{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:29:26Z","timestamp":1794029366886,"version":"4.8.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jare.2026.07.036","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:46:31Z","timestamp":1784097991000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mental health, biological aging, and lifestyle mediate the associations between social determinants of health and dementia"],"prefix":"10.1016","author":[{"given":"Jie","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-5357","authenticated-orcid":false,"given":"Erin R.","family":"Kulick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoguang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-065X","authenticated-orcid":false,"given":"Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2026.07.036_b0005","unstructured":"Organization WH. Health topics: Social determinants of health. World Health Organization https:\/\/www who int\/health-topics\/social-determinants-of-health# tab= tab_1. 2022."},{"key":"10.1016\/j.jare.2026.07.036_b0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev-publhealth-090419-102529","article-title":"Understanding and responding to health literacy as a social determinant of health","volume":"42","author":"Nutbeam","year":"2021","journal-title":"Annu Rev Public Health"},{"key":"10.1016\/j.jare.2026.07.036_b0015","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/jnci\/djac137","article-title":"Addressing social determinants of health: now is the time","volume":"114","author":"Bona","year":"2022","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jare.2026.07.036_b0020","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.4827","article-title":"Social determinants of health and response to disease associated with health outcomes of American Indian and Alaska Native patients","volume":"5","author":"Christensen","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jare.2026.07.036_b0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41746-023-00970-0","article-title":"Large language models to identify social determinants of health in electronic health records","volume":"7","author":"Guevara","year":"2024","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.jare.2026.07.036_b0030","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1093\/jamia\/ocab194","article-title":"Documentation and review of social determinants of health data in the EHR: measures and associated insights","volume":"28","author":"Wang","year":"2021","journal-title":"J Am Med Inform Assoc"},{"key":"10.1016\/j.jare.2026.07.036_b0035","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2026.07.036_b0040","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the lancet commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2026.07.036_b0045","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2019.4782","article-title":"Diagnosis and management of dementia: review","volume":"322","author":"Arvanitakis","year":"2019","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jare.2026.07.036_b0050","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2026.07.036_b0055","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1212\/WNL.59.6.887","article-title":"Midlife income, occupation, APOE status, and dementia: a population-based study","volume":"59","author":"Anttila","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jare.2026.07.036_b0060","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1001\/jamapsychiatry.2018.1012","article-title":"Individual and area-based socioeconomic factors associated with dementia incidence in England: evidence from a 12-year follow-up in the english longitudinal study of ageing","volume":"75","author":"Cadar","year":"2018","journal-title":"JAMA Psychiat"},{"key":"10.1016\/j.jare.2026.07.036_b0065","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1007\/s11357-023-00994-0","article-title":"Socioeconomic status, lifestyle and risk of incident dementia: a prospective cohort study of 276730 participants","volume":"46","author":"Ou","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.jare.2026.07.036_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102831","article-title":"Associations of socioeconomic status and healthy lifestyle with incident dementia and cognitive decline: two prospective cohort studies","volume":"76","author":"Wang","year":"2024","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jare.2026.07.036_b0075","doi-asserted-by":"crossref","first-page":"e693","DOI":"10.1016\/S2666-7568(23)00211-8","article-title":"Associations of socioeconomic status and healthy lifestyle with incident early-onset and late-onset dementia: a prospective cohort study","volume":"4","author":"Li","year":"2023","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.jare.2026.07.036_b0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/13872877241283823","article-title":"Intersectionality of gender with social determinants of health and asymptomatic Alzheimer's disease neuropathology","volume":"102","author":"Besser","year":"2024","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jare.2026.07.036_b0085","doi-asserted-by":"crossref","DOI":"10.1177\/23337214231190244","article-title":"Social determinants of health in community-dwelling dementia patients aged 65 and over: analysis of the 2019 national health interview survey","volume":"9","author":"Li","year":"2023","journal-title":"Gerontol Geriatr Med"},{"key":"10.1016\/j.jare.2026.07.036_b0090","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1002\/alz.14041","article-title":"Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America","volume":"20","author":"Llibre-Guerra","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jare.2026.07.036_b0095","article-title":"Dementia risk and social determinants of health among adults racialized as black: a community-based system dynamics perspective","author":"Trani","year":"2024","journal-title":"J Racial Ethn Health Disparities"},{"key":"10.1016\/j.jare.2026.07.036_b0100","doi-asserted-by":"crossref","first-page":"e542","DOI":"10.1016\/S2666-7568(24)00116-8","article-title":"Associations of social determinants of health with life expectancy and future health risks among individuals with type 2 diabetes: two nationwide cohort studies in the UK and USA","volume":"5","author":"Zhong","year":"2024","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.jare.2026.07.036_b0105","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glae128","article-title":"Social environment, lifestyle, and genetic predisposition with dementia risk: a long-term longitudinal study among older adults","volume":"79","author":"Chen","year":"2024","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jare.2026.07.036_b0110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jad.2024.11.005","article-title":"Joint effect of polysocial risk score, lifestyle and genetic susceptibility with the risk of dementia: a prospective cohort study","volume":"370","author":"Yang","year":"2025","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jare.2026.07.036_b0115","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1001\/jama.2022.1816","article-title":"Causal directed acyclic graphs","volume":"327","author":"Lipsky","year":"2022","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jare.2026.07.036_b0120","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf4428","article-title":"Prospective study design and data analysis in UK Biobank","volume":"16","author":"Allen","year":"2024","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jare.2026.07.036_b0125","article-title":"Effects of taxes and benefits on UK household income: financial year ending 2017. Office for National","author":"Webber","year":"2018","journal-title":"Statistics"},{"key":"10.1016\/j.jare.2026.07.036_b0130","article-title":"Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: two prospective cohort studies","volume":"373","author":"Zhang","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jare.2026.07.036_b0135","doi-asserted-by":"crossref","first-page":"e422","DOI":"10.1016\/S2468-2667(23)00081-6","article-title":"Social determinants of health and premature death among adults in the USA from 1999 to 2018: a national cohort study","volume":"8","author":"Bundy","year":"2023","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jare.2026.07.036_b0140","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41398-024-02927-7","article-title":"Physical frailty, genetic predisposition, and incident dementia: a large prospective cohort study","volume":"14","author":"Gao","year":"2024","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jare.2026.07.036_b0145","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jad.2024.05.055","article-title":"Neuroticism personality, social contact, and dementia risk: a prospective cohort study","volume":"358","author":"Liu","year":"2024","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jare.2026.07.036_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107084","article-title":"Residential green and blue space associated with lower risk of adult-onset inflammatory bowel disease: findings from a large prospective cohort study","volume":"160","author":"Zhang","year":"2022","journal-title":"Environ Int"},{"key":"10.1016\/j.jare.2026.07.036_b0155","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/eurheartj\/ehz849","article-title":"Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants","volume":"41","author":"Fan","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jare.2026.07.036_b0160","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/jama.2019.9879","article-title":"Association of lifestyle and genetic risk with incidence of dementia","volume":"322","author":"Lourida","year":"2019","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jare.2026.07.036_b0165","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10654-019-00499-1","article-title":"Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data","volume":"34","author":"Wilkinson","year":"2019","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jare.2026.07.036_b0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/jnc.15988","article-title":"Associations of liver dysfunction with incident dementia, cognition, and brain structure: a prospective cohort study of 431 699 adults","volume":"168","author":"Gao","year":"2024","journal-title":"J Neurochem"},{"key":"10.1016\/j.jare.2026.07.036_b0175","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/wps.20546","article-title":"Accelerated biological aging in serious mental disorders","volume":"17","author":"Wolkowitz","year":"2018","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jare.2026.07.036_b0180","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/s44220-023-00119-8","article-title":"Personality traits and brain health: a large prospective cohort study","volume":"1","author":"Zhang","year":"2023","journal-title":"Nat Ment Health"},{"key":"10.1016\/j.jare.2026.07.036_b0185","article-title":"Associations between physical multimorbidity patterns and common mental health disorders in middle-aged adults: a prospective analysis using data from the UK Biobank","volume":"8","author":"Ronaldson","year":"2021","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.jare.2026.07.036_b0190","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.52824","article-title":"Improvement of social isolation and loneliness and excess mortality risk in people with obesity","volume":"7","author":"Zhou","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jare.2026.07.036_b0195","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12916-022-02490-2","article-title":"Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank","volume":"20","author":"Jiang","year":"2022","journal-title":"BMC Med"},{"key":"10.1016\/j.jare.2026.07.036_b0200","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/s41467-023-38013-7","article-title":"Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants","volume":"14","author":"Gao","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.07.036_b0205","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.ado0431","article-title":"Human telomere length is chromosome end-specific and conserved across individuals","volume":"384","author":"Karimian","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.jare.2026.07.036_b0210","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jare.2026.07.036_b0215","doi-asserted-by":"crossref","first-page":"e576","DOI":"10.1016\/S2468-2667(18)30200-7","article-title":"The effect of socioeconomic deprivation on the association between an extended measurement of unhealthy lifestyle factors and health outcomes: a prospective analysis of the UK Biobank cohort","volume":"3","author":"Foster","year":"2018","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jare.2026.07.036_b0220","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/jama.2023.10875","article-title":"Accelerometer-derived \u201cweekend warrior\u201d physical activity and incident cardiovascular disease","volume":"330","author":"Khurshid","year":"2023","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jare.2026.07.036_b0225","article-title":"Plasma metabolomic signature of healthy lifestyle, structural brain reserve and risk of dementia","author":"Tian","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.jare.2026.07.036_b0230","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/s41380-022-01446-5","article-title":"Peripheral immunity is associated with the risk of incident dementia","volume":"27","author":"Zhang","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jare.2026.07.036_b0235","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/biostatistics\/kxr047","article-title":"A measure of explained risk in the proportional hazards model","volume":"13","author":"Heller","year":"2012","journal-title":"Biostatistics"},{"key":"10.1016\/j.jare.2026.07.036_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101335","article-title":"Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: a retrospective cohort study","volume":"45","author":"Shang","year":"2022","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jare.2026.07.036_b0245","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1097\/EDE.0000000000001378","article-title":"CMAverse: a suite of functions for reproducible causal mediation analyses","volume":"32","author":"Shi","year":"2021","journal-title":"Epidemiology"},{"key":"10.1016\/j.jare.2026.07.036_b0250","article-title":"Life expectancy difference and life expectancy ratio: two measures of treatment effects in randomised trials with non-proportional hazards","volume":"357","author":"Dehbi","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.jare.2026.07.036_b0255","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1002\/sim.3064","article-title":"Flexible parametric models for relative survival, with application in coronary heart disease","volume":"26","author":"Nelson","year":"2007","journal-title":"Stat Med"},{"key":"10.1016\/j.jare.2026.07.036_b0260","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/joim.12987","article-title":"Leisure-time physical activity and life expectancy in people with cardiometabolic multimorbidity and depression","volume":"287","author":"Chudasama","year":"2020","journal-title":"J Intern Med"},{"key":"10.1016\/j.jare.2026.07.036_b0265","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13195-024-01592-8","article-title":"Association of psychosocial state with subsequent risk of dementia: a prospective cohort study based on the UK Biobank","volume":"16","author":"Wang","year":"2024","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.jare.2026.07.036_b0270","article-title":"Package \u2018MatchIt\u2019","author":"Ho","year":"2018","journal-title":"Version[Google Scholar]"},{"key":"10.1016\/j.jare.2026.07.036_b0275","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJMoa1215740","article-title":"Glucose levels and risk of dementia","volume":"369","author":"Crane","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jare.2026.07.036_b0280","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1136\/jnnp-2019-321913","article-title":"Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials","volume":"91","author":"Yu","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jare.2026.07.036_b0285","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jare.2026.07.036_b0290","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-068005","article-title":"Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study","volume":"376","author":"Ben Hassen","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.jare.2026.07.036_b0295","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-068390","article-title":"Healthy lifestyle and life expectancy with and without Alzheimer's dementia: population based cohort study","volume":"377","author":"Dhana","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.jare.2026.07.036_b0300","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13195-024-01396-w","article-title":"Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study","volume":"16","author":"Li","year":"2024","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.jare.2026.07.036_b0305","doi-asserted-by":"crossref","first-page":"12965","DOI":"10.1038\/s41598-022-16771-6","article-title":"Social determinants and lifestyle factors for brain health: implications for risk reduction of cognitive decline and dementia","volume":"12","author":"Rohr","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2026.07.036_b0310","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.clinthera.2021.05.005","article-title":"Effect of social determinants of health on cognition and risk of Alzheimer disease and related dementias","volume":"43","author":"Majoka","year":"2021","journal-title":"Clin Ther"},{"issue":"Suppl","key":"10.1016\/j.jare.2026.07.036_b0315","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1177\/0022146510383498","article-title":"Social conditions as fundamental causes of health inequalities: theory, evidence, and policy implications","volume":"51","author":"Phelan","year":"2010","journal-title":"J Health Soc Behav"},{"issue":"Suppl 2","key":"10.1016\/j.jare.2026.07.036_b0320","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/00333549141291S206","article-title":"The social determinants of health: it's time to consider the causes of the causes","volume":"129","author":"Braveman","year":"2014","journal-title":"Public Health Rep"},{"key":"10.1016\/j.jare.2026.07.036_b0325","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1016\/S2468-2667(20)30284-X","article-title":"Cognitive and social activities and long-term dementia risk: the prospective UK Million Women Study","volume":"6","author":"Floud","year":"2021","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jare.2026.07.036_b0330","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158453","article-title":"Biological aging processes underlying cognitive decline and neurodegenerative disease","volume":"132","author":"Gonzales","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2026.07.036_b0335","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.biopsych.2023.10.008","article-title":"Depression in Alzheimer's disease: epidemiology, mechanisms, and treatment","volume":"95","author":"Huang","year":"2024","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jare.2026.07.036_b0340","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1192\/bjp.bp.105.020040","article-title":"Depression and socio-economic risk factors: 7-year longitudinal population study","volume":"190","author":"Lorant","year":"2007","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jare.2026.07.036_b0345","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.cpr.2011.01.005","article-title":"Social support and social negativity findings in depression: perceived responsiveness to basic psychological needs","volume":"31","author":"Ibarra-Rovillard","year":"2011","journal-title":"Clin Psychol Rev"},{"key":"10.1016\/j.jare.2026.07.036_b0350","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.38453","article-title":"Mindfulness meditation vs escitalopram for treatment of anxiety disorders: secondary analysis of a randomized clinical trial","volume":"7","author":"Hu","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jare.2026.07.036_b0355","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.psych.58.110405.085542","article-title":"Mediation analysis","volume":"58","author":"MacKinnon","year":"2007","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.jare.2026.07.036_b0360","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1023\/A:1026595011371","article-title":"Equivalence of the mediation, confounding and suppression effect","volume":"1","author":"MacKinnon","year":"2000","journal-title":"Prev Sci"},{"key":"10.1016\/j.jare.2026.07.036_b0365","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(21)02085-7","article-title":"Brain health and its social determinants","volume":"398","author":"The","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2026.07.036_b0370","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jare.2026.07.036_b0375","article-title":"Using street view imagery to examine the association between urban neighborhood disorder and the long-term recurrence risk of patients discharged with acute myocardial infarction in central Beijing","volume":"138","author":"Zhang","year":"2023","journal-title":"China Cities"},{"key":"10.1016\/j.jare.2026.07.036_b0380","article-title":"Artificial intelligence, ChatGPT, and other large language models for social determinants of health: current state and future directions","volume":"5","author":"Ong","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jare.2026.07.036_b0385","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.annepidem.2007.03.001","article-title":"Integrating social and biologic factors in health research: a systems view","volume":"17","author":"Diez Roux","year":"2007","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.jare.2026.07.036_b0390","article-title":"Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: prospective cohort study and individual participant meta-analysis","volume":"368","author":"Batty","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jare.2026.07.036_b0395","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41398-020-0839-1","article-title":"Depression-an underrecognized target for prevention of dementia in Alzheimer's disease","volume":"10","author":"Dafsari","year":"2020","journal-title":"Transl Psychiatry"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226005813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226005813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:27:19Z","timestamp":1784924839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226005813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":79,"alternative-id":["S2090123226005813"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.07.036","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mental health, biological aging, and lifestyle mediate the associations between social determinants of health and dementia","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.07.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}