{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:54:49Z","timestamp":1783698889552,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012126"],"award-info":[{"award-number":["2023A1515012126"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751342"],"award-info":[{"award-number":["2024M751342"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201069"],"award-info":[{"award-number":["82201069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jare.2026.04.058","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:18:56Z","timestamp":1776701936000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bone marrow mesenchymal stem cells have tissue-specific characteristic in promoting the potential of periodontal ligament stem cells for periodontal regeneration"],"prefix":"10.1016","author":[{"given":"Fen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-8862","authenticated-orcid":false,"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-1011","authenticated-orcid":false,"given":"Shaoqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2741-3181","authenticated-orcid":false,"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-2104","authenticated-orcid":false,"given":"Faming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jare.2026.04.058_b0005","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/ijms19040944","article-title":"Mesenchymal stem cells of dental origin for inducing tissue regeneration in periodontitis: a mini-review","volume":"19","author":"Hern\u00e1ndez-Monjaraz","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0010","doi-asserted-by":"crossref","first-page":"21244","DOI":"10.1038\/s41598-025-04359-9","article-title":"Association between conicity index and prevalence of periodontitis in US adults: the 2009-2014 NHANES cross-sectional study","volume":"15","author":"Xu","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2026.04.058_b0015","doi-asserted-by":"crossref","unstructured":"Isola G, Polizzi A, Serra S, Boato M, Sculean A. Relationship between periodontitis and systemic diseases: a bibliometric and visual study. doi: 10.1111\/prd.12621.","DOI":"10.1111\/prd.12621"},{"issue":"10194","key":"10.1016\/j.jare.2026.04.058_b0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: a global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jare.2026.04.058_b0025","first-page":"146","article-title":"25 Years of minimally invasive surgery and biologics in regenerative periodontal therapy","volume":"45","author":"Rasperini","year":"2025","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.jare.2026.04.058_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.750990","article-title":"Translational and clinical applications of dental stem cell-derived exosomes","volume":"12","author":"Mai","year":"2021","journal-title":"Front Genet"},{"issue":"5","key":"10.1016\/j.jare.2026.04.058_b0035","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/jbmr.1552","article-title":"Genetic evidence for the vital function of Osterix in cementogenesis","volume":"27","author":"Cao","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2026.04.058_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105700","article-title":"Human periodontal ligament stem cells and metformin to enhance periodontal regeneration in rats","volume":"156","author":"Zhao","year":"2025","journal-title":"J Dent"},{"issue":"4","key":"10.1016\/j.jare.2026.04.058_b0045","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2174\/1574888X17666220429123319","article-title":"Comparison of periodontal ligament stem cells with mesenchymal stem cells from other sources: a scoping systematic review of in vitro and in vivo studies","volume":"19","author":"Kadkhoda","year":"2024","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1016\/j.jare.2026.04.058_b0050","article-title":"Epigenetic regulation of dental-derived stem cells and their application in pulp and periodontal regeneration","volume":"11","author":"Chen","year":"2023","journal-title":"PeerJ"},{"issue":"5","key":"10.1016\/j.jare.2026.04.058_b0055","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.3390\/ijms22052472","article-title":"The cross-talk between mesenchymal stem cells and immune cells in tissue repair and regeneration","volume":"22","author":"Harrell","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jare.2026.04.058_b0060","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1902\/jop.2011.110267","article-title":"A novel mixed-type stem cell pellet for cementum\/periodontal ligament-like complex","volume":"83","author":"Xie","year":"2012","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.jare.2026.04.058_b0065","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/term.2077","article-title":"Tissue-specific composite cell aggregates drive periodontium tissue regeneration by reconstructing a regenerative microenvironment","volume":"11","author":"Zhu","year":"2017","journal-title":"J Tissue Eng Regen Med"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13062-023-00391-9","article-title":"Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt\/beta-catenin signaling pathway","volume":"18","author":"Zhang","year":"2023","journal-title":"Biol Direct"},{"issue":"5","key":"10.1016\/j.jare.2026.04.058_b0075","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/dvdy.20674","article-title":"Evolution and development of Hertwig's epithelial root sheath","volume":"235","author":"Luan","year":"2006","journal-title":"Dev Dyn"},{"issue":"7","key":"10.1016\/j.jare.2026.04.058_b0080","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1002\/jcp.30243","article-title":"Cell dynamics in Hertwig's epithelial root sheath are regulated by \u03b2-catenin activity during tooth root development","volume":"236","author":"Yang","year":"2021","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2319\/041923-286.1","article-title":"Root development differences between cleft-adjacent teeth on the cleft side in comparison to their analogs on the noncleft side in patients with nonsyndromic cleft lip and palate who received secondary alveolar bone grafting","volume":"94","author":"Vandersluis-Solomon","year":"2024","journal-title":"Angle Orthod"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cden.2021.06.002","article-title":"Stem cell applications in periodontal regeneration","volume":"66","author":"Bartold","year":"2022","journal-title":"Dent Clin N Am"},{"issue":"4","key":"10.1016\/j.jare.2026.04.058_b0095","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4103\/jisp.jisp_442_20","article-title":"Isolation and immunohistochemical characterization of periodontal ligament stem cells: a preliminary study","volume":"25","author":"Kukreja","year":"2021","journal-title":"J Indian Soc Periodontol"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0100","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/stem.3288","article-title":"Stem cell contributions to cementoblast differentiation in healthy periodontal ligament and periodontitis","volume":"39","author":"Zhao","year":"2021","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0105","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s13287-024-03939-2","article-title":"Antibacterial periodontal ligament stem cells enhance periodontal regeneration and regulate the oral microbiome","volume":"15","author":"You","year":"2024","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"10.1016\/j.jare.2026.04.058_b0110","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4252\/wjsc.v13.i6.605","article-title":"Therapeutic potential of periodontal ligament stem cells","volume":"13","author":"Queiroz","year":"2021","journal-title":"World J Stem Cells"},{"key":"10.1016\/j.jare.2026.04.058_b0115","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fimmu.2013.00201","article-title":"Mesenchymal stem cells in tissue repair","volume":"4","author":"Dimarino","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2026.04.058_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114228","article-title":"Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells","volume":"150","author":"Zheng","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"10.1016\/j.jare.2026.04.058_b0125","doi-asserted-by":"crossref","first-page":"558","DOI":"10.7150\/ijms.40918","article-title":"PDLSCs regulate angiogenesis of periodontal ligaments via VEGF transferred by exosomes in periodontitis","volume":"17","author":"Zhang","year":"2020","journal-title":"Int J Med Sci"},{"issue":"7","key":"10.1016\/j.jare.2026.04.058_b0130","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00784-025-06422-1","article-title":"Mechanistic insights into periodontal ligament stem cell-derived exosomes in tissue regeneration","volume":"29","author":"Ahmad","year":"2025","journal-title":"Clin Oral Invest"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0135","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1186\/s12903-025-06531-z","article-title":"Apoptotic extracellular vesicles derived from human dental pulp stem cells facilitate periodontal tissue regeneration","volume":"25","author":"Xia","year":"2025","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jare.2026.04.058_b0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.archoralbio.2018.07.019","article-title":"ACVR1 is essential for periodontium development and promotes alveolar bone formation","volume":"95","author":"Zhang","year":"2018","journal-title":"Arch Oral Biol"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12964-024-01999-8","article-title":"On the road: extracellular vesicles in intercellular communication","volume":"23","author":"Wessler","year":"2025","journal-title":"Cell Commun Signal"},{"issue":"5","key":"10.1016\/j.jare.2026.04.058_b0150","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.4103\/1673-5374.324840","article-title":"Significance of intercellular communication for neurodegenerative diseases","volume":"17","author":"Cihankaya","year":"2022","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jare.2026.04.058_b0155","article-title":"Plasmonic nano surface for neuronal differentiation and manipulation","volume":"21","author":"Pandanaboina","year":"2019","journal-title":"Nanomedicine"},{"issue":"Pt 1","key":"10.1016\/j.jare.2026.04.058_b0160","article-title":"Mesenchymal stem cells, exosomes and exosome-mimics as smart drug carriers for targeted cancer therapy","volume":"209","author":"Liu","year":"2022","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.jare.2026.04.058_b0165","first-page":"418","article-title":"The paradigm shifts of periodontal regeneration strategy: from reparative manipulation to developmental engineering","volume":"49","author":"Liu","year":"2025","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jare.2026.04.058_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2016.06.005","article-title":"Influence of co-culture on osteogenesis and angiogenesis of bone marrow mesenchymal stem cells and aortic endothelial cells","volume":"108","author":"Gurel Pekozer","year":"2016","journal-title":"Microvasc Res"},{"key":"10.1016\/j.jare.2026.04.058_b0175","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.actbio.2022.11.045","article-title":"Titanium dioxide nanotubes increase purinergic receptor P2Y6 expression and activate its downstream PKC\u03b1-ERK1\/2 pathway in bone marrow mesenchymal stem cells under osteogenic induction","volume":"157","author":"Wang","year":"2023","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2026.04.058_b0180","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.actbio.2017.07.039","article-title":"Effects of the incorporation of \u03b5-aminocaproic acid\/chitosan particles to fibrin on cementoblast differentiation and cementum regeneration","volume":"61","author":"Park","year":"2017","journal-title":"Acta Biomater"},{"issue":"7","key":"10.1016\/j.jare.2026.04.058_b0185","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/odi.13852","article-title":"Comparison of the effectiveness of ankaferd blood stopper\u00ae and emdogain in periodontal regeneration","volume":"28","author":"G\u00fcler","year":"2022","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0190","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00784-004-0288-x","article-title":"Formation of human cementum following different modalities of regenerative therapy","volume":"9","author":"Sculean","year":"2005","journal-title":"Clin Oral Invest"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0195","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10006-025-01390-y","article-title":"Evaluation of bone regeneration in rat calvaria using combination of enamel matrix derivate and bone graft substitute: a histological, histometric and immunohistochemical study","volume":"29","author":"de Carvalho Reis","year":"2025","journal-title":"Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.jare.2026.04.058_b0200","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s007840050113","article-title":"Healing of fenestration-type defects following treatment with guided tissue regeneration or enamel matrix proteins. An experimental study in monkeys","volume":"4","author":"Sculean","year":"2000","journal-title":"Clin Oral Invest"},{"issue":"5","key":"10.1016\/j.jare.2026.04.058_b0205","doi-asserted-by":"crossref","first-page":"476","DOI":"10.11607\/prd.00.0600","article-title":"Comparative study of enamel matrix derivative with or without GTR in the treatment of class II furcation lesions in dogs","volume":"24","author":"Regazzini","year":"2004","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"4","key":"10.1016\/j.jare.2026.04.058_b0210","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00784-025-06278-5","article-title":"Comparision of crosslinked hyaluronic acid vs. enamel matrix derivative for periodontal regeneration: an 18-month follow-up randomized clinical trial","volume":"29","author":"Rodr\u00edguez-A","year":"2025","journal-title":"Clin Oral Invest"},{"issue":"2","key":"10.1016\/j.jare.2026.04.058_b0215","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/cap.10159","article-title":"Enucleation of recurrent central odontogenic fibroma and bone regeneration of the osseous defect with enamel matrix derivative and bone allograft: case report with 5-year follow-up","volume":"13","author":"Do","year":"2023","journal-title":"Clin Adv Periodontics"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226003620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226003620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:47:02Z","timestamp":1783183622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226003620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S2090123226003620"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.04.058","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone marrow mesenchymal stem cells have tissue-specific characteristic in promoting the potential of periodontal ligament stem cells for periodontal regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.04.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}