{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:48:04Z","timestamp":1794433684666,"version":"4.9.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014161","name":"Conseil R\u00e9gional Hauts-de-France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011045","name":"Minist\u00e8re de l'Enseignement sup\u00e9rieur, de la Recherche et de l'Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010095","name":"Hauts-de-France Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"La Ligue Contre Le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jare.2026.07.022","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:48:42Z","timestamp":1783529322000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["SpiderMass ambient mass spectrometry and multimodal machine learning enable ex vivo ovarian cancer typing and exploratory immunoscoring"],"prefix":"10.1016","author":[{"given":"L\u00e9a","family":"Ledoux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanis","family":"Zirem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4442-6642","authenticated-orcid":false,"given":"Laurine","family":"Lagache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Hudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Meresse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Delbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Leblanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves-Marie","family":"Robin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Pasquesoone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Narducci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-0817","authenticated-orcid":false,"given":"Michel","family":"Salzet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-5044","authenticated-orcid":false,"given":"Isabelle","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2026.07.022_b0005","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/cancers14020416","article-title":"The evolution of ovarian carcinoma subclassification","volume":"14","author":"Kobel","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.jare.2026.07.022_b0010","first-page":"280","article-title":"Epithelial ovarian cancer: evolution of management in the era of precision medicine","volume":"69","author":"Lheureux","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jare.2026.07.022_b0015","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3390\/ijms20040952","article-title":"High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints","volume":"20","author":"Lisio","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2026.07.022_b0020","first-page":"209","article-title":"Global cancer statistics 2020","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jare.2026.07.022_b0025","doi-asserted-by":"crossref","first-page":"676.e1","DOI":"10.1016\/j.ajog.2007.10.495","article-title":"Relationship among surgical complexity, short-term morbidity, and overall survival in primary surgery for advanced ovarian cancer","volume":"197","author":"Aletti","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jare.2026.07.022_b0030","article-title":"Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses","volume":"3","author":"Ratnavelu","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jare.2026.07.022_b0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ijgo.13878","article-title":"Cancer of the ovary, fallopian tube, and peritoneum: 2021 update","volume":"155","author":"Berek","year":"2021","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.jare.2026.07.022_b0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ygyno.2006.03.051","article-title":"What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma?","volume":"103","author":"Chi","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jare.2026.07.022_b0045","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/annonc\/mdz062","article-title":"ESMO-ESGO consensus conference recommendations on ovarian cancer","volume":"30","author":"Colombo","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jare.2026.07.022_b0050","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/cncr.24149","article-title":"Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer","volume":"115","author":"Du Bois","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.jare.2026.07.022_b0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejca.2009.10.017","article-title":"Prediction of 30-day morbidity after primary cytoreductive surgery for advanced stage ovarian cancer","volume":"46","author":"Gerestein","year":"2010","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jare.2026.07.022_b0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2013776118","article-title":"Macrophages inhibit and enhance endometriosis depending on their origin","volume":"118","author":"Hogg","year":"2021","journal-title":"PNAS"},{"key":"10.1016\/j.jare.2026.07.022_b0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/biolre\/ioaa219","article-title":"Macrophages: an indispensable piece of ovarian health","volume":"104","author":"Zhang","year":"2021","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jare.2026.07.022_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.102902","article-title":"Long-chain polyunsaturated lipids associated with responsiveness to anti-PD-1 therapy are colocalized with immune infiltrates in the tumor microenvironment","volume":"299","author":"King","year":"2023","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2026.07.022_b0075","doi-asserted-by":"crossref","first-page":"14383","DOI":"10.1021\/acs.analchem.1c01692","article-title":"Robot-assisted SpiderMass for in vivo real-time topography mass spectrometry imaging","volume":"93","author":"Ogrinc","year":"2021","journal-title":"Anal Chem"},{"key":"10.1016\/j.jare.2026.07.022_b0080","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ccell.2018.09.009","article-title":"Real-time molecular diagnosis of tumors using water-assisted laser desorption\/ionization mass spectrometry technology","volume":"34","author":"Saudemont","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jare.2026.07.022_b0085","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1158\/0008-5472.CAN-16-3044","article-title":"Metabolic markers and statistical prediction of serous ovarian cancer aggressiveness by ambient ionization mass spectrometry imaging","volume":"77","author":"Sans","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.jare.2026.07.022_b0090","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1373\/clinchem.2018.299289","article-title":"Performance of the MasSpec Pen for rapid diagnosis of ovarian cancer","volume":"65","author":"Sans","year":"2019","journal-title":"Clin Chem"},{"key":"10.1016\/j.jare.2026.07.022_b0095","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jare.2026.07.022_b0100","article-title":"Real-time glioblastoma tumor microenvironment assessment by SpiderMass for improved patient management","volume":"5","author":"Zirem","year":"2024","journal-title":"Cell Rep Med"},{"issue":"1","key":"10.1016\/j.jare.2026.07.022_b0105","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btaf644","article-title":"Profiler: an open web platform for multi-omics analysis","volume":"42","author":"Zirem","year":"2026","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jare.2026.07.022_b0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of fatty acid metabolism in cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jare.2026.07.022_b0115","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1002\/eji.201343433","article-title":"The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells","volume":"43","author":"Lankry","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jare.2026.07.022_b0120","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jprot.2010.02.010","article-title":"Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids","volume":"73","author":"Meriaux","year":"2010","journal-title":"J Proteomics"},{"key":"10.1016\/j.jare.2026.07.022_b0125","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1016\/j.bbamem.2016.07.014","article-title":"Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties","volume":"1858","author":"Putta","year":"2016","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.jare.2026.07.022_b0130","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.3390\/ijms23095266","article-title":"Bilayer-forming phospholipids as targets for cancer therapy","volume":"23","author":"Stoica","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2026.07.022_b0135","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/14756366.2020.1748025","article-title":"Lipidomic analysis of cancer cells cultivated at acidic pH reveals phospholipid fatty acid remodelling associated with transcriptional reprogramming","volume":"35","author":"Urbanelli","year":"2020","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.jare.2026.07.022_b0140","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.nutres.2015.01.001","article-title":"Glucosylceramide attenuates inflammatory mediator expression in lipopolysaccharide-stimulated RAW264.7 cells","volume":"35","author":"Yeom","year":"2015","journal-title":"Nutr Res"},{"key":"10.1016\/j.jare.2026.07.022_b0145","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41598-017-00341-2","article-title":"Quantitative profiling of glycerophospholipids during mouse and human macrophage differentiation using targeted mass spectrometry","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jare.2026.07.022_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103285","article-title":"Protocol to analyze 1D and 2D mass spectrometry data from glioblastoma tissues for cancer diagnosis and immune cell identification","volume":"5","author":"Zirem","year":"2024","journal-title":"STAR Protoc"},{"key":"10.1016\/j.jare.2026.07.022_b0155","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3389\/fonc.2019.01512","article-title":"Evaluating the polarization of tumor-associated macrophages into M1 and M2 phenotypes in human cancer tissue","volume":"9","author":"Jayasingam","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.jare.2026.07.022_b0160","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10555-006-9001-7","article-title":"Role of tumor-associated macrophages in tumor progression and invasion","volume":"25","author":"Mantovani","year":"2006","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.jare.2026.07.022_b0165","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1021\/pr0700044","article-title":"Tag-mass: specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tags","volume":"6","author":"Lemaire","year":"2007","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jare.2026.07.022_b0170","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1021\/jasms.0c00473","article-title":"Highly multiplexed immunohistochemical MALDI-MS imaging of biomarkers in tissues","volume":"32","author":"Yagnik","year":"2021","journal-title":"J Am Soc Mass Spectrom"},{"key":"10.1016\/j.jare.2026.07.022_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/ACCESS.2024.3375755","article-title":"LightGBM: a leading force in breast cancer diagnosis through machine learning and image processing","volume":"12","author":"Kanber","year":"2024","journal-title":"IEEE Access"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226005400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226005400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:09:41Z","timestamp":1786018181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226005400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"alternative-id":["S2090123226005400"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.07.022","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SpiderMass ambient mass spectrometry and multimodal machine learning enable ex vivo ovarian cancer typing and exploratory immunoscoring","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}