{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:28:55Z","timestamp":1793413735944,"version":"4.5.0"},"reference-count":194,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401074"],"award-info":[{"award-number":["82401074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["YCJJ20252415"],"award-info":[{"award-number":["YCJJ20252415"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["2026JYYB19"],"award-info":[{"award-number":["2026JYYB19"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["X202510487134"],"award-info":[{"award-number":["X202510487134"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["2025153"],"award-info":[{"award-number":["2025153"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["2025JCYJ072"],"award-info":[{"award-number":["2025JCYJ072"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jare.2025.11.057","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:52:49Z","timestamp":1764391969000},"page":"443-463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Macrophage-induced immunomodulation in oral tissue repair and regeneration: Recent advances and future perspectives"],"prefix":"10.1016","volume":"86","author":[{"given":"Yujie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajie","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-400X","authenticated-orcid":false,"given":"Xin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10219","key":"10.1016\/j.jare.2025.11.057_b0005","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0140-6736(19)33016-8","article-title":"Oral diseases: a global public health challenge","volume":"395","author":"Bawaskar","year":"2020","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.jare.2025.11.057_b0010","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0022034513490168","article-title":"Global burden of oral conditions in 1990-2010: a systematic analysis","volume":"92","author":"Marcenes","year":"2013","journal-title":"J Dent Res"},{"issue":"13","key":"10.1016\/j.jare.2025.11.057_b0015","doi-asserted-by":"crossref","first-page":"7299","DOI":"10.3390\/ijms25137299","article-title":"Investigating the interplay: Periodontal disease and type 1 diabetes mellitus-a comprehensive review of clinical studies","volume":"25","author":"Vlachou","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.11.057_b0020","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-immunol-093019-111748","article-title":"Origins, biology, and diseases of tissue macrophages","volume":"39","author":"Cox","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0025","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2147\/IJN.S449388","article-title":"Macrophage-derived exosomes as advanced therapeutics for inflammation: current progress and future perspectives","volume":"19","author":"Song","year":"2024","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jare.2025.11.057_b0030","article-title":"Role of macrophages and their exosomes in orthopedic diseases","volume":"12","author":"Yuan","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.jare.2025.11.057_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1014013","article-title":"Advances in the research of the role of macrophage\/microglia polarization-mediated inflammatory response in spinal cord injury","volume":"13","author":"Fu","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","article-title":"The exosome journey: from biogenesis to uptake and intracellular signaling","volume":"19","author":"Gurung","year":"2021","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jare.2025.11.057_b0045","article-title":"TRIM21 aggravates cardiac injury after myocardial infarction by promoting M1 macrophage polarization","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102446","article-title":"LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization","volume":"56","author":"Chen","year":"2022","journal-title":"Redox Biol"},{"issue":"16","key":"10.1016\/j.jare.2025.11.057_b0055","doi-asserted-by":"crossref","first-page":"8457","DOI":"10.3390\/ijms22168457","article-title":"The macrophage iron signature in health and disease","volume":"22","author":"Mertens","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.11.057_b0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40164-017-0083-4","article-title":"Pivotal regulators of tissue homeostasis and cancer: Macrophages","volume":"6","author":"Chen","year":"2017","journal-title":"Exp Hematol Oncol"},{"key":"10.1016\/j.jare.2025.11.057_b0065","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.3389\/fimmu.2018.01930","article-title":"Chemokine-induced macrophage polarization in inflammatory conditions","volume":"9","author":"Ruytinx","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0070","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/8821610","article-title":"Regulatory mechanism of M1\/M2 macrophage polarization in the development of autoimmune diseases","volume":"2023","author":"Peng","year":"2023","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jare.2025.11.057_b0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"10.1016\/j.jare.2025.11.057_b0080","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41577-018-0056-9","article-title":"Perivascular macrophages in health and disease","volume":"18","author":"Lapenna","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0085","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1152\/physrev.00068.2017","article-title":"Macrophages and cardiovascular health","volume":"98","author":"Frodermann","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2025.11.057_b0090","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-031-55254-0","article-title":"Isoorientin ameliorates macrophage pyroptosis and atherogenesis by reducing KDM4A levels and promoting SKP1-cullin1-F-box E3 ligase-mediated NLRP3 ubiquitination","author":"Wang","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.jare.2025.11.057_b0095","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.3389\/fimmu.2019.02852","article-title":"Therapeutic targeting of hepatic macrophages for the treatment of liver diseases","volume":"10","author":"van der Heide","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101970","article-title":"Macrophagic and microglial complexity after neuronal injury","volume":"200","author":"Mesquida-Veny","year":"2021","journal-title":"Prog Neurobiol"},{"issue":"12","key":"10.1016\/j.jare.2025.11.057_b0105","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0110","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fonc.2019.00421","article-title":"Macrophage polarization in the development and progression of ovarian cancers: an overview","volume":"9","author":"Cheng","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.jare.2025.11.057_b0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.intimp.2019.02.050","article-title":"M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds","volume":"70","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2025.11.057_b0120","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8917804","article-title":"Macrophage polarization in chronic inflammatory diseases: killers or builders","volume":"2018","author":"Parisi","year":"2018","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.imbio.2017.10.005","article-title":"The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2","volume":"223","author":"Chistiakov","year":"2018","journal-title":"Immunobiology"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0130","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/14728222.2021.1901079","article-title":"Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease","volume":"25","author":"Du","year":"2021","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00011-015-0874-1","article-title":"Macrophage polarization: the link between inflammation and related diseases","volume":"65","author":"Bashir","year":"2016","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jare.2025.11.057_b0140","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cyto.2017.08.014","article-title":"Differential regulation of IL-23 production in M1 macrophages by TIR8\/SIGIRR through TLR4- or TLR7\/8-mediated signaling","volume":"99","author":"Yamaguchi","year":"2017","journal-title":"Cytokine"},{"issue":"8","key":"10.1016\/j.jare.2025.11.057_b0145","doi-asserted-by":"crossref","DOI":"10.1111\/pai.13835","article-title":"Dermatophagoides pteronyssinus allergen Der p 22: Cloning, expression, IgE-binding in asthmatic children, and immunogenicity","volume":"33","author":"Zhou","year":"2022","journal-title":"Pediatr Allergy Immunol"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0150","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0155","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.jare.2025.11.057_b0160","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/816460","article-title":"Understanding the mysterious M2 macrophage through activation markers and effector mechanisms","volume":"2015","author":"R\u0151szer","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jare.2025.11.057_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101812","article-title":"The serum soluble Klotho alleviates cardiac aging and regulates M2a\/M2c macrophage polarization via inhibiting TLR4\/Myd88\/NF-\u03baB pathway","volume":"76","author":"Wang","year":"2022","journal-title":"Tissue Cell"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0170","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/JLB.3RU1018-378RR","article-title":"M2b macrophage polarization and its roles in diseases","volume":"106","author":"Wang","year":"2019","journal-title":"J Leukoc Biol"},{"issue":"7","key":"10.1016\/j.jare.2025.11.057_b0175","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.imbio.2017.02.006","article-title":"Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing","volume":"222","author":"Lurier","year":"2017","journal-title":"Immunobiology"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0180","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/08820139.2020.1828911","article-title":"Epithelial-mesenchymal transition of peritoneal mesothelial cells is enhanced by M2c macrophage polarization","volume":"51","author":"Tian","year":"2022","journal-title":"Immunol Invest"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0185","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/cr.2010.52","article-title":"Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages","volume":"20","author":"Wang","year":"2010","journal-title":"Cell Res"},{"key":"10.1016\/j.jare.2025.11.057_b0190","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.addr.2020.04.004","article-title":"Extracellular vesicles as drug delivery systems: why and how","volume":"159","author":"Elsharkasy","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0195","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.tibtech.2020.05.012","article-title":"Technologies and standardization in research on extracellular vesicles","volume":"38","author":"Gandham","year":"2020","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.jare.2025.11.057_b0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-9-9","article-title":"Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages","volume":"9","author":"L\u00e4sser","year":"2011","journal-title":"J Transl Med"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0205","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s12094-023-03374-4","article-title":"Exosomal noncoding RNAs as noninvasive biomarkers in bladder cancer: a diagnostic meta-analysis","volume":"26","author":"Zhao","year":"2024","journal-title":"Clin Transl Oncol"},{"issue":"5","key":"10.1016\/j.jare.2025.11.057_b0210","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-022-00410-w","article-title":"Therapeutically harnessing extracellular vesicles","volume":"21","author":"Cheng","year":"2022","journal-title":"Nat Rev Drug Discov"},{"issue":"6478","key":"10.1016\/j.jare.2025.11.057_b0215","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jare.2025.11.057_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.715461","article-title":"The biogenesis, biological functions, and applications of macrophage-derived exosomes","volume":"8","author":"Shan","year":"2021","journal-title":"Front Mol Biosci"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0225","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00395-020-0781-7","article-title":"M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment","volume":"115","author":"Liu","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jare.2025.11.057_b0230","first-page":"273","article-title":"M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator","volume":"28","author":"Wang","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2025.11.057_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103016","article-title":"M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2\/HIF-1\u03b1 axis mediated metabolic reprogramming of macrophages","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox Biol"},{"issue":"15","key":"10.1016\/j.jare.2025.11.057_b0240","article-title":"Exosome processing and characterization approaches for research and technology development","volume":"9","author":"Lai","year":"2022","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0245","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1528109","article-title":"Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales","volume":"7","author":"Ludwig","year":"2018","journal-title":"J Extracell Vesicles"},{"issue":"8","key":"10.1016\/j.jare.2025.11.057_b0250","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.7150\/thno.41580","article-title":"Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0255","first-page":"3","article-title":"Multiplexed profiling of extracellular vesicles for biomarker development","volume":"14","author":"Jiang","year":"2021","journal-title":"Nanomicro Lett"},{"key":"10.1016\/j.jare.2025.11.057_b0260","doi-asserted-by":"crossref","first-page":"23978","DOI":"10.1038\/srep23978","article-title":"ExtraPEG: a polyethylene glycol-based method for enrichment of extracellular vesicles","volume":"6","author":"Rider","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.11.057_b0265","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4939-7253-1_18","article-title":"Detection and characterization of extracellular vesicles by transmission and cryo-transmission electron microscopy","volume":"1660","author":"Cizmar","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0270","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13367","article-title":"Preparation and characterization of extracellular vesicles","volume":"85","author":"Tiwari","year":"2021","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0275","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/bs.mie.2020.06.011","article-title":"Immunocapture-based ELISA to characterize and quantify exosomes in both cell culture supernatants and body fluids","volume":"645","author":"Logozzi","year":"2020","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jare.2025.11.057_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101954","article-title":"Nanoscopic and functional characterization of keratinocyte-originating exosomes in the wound fluid of non-diabetic and diabetic chronic wound patients","volume":"52","author":"Guda","year":"2023","journal-title":"Nano Today"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0285","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/cancers12020353","article-title":"Plasma next generation sequencing and droplet digital-qPCR-based quantification of circulating cell-free RNA for noninvasive early detection of cancer","volume":"12","author":"Metzenmacher","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.jare.2025.11.057_b0290","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1021\/acsnano.9b09119","article-title":"Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes","volume":"14","author":"Shin","year":"2020","journal-title":"ACS Nano"},{"issue":"Suppl 1","key":"10.1016\/j.jare.2025.11.057_b0295","first-page":"S159","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J Periodontol"},{"key":"10.1016\/j.jare.2025.11.057_b0300","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jdsr.2022.10.002","article-title":"Macrophages in periodontitis: a dynamic shift between tissue destruction and repair","volume":"58","author":"Yin","year":"2022","journal-title":"Jpn Dent Sci Rev"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0305","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1001\/jamaoncol.2017.4777","article-title":"Association of oral microbiome with risk for incident head and neck squamous cell cancer","volume":"4","author":"Hayes","year":"2018","journal-title":"JAMA Oncol"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0310","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/JPER.17-0674","article-title":"Memory T cell subsets in healthy gingiva and periodontitis tissues","volume":"89","author":"Mahanonda","year":"2018","journal-title":"J Periodontol"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0315","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1161\/ATVBAHA.120.314883","article-title":"Neutrophil extracellular trap degradation by differently polarized macrophage subsets","volume":"40","author":"Haider","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0320","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/ijms19061801","article-title":"Role of human macrophage polarization in inflammation during infectious diseases","volume":"19","author":"Atri","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0325","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0330","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.768479","article-title":"Innate phagocyte polarization in the oral cavity","volume":"12","author":"Metcalfe","year":"2022","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.jare.2025.11.057_b0335","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3390\/ijms20082023","article-title":"TET1 knockdown inhibits porphyromonas gingivalis LPS\/IFN-\u03b3-induced M1 macrophage polarization through the NF-\u03baB pathway in THP-1 cells","volume":"20","author":"Huang","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0340","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s00784-020-03501-3","article-title":"Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1\/2 commitment","volume":"25","author":"Ruiz-Heiland","year":"2021","journal-title":"Clin Oral Invest"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0345","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1159\/000494481","article-title":"High glucose-mediated cytokine regulation in gingival fibroblasts and THP-1 macrophage: a possible mechanism of severe periodontitis with diabetes","volume":"50","author":"Lew","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0350","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1002\/jcp.26521","article-title":"Biological effects of interleukin-6 on gingival fibroblasts: cytokine regulation in periodontitis","volume":"233","author":"Naruishi","year":"2018","journal-title":"J Cell Physiol"},{"issue":"23","key":"10.1016\/j.jare.2025.11.057_b0355","doi-asserted-by":"crossref","first-page":"9100","DOI":"10.3390\/ijerph17239100","article-title":"Levels of gene expression of immunological biomarkers in peri-implant and periodontal tissues","volume":"17","author":"Figueiredo","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"8","key":"10.1016\/j.jare.2025.11.057_b0360","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/0022034521995157","article-title":"Host modulation and treatment of periodontal disease","volume":"100","author":"Balta","year":"2021","journal-title":"J Dent Res"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0365","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/cre2.11","article-title":"Interleukin-6 receptor inhibitor tocilizumab ameliorates periodontal inflammation in patients with rheumatoid arthritis and periodontitis as well as tumor necrosis factor inhibitors","volume":"1","author":"Kobayashi","year":"2015","journal-title":"Clin Exp Dent Res"},{"issue":"14","key":"10.1016\/j.jare.2025.11.057_b0370","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.3390\/ijerph17144923","article-title":"The Role of matrix metalloproteinases in periodontal disease","volume":"17","author":"Checchi","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jare.2025.11.057_b0375","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763334","article-title":"Polarized macrophages in periodontitis: characteristics, function, and molecular signaling","volume":"12","author":"Sun","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0380","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11914-020-00559-6","article-title":"The interrelationship between diabetes, IL-17 and bone loss","volume":"18","author":"Huang","year":"2020","journal-title":"Curr Osteoporos Rep"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0385","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/00220345211059418","article-title":"Leptin aggravates periodontitis by promoting M1 polarization via NLRP3","volume":"101","author":"Han","year":"2022","journal-title":"J Dent Res"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0390","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00068-018-0956-1","article-title":"Macrophages play an essential role in trauma-induced sterile inflammation and tissue repair","volume":"44","author":"Peiseler","year":"2018","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0395","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00262-018-2184-2","article-title":"Absence of host NF-\u03baB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization","volume":"67","author":"Barberi","year":"2018","journal-title":"Cancer Immunol Immunother"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0400","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.jare.2025.11.057_b0405","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0410","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2174\/1574888X14666190214163815","article-title":"Macrophages in bone homeostasis","volume":"14","author":"Kong","year":"2019","journal-title":"Curr Stem Cell Res Ther"},{"issue":"5","key":"10.1016\/j.jare.2025.11.057_b0415","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.immuni.2014.03.011","article-title":"Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function","volume":"40","author":"Shouval","year":"2014","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0420","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.4049\/jimmunol.1800141","article-title":"Inhaled IL-10 suppresses lung tumorigenesis via abrogation of inflammatory macrophage-Th17 cell axis","volume":"201","author":"Li","year":"2018","journal-title":"J Immunol"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0425","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.4049\/jimmunol.173.10.6427","article-title":"The class a macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis","volume":"173","author":"Cotena","year":"2004","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.jare.2025.11.057_b0430","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.it.2014.06.006","article-title":"Homeostasis in the mononuclear phagocyte system","volume":"35","author":"Jenkins","year":"2014","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0435","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/0022034518805984","article-title":"Induction of M2 macrophages prevents bone loss in murine periodontitis models","volume":"98","author":"Zhuang","year":"2019","journal-title":"J Dent Res"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0440","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/JLB.1MA0121-001R","article-title":"Macrophage M1\/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation","volume":"110","author":"Liang","year":"2021","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0445","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12951-022-01314-y","article-title":"Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA","volume":"20","author":"Chen","year":"2022","journal-title":"J Nanobiotechnology"},{"issue":"27","key":"10.1016\/j.jare.2025.11.057_b0450","article-title":"Melatonin engineering M2 macrophage-derived exosomes mediate endoplasmic reticulum stress and immune reprogramming for periodontitis therapy","volume":"10","author":"Cui","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0455","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3233\/THC-220092","article-title":"Study on the imbalance of M1\/M2 macrophage polarization in severe chronic periodontitis","volume":"31","author":"Zhang","year":"2023","journal-title":"Technol Health Care"},{"key":"10.1016\/j.jare.2025.11.057_b0460","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.2147\/IJN.S420967","article-title":"Dental pulp stem cell-derived exosomes regulate anti-inflammatory and osteogenesis in periodontal ligament stem cells and promote the repair of experimental periodontitis in rats","volume":"18","author":"Qiao","year":"2023","journal-title":"Int J Nanomed"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0465","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/ijms17040498","article-title":"Triptolide modulates TREM-1 signal pathway to inhibit the inflammatory response in rheumatoid arthritis","volume":"17","author":"Fan","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0470","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/00220345211044681","article-title":"Trem1 induces periodontal inflammation via regulating M1 polarization","volume":"101","author":"Wu","year":"2022","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.jare.2025.11.057_b0475","first-page":"05","article-title":"NF-kappaB signaling in macrophages: dynamics, crosstalk, and signal integration","volume":"10","author":"Dorrington","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.11.057_b0480","first-page":"428","article-title":"Photothermal therapy with regulated Nrf2\/NF-\u03baB signaling pathway for treating bacteria-induced periodontitis","volume":"9","author":"Tian","year":"2021","journal-title":"Bioact Mater"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0485","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/jre.13246","article-title":"BBR affects macrophage polarization via inhibition of NF-\u03baB pathway to protect against T2DM-associated periodontitis","volume":"59","author":"Xia","year":"2024","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jare.2025.11.057_b0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114561","article-title":"GTS-21 alleviates sepsis-induced atrial fibrillation susceptibility by modulating macrophage polarization and Neuregulin-1 secretion","volume":"154","author":"Zhou","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0495","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s10753-022-01777-z","article-title":"Sema3A drives alternative macrophage activation in the resolution of periodontitis via PI3K\/AKT\/mTOR signaling","volume":"46","author":"Tian","year":"2023","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.jare.2025.11.057_b0500","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/0022034520910127","article-title":"Akt2 affects periodontal inflammation via altering the M1\/M2 ratio","volume":"99","author":"Wu","year":"2020","journal-title":"J Dent Res"},{"issue":"15","key":"10.1016\/j.jare.2025.11.057_b0505","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/scd.2019.0021","article-title":"Extracellular vesicles suppress basal and lipopolysaccharide-induced NF\u03baB activity in human periodontal ligament stem cells","volume":"28","author":"\u010cebatari\u016bnien\u0117","year":"2019","journal-title":"Stem Cells Dev"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0510","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/stmcls\/sxac087","article-title":"Inflammatory periodontal ligament stem cells drive M1 macrophage polarization via exosomal miR-143-3p-mediated regulation of PI3K\/AKT\/NF-\u03baB signaling","volume":"41","author":"Wang","year":"2023","journal-title":"Stem Cells"},{"issue":"11","key":"10.1016\/j.jare.2025.11.057_b0515","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/term.1899","article-title":"Dental pulp stem cells: function, isolation and applications in regenerative medicine","volume":"9","author":"Tatullo","year":"2015","journal-title":"J Tissue Eng Regen Med"},{"issue":"12","key":"10.1016\/j.jare.2025.11.057_b0520","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.joen.2021.09.010","article-title":"Bacterial invasion of pulp blood vessels in teeth with symptomatic irreversible pulpitis","volume":"47","author":"Ricucci","year":"2021","journal-title":"J Endod"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0525","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3390\/ijms22031480","article-title":"Inflammatory response mechanisms of the dentine-pulp complex and the periapical tissues","volume":"22","author":"Galler","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0530","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/0022034513518223","article-title":"Dental pulp dendritic cells migrate to regional lymph nodes","volume":"93","author":"Bhingare","year":"2014","journal-title":"J Dent Res"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0535","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202100747","article-title":"Landscape of cell communication in human dental pulp","volume":"5","author":"Yin","year":"2021","journal-title":"Small Methods"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0540","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139576","article-title":"Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction","volume":"131","author":"DeBerge","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2025.11.057_b0545","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molimm.2018.12.016","article-title":"Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and \u03b2-arrestin 2 in inflammatory macrophages","volume":"106","author":"Serafin","year":"2019","journal-title":"Mol Immunol"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0550","first-page":"1","article-title":"Deciphering reparative processes in the inflamed dental pulp","volume":"3","author":"El Karim","year":"2021","journal-title":"Front Dent Med"},{"key":"10.1016\/j.jare.2025.11.057_b0555","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jare.2025.11.057_b0560","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1177\/00220345221150383","article-title":"Development of rat caries-induced pulpitis model for vital pulp therapy","volume":"102","author":"Huang","year":"2023","journal-title":"J Dent Res"},{"issue":"11","key":"10.1016\/j.jare.2025.11.057_b0565","first-page":"1812","article-title":"Involvement of M1\/M2 macrophage polarization in reparative dentin formation","volume":"12","author":"Kadowaki","year":"2022","journal-title":"Life (Basel)"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0570","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1038\/s41598-022-08987-3","article-title":"Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro","volume":"12","author":"Kieu","year":"2022","journal-title":"Sci Rep"},{"issue":"20","key":"10.1016\/j.jare.2025.11.057_b0575","doi-asserted-by":"crossref","first-page":"12603","DOI":"10.1074\/jbc.M115.636506","article-title":"Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system","volume":"290","author":"Kobayashi","year":"2015","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0580","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/0022034519894957","article-title":"M2 phenotype macrophages colocalize with schwann cells in human dental pulp","volume":"99","author":"Yoshiba","year":"2020","journal-title":"J Dent Res"},{"issue":"34","key":"10.1016\/j.jare.2025.11.057_b0585","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1016\/j.biomaterials.2012.08.050","article-title":"Effect of modulating macrophage phenotype on peripheral nerve repair","volume":"33","author":"Mokarram","year":"2012","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0590","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/joor.13245","article-title":"Polarization of macrophages in the trigeminal ganglion of rats with pulpitis","volume":"49","author":"Gao","year":"2022","journal-title":"J Oral Rehabil"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0595","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/iej.13033","article-title":"Macrophage populations show an M1-to-M2 transition in an experimental model of coronal pulp tissue engineering with mesenchymal stem cells","volume":"52","author":"Gu","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.jare.2025.11.057_b0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101944","article-title":"The role of different macrophages-derived conditioned media in dental pulp tissue regeneration","volume":"79","author":"Zhou","year":"2022","journal-title":"Tissue Cell"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0605","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/biomedicines12020441","article-title":"Multifunctional exosomes derived from M2 macrophages with enhanced odontogenesis, neurogenesis and angiogenesis for regenerative endodontic therapy: an in vitro and in vivo investigation","volume":"12","author":"Wang","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jare.2025.11.057_b0610","doi-asserted-by":"crossref","first-page":"184","DOI":"10.22203\/eCM.v041a13","article-title":"The role of inflammation modulation in dental pulp regeneration","volume":"41","author":"Zaky","year":"2021","journal-title":"Eur Cell Mater"},{"issue":"11","key":"10.1016\/j.jare.2025.11.057_b0615","doi-asserted-by":"crossref","DOI":"10.1242\/dev.146589","article-title":"Wnt signaling in development and tissue homeostasis","volume":"145","author":"Steinhart","year":"2018","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0620","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/jre.13022","article-title":"LiCl-induced immunomodulatory periodontal regeneration via the activation of the Wnt\/\u03b2-catenin signaling pathway","volume":"57","author":"Zheng","year":"2022","journal-title":"J Periodontal Res"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0625","doi-asserted-by":"crossref","first-page":"20216","DOI":"10.1038\/s41598-020-77161-4","article-title":"Macrophage modulation of dental pulp stem cell activity during tertiary dentinogenesis","volume":"10","author":"Neves","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0630","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s41418-021-00904-x","article-title":"The osteoprotective role of USP26 in coordinating bone formation and resorption","volume":"29","author":"Li","year":"2022","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0635","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/ijerph20010477","article-title":"Underdiagnosis in background of emerging public health challenges related to peri-implant diseases: an interventional split-mouth study","volume":"20","author":"Djuran","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"Suppl 20","key":"10.1016\/j.jare.2025.11.057_b0640","first-page":"S286","article-title":"Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"45","author":"Berglundh","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0645","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s12903-022-02493-8","article-title":"What is the prevalence of peri-implantitis? A systematic review and meta-analysis","volume":"22","author":"Diaz","year":"2022","journal-title":"BMC Oral Health"},{"issue":"3","key":"10.1016\/j.jare.2025.11.057_b0650","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/clr.13568","article-title":"Characterization of macrophages infiltrating peri-implantitis lesions","volume":"31","author":"Fretwurst","year":"2020","journal-title":"Clin Oral Implant Res"},{"key":"10.1016\/j.jare.2025.11.057_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2023.102112","article-title":"Macrophage polarization in bone implant repair: a review","volume":"82","author":"Song","year":"2023","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jare.2025.11.057_b0660","article-title":"Immune dysregulation and macrophage polarization in peri-implantitis","volume":"12","author":"Li","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"issue":"12","key":"10.1016\/j.jare.2025.11.057_b0665","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/jcpe.13370","article-title":"Cellular expression of DNA damage\/repair and reactive oxygen\/nitrogen species in human periodontitis and peri-implantitis lesions","volume":"47","author":"Dionigi","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0670","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s00784-020-03556-2","article-title":"Macrophage polarization in peri-implantitis lesions","volume":"25","author":"Galarraga-Vinueza","year":"2021","journal-title":"Clin Oral Invest"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0675","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s40729-021-00391-2","article-title":"Influence of macrophage polarization on the effectiveness of surgical therapy of peri-implantitis","volume":"7","author":"Galarraga-Vinueza","year":"2021","journal-title":"Int J Implant Dent"},{"issue":"11","key":"10.1016\/j.jare.2025.11.057_b0680","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.3390\/microorganisms10112114","article-title":"Antibacterial and anti-inflammatory properties of peptide KN-17","volume":"10","author":"Zhang","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.jare.2025.11.057_b0685","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.actbio.2022.11.029","article-title":"Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization","volume":"157","author":"Li","year":"2023","journal-title":"Acta Biomater"},{"issue":"7","key":"10.1016\/j.jare.2025.11.057_b0690","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbm.a.36060","article-title":"Basis of bone metabolism around dental implants during osseointegration and peri-implant bone loss","volume":"105","author":"Insua","year":"2017","journal-title":"J Biomed Mater Res A"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0695","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/jre.12633","article-title":"Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model","volume":"54","author":"Wang","year":"2019","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jare.2025.11.057_b0700","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2147\/JIR.S401968","article-title":"Polarization behavior of bone macrophage as well as associated osteoimmunity in glucocorticoid-induced osteonecrosis of the femoral head","volume":"16","author":"Zhang","year":"2023","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jare.2025.11.057_b0705","article-title":"Naringenin is a potential anabolic treatment for bone loss by modulating osteogenesis, osteoclastogenesis, and macrophage polarization","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0710","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12903-023-03011-0","article-title":"IRAK4 inhibition: an effective strategy for immunomodulating peri-implant osseointegration via reciprocally-shifted polarization in the monocyte-macrophage lineage cells","volume":"23","author":"Zhao","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jare.2025.11.057_b0715","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.actbio.2015.12.003","article-title":"Titanium surface characteristics, including topography and wettability, alter macrophage activation","volume":"31","author":"Hotchkiss","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2025.11.057_b0720","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.biomaterials.2011.12.024","article-title":"Effects of micropitted\/nanotubular titania topographies on bone mesenchymal stem cell osteogenic differentiation","volume":"33","author":"Zhao","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2025.11.057_b0725","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.2147\/IJN.S163956","article-title":"Nanostructured titanium regulates osseointegration via influencing macrophage polarization in the osteogenic environment","volume":"13","author":"Wang","year":"2018","journal-title":"Int J Nanomed"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0730","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1177\/0885328220903249","article-title":"Immune response of macrophages on super-hydrophilic TiO2 nanotube arrays","volume":"34","author":"Gao","year":"2020","journal-title":"J Biomater Appl"},{"issue":"9","key":"10.1016\/j.jare.2025.11.057_b0735","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1021\/acsbiomaterials.0c01011","article-title":"Delivery of interleukin 4 from a titanium substrate coated with graphene oxide for enhanced osseointegration by regulating macrophage polarization","volume":"6","author":"Li","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.jare.2025.11.057_b0740","article-title":"Interaction between immuno-stem dual lineages in jaw bone formation and injury repair","volume":"12","author":"Liu","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0745","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.181.2.1232","article-title":"Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo","volume":"181","author":"Chang","year":"2008","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.jare.2025.11.057_b0750","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/jbmr.354","article-title":"Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model","volume":"26","author":"Alexander","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0755","first-page":"65","article-title":"The macrophage polarization regulates MSC osteoblast differentiation in vitro","volume":"46","author":"Gong","year":"2016","journal-title":"Ann Clin Lab Sci"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0760","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/stem.1040","article-title":"Induction of osteogenesis in mesenchymal stem cells by activated monocytes\/macrophages depends on oncostatin M signaling","volume":"30","author":"Guihard","year":"2012","journal-title":"Stem Cells"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0765","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41374-021-00622-5","article-title":"M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis","volume":"101","author":"Qi","year":"2021","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0770","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s10753-020-01331-9","article-title":"Amorphous calcium phosphate nps mediate the macrophage response and modulate BMSC osteogenesis","volume":"44","author":"Chen","year":"2021","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0775","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1302\/2046-3758.810.BJR-2018-0231.R2","article-title":"Precise immunomodulation of the M1 to M2 macrophage transition enhances mesenchymal stem cell osteogenesis and differs by sex","volume":"8","author":"Nathan","year":"2019","journal-title":"Bone Joint Res"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0780","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12951-020-00622-5","article-title":"M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3","volume":"18","author":"Xiong","year":"2020","journal-title":"J Nanobiotechnol"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0785","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12907","article-title":"Interleukin-4-loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF-\u03b21\/Smad pathway for repair of bone defect","volume":"53","author":"Zhang","year":"2020","journal-title":"Cell Prolif"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0790","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12903-023-03842-x","article-title":"M2 macrophages-derived exosomes regulate osteoclast differentiation by the CSF2\/TNF-\u03b1 axis","volume":"24","author":"Zhou","year":"2024","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jare.2025.11.057_b0795","first-page":"192","article-title":"M2 exosomes modified by hydrogen sulfide promoted bone regeneration by moesin mediated endocytosis","volume":"31","author":"Zhou","year":"2023","journal-title":"Bioact Mater"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0800","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jcms.2017.02.023","article-title":"Macrophage and osteoclast polarization in bisphosphonate associated necrosis and osteoradionecrosis","volume":"45","author":"Wehrhan","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"issue":"12","key":"10.1016\/j.jare.2025.11.057_b0805","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1158\/1078-0432.CCR-13-0042","article-title":"IL-17-mediated M1\/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws","volume":"19","author":"Zhang","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"40","key":"10.1016\/j.jare.2025.11.057_b0810","doi-asserted-by":"crossref","first-page":"44508","DOI":"10.1021\/acsami.0c13839","article-title":"Tetrahedral framework nucleic acid promotes the treatment of bisphosphonate-related osteonecrosis of the jaws by promoting angiogenesis and M2 polarization","volume":"12","author":"Zhao","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"issue":"5","key":"10.1016\/j.jare.2025.11.057_b0815","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1007\/s00784-020-03602-z","article-title":"The role of M1 and M2 macrophage polarization in progression of medication-related osteonecrosis of the jaw","volume":"25","author":"Paschalidi","year":"2021","journal-title":"Clin Oral Invest"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0820","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1096\/fj.201801791RR","article-title":"Zoledronic acid promotes TLR-4-mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw","volume":"33","author":"Zhu","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.jare.2025.11.057_b0825","article-title":"The investigation of Nf\u03bab inhibitors to block cell proliferation in OSCC cells lines","author":"Cheng","year":"2024","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jare.2025.11.057_b0830","article-title":"Osteogenic effect and mechanism of IL-10 in diabetic rat jaw defect mode","author":"Hu","year":"2023","journal-title":"Oral Dis"},{"issue":"13","key":"10.1016\/j.jare.2025.11.057_b0835","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.3390\/ijms25137278","article-title":"Targeting macrophage polarization for reinstating homeostasis following tissue damage","volume":"25","author":"Du","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.11.057_b0840","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110221","article-title":"The unique regulation of implant surface nanostructure on macrophages M1 polarization","volume":"106","author":"He","year":"2020","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"12","key":"10.1016\/j.jare.2025.11.057_b0845","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1002\/jbm.a.36490","article-title":"Multifunctional effects of a modification of SLA titanium implant surface with strontium-containing nanostructures on immunoinflammatory and osteogenic cell function","volume":"106","author":"Choi","year":"2018","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.jare.2025.11.057_b0850","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.actbio.2020.09.035","article-title":"Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice","volume":"117","author":"Shen","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2025.11.057_b0855","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2147\/IJN.S393080","article-title":"The 3D-printed ordered bredigite scaffold promotes pro-healing of critical-sized bone defects by regulating macrophage polarization","volume":"18","author":"Xuan","year":"2023","journal-title":"Int J Nanomed"},{"issue":"42","key":"10.1016\/j.jare.2025.11.057_b0860","doi-asserted-by":"crossref","first-page":"10648","DOI":"10.1073\/pnas.1806908115","article-title":"Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice","volume":"115","author":"Raimondo","year":"2018","journal-title":"PNAS"},{"issue":"11","key":"10.1016\/j.jare.2025.11.057_b0865","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.4049\/jimmunol.2400332","article-title":"Local controlled delivery of IL-4 decreases inflammatory bone loss in a murine model of periodontal disease","volume":"213","author":"Shehabeldin","year":"2024","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0870","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.7150\/thno.41622","article-title":"Cartilage repair mediated by thermosensitive photocrosslinkable TGF\u03b21-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis","volume":"10","author":"Ji","year":"2020","journal-title":"Theranostics"},{"issue":"22","key":"10.1016\/j.jare.2025.11.057_b0875","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2322935121","article-title":"Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation","volume":"121","author":"Wang","year":"2024","journal-title":"PNAS"},{"issue":"8","key":"10.1016\/j.jare.2025.11.057_b0880","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/j.bbadis.2018.05.010","article-title":"A multi-omics analysis of the regulatory changes induced by miR-223 in a monocyte\/macrophage cell line","volume":"1864","author":"M\u2019baya-Moutoula","year":"2018","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"10.1016\/j.jare.2025.11.057_b0885","article-title":"siAkt2-loaded nanoparticles reprogramming macrophages to M2 phenotype for effective bone defect repair","author":"Cui","year":"2025","journal-title":"Adv Mater"},{"issue":"4","key":"10.1016\/j.jare.2025.11.057_b0890","first-page":"1113","article-title":"Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism","volume":"5","author":"Shen","year":"2020","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2025.11.057_b0895","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes induce macrophage M2 polarization by antagonizing LPS-mediated stimulation of the NF-\u03baB and STAT3 pathways","author":"Tian","year":"2024","journal-title":"Comb Chem High Throughput Screen"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0900","doi-asserted-by":"crossref","DOI":"10.1080\/15476278.2024.2356341","article-title":"Exosomes derived from TNF-\u03b1-treated bone marrow mesenchymal stem cells ameliorate myocardial infarction injury in mice","volume":"20","author":"Wang","year":"2024","journal-title":"Organogenesis"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0905","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/s12951-024-02711-1","article-title":"Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats","volume":"22","author":"Yan","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.jare.2025.11.057_b0910","article-title":"ApoEVs transfer mitochondrial component to modulate macrophages in periodontal regeneration","author":"Liu","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.jare.2025.11.057_b0915","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114784","article-title":"Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia\/macrophage polarization in mice","volume":"377","author":"Fu","year":"2024","journal-title":"Exp Neurol"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0920","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1080\/17435889.2025.2493037","article-title":"Exosome-based nanomedicines for digestive system tumors therapy","volume":"20","author":"Song","year":"2025","journal-title":"Nanomedicine (Lond)"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0925","article-title":"Programmable macrophage vesicle based bionic self-adjuvanting vaccine for immunization against monkeypox virus","volume":"12","author":"Lin","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0930","article-title":"Engineered extracellular vesicle-delivered CRISPR\/CasRx as a novel RNA editing tool","volume":"10","author":"Li","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0935","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s12951-021-01084-z","article-title":"Targeted theranostic photoactivation on atherosclerosis","volume":"19","author":"Song","year":"2021","journal-title":"J Nanobiotechnol"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0940","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jcmgh.2024.01.012","article-title":"Optogenetic activation of cholinergic enteric neurons reduces inflammation in experimental colitis","volume":"17","author":"Rahman","year":"2024","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0945","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10103-024-04180-2","article-title":"Potential of combined red and near-infrared photobiomodulation to mitigate pro-osteoclastic and inflammatory gene expression in human mandibular osteogenic cells","volume":"39","author":"Palmisano","year":"2024","journal-title":"Lasers Med Sci"},{"issue":"10","key":"10.1016\/j.jare.2025.11.057_b0950","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.70031","article-title":"Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 promote infected wound healing via regulation of the wound microenvironment","volume":"17","author":"Yin","year":"2024","journal-title":"Microb Biotechnol"},{"issue":"1","key":"10.1016\/j.jare.2025.11.057_b0955","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2190304","article-title":"Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17\/Treg balance and gut microbiota structure","volume":"15","author":"Guo","year":"2023","journal-title":"Gut Microbes"},{"issue":"6","key":"10.1016\/j.jare.2025.11.057_b0960","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2020.05.014","article-title":"Determinants of resident tissue macrophage identity and function","volume":"52","author":"Bl\u00e9riot","year":"2020","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.jare.2025.11.057_b0965","doi-asserted-by":"crossref","first-page":"e658","DOI":"10.1002\/mco2.658","article-title":"Macrophage plasticity: signaling pathways, tissue repair, and regeneration","volume":"5","author":"Yan","year":"2024","journal-title":"MedComm (2020)"},{"issue":"2","key":"10.1016\/j.jare.2025.11.057_b0970","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/CIRCRESAHA.123.324011","article-title":"Macrophage heterogeneity and efferocytosis: beyond the M1\/M2 dichotomy","volume":"134","author":"Kumar Jha","year":"2024","journal-title":"Circ Res"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:48:35Z","timestamp":1789084115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225009543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":194,"alternative-id":["S2090123225009543"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.057","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage-induced immunomodulation in oral tissue repair and regeneration: Recent advances and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}