{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:42:17Z","timestamp":1792233737788,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171606"],"award-info":[{"award-number":["82171606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012259","name":"Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province","doi-asserted-by":"publisher","award":["20243BCE51014"],"award-info":[{"award-number":["20243BCE51014"]}],"id":[{"id":"10.13039\/501100012259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jare.2026.10.013","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:53:27Z","timestamp":1791672807000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["HFPO homologue exposure impairs human sperm function via calcium dyshomeostasis and mitochondrial dysfunction"],"prefix":"10.1016","author":[{"given":"Meiling","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaoliao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2026.10.013_b0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chemosphere.2014.05.044","article-title":"Helsing\u00f8r statement on poly- and perfluorinated alkyl substances (PFASs)","volume":"114","author":"Scheringer","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.jare.2026.10.013_b0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.envint.2013.08.021","article-title":"Fluorinated alternatives to long-chain perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their potential precursors","volume":"60","author":"Wang","year":"2013","journal-title":"Environ Int"},{"key":"10.1016\/j.jare.2026.10.013_b0015","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.watres.2017.07.024","article-title":"Emerging poly- and perfluoroalkyl substances in the aquatic environment: a review of current literature","volume":"124","author":"Xiao","year":"2017","journal-title":"Water Res"},{"key":"10.1016\/j.jare.2026.10.013_b0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.envint.2014.11.013","article-title":"Hazard assessment of fluorinated alternatives to long-chain perfluoroalkyl acids (PFAAs) and their precursors: status quo, ongoing challenges and possible solutions","volume":"75","author":"Wang","year":"2015","journal-title":"Environ Int"},{"key":"10.1016\/j.jare.2026.10.013_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.339740","article-title":"How perfluoroalkyl substances modify fluorinated self-assembled monolayer architectures: an electrochemical and computational study","volume":"1204","author":"Moro","year":"2022","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.jare.2026.10.013_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138121","article-title":"Degradation of novel PFOA alternatives in fluoropolymer production by UV activated persulfate: efficiency, mechanism and structural effects","volume":"492","author":"Gu","year":"2025","journal-title":"J Hazard Mater"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0035","first-page":"12","article-title":"Socioeconomic and environmental prospects of the food industry","volume":"2","author":"Bushueva","year":"2024","journal-title":"Agricultural & Rural Studies"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0040","first-page":"23","article-title":"Integrated natural resource management and sustainable livelihoods: a review of ecosystem-based approaches for sustainability and community resilience","volume":"3","author":"Bera","year":"2025","journal-title":"Agricultural & Rural Studies"},{"key":"10.1016\/j.jare.2026.10.013_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106204","article-title":"Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat","volume":"146","author":"Conley","year":"2021","journal-title":"Environ Int"},{"issue":"1","key":"10.1016\/j.jare.2026.10.013_b0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/acs.est.4c10349","article-title":"Hexafluoropropylene oxide trimer acid is an unsafe substitute to perfluorooctanoic acid due to its remarkable liver accumulation in mice disclosed by comprehensive toxicokinetic models","volume":"59","author":"Zhu","year":"2025","journal-title":"Environ Sci Technol"},{"issue":"8","key":"10.1016\/j.jare.2026.10.013_b0055","doi-asserted-by":"crossref","first-page":"89002","DOI":"10.1289\/EHP7962","article-title":"Erratum: \u201cmeasurement of novel, drinking water-associated PFAS in blood from adults and children in wilmington, North Carolina\u201d","volume":"128","author":"Kotlarz","year":"2020","journal-title":"Environ Health Perspect"},{"issue":"17","key":"10.1016\/j.jare.2026.10.013_b0060","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1021\/acs.est.7b02259","article-title":"First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: an emerging concern","volume":"51","author":"Pan","year":"2017","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.10.013_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128376","article-title":"Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice","volume":"430","author":"Xie","year":"2022","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jare.2026.10.013_b0070","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jes.2023.05.009","article-title":"Hexafluoropropylene oxide trimer acid, a perfluorooctanoic acid alternative, induces cardiovascular toxicity in zebrafish embryos","volume":"139","author":"Sun","year":"2024","journal-title":"J Environ Sci (China)"},{"key":"10.1016\/j.jare.2026.10.013_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118112","article-title":"Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: roles of peroxisome proliferator activated receptor alpha","volume":"290","author":"Xu","year":"2021","journal-title":"Environmental pollution (Barking Essex: 1987)"},{"key":"10.1016\/j.jare.2026.10.013_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169330","article-title":"Prenatal exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts the maternal gut microbiome and fecal metabolome homeostasis","volume":"912","author":"Shi","year":"2024","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jare.2026.10.013_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157313","article-title":"Perfluorooctanoic acid alternatives hexafluoropropylene oxides exert male reproductive toxicity by disrupting blood-testis barrier","volume":"846","author":"Peng","year":"2022","journal-title":"Sci Total Environ"},{"issue":"11","key":"10.1016\/j.jare.2026.10.013_b0085","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1002\/etc.5732","article-title":"Different life-stage exposure to hexafluoropropylene oxide trimer acid induces reproductive toxicity in adult zebrafish (Danio rerio)","volume":"42","author":"Dong","year":"2023","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"10.1016\/j.jare.2026.10.013_b0095","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40104-025-01177-x","article-title":"Single-cell transcriptomics reveals the cellular dynamics of hexafluoropropylene oxide dimer acid in exerting mouse male reproductive toxicity","volume":"16","author":"Zang","year":"2025","journal-title":"J Anim Sci Biotechnol"},{"key":"10.1016\/j.jare.2026.10.013_b0100","article-title":"Exogenous oxidative stress in human spermatozoa induces opening of the mitochondrial permeability transition pore: effect on mitochondrial function, sperm motility and induction of cell death","volume":"13","author":"Bravo","year":"2024","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"11","key":"10.1016\/j.jare.2026.10.013_b0105","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00109-012-0914-z","article-title":"Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans","volume":"90","author":"Yu","year":"2012","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.jare.2026.10.013_b0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-physiol-020911-153258","article-title":"The control of male fertility by spermatozoan ion channels","volume":"74","author":"Lishko","year":"2012","journal-title":"Annu Rev Physiol"},{"issue":"4","key":"10.1016\/j.jare.2026.10.013_b0115","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100122R","article-title":"Starvation induces an increase in intracellular calcium and potentiates the progesterone-induced mouse sperm acrosome reaction","volume":"35","author":"S\u00e1nchez-C\u00e1rdenas","year":"2021","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0120","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/humrep\/dey377","article-title":"A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters","volume":"34","author":"Luo","year":"2019","journal-title":"Hum Reprod"},{"issue":"6856","key":"10.1016\/j.jare.2026.10.013_b0125","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35098027","article-title":"A sperm ion channel required for sperm motility and male fertility","volume":"413","author":"Ren","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jare.2026.10.013_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102176","article-title":"Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation","volume":"48","author":"Ferreira","year":"2021","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0356","article-title":"Mitochondrial dysfunction and oxidative stress caused by cryopreservation in reproductive cells","volume":"10","author":"Gualtieri","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jare.2026.10.013_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125074","article-title":"PFOA evokes extracellular Ca (2+) influx and compromises progesterone-induced response in human sperm","volume":"241","author":"Yuan","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jare.2026.10.013_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122698","article-title":"Perfluorooctanoic acid (PFOA) inhibits steroidogenesis and mitochondrial function in bovine granulosa cells in vitro","volume":"338","author":"Kabakci","year":"2023","journal-title":"Environmental pollution (Barking, Essex: 1987)"},{"issue":"8","key":"10.1016\/j.jare.2026.10.013_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13082201","article-title":"In-vitro effects of perfluorooctanoic acid on human sperm function what are the clinical consequences?","volume":"13","author":"Alamo","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.jare.2026.10.013_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118435","article-title":"HFPO homologues, the novel alternatives to PFOA, impair male reproduction in mice through inducing mitochondrial dysfunction","volume":"300","author":"Le","year":"2025","journal-title":"Ecotoxicol Environ Saf"},{"issue":"2","key":"10.1016\/j.jare.2026.10.013_b0160","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1527-3466.2005.tb00164.x","article-title":"Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396","volume":"23","author":"Li","year":"2005","journal-title":"Cardiovasc Drug Rev"},{"issue":"5","key":"10.1016\/j.jare.2026.10.013_b0165","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s40618-019-01152-0","article-title":"Perfluoro-octanoic acid impairs sperm motility through the alteration of plasma membrane","volume":"43","author":"\u0160abovi\u0107","year":"2020","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jare.2026.10.013_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131470","article-title":"Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice","volume":"454","author":"Xu","year":"2023","journal-title":"J Hazard Mater"},{"issue":"2","key":"10.1016\/j.jare.2026.10.013_b0175","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/humrep\/dew332","article-title":"Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa","volume":"32","author":"Zou","year":"2017","journal-title":"Hum Reprod"},{"issue":"7338","key":"10.1016\/j.jare.2026.10.013_b0180","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature09767","article-title":"Progesterone activates the principal Ca2+ channel of human sperm","volume":"471","author":"Lishko","year":"2011","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jare.2026.10.013_b0185","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1074\/jbc.M112.439356","article-title":"Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm","volume":"288","author":"Alasmari","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2026.10.013_b0190","article-title":"Human sperm as an in vitro model to assess the efficacy of antioxidant supplements during sperm handling: a narrative review","volume":"12","author":"Moretti","year":"2023","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.jare.2026.10.013_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114942","article-title":"Lack of association between endocrine disrupting chemicals and male fertility: a systematic review and meta-analysis","volume":"217","author":"Mart\u00ednez","year":"2023","journal-title":"Environ Res"},{"issue":"6","key":"10.1016\/j.jare.2026.10.013_b0200","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1289\/ehp.0800517","article-title":"Do perfluoroalkyl compounds impair human semen quality?","volume":"117","author":"Joensen","year":"2009","journal-title":"Environ Health Perspect"},{"issue":"4","key":"10.1016\/j.jare.2026.10.013_b0205","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1210\/jc.2018-01855","article-title":"Endocrine disruption of androgenic activity by perfluoroalkyl substances: clinical and experimental evidence","volume":"104","author":"Di Nisio","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.jare.2026.10.013_b0210","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10285","article-title":"Maternal exposure to per- and polyfluoroalkyl substances (PFAS) and male reproductive function in young adulthood: combined exposure to seven PFAS","volume":"130","author":"H\u00e6rvig","year":"2022","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jare.2026.10.013_b0215","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.envint.2018.01.010","article-title":"Biomonitoring PFAAs in blood and semen samples: investigation of a potential link between PFAAs exposure and semen mobility in China","volume":"113","author":"Song","year":"2018","journal-title":"Environ Int"},{"issue":"4","key":"10.1016\/j.jare.2026.10.013_b0220","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/j.1939-4640.1991.tb00258.x","article-title":"Relationship between sperm motility assessed with the Hamilton-Thorn motility analyzer and fertilization rates in vitro","volume":"12","author":"Liu","year":"1991","journal-title":"J Androl"},{"key":"10.1016\/j.jare.2026.10.013_b0225","article-title":"Toxic effects of per- and polyfluoroalkyl substances on sperm: epidemiological and experimental evidence","volume":"14","author":"Sun","year":"2023","journal-title":"Front Endocrinol"},{"issue":"21","key":"10.1016\/j.jare.2026.10.013_b0230","doi-asserted-by":"crossref","first-page":"13389","DOI":"10.1021\/acs.est.0c02888","article-title":"Novel perfluoroalkyl ether carboxylic acids (PFECAs) and sulfonic acids (PFESAs): occurrence and association with serum biochemical parameters in residents living near a fluorochemical plant in China","volume":"54","author":"Yao","year":"2020","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jare.2026.10.013_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108092","article-title":"Accumulation and glucocorticoid signaling suppression by four emerging perfluoroethercarboxylic acids based on animal exposure and cell testing","volume":"178","author":"Zhang","year":"2023","journal-title":"Environ Int"},{"issue":"4","key":"10.1016\/j.jare.2026.10.013_b0240","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1021\/acs.est.3c08033","article-title":"Kynurenic acid plays a protective role in hepatotoxicity induced by HFPO-DA in male mice","volume":"58","author":"Hu","year":"2024","journal-title":"Environ Sci Technol"},{"issue":"1","key":"10.1016\/j.jare.2026.10.013_b0245","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humrep\/dey335","article-title":"Mitochondrial functionality modifies human sperm acrosin activity, acrosome reaction capability and chromatin integrity","volume":"34","author":"Zhang","year":"2019","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0250","article-title":"Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia","volume":"69","author":"Nowicka-Bauer","year":"2018","journal-title":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society"},{"issue":"1","key":"10.1016\/j.jare.2026.10.013_b0255","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.jare.2026.10.013_b0260","doi-asserted-by":"crossref","DOI":"10.1111\/and.13581","article-title":"Oxidative stress in the pathophysiology of male infertility","volume":"53","author":"Ritchie","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.jare.2026.10.013_b0265","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.redox.2015.11.010","article-title":"Interplay between oxidant species and energy metabolism","volume":"8","author":"Quijano","year":"2016","journal-title":"Redox Biol"},{"key":"10.1016\/j.jare.2026.10.013_b0270","article-title":"An update on mitochondrial reactive oxygen species production","volume":"9","author":"Mailloux","year":"2020","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"5","key":"10.1016\/j.jare.2026.10.013_b0275","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.fertnstert.2006.03.055","article-title":"The functionality of mitochondria differentiates human spermatozoa with high and low fertilizing capability","volume":"86","author":"Gallon","year":"2006","journal-title":"Fertil Steril"},{"issue":"8 Pt 1","key":"10.1016\/j.jare.2026.10.013_b0280","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/clinchem\/44.8.1616","article-title":"Correlation of sperm motility with mitochondrial enzymatic activities","volume":"44","author":"Ruiz-Pesini","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.jare.2026.10.013_b0285","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.2741\/3105","article-title":"Ca2+ signalling in the control of motility and guidance in mammalian sperm","volume":"13","author":"Publicover","year":"2008","journal-title":"Front Biosci"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0290","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ncb0307-235","article-title":"[Ca2+]i signalling in sperm\u2013making the most of what you've got","volume":"9","author":"Publicover","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0295","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/molehr\/3.3.169","article-title":"Molecular mechanisms regulating human sperm function","volume":"3","author":"Aitken","year":"1997","journal-title":"Mol Hum Reprod"},{"issue":"3","key":"10.1016\/j.jare.2026.10.013_b0300","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/humupd\/dmi050","article-title":"Calcium signalling in human spermatozoa: a specialized 'toolkit' of channels, transporters and stores","volume":"12","author":"Jimenez-Gonzalez","year":"2006","journal-title":"Hum Reprod Update"},{"issue":"10","key":"10.1016\/j.jare.2026.10.013_b0305","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/humrep\/dey275","article-title":"Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals","volume":"33","author":"Brenker","year":"2018","journal-title":"Hum Reprod"},{"issue":"7","key":"10.1016\/j.jare.2026.10.013_b0310","doi-asserted-by":"crossref","first-page":"758","DOI":"10.15252\/embr.201438869","article-title":"Direct action of endocrine disrupting chemicals on human sperm","volume":"15","author":"Schiffer","year":"2014","journal-title":"EMBO Rep"},{"issue":"5","key":"10.1016\/j.jare.2026.10.013_b0315","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/humrep\/deac042","article-title":"Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism","volume":"37","author":"Rehfeld","year":"2022","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.jare.2026.10.013_b0320","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1530\/jrf.0.0230193","article-title":"The movement of golden hamster spermatozoa before and after capacitation","volume":"23","author":"Yanagimachi","year":"1970","journal-title":"J Reprod Fertil"},{"issue":"6","key":"10.1016\/j.jare.2026.10.013_b0325","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/and.12314","article-title":"Effect of mitochondrial calcium uniporter blocking on human spermatozoa","volume":"47","author":"Bravo","year":"2015","journal-title":"Andrologia"},{"key":"10.1016\/j.jare.2026.10.013_b0330","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1478-811X-9-19","article-title":"Calcium signaling around mitochondria associated membranes (MAMs)","volume":"9","author":"Patergnani","year":"2011","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jare.2026.10.013_b0335","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2010.05634.x","article-title":"Oxidative stress caused by mitochondrial calcium overload","volume":"1201","author":"Peng","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jare.2026.10.013_b0340","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","article-title":"Calcium and ROS: a mutual interplay","volume":"6","author":"G\u00f6rlach","year":"2015","journal-title":"Redox Biol"},{"issue":"4","key":"10.1016\/j.jare.2026.10.013_b0345","first-page":"H778","article-title":"PKC\u03b4 causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction","volume":"318","author":"Joseph","year":"2020","journal-title":"Am J Phys Heart Circ Phys"},{"key":"10.1016\/j.jare.2026.10.013_b0350","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41420-018-0034-9","article-title":"Mycobacterium fortuitum-induced ER-Mitochondrial calcium dynamics promotes calpain\/caspase-12\/caspase-9 mediated apoptosis in fish macrophages","volume":"4","author":"Datta","year":"2018","journal-title":"Cell Death Discovery"},{"key":"10.1016\/j.jare.2026.10.013_b0355","article-title":"Targeting mitochondrial oxidative stress as a strategy to treat aging and age-related diseases","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants (Basel, Switzerland)"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226007745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226007745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:52:32Z","timestamp":1792230752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226007745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":71,"alternative-id":["S2090123226007745"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.10.013","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HFPO homologue exposure impairs human sperm function via calcium dyshomeostasis and mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}