{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:14:18Z","timestamp":1788671658205,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z210012"],"award-info":[{"award-number":["Z210012"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jare.2025.12.026","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T16:20:30Z","timestamp":1766247630000},"page":"341-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Potential biomarkers for human Ascending aortic aneurysm identified through metagenomic and metabolomic analyses: A case-control study"],"prefix":"10.1016","volume":"87","author":[{"given":"Mingxi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanduan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jare.2025.12.026_b0005","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/ejcts\/ezw235","article-title":"The incidence and mortality of acute thoracic aortic dissection: results from a whole nation study","volume":"50","author":"Melvinsdottir","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jare.2025.12.026_b0010","first-page":"14940","article-title":"Aortic local biomechanical properties in ascending aortic aneurysms","author":"Lin","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2025.12.026_b0015","first-page":"691","article-title":"El Hamamsy I, the ascending aortic aneurysm: when to intervene?","author":"Saliba","year":"2015","journal-title":"Int J Cardiol Heart Vasc"},{"issue":"12","key":"10.1016\/j.jare.2025.12.026_b0020","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1038\/s12276-023-01130-w","article-title":"Aortic aneurysms: current pathogenesis and therapeutic targets","volume":"55","author":"Cho","year":"2023","journal-title":"Exp Mol Med"},{"issue":"11","key":"10.1016\/j.jare.2025.12.026_b0025","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1161\/CIRCULATIONAHA.118.038809","article-title":"Abdominal Aortic Aneurysm Screening is Safe yet Lacks Effectiveness","volume":"139","author":"Arnaoutakis","year":"2019","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jare.2025.12.026_b0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00395-024-01053-1","article-title":"Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections","volume":"119","author":"Ganizada","year":"2024","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"10.1016\/j.jare.2025.12.026_b0035","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCRESAHA.120.316242","article-title":"Gut Microbiota and Cardiovascular Disease","volume":"127","author":"Witkowski","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jare.2025.12.026_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1406845","article-title":"Investigating the association between gut microbiome and aortic aneurysm diseases: a bidirectional two-sample Mendelian randomization analysis","author":"Sun","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"issue":"12","key":"10.1016\/j.jare.2025.12.026_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278995","article-title":"Gut dysbiosis and bacterial translocation in the aneurysmal wall and blood in patients with abdominal aortic aneurysm","volume":"17","author":"Nakayama","year":"2022","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.jare.2025.12.026_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25168844","article-title":"Relationship between Gut, Blood, Aneurysm Wall and Thrombus Microbiome in Abdominal Aortic Aneurysm patients","volume":"25","author":"Nemes-Nikod\u00e9m","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2025.12.026_b0055","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12872-020-01334-2","article-title":"Alterations in gut microbiota of abdominal aortic aneurysm mice","volume":"20","author":"Xie","year":"2020","journal-title":"BMC Cardiovasc Disord"},{"issue":"5","key":"10.1016\/j.jare.2025.12.026_b0060","first-page":"677","article-title":"Differences of Gut Microbiota Diversity between patients with Abdominal Aortic Aneurysm and Atherosclerosis","volume":"43","author":"Ji","year":"2021","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"issue":"10","key":"10.1016\/j.jare.2025.12.026_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2022.09.004","article-title":"Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation","volume":"30","author":"Tian","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jare.2025.12.026_b0070","first-page":"129179","article-title":"Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy","author":"Forte","year":"2019","journal-title":"J Mol Cell Cardiol"},{"issue":"19","key":"10.1016\/j.jare.2025.12.026_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/nu15194150","article-title":"Gut Microbiota-Derived Tryptophan Metabolite Indole-3-aldehyde Ameliorates Aortic Dissection","volume":"15","author":"Huang","year":"2023","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.jare.2025.12.026_b0080","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/CIRCRESAHA.117.309715","article-title":"Gut Microbiota in Cardiovascular Health and Disease","volume":"120","author":"Tang","year":"2017","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.jare.2025.12.026_b0085","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"von Elm","year":"2007","journal-title":"Ann Intern Med"},{"issue":"8","key":"10.1016\/j.jare.2025.12.026_b0090","first-page":"1168","article-title":"Ultrasound screening of the abdominal aorta: is it time to include it in the standard echocardiographic evaluation of men aged \u226560 years with clinical manifest vascular diseases?, Eur","volume":"29","author":"Cortese","year":"2022","journal-title":"J Prev Cardiol"},{"issue":"1","key":"10.1016\/j.jare.2025.12.026_b0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40168-016-0222-x","article-title":"Gut microbiota dysbiosis contributes to the development of hypertension","volume":"5","author":"Li","year":"2017","journal-title":"Microbiome"},{"issue":"11","key":"10.1016\/j.jare.2025.12.026_b0100","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1073\/pnas.76.11.5919","article-title":"Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances","volume":"76","author":"Whitaker","year":"1979","journal-title":"PNAS"},{"issue":"10","key":"10.1016\/j.jare.2025.12.026_b0105","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.122.318048","article-title":"Ceramide Metabolism in Cardiovascular Disease: a Network with High Therapeutic potential","volume":"42","author":"Zietzer","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jare.2025.12.026_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117093","article-title":"The role of serine\/threonine protein kinases in cardiovascular disease and potential therapeutic methods","author":"Wu","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"7341","key":"10.1016\/j.jare.2025.12.026_b0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jare.2025.12.026_b0120","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jadohealth.2017.09.012","article-title":"Ability of Nontraditional Risk Factors and Inflammatory Biomarkers for Cardiovascular Disease to Identify High Cardiometabolic Risk in Adolescents: results from the LabMed Physical activity Study","volume":"62","author":"Agostinis-Sobrinho","year":"2018","journal-title":"J Adolesc Health"},{"issue":"21","key":"10.1016\/j.jare.2025.12.026_b0125","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/eurheartj\/ehv144","article-title":"Aortic valve and aneurysms","volume":"36","author":"L\u00fcscher","year":"2015","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.jare.2025.12.026_b0130","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.athoracsur.2018.05.071","article-title":"Effect of Aneurysm and Bicuspid Aortic Valve on Layer-specific Ascending Aorta Mechanics","volume":"106","author":"Deveja","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jare.2025.12.026_b0135","first-page":"172899","article-title":"Inflammatory Markers and Aortic Aneurysms: Exploring the Role of Hs-CRP and MHR in Ascending Aortic Aneurysm Development","author":"K\u00f6pr\u00fcl\u00fc","year":"2024","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.jare.2025.12.026_b0140","article-title":"The gut microbiota in experimental abdominal aortic aneurysm","author":"Xiao","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.jare.2025.12.026_b0145","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2024.2390419","article-title":"Causal relationship between gut microbiota, plasma metabolites, inflammatory cytokines and abdominal aortic aneurysm: a Mendelian randomization study","volume":"46","author":"Li","year":"2024","journal-title":"Clin Exp Hypertens"},{"issue":"6","key":"10.1016\/j.jare.2025.12.026_b0150","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1016\/j.amjmed.2023.01.041","article-title":"A Rapidly Progressive Aortic Aneurysm due to Escherichia Coli","volume":"136","author":"Nagahata","year":"2023","journal-title":"Am J Med"},{"issue":"6","key":"10.1016\/j.jare.2025.12.026_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/nu14061222","article-title":"Bifidobacterium breve and Bifidobacterium longum Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in mice","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"issue":"17","key":"10.1016\/j.jare.2025.12.026_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/foods11172549","article-title":"The Mechanisms of the potential Probiotic Lactiplantibacillus plantarum against Cardiovascular Disease and the recent Developments in its Fermented Foods","volume":"11","author":"Wang","year":"2022","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.jare.2025.12.026_b0165","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jvs.2019.08.274","article-title":"Methicillin-resistant Staphylococcus aureus portends a poor prognosis after endovascular repair of mycotic aortic aneurysms and aortic graft infections","volume":"72","author":"Plotkin","year":"2020","journal-title":"J Vasc Surg"},{"issue":"8","key":"10.1016\/j.jare.2025.12.026_b0170","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/eurjpc\/zwad377","article-title":"The gut microbiome across the cardiovascular risk spectrum, Eur","volume":"31","author":"Prins","year":"2024","journal-title":"J Prev Cardiol"},{"key":"10.1016\/j.jare.2025.12.026_b0175","doi-asserted-by":"crossref","unstructured":"Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production, Gut 2024;73(12):1934-1943.https:\/\/doi.org\/10.1136\/gutjnl-2024-331880.","DOI":"10.1136\/gutjnl-2024-331880"},{"issue":"1","key":"10.1016\/j.jare.2025.12.026_b0180","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12866-023-02967-x","article-title":"Gut microbiome profile of chinese hypertension patients with and without type 2 diabetes mellitus","volume":"23","author":"Ding","year":"2023","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jare.2025.12.026_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.680101","article-title":"Dysbiosis of Gut Microbiota in patients with Acute Myocardial Infarction","author":"Han","year":"2021","journal-title":"Front Microbiol"},{"issue":"9","key":"10.1016\/j.jare.2025.12.026_b0190","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1093\/cvr\/cvab256","article-title":"Nitro-oleic acid reduces thoracic aortic aneurysm progression in a mouse model of Marfan syndrome","volume":"118","author":"Nettersheim","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.jare.2025.12.026_b0195","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1210\/clinem\/dgz174","article-title":"Dietary and Pharmacological Fatty Acids and Cardiovascular Health","volume":"105","author":"Wu","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jare.2025.12.026_b0200","first-page":"20511","article-title":"Effects of prostaglandins on autonomic function in vivo, with special emphasis on PGD2 and PGD3","author":"Hemker","year":"1981","journal-title":"Prog Lipid Res"},{"issue":"8","key":"10.1016\/j.jare.2025.12.026_b0205","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrcardio.2017.52","article-title":"Monocytes and macrophages in abdominal aortic aneurysm","volume":"14","author":"Raffort","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"11","key":"10.1016\/j.jare.2025.12.026_b0210","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s42255-019-0134-8","article-title":"Metabolic Messengers: ceramides","volume":"1","author":"Summers","year":"2019","journal-title":"Nat Metab"},{"issue":"10","key":"10.1016\/j.jare.2025.12.026_b0215","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41569-021-00536-1","article-title":"Ceramides and other sphingolipids as drivers of cardiovascular disease","volume":"18","author":"Choi","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jare.2025.12.026_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.576347","article-title":"Adipocyte Ceramides-the Nexus of Inflammation and Metabolic Disease","author":"Chaurasia","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jare.2025.12.026_b0225","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00726-017-2490-6","article-title":"Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth","volume":"50","author":"Li","year":"2018","journal-title":"Amino Acids"},{"issue":"8","key":"10.1016\/j.jare.2025.12.026_b0230","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082592","article-title":"Physiological Functions of Threonine in animals: beyond Nutrition Metabolism","volume":"13","author":"Tang","year":"2021","journal-title":"Nutrients"},{"issue":"9 Pt B","key":"10.1016\/j.jare.2025.12.026_b0235","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.jare.2025.12.026_b0240","doi-asserted-by":"crossref","unstructured":"Zuo K, Li J, Wang P, Liu Y, Liu Z, Yin X, et al., Duration of Persistent Atrial Fibrillation Is Associated with Alterations in Human Gut Microbiota and Metabolic Phenotypes, mSystems 2019;4(6).https:\/\/doi.org\/10.1128\/mSystems.00422-19.","DOI":"10.1128\/msystems.00422-19"},{"issue":"6","key":"10.1016\/j.jare.2025.12.026_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/biom14060731","article-title":"Unravelling the Gut Microbiome Role in Cardiovascular Disease: a Systematic Review and a Meta-Analysis","volume":"14","author":"Martins","year":"2024","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.jare.2025.12.026_b0250","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jiac.2020.11.008","article-title":"Infected aortic aneurysm caused by Streptococcus pyogenes: a case report","volume":"27","author":"Watanabe","year":"2021","journal-title":"J Infect Chemother"},{"issue":"10","key":"10.1016\/j.jare.2025.12.026_b0255","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.2169\/internalmedicine.2411-23","article-title":"Infected Aortic Aneurysm Secondary to Pyogenic Flexor Tenosynovitis from Streptococcus pyogenes","volume":"63","author":"Maruyama","year":"2024","journal-title":"Intern Med"},{"issue":"1","key":"10.1016\/j.jare.2025.12.026_b0260","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2351532","article-title":"Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-\u03baB signaling pathway","volume":"16","author":"Hao","year":"2024","journal-title":"Gut Microbes"},{"issue":"10","key":"10.1016\/j.jare.2025.12.026_b0265","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1002\/jcp.29518","article-title":"Trimethylamine N-oxide promotes apoE(-\/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB\/ROS pathway","volume":"235","author":"Wu","year":"2020","journal-title":"J Cell Physiol"},{"issue":"8","key":"10.1016\/j.jare.2025.12.026_b0270","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"10.1016\/j.jare.2025.12.026_b0275","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/s44161-023-00364-1","article-title":"Alkaline ceramidase 1-mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation, Nat","volume":"2","author":"Zhang","year":"2023","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.jare.2025.12.026_b0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126910","article-title":"Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis","volume":"10","author":"Kasumov","year":"2015","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.jare.2025.12.026_b0285","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1016\/j.jacc.2021.03.314","article-title":"Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in patients with Cardiovascular Disease","volume":"77","author":"Akawi","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jare.2025.12.026_b0290","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1152\/physrev.00008.2023","article-title":"Ceramides are fuel gauges on the drive to cardiometabolic disease","volume":"104","author":"Wilkerson","year":"2024","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2025.12.026_b0295","article-title":"Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation","author":"Zhang","year":"2017","journal-title":"VascPharmacol"},{"issue":"42","key":"10.1016\/j.jare.2025.12.026_b0300","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1093\/eurheartj\/ehab605","article-title":"Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection","volume":"42","author":"Cui","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jare.2025.12.026_b0305","doi-asserted-by":"crossref","unstructured":"Chang R, Wang H, Lu C, Chen J, Li Y, Qiao M, et al., Olink proteomics reveals TNFRSF9 as a biomarker for abdominal aortic aneurysms, iScience 2025;28(7):112828.https:\/\/doi.org\/10.1016\/j.isci.2025.112828.","DOI":"10.1016\/j.isci.2025.112828"},{"issue":"12","key":"10.1016\/j.jare.2025.12.026_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210253","article-title":"Plasma Lipidomics Analysis reveals the potential Role of Lysophosphatidylcholines in Abdominal Aortic Aneurysm Progression and Formation","volume":"24","author":"Xie","year":"2023","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225010161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123225010161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:28:27Z","timestamp":1788668907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123225010161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":62,"alternative-id":["S2090123225010161"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2025.12.026","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential biomarkers for human Ascending aortic aneurysm identified through metagenomic and metabolomic analyses: A case-control study","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2025.12.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}