{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:40:09Z","timestamp":1776199209279,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404831"],"award-info":[{"award-number":["82404831"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173963"],"award-info":[{"award-number":["82173963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3508600"],"award-info":[{"award-number":["2025YFC3508600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3500302"],"award-info":[{"award-number":["2022YFC3500302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024 M753635"],"award-info":[{"award-number":["2024 M753635"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jare.2026.04.010","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:22:04Z","timestamp":1775438524000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["AnnoNet-TCMs: An annotation network-driven discovery of novel active compounds and mechanisms in traditional Chinese medicine"],"prefix":"10.1016","author":[{"given":"Xiangyu","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanxing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhensheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyang","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-9673","authenticated-orcid":false,"given":"Hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2026.04.010_b0005","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/s41591-024-03169-2","article-title":"The traditional chinese medicine qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial","volume":"30","author":"Cheang","year":"2024","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.jare.2026.04.010_b0010","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1016\/j.apsb.2023.06.002","article-title":"Functional annotation map of natural compounds in traditional chinese medicines library: TCMs with myocardial protection as a case","volume":"13","author":"Xing","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jare.2026.04.010_b0015","doi-asserted-by":"crossref","first-page":"989","DOI":"10.7150\/ijbs.105086","article-title":"Traditional chinese medicine for viral pneumonia therapy: Pharmacological basis and mechanistic insights","volume":"21","author":"Bai","year":"2025","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jare.2026.04.010_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116306","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0025","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: Towards the artificial intelligence-based precision traditional chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jare.2026.04.010_b0030","doi-asserted-by":"crossref","unstructured":"X. Wen, Y. Wang, C. Su, Y. You, Z. Jiang, D. Zhu, Q. Fan, Integrating multi-omics technologies with traditional Chinese medicine to enhance cancer research and treatment, QJM (n.d.). DOI: 10.1093\/qjmed\/hcaf103.","DOI":"10.1093\/qjmed\/hcaf103"},{"key":"10.1016\/j.jare.2026.04.010_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118936","article-title":"Exploiting omic-based approaches to decipher traditional chinese medicine","volume":"337","author":"Li","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108754","article-title":"The pharmacodynamic and pharmacological mechanisms underlying nanovesicles of natural products: Developments and challenges","volume":"265","author":"Zhang","year":"2025","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jare.2026.04.010_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bib\/bbac229","article-title":"Network approaches for modeling the effect of drugs and diseases","volume":"23","author":"Rintala","year":"2022","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jare.2026.04.010_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01134","article-title":"Network-based methods for prediction of drug-target interactions","volume":"9","author":"Wu","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0055","doi-asserted-by":"crossref","first-page":"116366","DOI":"10.1109\/ACCESS.2023.3324985","article-title":"A review of random walk-based method for the identification of disease genes and disease modules","volume":"11","author":"Hui","year":"2023","journal-title":"IEEE Access"},{"key":"10.1016\/j.jare.2026.04.010_b0060","doi-asserted-by":"crossref","unstructured":"T. Can, O. \u00c7amo\u01e7lu, A.K. Singh, Analysis of protein-protein interaction networks using random walks, in: Proceedings of the 5th International Workshop on Bioinformatics, Association for Computing Machinery, New York, NY, USA, 2005: pp. 61\u201368. DOI: 10.1145\/1134030.1134042.","DOI":"10.1145\/1134030.1134042"},{"key":"10.1016\/j.jare.2026.04.010_b0065","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/bioinformatics\/btq108","article-title":"Genome-wide inferring gene\u2013phenotype relationship by walking on the heterogeneous network","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jare.2026.04.010_b0070","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1039\/C2MB00002D","article-title":"Drug\u2013target interaction prediction by random walk on the heterogeneous network","volume":"8","author":"Chen","year":"2012","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.jare.2026.04.010_b0075","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/s41467-021-21770-8","article-title":"Identification of disease treatment mechanisms through the multiscale interactome","volume":"12","author":"Ruiz","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.04.010_b0080","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jare.2026.04.010_b0085","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment- and reference-guided database of traditional chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jare.2026.04.010_b0090","doi-asserted-by":"crossref","first-page":"D1089","DOI":"10.1093\/nar\/gks1100","article-title":"TCMID: traditional chinese medicine integrative database for herb molecular mechanism analysis","volume":"41","author":"Xue","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jare.2026.04.010_b0095","doi-asserted-by":"crossref","first-page":"D433","DOI":"10.1093\/nar\/gki005","article-title":"STRING: known and predicted protein\u2013protein associations, integrated and transferred across organisms","volume":"33","author":"von Mering","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jare.2026.04.010_b0100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: Tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.jare.2026.04.010_b0105","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1038\/s41467-018-05116-5","article-title":"Network-based approach to prediction and population-based validation of in silico drug repurposing","volume":"9","author":"Cheng","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.04.010_b0110","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jep.2013.02.015","article-title":"Antidepressant-like effect of flavonoids extracted from apocynum venetum leaves on brain monoamine levels and dopaminergic system","volume":"147","author":"Zheng","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0115","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/nprot.2011.361","article-title":"A standardized protocol for repeated social defeat stress in mice","volume":"6","author":"Golden","year":"2011","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jare.2026.04.010_b0120","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jare.2026.04.010_b0125","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Rd","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.jare.2026.04.010_b0130","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh0215","article-title":"Network medicine framework reveals generic herb-symptom effectiveness of traditional chinese medicine","volume":"9","author":"Gan","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2026.04.010_b0135","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nchem.1243","article-title":"Quantifying the chemical beauty of drugs","volume":"4","author":"Bickerton","year":"2012","journal-title":"Nature Chem"},{"key":"10.1016\/j.jare.2026.04.010_b0140","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1021\/ci700286x","article-title":"Natural product-likeness score and its application for prioritization of compound libraries","volume":"48","author":"Ertl","year":"2008","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.jare.2026.04.010_b0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1476-4598-12-54","article-title":"Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase","volume":"12","author":"Lin","year":"2013","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jare.2026.04.010_b0150","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.fct.2011.04.014","volume":"49","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jare.2026.04.010_b0155","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008664","article-title":"Apoptotic and nonapoptotic caspase functions in animal development","volume":"4","author":"Miura","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jare.2026.04.010_b0160","doi-asserted-by":"crossref","unstructured":"A. Basu, S. Haldar, The relationship between BcI2, bax and p53: Consequences for cell cycle progression and cell death., (n.d.). DOI: 10.1093\/molehr\/4.12.1099.","DOI":"10.1093\/molehr\/4.12.1099"},{"key":"10.1016\/j.jare.2026.04.010_b0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0962-8924(98)01251-3","article-title":"Control of cell proliferation by myc","volume":"8","author":"Bouchard","year":"1998","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jare.2026.04.010_b0170","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/aob\/mcq243","article-title":"Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation","volume":"107","author":"Strzalka","year":"2011","journal-title":"Ann Bot"},{"key":"10.1016\/j.jare.2026.04.010_b0175","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1080\/13880209.2020.1812673","article-title":"Obacunone reduces inflammatory signalling and tumour occurrence in mice with chronic inflammation-induced colorectal cancer","volume":"58","author":"Luo","year":"2020","journal-title":"Pharm Biol"},{"key":"10.1016\/j.jare.2026.04.010_b0180","first-page":"e32","article-title":"Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants, Transl","volume":"1","author":"Avula","year":"2011","journal-title":"Psychiatry"},{"key":"10.1016\/j.jare.2026.04.010_b0185","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0006-3223(98)00090-0","article-title":"Association between serotonin transporter gene polymorphism and anxiety-related traits","volume":"45","author":"Katsuragi","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jare.2026.04.010_b0190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ajmg.b.20158","article-title":"Meta\u2010analysis of the association between a serotonin transporter promoter polymorphism (5\u2010HTTLPR) and anxiety\u2010related personality traits","volume":"127B","author":"Sen","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.jare.2026.04.010_b0195","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00406-008-0842-7","article-title":"Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population","volume":"259","author":"Gonda","year":"2009","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.jare.2026.04.010_b0200","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jad.2020.11.057","article-title":"Distinct grey matter volume alterations in adult patients with panic disorder and social anxiety disorder: a systematic review and voxel-based morphometry meta-analysis","volume":"281","author":"Wang","year":"2021","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jare.2026.04.010_b0205","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1038\/srep05632","article-title":"Antidepressant-like activity of adhyperforin, a novel constituent of hypericum perforatum L","volume":"4","author":"Tian","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2026.04.010_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2015.09.029","article-title":"Hyperforin alleviates mood deficits of adult rats suffered from early separation","volume":"608","author":"Zhu","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jare.2026.04.010_b0215","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0022-3565(24)35043-8","article-title":"Hyperforin, a major antidepressant constituent of st. john\u2019s wort, inhibits serotonin uptake by elevating free intracellular na+1 1","volume":"290","author":"Singer","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jare.2026.04.010_b0220","article-title":"\u03b2-sitosterol reduces anxiety and synergizes with established anxiolytic drugs in mice","volume":"2","author":"Panayotis","year":"2021","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jare.2026.04.010_b0225","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/md14070123","article-title":"Structural features and potent antidepressant effects of total sterols and \u03b2-sitosterol extracted from sargassum horneri","volume":"14","author":"Zhao","year":"2016","journal-title":"Mar Drugs"},{"key":"10.1016\/j.jare.2026.04.010_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116772","article-title":"The protective effect of an extract of salvia miltiorrhiza bunge (danshen) on cerebral ischemic injury in animal models: a systematic review and meta-analysis","volume":"317","author":"Xie","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115501","article-title":"Salvia miltiorrhiza and tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2","volume":"167","author":"Ma","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2026.04.010_b0240","article-title":"Astragalus (a traditional chinese medicine) for treating chronic kidney disease","author":"Zhang","year":"2014","journal-title":"Cochrane Db Syst Rev"},{"key":"10.1016\/j.jare.2026.04.010_b0250","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/738391","article-title":"Qi-shen-yi-qi dripping pills for the secondary prevention of myocardial infarction: a randomised clinical trial","volume":"2013","author":"Shang","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jare.2026.04.010_b0255","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jacc.2013.05.035","article-title":"A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the effects of qili qiangxin capsules in patients with chronic heart failure","volume":"62","author":"Li","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jare.2026.04.010_b0260","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1007\/s12035-016-0267-7","article-title":"Tanshinone I attenuates the effects of a challenge with H2O2 on the functions of tricarboxylic acid cycle and respiratory chain in SH-SY5Y cells","volume":"54","author":"de Oliveira","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jare.2026.04.010_b0265","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jep.2015.01.042","article-title":"Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of parkinson\u05f3s disease","volume":"164","author":"Wang","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0270","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.2147\/DDDT.S216596","article-title":"Tanshinone I inhibits IL-1\u03b2-induced apoptosis, inflammation and extracellular matrix degradation in chondrocytes CHON-001 cells and attenuates murine osteoarthritis","volume":"13","author":"Wang","year":"2019","journal-title":"DDDT"},{"key":"10.1016\/j.jare.2026.04.010_b0275","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12967-024-05168-w","article-title":"Blockade of PI3K\/AKT signaling pathway by astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier","volume":"22","author":"Zhang","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.jare.2026.04.010_b0280","article-title":"Chuanxiongzine-astragaloside IV decreases IL-1\u03b2 and caspase-3 gene expressions in rat brain damaged by cerebral ischemia\/reperfusion: a study of real-time quantitative PCR assay","author":"Zhen-Hong","year":"2011","journal-title":"Acta Physiologica Sinica"},{"key":"10.1016\/j.jare.2026.04.010_b0285","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/molecules24091838","article-title":"The role of astragaloside IV against cerebral ischemia\/reperfusion injury: suppression of apoptosis via promotion of P62-LC3-autophagy","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jare.2026.04.010_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109640","article-title":"Astragaloside IV alleviates sepsis-induced muscle atrophy by inhibiting the TGF-\u03b21\/smad signaling pathway","volume":"115","author":"Dai","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0295","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.3892\/mmr.2015.3212","article-title":"Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-\u03b2\/smad signaling suppression and inhibiting matrix metalloproteinase-1","volume":"11","author":"Chen","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jare.2026.04.010_b0300","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2011.02.040","article-title":"Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-\u03b21 signaling in coxsackievirus B3-induced cardiomyopathy","volume":"658","author":"Chen","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jare.2026.04.010_b0305","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad145","article-title":"Improving drug-target affinity prediction via feature fusion and knowledge distillation","volume":"24","author":"Lu","year":"2023","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jare.2026.04.010_b0310","series-title":"Proceedings of the National Academy of Sciences 118","article-title":"Deep learning identifies synergistic drug combinations for treating COVID-19","author":"Jin","year":"2021"},{"key":"10.1016\/j.jare.2026.04.010_b0315","article-title":"Exploration strategies for food and medicine homologous resources: future direction in food development","author":"Liu","year":"2026","journal-title":"Food & Medicine Homology"},{"key":"10.1016\/j.jare.2026.04.010_b0320","first-page":"1","article-title":"Knowledge graph-enhanced molecular contrastive learning with functional prompt","author":"Fang","year":"2023","journal-title":"Nat Mach Intell"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226002894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226002894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:34:27Z","timestamp":1776195267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226002894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":63,"alternative-id":["S2090123226002894"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.04.010","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AnnoNet-TCMs: An annotation network-driven discovery of novel active compounds and mechanisms in traditional Chinese medicine","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}