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\u03b2-elemene, and its derivatives in cancer therapy","volume":"13","author":"Zhai","year":"2018","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jare.2026.10.024_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122944","article-title":"PLGA nanoparticles loaded with curcumin produced luminescence for cell bioimaging","volume":"639","author":"Wang","year":"2023","journal-title":"Int J Pharm"},{"key":"10.1016\/j.jare.2026.10.024_b0410","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/abbs\/gmt063","article-title":"Superior anticancer efficacy of curcumin-loaded nanoparticles against lung cancer","volume":"45","author":"Yin","year":"2013","journal-title":"Acta Biochim Biophy Sin"},{"key":"10.1016\/j.jare.2026.10.024_b0415","first-page":"1651","article-title":"MPEG-g-CS-modified PLGA nanoparticle carrier for the codelivery of paclitaxel and epirubicin for breast cancer synergistic therapy","volume":"4","author":"Qin","year":"2018","journal-title":"ACS 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[Corrigendum]","volume":"14","author":"Zhang","year":"2019","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jare.2026.10.024_b0435","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1039\/D4TB02062F","article-title":"Progress in the treatment of Alzheimer's disease based on nanosized traditional chinese medicines","volume":"13","author":"Song","year":"2025","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.jare.2026.10.024_b0440","article-title":"Targeted chinese medicine delivery by a new family of biodegradable pseudo-protein nanoparticles for treating triple-negative breast cancer: in vitro and in vivo study","volume":"11","author":"Kwan","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.jare.2026.10.024_b0445","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ijbiomac.2017.02.030","article-title":"Enhanced apoptotic and anticancer potential of paclitaxel loaded biodegradable nanoparticles based on 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of metastatic breast cancer","volume":"7","author":"Liu","year":"2024","journal-title":"ACS Appl Nano Mater"},{"key":"10.1016\/j.jare.2026.10.024_b0485","first-page":"170","article-title":"Novel dual CAFs and tumour cell targeting pH and ROS dual sensitive micelles for targeting delivery of paclitaxel to liver cancer, Artif. 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