{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:46:04Z","timestamp":1792532764977,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370584"],"award-info":[{"award-number":["32370584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY24H260002"],"award-info":[{"award-number":["LY24H260002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jare.2026.09.005","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:33:28Z","timestamp":1788503608000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low-dose PFNA exposure exacerbates intestinal inflammation via caspase-11-dependent noncanonical NLRP3 inflammasome activation in macrophages"],"prefix":"10.1016","author":[{"given":"Kean","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2026.09.005_b0005","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/humupd\/dmaa018","article-title":"Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary","volume":"26","author":"Ding","year":"2020","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jare.2026.09.005_b0010","first-page":"111","article-title":"Isomer profiling of perfluorinated substances as a tool for source tracking: a review of early findings and future applications","volume":"208","author":"Benskin","year":"2010","journal-title":"Rev Environ Contam Toxicol"},{"key":"10.1016\/j.jare.2026.09.005_b0015","doi-asserted-by":"crossref","first-page":"6616","DOI":"10.1021\/acs.est.3c09746","article-title":"PFAS contamination in europe: generating knowledge and mapping known and likely contamination with \u201cexpert-reviewed\u201d journalism","volume":"58","author":"Cordner","year":"2024","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.09.005_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2025.124143","article-title":"Distribution, partitioning behaviors, and source identification of legacy and emerging per- and polyfluorinated alkyl substances in the Pearl River Estuary, South China","volume":"285","author":"Tang","year":"2025","journal-title":"Water Res"},{"key":"10.1016\/j.jare.2026.09.005_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.122979","article-title":"Occurrence, bioaccumulation and trophodynamics of per- and polyfluoroalkyl substances (PFAS) in terrestrial and marine ecosystems of Svalbard, Arctic","volume":"271","author":"Dai","year":"2025","journal-title":"Water Res"},{"key":"10.1016\/j.jare.2026.09.005_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109590","article-title":"Novel and legacy per- and polyfluoroalkyl substances in humans: long-term temporal variability and metabolic perturbations","volume":"201","author":"Chang","year":"2025","journal-title":"Environ Int"},{"key":"10.1016\/j.jare.2026.09.005_b0035","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41370-023-00593-3","article-title":"Biomonitoring of perfluoroalkyl and polyfluoroalkyl substances (PFAS) from the Survey of the Health of Wisconsin (SHOW) 2014\u20132016 and comparison with the National Health and Nutrition Examination Survey (NHANES)","volume":"33","author":"Schultz","year":"2023","journal-title":"J Eposure Sci Environ Epidemiol"},{"key":"10.1016\/j.jare.2026.09.005_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108850","article-title":"Quantifying levels of per- and polyfluoroalkyl Substances (PFAS) in water and serum after contamination from agricultural biosolid application","volume":"190","author":"Criswell","year":"2024","journal-title":"Environ Int"},{"key":"10.1016\/j.jare.2026.09.005_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108743","article-title":"A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid","volume":"179","author":"Girardi","year":"2019","journal-title":"Environ Res"},{"key":"10.1016\/j.jare.2026.09.005_b0050","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41575-022-00593-y","article-title":"Multiomics to elucidate inflammatory bowel disease risk factors and pathways","volume":"19","author":"Agrawal","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.09.005_b0055","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global evolution of inflammatory bowel disease across epidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.09.005_b0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrgastro.2017.136","article-title":"Environmental triggers in IBD: a review of progress and evidence","volume":"15","author":"Ananthakrishnan","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.09.005_b0065","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S2468-1253(22)00337-5","article-title":"Genomic diagnosis and care co-ordination for monogenic inflammatory bowel disease in children and adults: consensus guideline on behalf of the British Society of Gastroenterology and British Society of Paediatric Gastroenterology, Hepatology and Nutrition","volume":"8","author":"Kammermeier","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.09.005_b0070","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.cgh.2023.12.020","article-title":"Per- and poly-fluoroalkyl substances exposure is associated with later occurrence of inflammatory bowel disease","volume":"22","author":"Agrawal","year":"2024","journal-title":"Clinical Gastroenterology and Hepatology: the Official Clinical Practice J American Gastroenterological Association"},{"key":"10.1016\/j.jare.2026.09.005_b0075","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1289\/ehp.1206449","article-title":"Ulcerative colitis and perfluorooctanoic acid (PFOA) in a highly exposed population of community residents and workers in the mid-Ohio valley","volume":"121","author":"Steenland","year":"2013","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jare.2026.09.005_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176858","article-title":"Unraveling the long-term gastrointestinal impact of perinatal perfluorobutane sulfonate exposure on rat offspring: intestinal barrier dysfunction and Th17\/Treg imbalance","volume":"955","author":"Liu","year":"2024","journal-title":"Sci Total Environ"},{"issue":"2023","key":"10.1016\/j.jare.2026.09.005_b0085","article-title":"Early life exposure to low-dose perfluorooctane sulfonate disturbs gut barrier homeostasis and increases the risk of intestinal inflammation in offspring","volume":"329","author":"Liu","year":"1987","journal-title":"EnvironPollution (Barking Essex)"},{"key":"10.1016\/j.jare.2026.09.005_b0090","doi-asserted-by":"crossref","first-page":"11912","DOI":"10.1021\/acs.est.4c01511","article-title":"Insights into the enhanced bioavailability of per- and polyfluoroalkyl substances in food caused by chronic inflammatory bowel disease","volume":"58","author":"Zhu","year":"2024","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.09.005_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138378","article-title":"Per- and polyfluoroalkyl substances mixture impairs intestinal barrier function through microbiota-derived 21-deoxycortisol and cortisol metabolism dysregulation","volume":"494","author":"Lin","year":"2025","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2026.09.005_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135611","article-title":"Neurotoxicity and intestinal microbiota dysbiosis induced by per- and polyfluoroalkyl substances in crucian carp (Carassius auratus)","volume":"478","author":"Zhao","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2026.09.005_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127950","article-title":"Comparative chronic toxicities of PFOS and its novel alternatives on the immune system associated with intestinal microbiota dysbiosis in adult zebrafish","volume":"425","author":"Huang","year":"2022","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2026.09.005_b0110","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41575-023-00769-0","article-title":"Macrophages in intestinal homeostasis and inflammatory bowel disease","volume":"20","author":"Hegarty","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.09.005_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176786","article-title":"Environmentally relevant level of PFDA exacerbates intestinal inflammation by activating the cGAS\/STING\/NF-\u03baB signaling pathway","volume":"954","author":"Cui","year":"2024","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jare.2026.09.005_b0120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41577-024-01075-9","article-title":"Inflammasome components as new therapeutic targets in inflammatory disease","volume":"25","author":"Coll","year":"2025","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2026.09.005_b0125","article-title":"Molecular mechanisms underlying NLRP3 inflammasome activation and IL-1\u03b2 production in air pollution fine particulate matter (PM(2.5))-primed macrophages","volume":"341","author":"Caceres","year":"2024","journal-title":"EnvironPollution (Barking, Essex : 1987)"},{"key":"10.1016\/j.jare.2026.09.005_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117181","article-title":"Hexavalent chromium exposure induces lung injury via activation of NLRP3 and AIM2 inflammasomes in rats","volume":"286","author":"Li","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jare.2026.09.005_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117504","article-title":"NLRP3 inflammasome activation and disruption of IRS-1\/PI3K\/AKT signaling: potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats","volume":"289","author":"Liu","year":"2025","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jare.2026.09.005_b0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cytogfr.2021.03.003","article-title":"Biological functions of NLRP3 inflammasome: a therapeutic target in inflammatory bowel disease","volume":"60","author":"Song","year":"2021","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jare.2026.09.005_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105710","article-title":"Phytochemical inhibitors of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"170","author":"\u00d6zenver","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jare.2026.09.005_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104921","article-title":"Curcumin: an inflammasome silencer","volume":"159","author":"Hasanzadeh","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jare.2026.09.005_b0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.taap.2018.12.019","article-title":"Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination","volume":"365","author":"Chen","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jare.2026.09.005_b0160","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/jphp.13197","article-title":"Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis","volume":"72","author":"Qu","year":"2020","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jare.2026.09.005_b0165","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.biopha.2017.11.018","article-title":"Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammation and inflammation-driven tumorigenesis in mice","volume":"97","author":"Zhang","year":"2018","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.jare.2026.09.005_b0170","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s41423-020-0444-5","article-title":"Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y(12) signaling pathway","volume":"18","author":"Huang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jare.2026.09.005_b0175","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.immuni.2024.10.012","article-title":"Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation","volume":"58","author":"Saller","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.jare.2026.09.005_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131288","article-title":"Low-dose BPA and its substitute BPS promote ovarian cancer cell stemness via a non-canonical PINK1\/p53 mitophagic signaling","volume":"452","author":"Yuan","year":"2023","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2026.09.005_b0185","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.jare.2026.09.005_b0190","article-title":"Surface hydrophobicity and rigidity determines protein corona on orally delivered nanoparticles treating colitis","volume":"17","author":"Wu","year":"2026","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.09.005_b0195","doi-asserted-by":"crossref","first-page":"0345","DOI":"10.34133\/bmr.0345","article-title":"Autotaxin-scavenging nanoliposomes for prolonged colon retention and autophagy-mediated mucosal immune restoration in colitis","volume":"30","author":"Jeon","year":"2026","journal-title":"Biomater Res"},{"key":"10.1016\/j.jare.2026.09.005_b0200","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adl2184","article-title":"Vagal stimulation ameliorates murine colitis by regulating SUMOylation","volume":"16","author":"Youssef","year":"2024","journal-title":"Sci Translational Medicine"},{"key":"10.1016\/j.jare.2026.09.005_b0205","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1021\/acs.est.4c07971","article-title":"Arginine metabolism reprogramming in perfluorooctanoic acid (PFOA)-induced liver injury","volume":"59","author":"Gao","year":"2025","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.09.005_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114314","article-title":"Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice","volume":"248","author":"Blake","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jare.2026.09.005_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11030281","article-title":"Gut microbiome-host metabolome homeostasis upon exposure to PFOS and GenX in male mice","volume":"11","author":"Rashid","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.jare.2026.09.005_b0220","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1038\/s41467-024-48128-0","article-title":"Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis","volume":"15","author":"Heavey","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2026.09.005_b0225","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00204-018-2365-y","article-title":"Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model","volume":"93","author":"Kim","year":"2019","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jare.2026.09.005_b0230","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic and Clinical Pharmacy"},{"key":"10.1016\/j.jare.2026.09.005_b0235","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3892\/mmr.2012.1225","article-title":"Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis","volume":"7","author":"Zhao","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jare.2026.09.005_b0240","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41577-024-00995-w","article-title":"Mechanistic insights from inflammasome structures","volume":"24","author":"Fu","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jare.2026.09.005_b0245","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.jom.0000233380.13087.37","article-title":"Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters","volume":"48","author":"Emmett","year":"2006","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.jare.2026.09.005_b0250","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1021\/es900228k","article-title":"Tracking the pathways of human exposure to perfluorocarboxylates","volume":"43","author":"Vestergren","year":"2009","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.09.005_b0255","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1081\/DCT-100101973","article-title":"Plasma cholecystokinin and hepatic enzymes, cholesterol and lipoproteins in ammonium perfluorooctanoate production workers","volume":"23","author":"Olsen","year":"2000","journal-title":"Drug Chem Toxicol"},{"key":"10.1016\/j.jare.2026.09.005_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114004","article-title":"A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis","volume":"43","author":"Wright","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.jare.2026.09.005_b0265","doi-asserted-by":"crossref","first-page":"9314","DOI":"10.1021\/acs.est.4c00686","article-title":"Time is ripe for targeting per- and polyfluoroalkyl substances-induced hormesis: global aquatic hotspots and implications for ecological risk assessment","volume":"58","author":"Sun","year":"2024","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.09.005_b0270","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/toxsci\/kfaa172","article-title":"An 'Omics approach to unraveling the paradoxical effect of diet on perfluorooctanesulfonic acid (PFOS) and perfluorononanoic acid (PFNA)-induced hepatic steatosis","volume":"180","author":"Pfohl","year":"2021","journal-title":"Toxicolo Sci: An Official J Society of Toxicol"},{"key":"10.1016\/j.jare.2026.09.005_b0275","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.aquatox.2016.03.026","article-title":"PFOS, PFNA, and PFOA sub-lethal exposure to embryonic zebrafish have different toxicity profiles in terms of morphometrics, behavior and gene expression","volume":"175","author":"Jantzen","year":"2016","journal-title":"Aquat Toxicol"},{"key":"10.1016\/j.jare.2026.09.005_b0280","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1021\/acschemneuro.4c00652","article-title":"Investigating the mechanism of neurotoxic effects of PFAS in differentiated neuronal cells through transcriptomics and lipidomics analysis","volume":"15","author":"Running","year":"2024","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.jare.2026.09.005_b0285","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jare.2026.09.005_b0290","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41564-025-02032-5","article-title":"Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances","volume":"10","author":"Lindell","year":"2025","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jare.2026.09.005_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135218","article-title":"Microplastic co-exposure elevates cadmium accumulation in mouse tissue after rice consumption: mechanisms and health implications","volume":"476","author":"Chen","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2026.09.005_b0300","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41586-021-03891-8","article-title":"Bioaccumulation of therapeutic drugs by human gut bacteria","volume":"597","author":"Kl\u00fcnemann","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.09.005_b0305","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/acs.est.2c05254","article-title":"Triclosan reprograms immunometabolism and activates the inflammasome in human macrophages","volume":"57","author":"Yuan","year":"2023","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.09.005_b0310","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41586-023-06742-w","article-title":"Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome","volume":"624","author":"Shi","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.09.005_b0315","article-title":"Myricetin: a review of the most recent research","volume":"134","author":"Song","year":"2021","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.jare.2026.09.005_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154858","article-title":"Myricetin possesses the potency against SARS-CoV-2 infection through blocking viral-entry facilitators and suppressing inflammation in rats and mice","volume":"116","author":"Pan","year":"2023","journal-title":"Phytomedicine: Int J Phytotherapy and Phytopharmacol"},{"key":"10.1016\/j.jare.2026.09.005_b0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210402","article-title":"Regulatory roles of flavonoids in caspase-11 non-canonical inflammasome-mediated inflammatory responses and diseases","volume":"24","author":"Yi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2026.09.005_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105244","article-title":"Multiple pathways of human exposure to poly- and perfluoroalkyl substances (PFASs): from external exposure to human blood","volume":"134","author":"Poothong","year":"2020","journal-title":"Environ Int"},{"key":"10.1016\/j.jare.2026.09.005_b0335","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acs.jafc.6b04683","article-title":"Per- and Polyfluoroalkyl substances (PFASs) in food and human dietary intake: a review of the recent scientific literature","volume":"65","author":"Domingo","year":"2017","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jare.2026.09.005_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106843","article-title":"Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury","volume":"157","author":"Roth","year":"2021","journal-title":"Environ Int"},{"key":"10.1016\/j.jare.2026.09.005_b0345","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2011.01.003","article-title":"Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse","volume":"281","author":"Tatum-Gibbs","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.jare.2026.09.005_b0350","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41577-020-0385-3","article-title":"Peritoneal sex differences","volume":"20","author":"Minton","year":"2020","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226007034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226007034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:22:13Z","timestamp":1789125733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226007034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":70,"alternative-id":["S2090123226007034"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.09.005","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-dose PFNA exposure exacerbates intestinal inflammation via caspase-11-dependent noncanonical NLRP3 inflammasome activation in macrophages","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}