{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:59:37Z","timestamp":1790114377270,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402788"],"award-info":[{"award-number":["32402788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH-TZ2403"],"award-info":[{"award-number":["LBH-TZ2403"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Heilongjiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["PL2025C016"],"award-info":[{"award-number":["PL2025C016"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jare.2026.06.031","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:43:26Z","timestamp":1782949406000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel \u03b2-hairpin amphiphiles utilizing tryptophan-interacting propensities exhibit multimodal antibacterial mechanism and promote wound healing in drug-resistant infections"],"prefix":"10.1016","author":[{"given":"Mengcheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanmengxue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-1305","authenticated-orcid":false,"given":"Changxuan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7895","key":"10.1016\/j.jare.2026.06.031_b0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41586-021-04265-w","article-title":"Emergence of methicillin resistance predates the clinical use of antibiotics","volume":"602","author":"Larsen","year":"2022","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jare.2026.06.031_b0010","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41579-025-01169-8","article-title":"The global resistance problem and the clinical antibacterial pipeline","volume":"23","author":"Theuretzbacher","year":"2025","journal-title":"Nat Rev Microbiol"},{"issue":"10442","key":"10.1016\/j.jare.2026.06.031_b0015","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1016\/S0140-6736(24)00876-6","article-title":"The scope of the antimicrobial resistance challenge","volume":"403","author":"Okeke","year":"2024","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jare.2026.06.031_b0020","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.jiph.2023.04.014","article-title":"Efficacy and mortality of ceftazidime\/avibactam-based regimens in carbapenem-resistant gram-negative bacteria infections: a retrospective multicenter observational study","volume":"16","author":"Zhuang","year":"2023","journal-title":"J Infect Public Health"},{"issue":"10459","key":"10.1016\/j.jare.2026.06.031_b0025","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(24)01885-3","article-title":"Global burden of antimicrobial resistance and forecasts to 2050","volume":"404","author":"Kariuki","year":"2024","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jare.2026.06.031_b0030","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41579-023-00993-0","article-title":"Alternative therapeutic strategies to treat antibiotic-resistant pathogens","volume":"22","author":"MacNair","year":"2024","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jare.2026.06.031_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100954","article-title":"Antimicrobial peptides for combating drug-resistant bacterial infections","volume":"68","author":"Xuan","year":"2023","journal-title":"Drug Resist Updat"},{"issue":"6490","key":"10.1016\/j.jare.2026.06.031_b0040","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau5480","article-title":"Antimicrobial peptides: application informed by evolution","volume":"368","author":"Lazzaro","year":"2020","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.jare.2026.06.031_b0045","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1021\/acs.accounts.1c00040","article-title":"Peptides and antibiotic therapy: advances in design and delivery","volume":"54","author":"Schafer","year":"2021","journal-title":"Acc Chem Res"},{"issue":"1","key":"10.1016\/j.jare.2026.06.031_b0050","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","article-title":"Designing antimicrobial peptides: form follows function","volume":"11","author":"Fjell","year":"2011","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"10.1016\/j.jare.2026.06.031_b0055","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41564-018-0164-0","article-title":"Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides","volume":"3","author":"L\u00e1z\u00e1r","year":"2018","journal-title":"Nat Microbiol"},{"issue":"2","key":"10.1016\/j.jare.2026.06.031_b0060","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1021\/acsnano.0c09509","article-title":"Synthetic biology and computer-based frameworks for antimicrobial peptide discovery","volume":"15","author":"Torres","year":"2021","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.jare.2026.06.031_b0065","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1007\/s00726-015-2029-7","article-title":"Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like \u03b2-hairpin antimicrobial peptides","volume":"47","author":"Xu","year":"2015","journal-title":"Amino Acids"},{"issue":"8","key":"10.1016\/j.jare.2026.06.031_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2020.183273","article-title":"Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria","volume":"1862","author":"Nehls","year":"2020","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"45","key":"10.1016\/j.jare.2026.06.031_b0075","doi-asserted-by":"crossref","first-page":"24137","DOI":"10.1002\/anie.202107861","article-title":"Insight on the order of regioselective ultrafast formation of disulfide bonds in (antimicrobial) peptides and miniproteins","volume":"60","author":"Laps","year":"2021","journal-title":"Angew Chem Int Ed Engl"},{"issue":"7","key":"10.1016\/j.jare.2026.06.031_b0080","article-title":"Cross-strand interaction, central bending, and sequence pattern act as biomodulators of simplified \u03b2-hairpin antimicrobial amphiphiles","volume":"17","author":"Shao","year":"2021","journal-title":"Small"},{"issue":"12","key":"10.1016\/j.jare.2026.06.031_b0085","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1021\/acschembio.3c00553","article-title":"Tunable CH\/\u03c0 interactions within a tryptophan zipper motif to stabilize the fold of long \u03b2-hairpin peptides","volume":"18","author":"Richaud","year":"2023","journal-title":"ACS Chem Biol"},{"issue":"6","key":"10.1016\/j.jare.2026.06.031_b0090","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/bip.21436","article-title":"Tryptophan residues: scarce in proteins but strong stabilizers of \u03b2-hairpin peptides","volume":"94","author":"Santiveri","year":"2010","journal-title":"Biopolymers"},{"issue":"3","key":"10.1016\/j.jare.2026.06.031_b0095","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1021\/acsnano.4c09347","article-title":"Combating antibiotic-resistant bacterial infection using coassembled dimeric antimicrobial peptide-based nanofibers","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.jare.2026.06.031_b0100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jare.2026.06.031_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139128","article-title":"Novel design of simplified \u03b2-hairpin antimicrobial peptide as a potential food preservative based on Trp-pocket backbone","volume":"448","author":"Shao","year":"2024","journal-title":"Food Chem"},{"issue":"16","key":"10.1016\/j.jare.2026.06.031_b0110","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1021\/acs.jmedchem.3c00856","article-title":"Ultrashort all-hydrocarbon stapled \u03b1-helix amphiphile as a potent and stable antimicrobial compound","volume":"66","author":"Shao","year":"2023","journal-title":"J Med Chem"},{"issue":"4","key":"10.1016\/j.jare.2026.06.031_b0115","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1021\/acsnano.8b09403","article-title":"Anti-biofilm activity of graphene quantum dots via self-assembly with bacterial amyloid proteins","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.jare.2026.06.031_b0120","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s42765-024-00410-y","article-title":"Revolutionizing antimicrobial biomaterials: integrating an enzyme degradation-resistant sequence into self-assembled nanosystems to overcome stability limitations of peptide-based drugs","volume":"6","author":"Yu","year":"2024","journal-title":"Adv Fiber Mater"},{"issue":"24","key":"10.1016\/j.jare.2026.06.031_b0125","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1002\/1873-3468.12477","article-title":"Hairpin structure stability plays a role in the activity of two antimicrobial peptides","volume":"590","author":"Sivanesam","year":"2016","journal-title":"FEBS Lett"},{"issue":"35","key":"10.1016\/j.jare.2026.06.031_b0130","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1021\/bi801045n","article-title":"Using fluorous amino acids to probe the effects of changing hydrophobicity on the physical and biological properties of the beta-hairpin antimicrobial peptide protegrin-1","volume":"47","author":"Gottler","year":"2008","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/j.jare.2026.06.031_b0135","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1073\/pnas.091100898","article-title":"Tryptophan zippers: stable, monomeric beta-hairpins","volume":"98","author":"Cochran","year":"2001","journal-title":"PNAS"},{"issue":"43","key":"10.1016\/j.jare.2026.06.031_b0140","doi-asserted-by":"crossref","first-page":"10362","DOI":"10.1021\/bi901249d","article-title":"Role of tryptophan-tryptophan interactions in Trpzip beta-hairpin formation, structure, and stability","volume":"48","author":"Wu","year":"2009","journal-title":"Biochemistry"},{"issue":"22","key":"10.1016\/j.jare.2026.06.031_b0145","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1021\/bi100491s","article-title":"Geometry and efficacy of cross-strand Trp\/Trp, Trp\/Tyr, and Tyr\/Tyr aromatic interaction in a beta-hairpin peptide","volume":"49","author":"Wu","year":"2010","journal-title":"Biochemistry"},{"issue":"5114","key":"10.1016\/j.jare.2026.06.031_b0150","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1126\/science.8503008","article-title":"Structural basis of amino acid alpha helix propensity","volume":"260","author":"Blaber","year":"1993","journal-title":"Science"},{"issue":"13","key":"10.1016\/j.jare.2026.06.031_b0155","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1039\/C3OB42247J","article-title":"Comparative analysis of cross strand aromatic-Phe interactions in designed peptide \u03b2-hairpins","volume":"12","author":"Makwana","year":"2014","journal-title":"Org Biomol Chem"},{"issue":"1","key":"10.1016\/j.jare.2026.06.031_b0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/1097-0282(2000)55:1<31::AID-BIP40>3.0.CO;2-9","article-title":"Structural features and biological activities of the cathelicidin-derived antimicrobial peptides","volume":"55","author":"Gennaro","year":"2000","journal-title":"Biopolymers"},{"issue":"W1","key":"10.1016\/j.jare.2026.06.031_b0165","doi-asserted-by":"crossref","first-page":"W174","DOI":"10.1093\/nar\/gkv342","article-title":"I-TASSER server: new development for protein structure and function predictions","volume":"43","author":"Yang","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jare.2026.06.031_b0170","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat Methods"},{"issue":"4","key":"10.1016\/j.jare.2026.06.031_b0175","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1128\/AAC.00925-06","article-title":"Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides","volume":"51","author":"Chen","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"10.1016\/j.jare.2026.06.031_b0180","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/psc.2788","article-title":"Role of peptide self-assembly in antimicrobial peptides","volume":"21","author":"Tian","year":"2015","journal-title":"J Pept Sci"},{"issue":"3","key":"10.1016\/j.jare.2026.06.031_b0185","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1007\/s12602-018-9501-0","article-title":"Alanine scanning studies of the antimicrobial peptide Aurein 1.2","volume":"11","author":"Migo\u0144","year":"2019","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"25","key":"10.1016\/j.jare.2026.06.031_b0190","doi-asserted-by":"crossref","first-page":"13301","DOI":"10.1074\/jbc.M116.719575","article-title":"Role of aromatic amino acids in lipopolysaccharide and membrane interactions of antimicrobial peptides for use in plant disease control","volume":"291","author":"Datta","year":"2016","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.jare.2026.06.031_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23102722","article-title":"Design, synthesis, and evaluation of amphiphilic cyclic and linear peptides composed of hydrophobic and positively-charged amino acids as antibacterial agents","volume":"23","author":"Riahifard","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jare.2026.06.031_b0200","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ces.2013.02.063","article-title":"Biomolecular engineering of a human beta defensin model for increased salt resistance","volume":"95","author":"Li","year":"2013","journal-title":"Chem Eng Sci"},{"key":"10.1016\/j.jare.2026.06.031_b0205","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2014.10.013","article-title":"Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials","volume":"78","author":"Ong","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"issue":"15","key":"10.1016\/j.jare.2026.06.031_b0210","doi-asserted-by":"crossref","first-page":"11472","DOI":"10.1021\/acs.jmedchem.1c00795","article-title":"Rationally modified antimicrobial peptides from the N-terminal domain of human RNase 3 show exceptional serum stability","volume":"64","author":"Sand\u00edn","year":"2021","journal-title":"J Med Chem"},{"issue":"14","key":"10.1016\/j.jare.2026.06.031_b0215","doi-asserted-by":"crossref","first-page":"16062","DOI":"10.1021\/acsami.1c01643","article-title":"Structural disruptions of the outer membranes of gram-negative bacteria by rationally designed amphiphilic antimicrobial peptides","volume":"13","author":"Gong","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"issue":"11","key":"10.1016\/j.jare.2026.06.031_b0220","doi-asserted-by":"crossref","first-page":"16162","DOI":"10.1038\/nmicrobiol.2016.162","article-title":"Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers","volume":"1","author":"Lam","year":"2016","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.jare.2026.06.031_b0225","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/s41467-020-17736-x","article-title":"The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure","volume":"11","author":"Engelberg","year":"2020","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.jare.2026.06.031_b0230","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads3844","article-title":"Self-assembling peptide with dual function of cell penetration and antibacterial as a nano weapon to combat intracellular bacteria","volume":"11","author":"Zhu","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.jare.2026.06.031_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.105123","article-title":"Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria","volume":"141","author":"Zhong","year":"2020","journal-title":"Eur J Pharm Sci"},{"issue":"4","key":"10.1016\/j.jare.2026.06.031_b0240","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn0771","article-title":"Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci Adv"},{"issue":"8","key":"10.1016\/j.jare.2026.06.031_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/ph15080928","article-title":"Novel antimicrobial peptide \u201coctoprohibitin\u201d against multidrug resistant Acinetobacter baumannii","volume":"15","author":"Jayathilaka","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"issue":"4","key":"10.1016\/j.jare.2026.06.031_b0250","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0092-8674(02)00619-0","article-title":"Ribosome structure and the mechanism of translation","volume":"108","author":"Ramakrishnan","year":"2002","journal-title":"Cell"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226005151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226005151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:00:14Z","timestamp":1790110814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226005151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":50,"alternative-id":["S2090123226005151"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.06.031","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel \u03b2-hairpin amphiphiles utilizing tryptophan-interacting propensities exhibit multimodal antibacterial mechanism and promote wound healing in drug-resistant infections","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}