{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:14:55Z","timestamp":1788448495783,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2021-I2M-1-031"],"award-info":[{"award-number":["2021-I2M-1-031"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jare.2025.11.068","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T23:07:37Z","timestamp":1765148857000},"page":"557-571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-337X","authenticated-orcid":false,"given":"Haiyan","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaochan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxue","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2025.11.068_b0005","unstructured":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 [J]. Lancet, 2020, 396(10258): 1204-22."},{"issue":"9","key":"10.1016\/j.jare.2025.11.068_b0010","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/17474930221123175","article-title":"Global stroke statistics 2022 [J]","volume":"17","author":"Thayabaranathan","year":"2022","journal-title":"Int J Stroke"},{"issue":"10446","key":"10.1016\/j.jare.2025.11.068_b0015","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke [J]","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jare.2025.11.068_b0020","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jamaneurol.2023.1871","article-title":"Efficacy and Safety of Butylphthalide in patients with Acute Ischemic Stroke: a Randomized Clinical Trial [J]","volume":"80","author":"Wang","year":"2023","journal-title":"JAMA Neurol"},{"issue":"5","key":"10.1016\/j.jare.2025.11.068_b0025","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/1871527317666180612125843","article-title":"Dl-3-n-Butylphthalide (NBP): a Promising Therapeutic Agent for Ischemic Stroke [J]","volume":"17","author":"Wang","year":"2018","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.jare.2025.11.068_b0030","article-title":"DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress [J]","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"issue":"12","key":"10.1016\/j.jare.2025.11.068_b0035","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/s41401-023-01137-z","article-title":"Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog [J]","volume":"44","author":"Dai","year":"2023","journal-title":"Acta Pharmacol Sin"},{"issue":"11","key":"10.1016\/j.jare.2025.11.068_b0040","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.4103\/1673-5374.371366","article-title":"Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis [J]","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen Res"},{"issue":"2","key":"10.1016\/j.jare.2025.11.068_b0045","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.5070","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (Review) [J]","volume":"49","author":"Zhao","year":"2022","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.jare.2025.11.068_b0050","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/cns.13561","article-title":"Neurovascular Unit: a critical role in ischemic stroke [J]","volume":"27","author":"Wang","year":"2021","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"10.1016\/j.jare.2025.11.068_b0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/1673-5374.264442","article-title":"Angiogenesis and neuronal remodeling after ischemic stroke [J]","volume":"15","author":"Hatakeyama","year":"2020","journal-title":"Neural Regen Res"},{"issue":"7\u20138","key":"10.1016\/j.jare.2025.11.068_b0060","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1101\/gad.349358.122","article-title":"Roles of vimentin in health and disease [J]","volume":"36","author":"Ridge","year":"2022","journal-title":"Genes Dev"},{"issue":"3","key":"10.1016\/j.jare.2025.11.068_b0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/01.ATV.20.3.611","article-title":"Altered flow-induced arterial remodeling in vimentin-deficient mice [J]","volume":"20","author":"Schiffers","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.jare.2025.11.068_b0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10456-012-9262-4","article-title":"Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation [J]","volume":"15","author":"Kwak","year":"2012","journal-title":"Angiogenesis"},{"issue":"7","key":"10.1016\/j.jare.2025.11.068_b0075","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3109\/10715762.2014.911853","article-title":"Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt\/Nrf2 pathways [J]","volume":"48","author":"Meng","year":"2014","journal-title":"Free Radic Res"},{"issue":"11","key":"10.1016\/j.jare.2025.11.068_b0080","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats [J]","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.jare.2025.11.068_b0085","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/01616412.1997.11740874","article-title":"Monofilament intraluminal middle cerebral artery occlusion in the mouse [J]","volume":"19","author":"Clark","year":"1997","journal-title":"Neurol Res"},{"key":"10.1016\/j.jare.2025.11.068_b0090","article-title":"Notoginsenoside R1 Improves Cerebral Ischemia\/Reperfusion Injury by Promoting Neurogenesis via the BDNF\/Akt\/CREB Pathway [J]","volume":"12","author":"Zhu","year":"2021","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.jare.2025.11.068_b0095","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jgr.2024.08.004","article-title":"Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury [J]","volume":"48","author":"Xiao","year":"2024","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jare.2025.11.068_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111693","article-title":"Notoginsenoside R1 activates the NAMPT-NAD(+)-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling [J]","volume":"140","author":"Zhu","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2025.11.068_b0105","doi-asserted-by":"crossref","unstructured":"Zhu Y, Wang L, Li J, et al. Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice [J]. Cell Chem Biol, 2024, 31(3): 452-64.e10.","DOI":"10.1016\/j.chembiol.2023.10.003"},{"issue":"9","key":"10.1016\/j.jare.2025.11.068_b0110","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells [J]","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jare.2025.11.068_b0115","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-1-4939-2269-7_22","article-title":"Drug affinity responsive target stability (DARTS) for small-molecule target identification [J]","volume":"1263","author":"Pai","year":"2015","journal-title":"Methods Mol Biol"},{"issue":"3","key":"10.1016\/j.jare.2025.11.068_b0120","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/jbm.a.35263","article-title":"Mechanisms of TiO2 nanoparticle-induced neuronal apoptosis in rat primary cultured hippocampal neurons [J]","volume":"103","author":"Sheng","year":"2015","journal-title":"J Biomed Mater Res A"},{"issue":"11","key":"10.1016\/j.jare.2025.11.068_b0125","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.tins.2022.08.004","article-title":"Neurovascular coupling: motive unknown [J]","volume":"45","author":"Drew","year":"2022","journal-title":"Trends Neurosci"},{"issue":"2","key":"10.1016\/j.jare.2025.11.068_b0130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408347.2014.881250","article-title":"Surface plasmon resonance (SPR) biosensors in pharmaceutical analysis [J]","volume":"45","author":"Olaru","year":"2015","journal-title":"Crit Rev Anal Chem"},{"issue":"13","key":"10.1016\/j.jare.2025.11.068_b0135","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1039\/C5LC00133A","article-title":"High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels [J]","volume":"15","author":"M\u00fcLLER","year":"2015","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.jare.2025.11.068_b0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2012.08.018","article-title":"Angiopoietins in angiogenesis [J]","volume":"328","author":"Fagiani","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jare.2025.11.068_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.567537","article-title":"GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases [J]","volume":"8","author":"Chung","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jare.2025.11.068_b0150","doi-asserted-by":"crossref","unstructured":"LEAL G, COMPRIDO D, DUARTE C B. BDNF-induced local protein synthesis and synaptic plasticity [J]. Neuropharmacology, 2014, 76 Pt C: 639-56.","DOI":"10.1016\/j.neuropharm.2013.04.005"},{"issue":"4","key":"10.1016\/j.jare.2025.11.068_b0155","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.semcdb.2012.02.005","article-title":"Notch and disease: a growing field [J]","volume":"23","author":"Louvi","year":"2012","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jare.2025.11.068_b0160","doi-asserted-by":"crossref","unstructured":"Van Engeland N C A, Suarez Rodriguez F, Rivero-M\u00fcller A, et al. Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress [J]. Sci Rep, 2019, 9(1): 12415.","DOI":"10.1038\/s41598-019-48218-w"},{"issue":"8","key":"10.1016\/j.jare.2025.11.068_b0165","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41583-020-0322-2","article-title":"Neuronal regulation of the blood-brain barrier and neurovascular coupling [J]","volume":"21","author":"Kaplan","year":"2020","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"10.1016\/j.jare.2025.11.068_b0170","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/cns.13104","article-title":"Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats [J]","volume":"25","author":"Zhou","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jare.2025.11.068_b0175","article-title":"Dl-3-N-Butylphthalide Promotes Angiogenesis in an Optimized Model of Transient Ischemic Attack in C57BL\/6 mice [J]","volume":"12","author":"Wang","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2025.11.068_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111068","article-title":"Regulatory mechanisms and clinical significance of vimentin in breast cancer [J]","volume":"133","author":"Chen","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.jare.2025.11.068_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/rcmb.2013-0314TR","article-title":"The role of vimentin intermediate filaments in the progression of lung cancer [J]","volume":"50","author":"Kidd","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"10.1016\/j.jare.2025.11.068_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/cells7100147","article-title":"Vimentin Diversity in Health and Disease [J]","volume":"7","author":"Danielsson","year":"2018","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.jare.2025.11.068_b0195","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202000078","article-title":"Mechanical and Non-Mechanical Functions of Filamentous and Non-Filamentous Vimentin [J]","volume":"42","author":"Patteson","year":"2020","journal-title":"Bioessays"},{"issue":"4","key":"10.1016\/j.jare.2025.11.068_b0200","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/micc.12111","article-title":"Vimentin as an integral regulator of cell adhesion and endothelial sprouting [J]","volume":"21","author":"Dave","year":"2014","journal-title":"Microcirculation"},{"issue":"6","key":"10.1016\/j.jare.2025.11.068_b0205","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1172\/JCI119675","article-title":"Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance [J]","volume":"100","author":"Terzi","year":"1997","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.jare.2025.11.068_b0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072354","article-title":"Hypergravity activates a pro-angiogenic homeostatic response by human capillary endothelial cells [J]","volume":"21","author":"de Cesari","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jare.2025.11.068_b0215","doi-asserted-by":"crossref","first-page":"C363","DOI":"10.1152\/ajpcell.00057.2010","article-title":"Regulation of vimentin intermediate filaments in endothelial cells by hypoxia [J]","volume":"299","author":"Liu","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jare.2025.11.068_b0220","article-title":"Deciphering glial scar after spinal cord injury [J]. Burns","volume":"9","author":"Zhang","year":"2021","journal-title":"Trauma"},{"issue":"46","key":"10.1016\/j.jare.2025.11.068_b0225","doi-asserted-by":"crossref","first-page":"11970","DOI":"10.1523\/JNEUROSCI.3724-08.2008","article-title":"Two-photon imaging during prolonged middle cerebral artery occlusion in mice reveals recovery of dendritic structure after reperfusion [J]","volume":"28","author":"Li","year":"2008","journal-title":"J Neurosci"},{"issue":"12","key":"10.1016\/j.jare.2025.11.068_b0230","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/glia.22723","article-title":"Beneficial effects of gfap\/vimentin reactive astrocytes for axonal remodeling and motor behavioral recovery in mice after stroke [J]","volume":"62","author":"Liu","year":"2014","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.jare.2025.11.068_b0235","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/jcbfm.2009.100","article-title":"Implications of vascular endothelial growth factor for postischemic neurovascular remodeling [J]","volume":"29","author":"Hermann","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"issue":"7483","key":"10.1016\/j.jare.2025.11.068_b0240","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature12821","article-title":"Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period [J]","volume":"505","author":"Whiteus","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jare.2025.11.068_b0245","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.neuron.2014.07.034","article-title":"Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex [J]","volume":"83","author":"Lacoste","year":"2014","journal-title":"Neuron"},{"issue":"19","key":"10.1016\/j.jare.2025.11.068_b0250","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202638","article-title":"Engineering Neurovascular Unit and Blood-Brain Barrier for Ischemic Stroke Modeling [J]","volume":"12","author":"Liu","year":"2023","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"10.1016\/j.jare.2025.11.068_b0255","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit coming of Age: a Journey through Neurovascular Coupling in Health and Disease [J]","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.jare.2025.11.068_b0260","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1177\/0271678X15617954","article-title":"Neurovascular coupling in humans: Physiology, methodological advances and clinical implications [J]","volume":"36","author":"Phillips","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"issue":"11","key":"10.1016\/j.jare.2025.11.068_b0265","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1364\/BOE.408481","article-title":"Relative retinal flow velocity detection using optical coherence tomography angiography imaging [J]","volume":"11","author":"Richter","year":"2020","journal-title":"Biomed Opt Express"},{"issue":"7","key":"10.1016\/j.jare.2025.11.068_b0270","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.celrep.2015.01.049","article-title":"Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans [J]","volume":"10","author":"Han","year":"2015","journal-title":"Cell Rep"},{"issue":"7","key":"10.1016\/j.jare.2025.11.068_b0275","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/jcbfm.2008.32","article-title":"Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF [J]","volume":"28","author":"Wang","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"10.1016\/j.jare.2025.11.068_b0280","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical Notch signaling pathway: unfolding the activation mechanism [J]","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jare.2025.11.068_b0285","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.devcel.2009.01.015","article-title":"Angiogenesis: a team effort coordinated by notch [J]","volume":"16","author":"Phng","year":"2009","journal-title":"Dev Cell"},{"issue":"1","key":"10.1016\/j.jare.2025.11.068_b0290","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00441-017-2641-9","article-title":"Notch: an interactive player in neurogenesis and disease [J]","volume":"371","author":"Zhang","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"4","key":"10.1016\/j.jare.2025.11.068_b0295","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/01.ATV.0000060892.81529.8F","article-title":"Notch signaling in vascular development [J]","volume":"23","author":"Iso","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"23","key":"10.1016\/j.jare.2025.11.068_b0300","doi-asserted-by":"crossref","first-page":"E4574","DOI":"10.1073\/pnas.1703057114","article-title":"Selective regulation of Notch ligands during angiogenesis is mediated by vimentin [J]","volume":"114","author":"Antfolk","year":"2017","journal-title":"PNAS"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225009646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:07:15Z","timestamp":1788379635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225009646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":60,"alternative-id":["S2090123225009646"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.068","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.11.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}