"2024","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jare.2025.11.028_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108652","article-title":"Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm","volume":"259","author":"Zhao","year":"2024","journal-title":"Pharmacol Ther"},{"issue":"25","key":"10.1016\/j.jare.2025.11.028_b0015","doi-asserted-by":"crossref","first-page":"17201","DOI":"10.1021\/jacs.4c03344","article-title":"Biomimetic-structured cobalt nanocatalyst suppresses aortic dissection progression by catalytic antioxidation","volume":"146","author":"Yang","year":"2024","journal-title":"J Am Chem Soc"},{"issue":"12","key":"10.1016\/j.jare.2025.11.028_b0020","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14008","article-title":"The role of cardiac resident macrophage in cardiac aging","volume":"22","author":"Li","year":"2023","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.jare.2025.11.028_b0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-023-01325-7","article-title":"The mechanism and therapy of aortic aneurysms","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jare.2025.11.028_b0030","article-title":"m(7)G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes","volume":"314","author":"Long","year":"2024","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jare.2025.11.028_b0035","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s10020-024-00926-4","article-title":"ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch","volume":"30","author":"Jiang","year":"2024","journal-title":"Mol Med"},{"key":"10.1016\/j.jare.2025.11.028_b0040","article-title":"Sodium-glucose exchanger 2 inhibitor canagliflozin promotes mitochondrial metabolism and alleviates salt-induced cardiac hypertrophy via preserving SIRT3 expression","author":"Zhao","year":"2024","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2025.11.028_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103224","article-title":"Activation of Sirtuin3 by honokiol ameliorates alveolar epithelial cell senescence in experimental silicosis via the cGAS-STING pathway","volume":"74","author":"Zhou","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2025.11.028_b0050","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.2147\/IJN.S431409","article-title":"Nanotechnology-based drug delivery systems for honokiol: enhancing therapeutic potential and overcoming limitations","volume":"18","author":"Yang","year":"2023","journal-title":"Int J Nanomed"},{"issue":"15","key":"10.1016\/j.jare.2025.11.028_b0055","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1039\/D2CS00099G","article-title":"Degradable polyprodrugs: design and therapeutic efficiency","volume":"51","author":"Seidi","year":"2022","journal-title":"Chem Soc Rev"},{"issue":"1","key":"10.1016\/j.jare.2025.11.028_b0060","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/s41467-019-09566-3","article-title":"Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jare.2025.11.028_b0065","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1021\/acs.nanolett.0c05028","article-title":"Dual-drug backboned polyprodrug with a predefined drug combination for synergistic chemotherapy","volume":"21","author":"Yu","year":"2021","journal-title":"Nano Lett"},{"issue":"4","key":"10.1016\/j.jare.2025.11.028_b0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41573-018-0005-0","article-title":"Polymer\u2013drug conjugate therapeutics: advances, insights and prospects","volume":"18","author":"Ekladious","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jare.2025.11.028_b0075","first-page":"155","article-title":"Recent developments in synthetic approaches for macromolecular prodrugs","author":"Alex","year":"2024","journal-title":"Prog Polym Sci"},{"issue":"4","key":"10.1016\/j.jare.2025.11.028_b0080","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1988","article-title":"Polymer-drug and polymer-protein conjugated nanocarriers: design, drug delivery, imaging, therapy, and clinical applications","volume":"16","author":"Guo","year":"2024","journal-title":"Wiley Interdiscip Rev-Nanomed Nanobiotechnol"},{"issue":"6","key":"10.1016\/j.jare.2025.11.028_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202107434","article-title":"Polyprodrug nanomedicines: an emerging paradigm for cancer therapy","volume":"34","author":"Yang","year":"2022","journal-title":"Adv Mater"},{"key":"10.1016\/j.jare.2025.11.028_b0090","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jconrel.2020.07.010","article-title":"Controlled drug delivery with nanoassemblies of redox-responsive prodrug and polyprodrug amphiphiles","volume":"326","author":"Deng","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.jare.2025.11.028_b0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.biomaterials.2015.10.056","article-title":"Smart and hyper-fast responsive polyprodrug nanoplatform for targeted cancer therapy","volume":"76","author":"Xu","year":"2016","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.jare.2025.11.028_b0100","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202107434","article-title":"Polyprodrug nanomedicines: an emerging paradigm for cancer therapy","volume":"34","author":"Yang","year":"2022","journal-title":"Adv Mater"},{"issue":"14","key":"10.1016\/j.jare.2025.11.028_b0105","doi-asserted-by":"crossref","DOI":"10.1002\/marc.202100918","article-title":"Rationally driven drug nonradiative decay via a label-free polyprodrug strategy to renew tumor cascade photothermal-chemotherapy","volume":"43","author":"Zhang","year":"2022","journal-title":"Macromol Rapid Commun"},{"issue":"45","key":"10.1016\/j.jare.2025.11.028_b0110","doi-asserted-by":"crossref","first-page":"10725","DOI":"10.1002\/chem.201702966","article-title":"Phenol-yne click polymerization: an efficient technique to facilely access regio- and stereoregular poly(vinylene ether ketone)s","volume":"23","author":"Shi","year":"2017","journal-title":"Chem \u2013 Eur J"},{"key":"10.1016\/j.jare.2025.11.028_b0115","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3152870","article-title":"A simple approach to bioconjugation at diverse levels: metal-free click reactions of activated alkynes with native groups of biotargets without prefunctionalization","author":"Hu","year":"2018","journal-title":"Research"},{"key":"10.1016\/j.jare.2025.11.028_b0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.actbio.2022.04.034","article-title":"Amino acids and doxorubicin as building blocks for metal ion\u2010driven self\u2010assembly of biodegradable polyprodrugs for tumor theranostics","volume":"147","author":"Wang","year":"2022","journal-title":"Acta Biomater"},{"issue":"12","key":"10.1016\/j.jare.2025.11.028_b0125","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1021\/acs.chemrev.0c01076","article-title":"Click nucleophilic conjugate additions to activated alkynes: exploring thiol-yne, amino-yne, and hydroxyl-yne reactions from (bio)organic to polymer chemistry","volume":"121","author":"Worch","year":"2021","journal-title":"Chem Rev"},{"key":"10.1016\/j.jare.2025.11.028_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111790","article-title":"Construction of hyperbranched and pH-responsive polymeric nanocarriers by yne-phenol click-reaction for tumor synergistic chemotherapy","volume":"204","author":"Zhang","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"4","key":"10.1016\/j.jare.2025.11.028_b0135","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1039\/c2py00586g","article-title":"Metal-free click polymerization of propiolates and azides: facile synthesis of functional poly(aroxycarbonyltriazole)s","volume":"3","author":"Li","year":"2012","journal-title":"Polym Chem"},{"issue":"12","key":"10.1016\/j.jare.2025.11.028_b0140","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1021\/ma900076z","article-title":"Facile polycyclotrimerization of \u201csimple\u201d arylene bipropiolates: a metal-free, regioselective route to functional hyperbranched polymers with high optical transparency, tunable refractive index, low chromatic aberration, and photoresponsive patternability","volume":"42","author":"Jim","year":"2009","journal-title":"Macromolecules"},{"issue":"11","key":"10.1016\/j.jare.2025.11.028_b0145","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1007\/s11427-024-2693-5","article-title":"Role of macrophages in aortic dissection pathogenesis: insights from preclinical studies to translational prospective","volume":"67","author":"Li","year":"2024","journal-title":"Sci China Life Sci"},{"issue":"13","key":"10.1016\/j.jare.2025.11.028_b0150","first-page":"1","article-title":"Deaths: final data for 2018","volume":"69","author":"Murphy","year":"2021","journal-title":"Natl Vital Stat Rep"},{"key":"10.1016\/j.jare.2025.11.028_b0155","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2024.02.006","article-title":"Cannabidiol protects against acute aortic dissection by inhibiting macrophage infiltration and PMAIP1-induced vascular smooth muscle cell apoptosis","volume":"189","author":"Guo","year":"2024","journal-title":"J Mol Cell Cardiol"},{"issue":"5","key":"10.1016\/j.jare.2025.11.028_b0160","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.athoracsur.2019.04.014","article-title":"Early outcomes after thoracoabdominal aortic aneurysm repair with hypothermic circulatory arrest","volume":"108","author":"Kouchoukos","year":"2019","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.jare.2025.11.028_b0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-022-00340-w","article-title":"HCMV-miR-US33-5p promotes apoptosis of aortic vascular smooth muscle cells by targeting EPAS1\/SLC3A2 pathway","volume":"27","author":"Dong","year":"2022","journal-title":"Cell Mol Biol Lett"},{"issue":"9","key":"10.1016\/j.jare.2025.11.028_b0170","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCULATIONAHA.121.056640","article-title":"Legumain is an Endogenous Modulator Of Integrin Alphavbeta3 Triggering Vascular Degeneration, Dissection, And Rupture","volume":"145","author":"Pan","year":"2022","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jare.2025.11.028_b0175","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/gtc.12842","article-title":"Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair","volume":"26","author":"Yasuda","year":"2021","journal-title":"Genes Cells"},{"key":"10.1016\/j.jare.2025.11.028_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116004","article-title":"SIRT3 regulates mitochondrial function: a promising star target for cardiovascular disease therapy","volume":"170","author":"Zhang","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2025.11.028_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132026","article-title":"New insight into molecular mechanisms of different polyphenols affecting Sirtuin 3 deacetylation activity","volume":"270","author":"Wei","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jare.2025.11.028_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.675647","article-title":"Sirt3 protects against thoracic aortic dissection formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of smooth muscle cells","volume":"8","author":"Qiu","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"38","key":"10.1016\/j.jare.2025.11.028_b0195","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1039\/C8PY01190G","article-title":"Sequence-definition from controlled polymerization: the next generation of materials","volume":"9","author":"De Neve","year":"2018","journal-title":"Polym Chem"},{"key":"10.1016\/j.jare.2025.11.028_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.giant.2023.100168","article-title":"Sequence-controlled polymers constructed by alkyne-based polymerizations","volume":"15","author":"Long","year":"2023","journal-title":"Giant"},{"issue":"19","key":"10.1016\/j.jare.2025.11.028_b0205","doi-asserted-by":"crossref","first-page":"6864","DOI":"10.1021\/bi972449j","article-title":"Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation","volume":"37","author":"Hazen","year":"1998","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.jare.2025.11.028_b0210","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1042\/bj2160081","article-title":"Metabolism of malonic semialdehyde in man","volume":"216","author":"Scholem","year":"1983","journal-title":"Biochem J"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:47:38Z","timestamp":1789084058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225009221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":42,"alternative-id":["S2090123225009221"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.028","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT3-activating, biodegradable poly-honokiol with high drug loading for thoracic aortic dissection therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}