{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:11:02Z","timestamp":1789085462799,"version":"build-2803163510"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["TJWJ2022XK002"],"award-info":[{"award-number":["TJWJ2022XK002"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472414"],"award-info":[{"award-number":["82472414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jare.2025.11.058","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:58:29Z","timestamp":1764291509000},"page":"817-832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Arachidonic acid metabolism in spinal cord injury"],"prefix":"10.1016","volume":"86","author":[{"given":"Xue","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.11.058_b0005","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awaf040","article-title":"On the use of sham transcutaneous spinal cord stimulation in spinal cord injury clinical trials","author":"Kramer","year":"2025","journal-title":"Brain J Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0010","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S1474-4422(24)00260-6","article-title":"Tissue bridge widths and outcome after spinal cord injury","volume":"23","author":"Guest","year":"2024","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41413-022-00199-9","article-title":"Progression in translational research on spinal cord injury based on microenvironment imbalance","volume":"10","author":"Fan","year":"2022","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2025.11.058_b0020","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S1474-4422(23)00366-6","article-title":"Global burden of spinal cord injury: future directions","volume":"22","author":"Crispo","year":"2023","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0025","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S1474-4422(23)00287-9","volume":"22","year":"2023","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0030","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41582-019-0270-5","article-title":"Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging","volume":"15","author":"David","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0035","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1152\/physrev.00017.2017","article-title":"The biology of regeneration failure and success after spinal cord injury","volume":"98","author":"Tran","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2025.11.058_b0040","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jare.2025.11.058_bib665","doi-asserted-by":"crossref","first-page":"100081","DOI":"10.1016\/j.jnrt.2023.100081","article-title":"Lithium ameliorates spinal cord injury through endoplasmic reticulum stress-regulated autophagy and alleviated apoptosis through IRE1 and PERK\/eIF2\u03b1 signaling pathways","volume":"11","author":"Wang","year":"2023","journal-title":"Journal of Neurorestoratology"},{"key":"10.1016\/j.jare.2025.11.058_b0045","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1177\/1747493018778713","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"Sacks","year":"2018","journal-title":"Int J Stroke"},{"key":"10.1016\/j.jare.2025.11.058_b0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF02537187","article-title":"Diets rich in lean beef increase arachidonic acid and long-chain omega 3 polyunsaturated fatty acid levels in plasma phospholipids","volume":"29","author":"Sinclair","year":"1994","journal-title":"Lipids"},{"key":"10.1016\/j.jare.2025.11.058_b0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13046-021-02118-y","article-title":"Arachidonic acid drives adaptive responses to chemotherapy-induced stress in malignant mesothelioma","volume":"40","author":"Cioce","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.jare.2025.11.058_b0060","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.semcancer.2016.02.001","article-title":"Targeting arachidonic acid pathway by natural products for cancer prevention and therapy","volume":"40\u201341","author":"Yarla","year":"2016","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jare.2025.11.058_b0065","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jare.2025.11.058_b0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuropharm.2018.11.026","article-title":"Distinct influence of COX-1 and COX-2 on neuroinflammatory response and associated cognitive deficits during high altitude hypoxia","volume":"146","author":"Chauhan","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jare.2025.11.058_b0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.freeradbiomed.2022.10.303","article-title":"LC-MS\/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products","volume":"193","author":"Pang","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jare.2025.11.058_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109898","article-title":"Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery","volume":"37","author":"Penkert","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.jare.2025.11.058_b0085","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1096\/fj.11-183186","article-title":"Phospholipase A2 superfamily members play divergent roles after spinal cord injury","volume":"25","author":"L\u00f3pez-Vales","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.jare.2025.11.058_b0090","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1097\/01.tp.0000179113.34334.fc","article-title":"Reactivation of herpes simplex virus after liver transplantation","volume":"80","author":"Griffiths","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.jare.2025.11.058_b0095","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1080\/09540121.2012.674094","article-title":"Prevalence and correlates of insecticide-treated bednet use among HIV-1-infected adults in Kenya","volume":"24","author":"Nnedu","year":"2012","journal-title":"AIDS Care"},{"key":"10.1016\/j.jare.2025.11.058_b0100","first-page":"1026","article-title":"The novel pathophysiological function of macrophage migration inhibitory factor","volume":"69","author":"Nishihira","year":"1997","journal-title":"Seikagaku"},{"key":"10.1016\/j.jare.2025.11.058_b0105","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/ana.24134","article-title":"Cytosolic phospholipase A2 protein as a novel therapeutic target for spinal cord injury","volume":"75","author":"Liu","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0110","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/ana.20798","article-title":"A novel role of phospholipase A2 in mediating spinal cord secondary injury","volume":"59","author":"Liu","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0115","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1089\/neu.2014.3690","article-title":"Inhibition of cytosolic phospholipase A2 has neuroprotective effects on motoneuron and muscle atrophy after spinal cord injury","volume":"38","author":"Liu","year":"2021","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jare.2025.11.058_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-024-84936-6","article-title":"Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice","volume":"15","author":"Glaser","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.11.058_b0125","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1038\/s41598-021-85863-6","article-title":"The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation","volume":"11","author":"Kopper","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2025.11.058_b0130","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/nen.0b013e3181567d59","article-title":"Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury","volume":"66","author":"Liu","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0135","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1471-4159.2010.07160.x","article-title":"Inhibition of cPLA2 activation by Ginkgo biloba extract protects spinal cord neurons from glutamate excitotoxicity and oxidative stress-induced cell death","volume":"116","author":"Zhao","year":"2011","journal-title":"J Neurochem"},{"key":"10.1016\/j.jare.2025.11.058_b0140","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/bph.16255","article-title":"DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A(2) mediated lysosomal membrane permeabilization after spinal cord injury","volume":"181","author":"Chen","year":"2024","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0145","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12974-023-02690-4","article-title":"Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization","volume":"20","author":"Zhang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.11.058_b0150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrrheum.2014.2","article-title":"The skeletal muscle arachidonic acid cascade in health and inflammatory disease","volume":"10","author":"Korotkova","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jare.2025.11.058_b0155","doi-asserted-by":"crossref","first-page":"272-","DOI":"10.1016\/j.pharmthera.2013.10.010","article-title":"Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease","volume":"141","author":"Yates","year":"2014","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jare.2025.11.058_b0160","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/bph.15726","article-title":"20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin","volume":"179","author":"Hamers","year":"2022","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1248873","article-title":"Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway","volume":"14","author":"Chandrasekaran","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0170","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0165-5728(00)00372-6","article-title":"Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia\/macrophages and upregulation by endothelium following spinal cord injury","volume":"111","author":"Schwab","year":"2000","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jare.2025.11.058_b0175","doi-asserted-by":"crossref","first-page":"53S","DOI":"10.2967\/jnumed.121.263199","article-title":"Cyclooxygenases as potential PET imaging biomarkers to explore neuroinflammation in dementia","volume":"63","author":"Kenou","year":"2022","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jare.2025.11.058_b0180","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1074\/jbc.M111.327874","article-title":"Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes","volume":"287","author":"Font-Nieves","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2025.11.058_b0185","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.pharmthera.2005.04.011","article-title":"Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system","volume":"112","author":"Hewett","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jare.2025.11.058_b0190","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-5793(96)00604-7","article-title":"Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation","volume":"390","author":"Beiche","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jare.2025.11.058_b0195","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1096\/fasebj.12.12.1063","article-title":"Cyclooxygenase in biology and disease","volume":"12","author":"Dubois","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.jare.2025.11.058_b0200","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/ana.20078","article-title":"Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity","volume":"55","author":"Manabe","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105190","article-title":"Blocking the EGFR\/p38\/NF-\u03baB signaling pathway alleviates disruption of BSCB and subsequent inflammation after spinal cord injury","volume":"150","author":"Li","year":"2021","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jare.2025.11.058_b0210","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1021\/acschemneuro.1c00054","article-title":"Bradykinin activates the bradykinin B2 receptor to ameliorate neuronal injury in a rat model of spinal cord ischemia-reperfusion injury","volume":"12","author":"Yang","year":"2021","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.jare.2025.11.058_b0215","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12974-021-02186-z","article-title":"D-dopachrome tautomerase activates COX2\/PGE(2) pathway of astrocytes to mediate inflammation following spinal cord injury","volume":"18","author":"Ji","year":"2021","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.11.058_b0220","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12974-019-1468-6","article-title":"Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury","volume":"16","author":"Zhang","year":"2019","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.11.058_b0225","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.4103\/1673-5374.303039","article-title":"High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2\/prostaglandin E2 signaling following spinal cord injury","volume":"16","author":"Song","year":"2021","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jare.2025.11.058_b0230","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/glia.21138","article-title":"Signaling pathways of ATP-induced PGE2 release in spinal cord astrocytes are EGFR transactivation-dependent","volume":"59","author":"Xia","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.jare.2025.11.058_b0235","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.spinee.2018.01.010","article-title":"Upregulation of calcium channel alpha-2-delta-1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia","volume":"18","author":"Kusuyama","year":"2018","journal-title":"Spine J"},{"key":"10.1016\/j.jare.2025.11.058_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1430288","article-title":"Progress in treatment of pathological neuropathic pain after spinal cord injury","volume":"15","author":"Li","year":"2024","journal-title":"Front Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0245","article-title":"Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2025.11.058_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.137663","article-title":"COX2 expression plays a role in spinal cord injury-induced neuropathic pain","volume":"823","author":"Toi","year":"2024","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jare.2025.11.058_b0255","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/j.pain.0000000000002989","article-title":"Biodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury","volume":"165","author":"Saunders","year":"2024","journal-title":"Pain"},{"key":"10.1016\/j.jare.2025.11.058_b0260","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ptr.8039","article-title":"Stigmasterol regulates microglial M1\/M2 polarization via the TLR4\/NF-\u03baB pathway to alleviate neuropathic pain","volume":"38","author":"Si","year":"2024","journal-title":"Phytother Res"},{"key":"10.1016\/j.jare.2025.11.058_b0265","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0064-17.2017","article-title":"Microglial TNF\u03b1 induces COX2 and PGI2 synthase expression in spinal endothelial cells during neuropathic pain","volume":"4","author":"Kanda","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.jare.2025.11.058_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147153","article-title":"Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain","volume":"1750","author":"Kanda","year":"2021","journal-title":"Brain Res"},{"key":"10.1016\/j.jare.2025.11.058_b0275","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.prostaglandins.2009.04.003","article-title":"Emerging roles of PGE2 receptors in models of neurological disease","volume":"91","author":"Andreasson","year":"2010","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jare.2025.11.058_b0390","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/glia.21128","article-title":"Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury","volume":"59","author":"Redensek","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.jare.2025.11.058_b0340","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/SHK.0b013e31815dd381","article-title":"Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury","volume":"30","author":"Genovese","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.jare.2025.11.058_b0350","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/glia.20630","article-title":"The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury","volume":"56","author":"Kerr","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.jare.2025.11.058_b0310","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.neuropharm.2006.08.022","article-title":"Activation of sensory neurons contributes to reduce spinal cord injury in rats","volume":"52","author":"Kitamura","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jare.2025.11.058_b0475","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.2353\/ajpath.2010.090839","article-title":"The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury","volume":"176","author":"Saiwai","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jare.2025.11.058_b0520","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-016-0540-8","article-title":"Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection","volume":"13","author":"Martini","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jare.2025.11.058_b0560","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s12035-015-9118-1","article-title":"Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury","volume":"53","author":"Chen","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jare.2025.11.058_b0580","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13578-025-01345-6","article-title":"Maladaptive changes in the homeostasis of AEA-TRPV1\/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury","volume":"15","author":"Hu","year":"2025","journal-title":"Cell Biosci"},{"key":"10.1016\/j.jare.2025.11.058_b0280","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s11658-024-00672-9","article-title":"Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2","volume":"29","author":"Wu","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.jare.2025.11.058_b0285","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1476-5381.1994.tb13139.x","article-title":"Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice","volume":"112","author":"Minami","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0290","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1097\/00000542-200211000-00032","article-title":"Role of prostaglandin receptor EP1 in the spinal dorsal horn in carrageenan-induced inflammatory pain","volume":"97","author":"Nakayama","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jare.2025.11.058_b0295","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1172\/JCI23618","article-title":"Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype","volume":"115","author":"Reinold","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2025.11.058_b0300","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3171\/jns.1986.64.6.0951","article-title":"A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia","volume":"64","author":"Hall","year":"1986","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jare.2025.11.058_b0305","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3171\/jns.1997.86.6.1007","article-title":"Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog","volume":"86","author":"Taoka","year":"1997","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jare.2025.11.058_b0315","first-page":"950","article-title":"Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury","volume":"39","author":"Nishisho","year":"1996","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jare.2025.11.058_b0320","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1212\/WNL.35.7.1003","article-title":"Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury","volume":"35","author":"Hsu","year":"1985","journal-title":"Neurology"},{"key":"10.1016\/j.jare.2025.11.058_b0325","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0022-510X(86)90114-0","article-title":"Increased thromboxane level in experimental spinal cord injury","volume":"74","author":"Hsu","year":"1986","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jare.2025.11.058_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.108183","article-title":"15-Deoxy-\u0394(12,14)-prostaglandin J(2) ameliorates dextran sulfate sodium-induced colitis in mice through heme oxygenase-1 induction","volume":"677","author":"Takagi","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jare.2025.11.058_b0335","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/abee61","article-title":"Regeneration potential of decellularized periodontal ligament cell sheets combined with 15-deoxy-\u039412,14-prostaglandin J2 nanoparticles in a rat periodontal defect","volume":"16","author":"Jiang","year":"2021","journal-title":"Biomed Mater"},{"key":"10.1016\/j.jare.2025.11.058_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.019","article-title":"Cyclopentenone prostaglandins and structurally related oxidized lipid species instigate and share distinct pro- and anti-inflammatory pathways","volume":"30","author":"Muri","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jare.2025.11.058_b0355","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.4049\/jimmunol.168.5.2508","article-title":"Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis","volume":"168","author":"Diab","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jare.2025.11.058_b0360","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1007\/s12035-018-1347-7","article-title":"Sodium butyrate exerts neuroprotective effects in spinal cord injury","volume":"56","author":"Lanza","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jare.2025.11.058_b0365","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s10072-013-1295-y","article-title":"Tempol reduces injury area in rat model of spinal cord contusion injury through suppression of iNOS and COX-2 expression","volume":"34","author":"Quan","year":"2013","journal-title":"Neurol Sci"},{"key":"10.1016\/j.jare.2025.11.058_b0370","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1529-9430(01)00117-6","article-title":"Selective cyclooxygenase 2 inhibition lowers spinal cord prostaglandin concentrations after injury","volume":"1","author":"Resnick","year":"2001","journal-title":"Spine J"},{"key":"10.1016\/j.jare.2025.11.058_b0375","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s12028-023-01827-w","article-title":"Early celecoxib use in patients with traumatic brain injury","volume":"40","author":"Bhanja","year":"2024","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.jare.2025.11.058_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104044","article-title":"Neuroprotective effect of novel celecoxib derivatives against spinal cord injury via attenuation of COX-2, oxidative stress, apoptosisand inflammation","volume":"101","author":"An","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.jare.2025.11.058_b0385","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1089\/neu.1998.15.1005","article-title":"Role of cyclooxygenase 2 in acute spinal cord injury","volume":"15","author":"Resnick","year":"1998","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jare.2025.11.058_b0395","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1160\/TH03-06-0385","article-title":"Antithrombin reduces the ischemia\/reperfusion-induced spinal cord injury in rats by attenuating inflammatory responses","volume":"91","author":"Hirose","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jare.2025.11.058_b0400","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1523\/JNEUROSCI.6128-11.2013","article-title":"Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury","volume":"33","author":"Dulin","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.jare.2025.11.058_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177025","article-title":"Protective effects of licofelone on scopolamine-induced spatial learning and memory impairment by enhancing parkin-dependent mitophagy and promotion of neural regeneration and in adult mice","volume":"984","author":"Goudarzi","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0410","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jneuroim.2005.05.009","article-title":"Involvement of 5-lipoxygenase in spinal cord injury","volume":"166","author":"Genovese","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jare.2025.11.058_b0415","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s40478-020-00989-4","article-title":"Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice","volume":"8","author":"Michael","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.jare.2025.11.058_b0420","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.849854","article-title":"Edaravone Modulates Neuronal GPX4\/ACSL4\/5-LOX to Promote Recovery after Spinal Cord Injury","volume":"10","author":"Pang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jare.2025.11.058_b0425","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1792894","article-title":"5-Lipoxygenase inhibition protects retinal pigment epithelium from sodium iodate-induced ferroptosis and prevents retinal degeneration","volume":"2022","author":"Lee","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jare.2025.11.058_b0430","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ana.25356","article-title":"N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice","volume":"84","author":"Karuppagounder","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jare.2025.11.058_b0435","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bbrc.2019.06.118","article-title":"Knockout of ALOX12 protects against spinal cord injury-mediated nerve injury by inhibition of inflammation and apoptosis","volume":"516","author":"Li","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jare.2025.11.058_b0440","article-title":"12\/15-Lipoxygenase regulation of diabetic cognitive dysfunction is determined by interfering with inflammation and cell apoptosis","volume":"23","author":"Chen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2025.11.058_b0445","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1111\/cns.14150","article-title":"Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jare.2025.11.058_b0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116734","article-title":"Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15","volume":"175","author":"Zhu","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2025.11.058_b0455","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.4103\/1673-5374.371377","article-title":"Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jare.2025.11.058_b0460","doi-asserted-by":"crossref","first-page":"32049","DOI":"10.1074\/jbc.R500007200","article-title":"Leukotriene B4 receptor and the function of its helix 8","volume":"280","author":"Okuno","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2025.11.058_b0465","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.722360","article-title":"Berberine alleviates insulin resistance and inflammation via inhibiting the LTB4-BLT1 axis","volume":"12","author":"Gong","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0470","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1182\/blood.2019003525","article-title":"NADPH oxidase controls pulmonary neutrophil infiltration in the response to fungal cell walls by limiting LTB4","volume":"135","author":"Song","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jare.2025.11.058_b0480","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.plefa.2005.05.002","article-title":"Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution","volume":"73","author":"Serhan","year":"2005","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"10.1016\/j.jare.2025.11.058_b0485","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.biopha.2017.10.092","article-title":"Lipoxin A4 protects against spinal cord injury via regulating Akt\/nuclear factor (erythroid-derived 2)-like 2\/heme oxygenase-1 signaling","volume":"97","author":"Lu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2025.11.058_b0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.01.037","article-title":"Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury","volume":"1502","author":"Luo","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.jare.2025.11.058_b0495","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.intimp.2014.12.033","article-title":"Lipoxin A4 attenuates endothelial dysfunction during experimental cerebral malaria","volume":"24","author":"Souza","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0500","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.688","article-title":"Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A(4) analog: protective mechanisms and long-term effects on neurological recovery","volume":"7","author":"Hawkins","year":"2017","journal-title":"Brain Behav"},{"key":"10.1016\/j.jare.2025.11.058_b0505","article-title":"Lipoxins in the nervous system: brighter prospects for neuroprotection","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0510","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/alz.12893","article-title":"Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: insight into shared mechanisms between depression and dementia","volume":"19","author":"Gon\u00e7alves","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jare.2025.11.058_b0515","first-page":"12826","article-title":"Lipoxin A4 ameliorates ischemia\/reperfusion induced spinal cord injury in rabbit model","volume":"8","author":"Liu","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.jare.2025.11.058_b0525","doi-asserted-by":"crossref","first-page":"11731","DOI":"10.1523\/JNEUROSCI.1395-17.2017","article-title":"Maresin 1 promotes inflammatory resolution, neuroprotection, and functional neurological recovery after spinal cord injury","volume":"37","author":"Francos-Quijorna","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.jare.2025.11.058_b0530","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jare.2025.11.058_b0535","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s12031-015-0525-6","article-title":"Lipoxin A4 activates Nrf2 pathway and ameliorates cell damage in cultured cortical astrocytes exposed to oxygen-glucose deprivation\/reperfusion insults","volume":"56","author":"Wu","year":"2015","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.jare.2025.11.058_b0540","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/sj.bjp.0707577","article-title":"Effects of zileuton and montelukast in mouse experimental spinal cord injury","volume":"153","author":"Genovese","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0545","first-page":"314","article-title":"Zileuton ameliorates neuronal ferroptosis and functional recovery after spinal cord injury","volume":"29","author":"Sun","year":"2023","journal-title":"Altern Ther Health Med"},{"key":"10.1016\/j.jare.2025.11.058_b0550","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.2147\/DDDT.S154814","article-title":"Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice","volume":"12","author":"Chen","year":"2018","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.jare.2025.11.058_b0555","article-title":"The lipoxin A4 receptor agonist BML-111 Alleviates inflammatory injury and oxidative stress in spinal cord injury","volume":"26","author":"Liu","year":"2020","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jare.2025.11.058_b0565","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2025.13717","article-title":"Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury","volume":"33","author":"Zhou","year":"2025","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jare.2025.11.058_b0570","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1111\/febs.12152","article-title":"Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways","volume":"280","author":"Ueda","year":"2013","journal-title":"FEBS J"},{"key":"10.1016\/j.jare.2025.11.058_b0575","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1073\/pnas.1103566108","article-title":"Unique pathway for anandamide synthesis and liver regeneration","volume":"108","author":"Izzo","year":"2011","journal-title":"PNAS"},{"key":"10.1016\/j.jare.2025.11.058_b0585","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.nbd.2010.02.002","article-title":"The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury","volume":"38","author":"Arevalo-Martin","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jare.2025.11.058_b0590","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049057","article-title":"Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery","volume":"7","author":"Arevalo-Martin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jare.2025.11.058_b0595","doi-asserted-by":"crossref","DOI":"10.3390\/cells12091275","article-title":"Therapeutic effects of combined treatment with the AEA hydrolysis inhibitor PF04457845 and the substrate selective COX-2 inhibitor LM4131 in the mouse model of neuropathic pain","volume":"12","author":"Wen","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jare.2025.11.058_b0600","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0014-5793(01)02998-2","article-title":"Biomarkers of free radical injury during spinal cord ischemia","volume":"508","author":"Basu","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jare.2025.11.058_b0605","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/sj.bjp.0707577","article-title":"Effects of zileuton and montelukast in mouse experimental spinal cord injury","volume":"153","author":"Genovese","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jare.2025.11.058_b0610","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/2211-5463.13203","article-title":"Lipoxin A4 protects primary spinal cord neurons fromErastin-induced ferroptosis by activating the Akt\/Nrf2\/HO-1 signaling pathway","volume":"11","author":"Wei","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.jare.2025.11.058_b0615","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41419-019-1764-1","article-title":"cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jare.2025.11.058_b0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2025.09.001","article-title":"Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism","author":"Qin","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.jare.2025.11.058_bib661","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0304-3959(02)00452-9","article-title":"A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury","volume":"103","author":"Siddall","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.jare.2025.11.058_bib662","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpain.2013.09.008","article-title":"Phenotypes and predictors of pain following traumatic spinal cord injury: a prospective study","volume":"15","author":"Finnerup","year":"2013","journal-title":"J Pain"},{"key":"10.1016\/j.jare.2025.11.058_bib663","doi-asserted-by":"crossref","unstructured":"T.N. Bryce, F. Biering-S\u00f8rensen, N.B. Finnerup, D.D. Cardenas, R. Defrin, T. Lundeberg, et al. International spinal cord injury pain classification: part I. Background and description. March 6-7, 2009. Spinal Cord 2011;50:413-17. https:\/\/doi.org\/10.1038\/sc.2011.156.","DOI":"10.1038\/sc.2011.156"},{"key":"10.1016\/j.jare.2025.11.058_bib673","doi-asserted-by":"crossref","unstructured":"D. Jerab, F. Blangero, P.C.T. da Costa, J.L. de Brito Alves, R. Kefi, H. Jamoussi, et al. Beneficial Effects of Omega-3 Fatty Acids on Obesity and Related Metabolic and Chronic Inflammatory Diseases. Nutrients 2025;17. https:\/\/doi.org\/10.3390\/nu17071253.","DOI":"10.3390\/nu17071253"},{"key":"10.1016\/j.jare.2025.11.058_bib674","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113147","article-title":"Regulation of Inflammasomes by Application of Omega-3 Polyunsaturated Fatty Acids in a Spinal Cord Injury Model","author":"Baazm","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jare.2025.11.058_bib671","first-page":"18","article-title":"Comprehensive Analysis of Gastrointestinal Injury Induced by Nonsteroidal Anti-Inflammatory Drugs Using Data from FDA Adverse Event Reporting System Database","author":"Kei","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jare.2025.11.058_bib672","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jchemneu.2017.08.001","article-title":"Acute spinal cord injury: A review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention","volume":"87","author":"Hayta","year":"2017","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.jare.2025.11.058_b0620","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.sc.3101309","article-title":"Neurogenic heterotopic ossification in spinal cord injury","volume":"40","author":"van Kuijk","year":"2002","journal-title":"Spinal Cord"},{"key":"10.1016\/j.jare.2025.11.058_b0625","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1302\/0301-620X.100B7.BJJ-2017-1467.R1","article-title":"Non-steroidal anti-inflammatory drugs for heterotopic ossification prophylaxis after total hip arthroplasty: a systematic review and meta-analysis","volume":"100-B","author":"Joice","year":"2018","journal-title":"Bone Joint J"},{"key":"10.1016\/j.jare.2025.11.058_b0630","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/sj.sc.3101628","article-title":"Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib)","volume":"42","author":"Banovac","year":"2004","journal-title":"Spinal Cord"},{"key":"10.1016\/j.jare.2025.11.058_b0635","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/sj.sc.3101166","article-title":"Prevention of heterotopic ossification after spinal cord injury with indomethacin","volume":"39","author":"Banovac","year":"2001","journal-title":"Spinal Cord"},{"key":"10.1016\/j.jare.2025.11.058_b0640","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41393-018-0199-3","article-title":"Use of nonsteroidal anti-inflammatory drugs to prevent heterotopic ossification after spinal cord injury: a retrospective chart review","volume":"57","author":"Zakrasek","year":"2018","journal-title":"Spinal Cord"},{"key":"10.1016\/j.jare.2025.11.058_b0645","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12868-016-0269-4","article-title":"Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury","volume":"17","author":"Russell","year":"2016","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.jare.2025.11.058_b0650","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1529-9430(01)00130-9","article-title":"Regional and temporal changes in prostaglandin E2 and thromboxane B2 concentrations after spinal cord injury","volume":"1","author":"Resnick","year":"2001","journal-title":"Spine J"},{"key":"10.1016\/j.jare.2025.11.058_b0655","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1418615","article-title":"Targeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury","volume":"18","author":"Shi","year":"2024","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jare.2025.11.058_bib664","article-title":"Time is spine: a review of translational advances in spinal cord injury","volume":"30","author":"Badhiwala","year":"2018","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.jare.2025.11.058_bib666","first-page":"21","article-title":"Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study","author":"Capirossi","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.jare.2025.11.058_bib667","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1007\/s12015-025-10966-w","article-title":"Spinal Cord Injury 2.0: Bridging the Gap Between Neurobiology, Technology, and Hope in the Era of Precision Medicine","volume":"21","author":"Wang","year":"2025","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.jare.2025.11.058_bib668","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.4103\/1673-5374.391306","article-title":"Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning","volume":"19","author":"Li","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jare.2025.11.058_bib669","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1109\/RBME.2024.3449790","article-title":"Non-Invasive Brain-Computer Interfaces: State of the Art and Trends","volume":"18","author":"Edelman","year":"2025","journal-title":"IEEE Rev Biomed Eng"},{"key":"10.1016\/j.jare.2025.11.058_bib670","doi-asserted-by":"crossref","first-page":"618626","DOI":"10.3389\/fnhum.2021.618626","article-title":"An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention","volume":"15","author":"Zaer","year":"2021","journal-title":"Front Hum Neurosci"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:45:45Z","timestamp":1789083945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225009531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":146,"alternative-id":["S2090123225009531"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.058","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arachidonic acid metabolism in spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}