{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:57:57Z","timestamp":1792706277397,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22377056"],"award-info":[{"award-number":["22377056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401077"],"award-info":[{"award-number":["82401077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201063"],"award-info":[{"award-number":["82201063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571107"],"award-info":[{"award-number":["82571107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019334","name":"Key Project of Science and Technology Development of Nanjing Medicine","doi-asserted-by":"publisher","award":["ZKX24058"],"award-info":[{"award-number":["ZKX24058"]}],"id":[{"id":"10.13039\/501100019334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["ZD2022025"],"award-info":[{"award-number":["ZD2022025"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20240266"],"award-info":[{"award-number":["BK20240266"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20240268"],"award-info":[{"award-number":["BK20240268"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jare.2026.08.001","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T22:25:42Z","timestamp":1786227942000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resolvin D1 alleviates periodontitis by promoting FPR2-dependent macrophage pro-resolving polarization and efferocytosis"],"prefix":"10.1016","author":[{"given":"Xuan-Xuan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yao","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Yang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Yan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Lun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2488-814X","authenticated-orcid":false,"given":"Zi-Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge-Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-3982","authenticated-orcid":false,"given":"Huang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-8762","authenticated-orcid":false,"given":"Jie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jare.2026.08.001_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061414","article-title":"Periodontal disease: a risk factor for diabetes and cardiovascular disease","volume":"20","author":"Liccardo","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jare.2026.08.001_b0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12297","article-title":"The role of inflammation and genetics in periodontal disease","volume":"83","author":"Loos","year":"2020","journal-title":"Periodontol"},{"issue":"7203","key":"10.1016\/j.jare.2026.08.001_b0015","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jare.2026.08.001_b0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5009\/gnl240247","article-title":"Risk of lower gastrointestinal bleeding in nonsteroidal anti-inflammatory drug (NSAID) and proton pump inhibitor users compared with NSAID-only users: a common data model analysis","volume":"19","author":"Lee","year":"2025","journal-title":"Gut Liver"},{"key":"10.1016\/j.jare.2026.08.001_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177808","article-title":"The overlooked complexity of resolution: specialized pro-resolving mediators in focus","volume":"1002","author":"Jha","year":"2025","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"10.1016\/j.jare.2026.08.001_b0030","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","article-title":"The clearance of dead cells by efferocytosis","volume":"21","author":"Boada-Romero","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.jare.2026.08.001_b0035","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tips.2025.04.001","article-title":"Efferocytosis in inflammatory bone disorders","volume":"46","author":"Wen","year":"2025","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jare.2026.08.001_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763334","article-title":"Polarized macrophages in periodontitis: characteristics, function, and molecular signaling","volume":"12","author":"Sun","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jare.2026.08.001_b0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: facts, fallacies and the future","volume":"75","author":"Slots","year":"2000","journal-title":"Periodontol"},{"issue":"9","key":"10.1016\/j.jare.2026.08.001_b0050","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/jcpe.13841","article-title":"Inhibition of gingival fibroblast necroptosis mediated by RIPK3\/MLKL attenuates periodontitis","volume":"50","author":"Zhang","year":"2023","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jare.2026.08.001_b0055","article-title":"Identification of ferroptosis, necroptosis, and pyroptosis-associated genes in periodontitis-affected human periodontal tissue using integrated bioinformatic analysis","volume":"13","author":"Pan","year":"2022","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.jare.2026.08.001_b0060","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.ajpath.2012.01.028","article-title":"Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs","volume":"180","author":"Krishnamoorthy","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jare.2026.08.001_b0065","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.biomaterials.2015.02.120","article-title":"Development of an immunomodulatory biomaterial: using resolvin D1 to modulate inflammation","volume":"53","author":"Vasconcelos","year":"2015","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.jare.2026.08.001_b0070","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1096\/fj.201700082R","article-title":"Biosynthesis of proresolving lipid mediators by vascular cells and tissues","volume":"31","author":"Chatterjee","year":"2017","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.jare.2026.08.001_b0075","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2026.08.001_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105877","article-title":"RvD1 ameliorates LPS-induced acute lung injury via the suppression of neutrophil infiltration by reducing CXCL2 expression and release from resident alveolar macrophages","volume":"76","author":"Zhang","year":"2019","journal-title":"Int Immunopharmacol"},{"issue":"15","key":"10.1016\/j.jare.2026.08.001_b0085","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1016\/j.cell.2021.05.013","article-title":"Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity","volume":"184","author":"Williams","year":"2021","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jare.2026.08.001_b0090","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/thno.65694","article-title":"Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"issue":"7","key":"10.1016\/j.jare.2026.08.001_b0095","article-title":"Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jare.2026.08.001_b0100","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/959471","article-title":"A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations","author":"Elburki","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jare.2026.08.001_b0105","first-page":"242","article-title":"Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-kappaB signaling pathway","volume":"23","author":"Yin","year":"2017","journal-title":"Mol Vis"},{"issue":"8","key":"10.1016\/j.jare.2026.08.001_b0110","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1182\/blood.V83.8.2294.2294","article-title":"Paracrine downregulation of Fc gamma RIII in human monocyte-derived macrophages induced by phagocytosis of nonopsonized particles","volume":"83","author":"Liao","year":"1994","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jare.2026.08.001_b0115","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1007\/s00784-022-04593-9","article-title":"The resolvin D1 levels before and after periodontal therapy in periodontitis patients","volume":"26","author":"Gokmenoglu","year":"2022","journal-title":"Clin Oral Investig"},{"issue":"2","key":"10.1016\/j.jare.2026.08.001_b0120","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41418-019-0370-1","article-title":"Resolvin D1 promotes the targeting and clearance of necroptotic cells","volume":"27","author":"Gerlach","year":"2020","journal-title":"Cell Death Differ"},{"issue":"2","key":"10.1016\/j.jare.2026.08.001_b0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MOL.0000000000000394","article-title":"The walking dead: macrophage inflammation and death in atherosclerosis","volume":"28","author":"Kavurma","year":"2017","journal-title":"Curr Opin Lipidol"},{"issue":"4","key":"10.1016\/j.jare.2026.08.001_b0130","doi-asserted-by":"crossref","first-page":"C776","DOI":"10.1152\/ajpcell.00145.2019","article-title":"Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT1R\/ROS\/p38 MAPK\/ADAM17 pathway","volume":"317","author":"Zhang","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"10.1016\/j.jare.2026.08.001_b0135","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1007\/s10753-018-0864-x","article-title":"Antibody cross-linking of CD14 activates MerTK and promotes human macrophage clearance of apoptotic neutrophils: the dual role of CD14 at the crossroads between M1 and M2c polarization","volume":"41","author":"Zizzo","year":"2018","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.jare.2026.08.001_b0140","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.numecd.2016.05.011","article-title":"Inhibition of transglutaminase 2 reduces efferocytosis in human macrophages: Role of CD14 and SR-AI receptors","volume":"26","author":"Eligini","year":"2016","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"23","key":"10.1016\/j.jare.2026.08.001_b0145","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1073\/pnas.1524292113","article-title":"MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation","volume":"113","author":"Cai","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.jare.2026.08.001_b0150","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/sj.cdd.4401168","article-title":"CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidylserine","volume":"10","author":"Devitt","year":"2003","journal-title":"Cell Death Differ"},{"issue":"2","key":"10.1016\/j.jare.2026.08.001_b0155","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/BJ20110327","article-title":"Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution","volume":"437","author":"Fredman","year":"2011","journal-title":"Biochem J"},{"issue":"11","key":"10.1016\/j.jare.2026.08.001_b0160","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201114R","article-title":"Resolution of inflammation via RvD1\/FPR2 signaling mitigates Nox2 activation and ferroptosis of macrophages in experimental abdominal aortic aneurysms","volume":"36","author":"Filiberto","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.jare.2026.08.001_b0165","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jss.2020.06.062","article-title":"Maresin1 promotes M2 macrophage polarization through peroxisome proliferator-activated receptor-gamma activation to expedite resolution of acute lung injury","volume":"256","author":"Qiao","year":"2020","journal-title":"J Surg Res"},{"issue":"9 Pt A","key":"10.1016\/j.jare.2026.08.001_b0170","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bbalip.2016.06.002","article-title":"Resolvin D1 protects the liver from ischemia\/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis","volume":"1861","author":"Kang","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"10.1016\/j.jare.2026.08.001_b0175","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.cmet.2021.10.015","article-title":"Efferocytosis induces macrophage proliferation to help resolve tissue injury","volume":"33","author":"Gerlach","year":"2021","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.jare.2026.08.001_b0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/imr.13214","article-title":"The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation","volume":"319","author":"Schilperoort","year":"2023","journal-title":"Immunol Rev"},{"issue":"5","key":"10.1016\/j.jare.2026.08.001_b0185","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/jcb.22351","article-title":"Neutrophil apoptosis: a target for enhancing the resolution of inflammation","volume":"108","author":"Filep","year":"2009","journal-title":"J Cell Biochem"},{"issue":"11","key":"10.1016\/j.jare.2026.08.001_b0190","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400656R","article-title":"LL37\/FPR2 regulates neutrophil mPTP promoting the development of neutrophil extracellular traps in diabetic retinopathy","volume":"38","author":"Lou","year":"2024","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.jare.2026.08.001_b0195","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41565-024-01687-1","article-title":"Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment","volume":"19","author":"He","year":"2024","journal-title":"Nat Nanotechnol"},{"issue":"6","key":"10.1016\/j.jare.2026.08.001_b0200","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.4049\/jimmunol.1502268","article-title":"Resolvin D3 Is dysregulated in arthritis and reduces arthritic inflammation","volume":"197","author":"Arnardottir","year":"2016","journal-title":"J Immunol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226006107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226006107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:07:28Z","timestamp":1786565248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226006107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"alternative-id":["S2090123226006107"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.08.001","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resolvin D1 alleviates periodontitis by promoting FPR2-dependent macrophage pro-resolving polarization and efferocytosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}