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Full-length antithrombin frameshift variant with aberrant C-terminus causes endoplasmic reticulum retention with a dominant-negative effect. JCI Insight. Oct 10 2022;7(19)doi:10.1172\/jci.insight.161430.","DOI":"10.1172\/jci.insight.161430"},{"key":"10.1016\/j.jare.2026.01.029_b0300","doi-asserted-by":"crossref","unstructured":"Ron D. Translational control in the endoplasmic reticulum stress response. The Journal of Clinical Investigation. 11\/15\/ 2002;110(10):1383-1388. doi:10.1172\/JCI16784.","DOI":"10.1172\/JCI0216784"},{"key":"10.1016\/j.jare.2026.01.029_b0305","doi-asserted-by":"crossref","unstructured":"Lundgren S, Huuhtanen J, Ker\u00e4nen M, et al. Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8<sup>+<\/sup> T cells with a disease-associated TCR signature. Science Translational Medicine. 2025;17(787):eadl6758. doi:doi:10.1126\/scitranslmed.adl6758.","DOI":"10.1126\/scitranslmed.adl6758"},{"issue":"6","key":"10.1016\/j.jare.2026.01.029_b0310","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3390\/cells13060521","article-title":"TNF-related apoptosis-inducing ligand: non-apoptotic signalling","volume":"13","author":"Guerrache","year":"2024","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.jare.2026.01.029_b0315","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s12276-025-01416-1","article-title":"SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells","volume":"57","author":"Chae","year":"2025","journal-title":"Exp Mol Med"},{"issue":"16","key":"10.1016\/j.jare.2026.01.029_b0320","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1242\/jcs.204909","article-title":"Emerging functions of the Fanconi anemia pathway at a glance","volume":"130","author":"Sumpter","year":"2017","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jare.2026.01.029_b0325","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.trsl.2022.08.011","article-title":"The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions","volume":"252","author":"Salgar","year":"2023","journal-title":"Transl Res"},{"issue":"12","key":"10.1016\/j.jare.2026.01.029_b0330","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1172\/JCI123501","article-title":"Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation","volume":"129","author":"H\u00f6chsmann","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2026.01.029_b0335","doi-asserted-by":"crossref","unstructured":"McLemore AF, Hou HA, Meyer BS, et al. Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS\/STING\/NLRP3 axis in myelodysplastic syndromes. JCI Insight. Aug 8 2022;7(15)doi:10.1172\/jci.insight.159430.","DOI":"10.1172\/jci.insight.159430"},{"key":"10.1016\/j.jare.2026.01.029_b0340","doi-asserted-by":"crossref","unstructured":"Zhou J, Qiu J, Song Y, et al. Pyroptosis and degenerative diseases of the elderly. Cell death & disease. Feb 9 2023;14(2):94. doi:10.1038\/s41419-023-05634-1.","DOI":"10.1038\/s41419-023-05634-1"},{"key":"10.1016\/j.jare.2026.01.029_b0345","doi-asserted-by":"crossref","unstructured":"Chen Y, Chen S, Liu Z, et al. Red blood cells undergo lytic programmed cell death involving NLRP3. Cell. doi:10.1016\/j.cell.2025.03.039.","DOI":"10.1016\/j.cell.2025.03.039"},{"issue":"11","key":"10.1016\/j.jare.2026.01.029_b0350","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.celrep.2018.07.068","article-title":"FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury","volume":"24","author":"Han","year":"2018","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.jare.2026.01.029_b0355","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab"},{"issue":"17","key":"10.1016\/j.jare.2026.01.029_b0360","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/cvr\/cvae214","article-title":"GDF15 antagonism limits severe heart failure and prevents cardiac cachexia","volume":"120","author":"Takaoka","year":"2024","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jare.2026.01.029_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113965","article-title":"Repressing cytokine storm-like response in macrophages by targeting the eIF2\u03b1-integrated stress response pathway","volume":"147","author":"Wang","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10.1016\/j.jare.2026.01.029_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114069","article-title":"Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress","volume":"43","author":"Magg","year":"2024","journal-title":"Cell Rep"},{"issue":"12","key":"10.1016\/j.jare.2026.01.029_b0375","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.4049\/jimmunol.2100813","article-title":"Absence of ERAP1 in B cells increases susceptibility to central nervous system autoimmunity, alters B cell biology, and mechanistically explains genetic associations between ERAP1 and multiple sclerosis","volume":"207","author":"O'Connell","year":"2021","journal-title":"J Immunol"},{"key":"10.1016\/j.jare.2026.01.029_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.01.042","article-title":"Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS\/CALR\/Caspase-3\/GSDME pathway","author":"Liang","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2026.01.029_b0385","doi-asserted-by":"crossref","unstructured":"Beltr\u00e1n-Visiedo M, Serrano-Del Valle A, Jim\u00e9nez-Ald\u00faan N, et al. Chapter Twelve - Cytofluorometric assessment of calreticulin exposure on CD38+ plasma cells from the human bone marrow. In: Bloy N, Charpentier M, Galluzzi L, eds. Methods in Cell Biology. Academic Press; 2024:189-206.","DOI":"10.1016\/bs.mcb.2024.05.009"},{"key":"10.1016\/j.jare.2026.01.029_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114503","article-title":"Immunogenic cell death inducer peptides: a new approach for cancer therapy, current status and future perspectives","volume":"161","author":"Aria","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"6613","key":"10.1016\/j.jare.2026.01.029_b0395","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1126\/science.abo4837","article-title":"Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality","volume":"377","author":"Wattrus","year":"2022","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.jare.2026.01.029_b0400","doi-asserted-by":"crossref","unstructured":"Pessoa Rodrigues C, Collins JM, Yang S, et al. Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. 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