{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:12:44Z","timestamp":1787508764329,"version":"build-2736575974"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017548","name":"National Defense Science and Technology Innovation Fund of the Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017548","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jare.2026.02.048","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T16:18:48Z","timestamp":1771690728000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lactiplantibacillus plantarum AR113 alleviates Western Diet-Induced colitis and liver injury via bidirectional modulation of the Intestinal-Hepatic FXR signaling axis"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8152-5698","authenticated-orcid":false,"given":"Junlin","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianzhong","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2026.02.048_b0005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/apt.16120","article-title":"5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis","volume":"53","author":"Hibiya","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jare.2026.02.048_b0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S2468-1253(19)30012-3","article-title":"Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study","volume":"4","author":"Kennedy","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.02.048_b0015","article-title":"Association between tumour necrosis factor-\u03b1 inhibitors and risk of serious infections in people with inflammatory bowel disease: nationwide danish cohort study","volume":"350","author":"Nyboe Andersen","year":"2015","journal-title":"BMJ (Clinical research ed)"},{"key":"10.1016\/j.jare.2026.02.048_b0020","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.cgh.2018.07.013","article-title":"Balancing Benefit vs risk of Immunosuppressive Therapy for Individual patients with Inflammatory Bowel Diseases","volume":"17","author":"Beaugerie","year":"2019","journal-title":"Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association"},{"key":"10.1016\/j.jare.2026.02.048_b0025","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2192478","article-title":"Clostridioides difficile aggravates dextran sulfate solution (DSS)-induced colitis by shaping the gut microbiota and promoting neutrophil recruitment","volume":"15","author":"Dong","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jare.2026.02.048_b0030","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1021\/acs.jafc.2c08631","article-title":"bsh1 gene of Lactobacillus plantarum ar113 plays an important role in ameliorating western diet-aggravated colitis","volume":"71","author":"Shao","year":"2023","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jare.2026.02.048_b0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41577-019-0156-1","article-title":"The Western lifestyle has lasting effects on metaflammation","volume":"19","author":"Christ","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2026.02.048_b0040","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jhep.2023.12.024","article-title":"Ileitis promotes MASLD progression via bile acid modulation and enhanced TGR5 signaling in ileal CD8(+) T cells","volume":"80","author":"Zheng","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.jare.2026.02.048_b0045","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jare.2026.02.048_b0050","article-title":"Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol","volume":"14","author":"Yang","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.02.048_b0055","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.immuni.2024.02.014","article-title":"Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions","volume":"57","author":"Cong","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.jare.2026.02.048_b0060","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: Pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.jare.2026.02.048_b0065","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.02.048_b0070","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/nm.4185","article-title":"Signals from the gut microbiota to distant organs in physiology and disease","volume":"22","author":"Schroeder","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jare.2026.02.048_b0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41575-020-00404-2","article-title":"The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer","volume":"18","author":"Sun","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.02.048_b0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.02.048_b0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12347","article-title":"Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome","volume":"499","author":"Yoshimoto","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.02.048_b0090","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","article-title":"Review: microbial transformations of human bile acids","volume":"9","author":"Guzior","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.jare.2026.02.048_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1819155","article-title":"Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation","volume":"12","author":"Wang","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jare.2026.02.048_b0100","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1038\/s41564-024-01862-z","article-title":"Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis","volume":"9","author":"Zhang","year":"2024","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jare.2026.02.048_b0105","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.cmet.2021.06.012","article-title":"FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption","volume":"33","author":"Clifford","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2026.02.048_b0110","article-title":"Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress","volume":"7;37(1):104\u2013120.e9","author":"Song","year":"2024","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2026.02.048_b0115","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41574-019-0266-7","article-title":"Bile acids in glucose metabolism and insulin signalling - mechanisms and research needs","volume":"15","author":"Ahmad","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2026.02.048_b0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstrom","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2026.02.048_b0125","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cmet.2024.09.008","article-title":"Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress","volume":"37","author":"Song","year":"2025","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2026.02.048_b0130","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.1840040416","article-title":"Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties\u2013studies on isolated hepatocytes and lipid membrane vesicles","volume":"4","author":"Sch\u00f6lmerich","year":"1984","journal-title":"Hepatology"},{"key":"10.1016\/j.jare.2026.02.048_b0135","doi-asserted-by":"crossref","first-page":"35660","DOI":"10.1074\/jbc.M113.519116","article-title":"Bile acids modulate signaling by functional perturbation of plasma membrane domains","volume":"288","author":"Zhou","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2026.02.048_b0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfn268","article-title":"Bile Acid sulfation: a pathway of bile acid elimination and detoxification","volume":"108","author":"Alnouti","year":"2009","journal-title":"Toxicological sciences: an official journal of the Society of Toxicology"},{"key":"10.1016\/j.jare.2026.02.048_b0145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1081\/DMR-200033475","article-title":"Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity","volume":"36","author":"Hofmann","year":"2004","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jare.2026.02.048_b0150","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.20784","article-title":"CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice","volume":"42","author":"Wagner","year":"2005","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jare.2026.02.048_b0155","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1039\/C8FO02181C","article-title":"Cholesterol-lowering potentials of Lactobacillus strain overexpression of bile salt hydrolase on high cholesterol diet-induced hypercholesterolemic mice","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct"},{"key":"10.1016\/j.jare.2026.02.048_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.111208","article-title":"Specific bile salt hydrolase genes in Lactobacillus plantarum AR113 and relationship with bile salt resistance","volume":"145","author":"Wang","year":"2021","journal-title":"LWT"},{"issue":"3","key":"10.1016\/j.jare.2026.02.048_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106196","article-title":"Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis","volume":"26","author":"Feng","year":"2023","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.jare.2026.02.048_b0170","doi-asserted-by":"crossref","first-page":"885","DOI":"10.26599\/FSHW.2022.9250076","article-title":"Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress","volume":"13","author":"Xia","year":"2024","journal-title":"Food Sci Human Wellness"},{"key":"10.1016\/j.jare.2026.02.048_b0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0147-619X(89)90082-6","article-title":"Characterization of a gram-positive broad-host-range plasmid isolated from Lactobacillus hilgardii","volume":"21","author":"Josson","year":"1989","journal-title":"Plasmid"},{"issue":"1","key":"10.1016\/j.jare.2026.02.048_b0180","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41538-025-00373-3","article-title":"The bsh1 gene of Lactobacillus plantarum AR113 ameliorates liver injury in colitis mice","volume":"9","author":"Shao","year":"2025","journal-title":"npj Sci Food"},{"key":"10.1016\/j.jare.2026.02.048_b0185","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"5517","key":"10.1016\/j.jare.2026.02.048_b0190","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.1059108","article-title":"Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death [J]","volume":"292","author":"Wei","year":"2001","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.jare.2026.02.048_b0195","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/metabo10070282","article-title":"Development and validation of a highly sensitive lc-ms\/ms method for the analysis of bile acids in serum, plasma, and liver tissue samples","volume":"10","author":"G\u00f3mez","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.jare.2026.02.048_b0200","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/s41586-023-06990-w","article-title":"Bile salt hydrolase catalyses formation of amine-conjugated bile acids","volume":"626","author":"Rimal","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.02.048_b0205","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41575-022-00658-y","article-title":"The metabolic nature of inflammatory bowel diseases","volume":"19","author":"Adolph","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.02.048_b0210","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ajg.2011.44","article-title":"Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature","volume":"106","author":"Hou","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jare.2026.02.048_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/nu11071498","article-title":"Diet in the Pathogenesis and Management of Ulcerative Colitis; a Review of Randomized Controlled Dietary Interventions","volume":"11","author":"Keshteli","year":"2019","journal-title":"Nutrients"},{"issue":"375\u2013390","key":"10.1016\/j.jare.2026.02.048_b0220","first-page":"e11","article-title":"Glutamine Links Obesity to Inflammation in Human White Adipose Tissue","volume":"31","author":"Petrus","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2026.02.048_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2040-4603.2018.tb00008.x","article-title":"Triglyceride Metabolism in the Liver","volume":"8","author":"Alves-Bezerra","year":"2017","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jare.2026.02.048_b0230","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/hep.26672","article-title":"Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes","volume":"59","author":"Birkenfeld","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jare.2026.02.048_b0235","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"Sinal","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jare.2026.02.048_b0240","doi-asserted-by":"crossref","unstructured":"Zheng M, Zhai Y, Yu Y, Shen J, Chu S, Focaccia E, et al. TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response. Cell Metabolism. 2024; 36:2086-103.e9.","DOI":"10.1016\/j.cmet.2024.06.008"},{"key":"10.1016\/j.jare.2026.02.048_b0245","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jare.2024.03.026","article-title":"Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice","volume":"69","author":"Li","year":"2024","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2026.02.048_b0250","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.3760","article-title":"Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance","volume":"21","author":"Fang","year":"2015","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.jare.2026.02.048_b0255","article-title":"Clostridium Scindens protects against vancomycin-induced cholestasis and liver fibrosis by activating intestinal FXR-FGF15\/19 signaling","volume":"12","author":"Xiao","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jare.2026.02.048_b0260","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.chom.2022.02.004","article-title":"Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis","volume":"30","author":"Cai","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jare.2026.02.048_b0265","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.chom.2021.04.004","article-title":"Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation","volume":"29","author":"Liu","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jare.2026.02.048_b0270","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1039\/C8FO01143E","article-title":"Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct"},{"key":"10.1016\/j.jare.2026.02.048_b0275","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s10620-020-06208-3","article-title":"Deoxycholic acid-induced gut dysbiosis disrupts bile acid enterohepatic circulation and promotes intestinal inflammation","volume":"66","author":"Xu","year":"2021","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jare.2026.02.048_b0280","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/ecco-jcc\/jjab003","article-title":"Modulation of the gut microbiota-farnesoid x receptor axis improves deoxycholic acid-induced intestinal inflammation in mice","volume":"15","author":"Xu","year":"2021","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jare.2026.02.048_b0285","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-019-1785-z","article-title":"Bile acid metabolites control T(H)17 and T(reg) cell differentiation","volume":"576","author":"Hang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.02.048_b0290","doi-asserted-by":"crossref","unstructured":"Ward JBJ, Lajczak NK, Kelly OB, O'Dwyer AM, Giddam AK, J NG, et al. Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon. American journal of physiology Gastrointestinal and liver physiology. 2017; 312(6): G550-G558.","DOI":"10.1152\/ajpgi.00256.2016"},{"key":"10.1016\/j.jare.2026.02.048_b0295","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2026.02.048_b0300","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/ncomms3384","article-title":"Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity","volume":"4","author":"Li","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.02.048_b0305","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1172\/JCI76738","article-title":"Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease","volume":"125","author":"Jiang","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2026.02.048_b0310","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/s42255-024-01072-1","article-title":"Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption","volume":"6","author":"Li","year":"2024","journal-title":"Nat Metab"},{"key":"10.1016\/j.jare.2026.02.048_b0315","doi-asserted-by":"crossref","first-page":"e1879","DOI":"10.1038\/cddis.2015.248","article-title":"ER stress induces NLRP3 inflammasome activation and hepatocyte death","volume":"6","author":"Lebeaupin","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jare.2026.02.048_b0320","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2390176","article-title":"Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion","volume":"16","author":"Wu","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jare.2026.02.048_b0325","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300731","article-title":"A Probiotic Targets bile acids metabolism to alleviate ulcerative colitis by reducing conjugated bile acids","volume":"68","author":"Jingjing","year":"2024","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jare.2026.02.048_b0330","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/19490976.2015.1005474","article-title":"Changes in bile acids, FGF-19 and sterol absorption in response to bile salt hydrolase active L. reuteri NCIMB 30242","volume":"6","author":"Martoni","year":"2015","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jare.2026.02.048_b0335","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41586-024-07017-8","article-title":"Bile salt hydrolase acyltransferase activity expands bile acid diversity","volume":"626","author":"Guzior","year":"2024","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.jare.2026.02.048_b0340","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017709118","article-title":"Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization","volume":"118","author":"Foley","year":"2021","journal-title":"PNAS"},{"key":"10.1016\/j.jare.2026.02.048_b0345","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41467-023-36089-9","article-title":"Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.02.048_b0350","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/j.cell.2022.06.050","article-title":"Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes","volume":"185","author":"Russell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jare.2026.02.048_b0355","article-title":"Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children","volume":"12(12):CD006095","author":"Goldenberg","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1016\/j.jare.2026.02.048_b0360","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/gut.2003.037747","article-title":"Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine","volume":"53","author":"Kruis","year":"2004","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.jare.2026.02.048_b0365","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/ajg.2014.202","article-title":"Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis","volume":"109","author":"Ford","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1016\/j.jare.2026.02.048_b0370","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.3390\/nu13082820","article-title":"Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and sleep Quality in Self-Reported Insomniacs: a Randomized, Double-blind, Placebo-Controlled pilot Trial","volume":"13","author":"Ho","year":"2021","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.jare.2026.02.048_b0375","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.chom.2024.07.028","article-title":"Engineered probiotic ameliorates ulcerative colitis by restoring gut microbiota and redox homeostasis","volume":"32","author":"Guo","year":"2024","journal-title":"Cell Host Microbe"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226001803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226001803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:13:08Z","timestamp":1777623188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226001803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":75,"alternative-id":["S2090123226001803"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.02.048","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactiplantibacillus plantarum AR113 alleviates Western Diet-Induced colitis and liver injury via bidirectional modulation of the Intestinal-Hepatic FXR signaling axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.02.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}